4.6 Article

Exosomes in multiple sclerosis and Alzheimer's disease – Adversary and ally

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Editorial Material Cell Biology

Senescence and extracellular vesicles: novel partners in vascular amyloidosis

Meredith Whitehead et al.

AGING-US (2023)

Article Biochemistry & Molecular Biology

Myelin Basic Protein in Oligodendrocyte-Derived Extracellular Vesicles as a Diagnostic and Prognostic Biomarker in Multiple Sclerosis: A Pilot Study

Cristina Agliardi et al.

Summary: Approximately 15% of MS patients develop primary progressive form of disease, which is difficult to diagnose and treat. Brain-derived EVs and their protein cargoes could potentially serve as biomarkers for MS. The study found that MBP concentration in ODEVs was significantly increased in MS patients and correlated with disease severity. A minimally invasive blood test measuring MBP concentration in ODEVs could be a promising tool for MS diagnosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Review Biochemistry & Molecular Biology

Extracellular Vesicles as Therapeutic Resources in the Clinical Environment

Jorge Sanz-Ros et al.

Summary: The native role of extracellular vesicles (EVs) in mediating the transfer of biomolecules between cells has raised the possibility to use them as therapeutic vehicles. The development of therapies based on EVs is now expanding rapidly; here we will describe the current knowledge on different key points regarding the use of EVs in a clinical setting. These points are related to cell sources of EVs, isolation, storage, and delivery methods, as well as modifications to the releasing cells for improved production of EVs. Finally, we will depict the application of EVs therapies in clinical trials, considering the impact of the COVID-19 pandemic on the development of these therapies, pointing out that although it is a promising therapy for human diseases, we are still in the initial phase of its application to patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Chemistry, Multidisciplinary

Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia

Xue Zheng et al.

Summary: A synthetic sialic acid analogue was successfully used for exosome labeling, leading to the development of a resveratrol-loaded exosome formulation for multiple sclerosis treatment. The study demonstrated the feasibility and efficacy of engineered exosome administration as a potential therapeutic strategy for CNS diseases.

JOURNAL OF CONTROLLED RELEASE (2023)

Review Clinical Neurology

Extracellular vesicles as contributors in the pathogenesis of multiple sclerosis

Silvia Zamboni et al.

Summary: Extracellular vesicles (EVs) are released by all cell types and play important roles in intercellular communication. They carry bioactive molecules and can cause changes in recipient cells, making them important mediators of homeostasis and pathogenesis. In neurological diseases like multiple sclerosis (MS), EVs' ability to cross the BBB and move between CNS and peripheral circulation has sparked interest in studying their role in the field of neurology. This review provides an overview of recent advances in understanding the pathogenic role of EVs in immune response, BBB dysfunction, and CNS inflammatory processes.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2023)

Review Immunology

The roles of extracellular vesicles in the immune system

Edit I. Buzas

Summary: This Review provides an updated comprehensive overview of the roles of extracellular vesicles in the immune system, including their involvement in innate and adaptive immunity, inflammation, antigen presentation, and various immune responses. It also highlights the potential use of extracellular vesicles in diagnosis and therapy.

NATURE REVIEWS IMMUNOLOGY (2023)

Article Cell Biology

Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain

Yang You et al.

Summary: In this study, the proteomic profiles of EVs derived from different types of neural cells were investigated. Cell type-specific EV protein markers were identified, and the role of astrocyte-specific EVs in Alzheimer's disease (AD) progression was explored. The hub protein ITGB1 was found to be significantly elevated in astrocyte-specific EVs and associated with AD pathology.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

Article Neurosciences

CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis

Michael Mazzucco et al.

Summary: This study developed a novel method to identify central nervous system (CNS) endothelial derived extracellular vesicles (EV) in human blood samples, and found that the plasma concentration of CNS endothelial derived EV was significantly increased in patients with active multiple sclerosis (MS), suggesting that it may serve as a biomarker of blood-brain barrier permeability and active disease in MS.

