期刊
NATURE CHEMICAL BIOLOGY
卷 12, 期 11, 页码 896-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.2168
关键词
-
资金
- DOE Office of Science by Argonne National Laboratory [DE-AC02-06CH11357]
The With-No-Lysine (K) (WNK) kinases play a critical role in blood pressure regulation and body fluid and electrolyte homeostasis. Herein, we introduce the first orally bioavailable pan-WNK-kinase inhibitor, WNK463, that exploits unique structural features of the WNK kinases for both affinity and kinase selectivity. In rodent models of hypertension, WNK463 affects blood pressure and body fluid and electrolyte homeostasis, consistent with WNK-kinase-associated physiology and pathophysiology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据