期刊
NATURE
卷 538, 期 7624, 页码 201-+出版社
NATURE PORTFOLIO
DOI: 10.1038/nature18964
关键词
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资金
- Simons Foundation [SFARI 280376]
- US National Science Foundation [BCS-1032255]
- Human Frontier Science program [LT001095/2014]
- Wenner-Gren foundation
- Swedish Research Council (VR) [2014-453]
- NIJ [2014-DN-BX-K089]
- Career Award at the Scientific Interface from the Burroughs Wellcome Fund
- Natural Sciences and Engineering Research Council of Canada
- ERC [FP7- 261213]
- Russian Foundation for Basic Research [15-04-02543, 16-34-00599, 11-04-00725-a, 16-06-00303, 16-04-00890]
- Russian Scientific Fund [14-04-00827]
- Estonian Research Council
- European Regional Development Fund (European Union) through the Centre of Excellence in Genomics to Estonian Biocentre
- University of Tartu
- Spanish MINECO [CGL-44351-P]
- NIH [GM59290, 5DPIES022577 05, 1R01DK104339-01, 1R01GM113657-01, R01-GM094402, GM100233]
- Wellcome Trust [093051]
- NSF [0924726, 1153911]
- CSIR Network Project grant [GENESIS: BSC0121]
- Packard Fellowship for Science and Engineering
- Max Planck Society
- BBSRC [BB/H008802/1, BB/H008802/2] Funding Source: UKRI
- Russian Science Foundation [14-14-00827] Funding Source: Russian Science Foundation
- Biotechnology and Biological Sciences Research Council [BB/H008802/1, BB/H008802/2] Funding Source: researchfish
- Direct For Social, Behav & Economic Scie
- Division Of Behavioral and Cognitive Sci [1032255] Funding Source: National Science Foundation
- Division Of Behavioral and Cognitive Sci
- Direct For Social, Behav & Economic Scie [1153911, 0924726] Funding Source: National Science Foundation
Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.
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