FLUIDS AND BARRIERS OF THE CNS (2022)

Article Clinical Neurology

Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease

Martina Gabrielli et al.

Summary: The study reveals that microglial extracellular vesicles carrying amyloid-beta can move along axons and spread synaptic dysfunction. Inhibiting the motion of these vesicles restricts the spread of dysfunction, suggesting a potential strategy to delay Alzheimer's disease progression.
Article Biotechnology & Applied Microbiology

Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies

Elodie Leroux et al.

Summary: Tauopathies are neurodegenerative diseases characterized by tau inclusions in brain cells. This study suggests that extracellular vesicles (EVs) may play a role in the prion-like propagation of tau pathology among different tauopathies. The researchers isolated EVs from different brain regions in various tauopathies and found that EVs from Alzheimer's disease patients contained pathological tau species that could induce tau lesions in vivo. These findings have implications for diagnostic and therapeutic strategies.

MOLECULAR THERAPY (2022)

Article Immunology

Analysis of Plasma Using Flow Cytometry Reveals Increased Immune Cell-Derived Extracellular Vesicles in Untreated Relapsing-Remitting Multiple Sclerosis

Stephanie N. Blandford et al.

Summary: Extracellular vesicles (EVs) secreted from cells have emerged as potential biomarkers for neurological conditions, including multiple sclerosis (MS). This study found that immune cell-derived EVs were significantly increased in the plasma of untreated RRMS patients, despite limited changes in circulating immune cells.

FRONTIERS IN IMMUNOLOGY (2022)

Article Neurosciences

Extracellular vesicles and Alzheimer's disease in the novel era of Precision Medicine: implications for disease progression, diagnosis and treatment

Patricia Gomes et al.

Summary: Extracellular vesicles play a critical role in the pathogenesis and progression of Alzheimer's disease, both by spreading toxic proteins and reducing amyloid-beta deposition. They also have the potential for diagnosis and treatment of other brain disorders.

EXPERIMENTAL NEUROLOGY (2022)

Review Immunology

B cells in central nervous system disease: diversity, locations and pathophysiology

Rajiv W. Jain et al.

Summary: Although B cells constitute a minor cell population in the central nervous system (CNS), they can contribute to CNS pathology, especially in multiple sclerosis, through secretion of antibodies and effector molecules and presentation of antigens. Jain and Yong discuss the roles of B cells in the CNS and the potential for targeting these cells in various neurological conditions.

NATURE REVIEWS IMMUNOLOGY (2022)

Article Clinical Neurology

Blood neuro-exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage

Longfei Jia et al.

Summary: This study showed that exosomal GAP43, neurogranin, SNAP25, and synaptotagmin 1 serve as effective biomarkers for predicting AD 5 to 7 years before cognitive impairment.

ALZHEIMERS & DEMENTIA (2021)

Article Clinical Neurology

Synaptic and complement markers in extracellular vesicles in multiple sclerosis

Pavan Bhargava et al.

Summary: This study found lower levels of NEV synaptic proteins and higher levels of multiple complement cascade components in AEVs in patients with multiple sclerosis compared to controls, suggesting that circulating EVs could serve as biomarkers for synaptic loss in MS and indicating a link between astrocytic complement production and synaptic loss.

MULTIPLE SCLEROSIS JOURNAL (2021)

Review Cell Biology

Synaptic basis of Alzheimer's disease: Focus on synaptic amyloid beta, P-tau and mitochondria

Albin John et al.

Summary: Alzheimer's disease is a progressive disease associated with synaptic dysfunction, with researchers striving to find more information on disease progression and pathogenesis. Synaptic pathology and mitochondrial oxidative damage are early events in the progression of AD, with synaptic loss and damage being key correlates of cognitive deficits in patients. As the disease advances, significant changes occur at the synapse, shedding light on the disease progression and serving as potential markers and therapeutic targets.

AGEING RESEARCH REVIEWS (2021)

Article Clinical Neurology

Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons

Zhi Ruan et al.

