期刊
NATURE CHEMICAL BIOLOGY
卷 12, 期 10, 页码 770-+出版社
NATURE PORTFOLIO
DOI: 10.1038/nchembio.2144
关键词
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资金
- NIH Office of Research Infrastructure Programs [P40 OD010440]
- NemaGENETAG consortium
- NIH [GM118775]
- NSF [1555050]
- Ellison Medical Foundation [AG-NS-0963-12]
- Alfred P. Sloan Foundation [BR2014-071]
- National High Magnetic Field Laboratory
- NSF Cooperative [DMR-1157490]
- State of Florida
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1555050] Funding Source: National Science Foundation
Polyketides and nonribosomal peptides are two important types of natural products that are produced by many species of bacteria and fungi but are exceedingly rare in metazoans. Here, we elucidate the structure of a hybrid polyketide-nonribosomal peptide from Caenorhabditis elegans that is produced in the canal-associated neurons (CANs) and promotes survival during starvation-induced larval arrest. Our results uncover a novel mechanism by which animals respond to nutrient fluctuations to extend survival.
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