4.8 Article

Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

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NATURE CHEMICAL BIOLOGY
卷 13, 期 1, 页码 18-20

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NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.2228

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资金

  1. Medical Research Council Career Development Award [G1000526]
  2. Bank of Butterfield Foundation in Bermuda
  3. Lorraine University [UMR 7365]
  4. European Alternative Splicing Network of Excellence (EURASNET, FP6 life sciences, genomics and biotechnology for health) [LSHG-CT-2005-518238]
  5. CNRS
  6. Medical Research Council [G1000526] Funding Source: researchfish
  7. MRC [G1000526] Funding Source: UKRI

向作者/读者索取更多资源

RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.

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