Summary: This study comprehensively characterized the physicochemical structure and pathogenic function of extracellular vesicles derived from human brains in Alzheimer's disease, prodromal Alzheimer's disease, and non-demented control cases. It was found that extracellular vesicles from Alzheimer's disease cases had higher levels of tau oligomers and exhibited more efficient propagation and misfolding of tau, suggesting a novel mechanism for tau spread in the hippocampus.
Article Clinical Neurology

Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer's disease

Lauren A. Apodaca et al.

Summary: The study demonstrated the regenerative potential of EVs derived from human neural stem cells in mitigating neurocognitive and neuropathologic hallmarks of Alzheimer's disease. The EV treatment showed neuroprotective effects in restoring fear extinction memory, reducing anxiety, decreasing amyloid plaque accumulation, and protecting against synaptic loss in the AD brain. MiRNA analysis of the EV cargo revealed promising candidates targeting neuroinflammation and synaptic function.

ALZHEIMERS RESEARCH & THERAPY (2021)

Article Geriatrics & Gerontology

Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer's Disease Patient Astrocytes Impair Neuroglial and Vascular Components

Luis Alfonso Gonzalez-Molina et al.

Summary: Research indicates that EVs released by astrocytes in Alzheimer's disease (AD) affect neuroglial and vascular components, leading to cell death and neurotoxicity.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Article Pharmacology & Pharmacy

Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures

Whitaker Cohn et al.

Summary: This study analyzed the composition of EVs derived from microglial cells in the brains of AD patients, revealing significant changes in certain markers in AD EVs compared to normal cases, indicating a potential role for EVs in the progression of AD.

FRONTIERS IN PHARMACOLOGY (2021)

Article Neurosciences

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

Kevin Clayton et al.

Summary: Our findings suggest that MGnD microglia hyper-secrete p-tau(+) EVs while compacting A beta plaques and clearing NP tau, which we propose as a novel mechanistic link between amyloid plaque deposition and exacerbation of tau propagation in App(NL-G-F) mice.

MOLECULAR NEURODEGENERATION (2021)

Article Multidisciplinary Sciences

Human umbilical cord mesenchymal stem cell-derived extracellular vesicles attenuate experimental autoimmune encephalomyelitis via regulating pro and anti-inflammatory cytokines

Samira Ahmadvand Koohsari et al.

Summary: Intravenous administration of extracellular vesicles derived from human umbilical cord-MSCs can alleviate induced experimental autoimmune encephalomyelitis (EAE) by reducing pro-inflammatory cytokines, decreasing inflammatory score, and increasing anti-inflammatory cytokines.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer's Disease Pathology and Improve Cognitive Deficits

Yi-An Chen et al.

Summary: The study evaluated the therapeutic performance of MSC-exosomes in AD, showing that they could reduce Aβ expression, restore the expression of neuronal memory/synaptic plasticity-related genes, improve brain glucose metabolism and cognitive function in AD transgenic mice.

BIOMEDICINES (2021)

Article Medicine, Research & Experimental

Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model

Allaura S. Cone et al.

Summary: Research has shown that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have potential therapeutic effects for Alzheimer's disease, slowing down disease progression and improving cognitive function when administered intranasally in mice.

THERANOSTICS (2021)

Review Biochemistry & Molecular Biology

Extracellular Vesicles in neural cell interaction and CNS homeostasis

Andrea Schnatz et al.

Summary: Extracellular vesicles (EVs) play a crucial role in CNS homeostasis by serving as versatile messengers in intercellular communication. They are involved in various physiological processes such as clearance of cellular components, mediation of trophic support, promotion of axonal maintenance, and modulation of neuroinflammation. Novel transgenic models and imaging technologies provide deeper insights into the functions and mechanisms of EVs in the nervous system.

FASEB BIOADVANCES (2021)

Review Biochemistry & Molecular Biology

An emerging interplay between extracellular vesicles and cytokines

Alessandra Aiello et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

Article Agriculture, Multidisciplinary

Comprehensive Analysis of the Glycome and Glycoproteome of Bovine Milk-Derived Exosomes

Wenyan Chen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

Article Clinical Neurology

Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition

Clare Walton et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Review Neurosciences

Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

Jean-Christophe Delpech et al.

