Cardiorespiratory Effects and Desflurane Requirement in Dogs Undergoing Ovariectomy after Administration Maropitant or Methadone

Simple Summary Opioids such as methadone are the most potent and most used analgesic drugs in anesthetic protocols, but they have several dose-dependent adverse effects. Some drugs other than opioids also have analgesic effects. Analgesic drugs in the anesthetic protocol can reduce the requirement of other drugs, particularly inhalant agents. Maropitant is an antiemetic for dogs and cats that has been shown to also exert analgesic effects, especially on visceral pain. The purpose of this study is to evaluate the cardiorespiratory effects and analgesic properties of maropitant and methadone combined with desflurane in dogs undergoing ovariectomy. Forty dogs were randomly assigned to receive either maropitant or methadone. Maropitant produced analgesia and reduced the requirement of inhalant agent in amounts very similar to those determined by methadone, while maintaining heart rate, arterial blood pressure, respiratory rate and carbon dioxide end-tidal partial pressure even at a more satisfactory level. Therefore, maropitant can be suggested as an analgesic drug for abdominal surgery not only in healthy dogs but also in those with reduced cardiorespiratory compensatory capacities or at risk of hypotension, especially when combined with a sedative such as dexmedetomidine. General anesthesia for ovariectomy in dogs is based on a balanced anesthesia protocol such as using analgesics along with an inhalant agent. While opioids such as fentanyl and methadone are commonly used for their analgesic potency, other drugs can also have analgesic effects. Maropitant, an antiemetic for dogs and cats, has also been shown to exert analgesic effects, especially on visceral pain. The aim of this study was to compare the cardiorespiratory effects and analgesic properties of maropitant and methadone combined with desflurane in dogs undergoing ovariectomy. Two groups of 20 healthy mixed-breeds bitches undergoing elective ovariectomy received intravenous either maropitant at antiemetic dose of 1 mg kg(-1) or methadone at the dose of 0.3 mg kg(-1). Cardiorespiratory variables were collected before premedication, 10 min after sedation and during surgery. Recovery quality and postoperative pain were evaluated 15, 30, 60, 120, 240 and 360 min postoperatively. Results showed that maropitant produced analgesia and reduced the requirement of desflurane in amounts similar to those determined by methadone (5.39 & PLUSMN; 0.20% and 4.91 & PLUSMN; 0.26%, respectively) without significant difference, while maintaining heart rate, arterial blood pressure, respiratory rate and carbon dioxide end-tidal partial pressure even at a more satisfactory level. Therefore, maropitant may be recommended as an analgesic drug for abdominal surgery not only in healthy dogs but also in those with reduced cardiorespiratory compensatory capacities or at risk of hypotension, especially when combined with a sedative such as dexmedetomidine.

Automated summary

This study evaluated the cardiorespiratory effects and analgesic properties of maropitant and methadone combined with desflurane in dogs undergoing ovariectomy. The results showed that maropitant produced analgesia and reduced the requirement of desflurane, while maintaining cardiovascular and respiratory parameters at a satisfactory level.