期刊
NATURE
卷 529, 期 7586, 页码 326-335出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature17041
关键词
-
资金
- US National Institutes of Health [R37 DK042394, R01 DK088227, R01 DK103183, CA128814]
In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of proteins that enter the secretory pathway. Environmental insults or increased protein synthesis often lead to protein misfolding in the organelle, the accumulation of misfolded or unfolded proteins - known as endoplasmic reticulum stress - and the activation of the adaptive unfolded protein response to restore homeostasis. If protein misfolding is not resolved, cells die. Endoplasmic reticulum stress and activation of the unfolded protein response help to determine cell fate and function. Furthermore, endoplasmic reticulum stress contributes to the aetiology of many human diseases.
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