TRENDS IN NEUROSCIENCES (2019)

Article Chemistry, Multidisciplinary

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

Milad Riazifar et al.

ACS NANO (2019)

Article Multidisciplinary Sciences

Extracellular vesicle fibrinogen induces encephalitogenic CD8+T cells in a mouse model of multiple sclerosis

Cory M. Willis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Clinical Neurology

Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia

Charisse N. Winston et al.

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING (2019)

Article Clinical Neurology

Multiple sclerosis: Serum-derived exosomes express myelin proteins

Grazyna Galazka et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Article Clinical Neurology

Multiple sclerosis: Serum-derived exosomes express myelin proteins

Grazyna Galazka et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Article Clinical Neurology

Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Maitrayee Sardar Sinha et al.

ACTA NEUROPATHOLOGICA (2018)

Article Clinical Neurology

High complement levels in astrocyte-derived exosomes of Alzheimer disease

Edward J. Goetzl et al.

ANNALS OF NEUROLOGY (2018)

Article Biotechnology & Applied Microbiology

Extracellular Vesicles Containing IL-4 Modulate Neuroinflammation in a Mouse Model of Multiple Sclerosis

Giacomo Casella et al.

MOLECULAR THERAPY (2018)

Article Multidisciplinary Sciences

Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis

Kimitoshi Kimura et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

Andre M. Miranda et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Exosomal microRNA signatures in multiple sclerosis reflect disease status

Saeideh Ebrahimkhani et al.

SCIENTIFIC REPORTS (2017)

Article Clinical Neurology

Global Exosome Transcriptome Profiling Reveals Biomarkers for Multiple Sclerosis

Igor Selmaj et al.

ANNALS OF NEUROLOGY (2017)

Review Clinical Neurology

Extracellular vesicles in neurodegenerative disease - pathogenesis to biomarkers

Alexander G. Thompson et al.

NATURE REVIEWS NEUROLOGY (2016)

Review Neurosciences

Extracellular vesicles round off communication in the nervous system

Vivian Budnik et al.

NATURE REVIEWS NEUROSCIENCE (2016)

Review Clinical Neurology

Neuroinflammation in Alzheimer's disease

Michael T. Heneka et al.

LANCET NEUROLOGY (2015)

Article Neurosciences

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Hirohide Asai et al.

NATURE NEUROSCIENCE (2015)

Article Biochemistry & Molecular Biology

A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide

Kohei Yuyama et al.

FEBS LETTERS (2015)

Article Clinical Neurology

Low neural exosomal levels of cellular survival factors in Alzheimer's disease

Edward J. Goetzl et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2015)

Article Biochemistry & Molecular Biology

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

P. Joshi et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Biochemistry & Molecular Biology

Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

Kohei Yuyama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Cell Biology

Extracellular vesicles: Exosomes, microvesicles, and friends

Graca Raposo et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Clinical Neurology

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

Claudia Verderio et al.

ANNALS OF NEUROLOGY (2012)

Review Biochemistry & Molecular Biology

The Toxicity of Amyloid β Oligomers

Li Na Zhao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

Article Biochemistry & Molecular Biology

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

Kohei Yuyama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

The molecular basis of neurodegeneration in multiple sclerosis

Hans Lassmann et al.

FEBS LETTERS (2011)

Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

Article Multidisciplinary Sciences

Monocyte Derived Microvesicles Deliver a Cell Death Message via Encapsulated Caspase-1

Anasuya Sarkar et al.

PLOS ONE (2009)

Article Multidisciplinary Sciences

Alzheimer's disease β-amyloid peptides are released in association with exosomes

Lawrence Rajendran et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Endothelial microparticles (EMP) bind and activate monocytes: Elevated empmonocyte conjugates in multiple sclerosis

W Jy et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2004)

Article Clinical Neurology

Elevated plasma endothelial microparticles in multiple sclerosis

A Minagar et al.

NEUROLOGY (2001)