期刊
NATURE
卷 529, 期 7586, 页码 336-343出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature17042
关键词
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资金
- Natural Sciences and Engineering Research Council of Canada [RGPIN 04384-2014, RGPIN 237480]
- Canada Research Chairs Program
- Canadian Institutes of Health Research [MOP-81330, MOP-15496, MT-13536]
The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians, researchers, policymakers, politicians and the public at large. The evolution and widespread distribution of antibiotic-resistance elements in bacterial pathogens has made diseases that were once easily treatable deadly again. Unfortunately, accompanying the rise in global resistance is a failure in antibacterial drug discovery. Lessons from the history of antibiotic discovery and fresh understanding of antibiotic action and the cell biology of microorganisms have the potential to deliver twenty-first century medicines that are able to control infection in the resistance era.
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