相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Fragment-to-Lead Medicinal Chemistry Publications in 2021
Louise Walsh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2023)
LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials
Beatrice Noce et al.
FRONTIERS IN PHARMACOLOGY (2023)
Lysine-Specific Demethylase 1 Promises to Be a Novel Target in Cancer Drug Resistance: Therapeutic Implications
Fei-Fei Yang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2023)
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses
Andreas Luttens et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)
Asciminib: a new therapeutic option in chronic-phase CML with treatment failure
David T. Yeung et al.
BLOOD (2022)
Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
Edward A. FitzGerald et al.
RSC ADVANCES (2021)
Establishing Trypanosoma cruzi farnesyl pyrophosphate synthase as a viable target for biosensor driven fragment-based lead discovery
Giulia Opassi et al.
PROTEIN SCIENCE (2020)
Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
Jie Yang et al.
ACS OMEGA (2020)
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate
Sang-Ah Kim et al.
MOLECULAR CELL (2020)
Fragment-Based Discovery of Non-bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase
Lena Munzker et al.
CHEMBIOCHEM (2020)
KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors
David S. Hong et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Major Kinds of Drug Targets in Chagas Disease or American Trypanosomiasis
Vilma G. Duschak
CURRENT DRUG TARGETS (2019)
Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration
Fred Yeboah et al.
NEUROBIOLOGY OF DISEASE (2019)
Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS)
Yuting Feng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells
Shuai Han et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Open for collaboration: an academic platform for drug discovery and development at SciLifeLab
Per I. Arvidsson et al.
DRUG DISCOVERY TODAY (2016)
Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library
Franziska U. Huschmann et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2016)
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor
W. D. Tap et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor
Radovan Spurny et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Applications of Biophysics in High-Throughput Screening Hit Validation
Christine Clougherty Genick et al.
JOURNAL OF BIOMOLECULAR SCREENING (2014)
The 'rule of three' for fragment-based drug discovery: where are we now?
Harren Jhoti et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Histaminergic pharmacology of homo-oligomeric β3 γ-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology
Christian Seeger et al.
BIOCHEMICAL PHARMACOLOGY (2012)
Quantification of interactions between drug leads and serum proteins by use of binding efficiency
Sofia S. Gustafsson et al.
ANALYTICAL BIOCHEMISTRY (2011)
Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments
Peter Brandt et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Experimental Validation of a Fragment Library for Lead Discovery Using SPR Biosensor Technology
Malin Elinder et al.
JOURNAL OF BIOMOLECULAR SCREENING (2011)
Interaction Kinetic and Structural Dynamic Analysis of Ligand Binding to Acetylcholine-Binding Protein
Matthis Geitmann et al.
BIOCHEMISTRY (2010)
Fragment Library Screening and Lead Characterization Using SPR Biosensors
U. Helena Danielson
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2009)
Identification of MMP-12 inhibitors by using biosensor-based screening of a fragment library
Helena Nordstrom et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
James Tsai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures
PHN Celie et al.
NEURON (2004)
Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
YJ Shi et al.
CELL (2004)
Molecular shape diversity of combinatorial libraries: A prerequisite for broad bioactivity
WHB Sauer et al.
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES (2003)