期刊
NATURE
卷 540, 期 7631, 页码 69-+出版社
NATURE PORTFOLIO
DOI: 10.1038/nature20151
关键词
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资金
- University of Vienna
- FWF [AY0041321]
- HFSP [RGY0082/2010]
- ERC [337011]
- DFG [HE5398/4-1]
- Vienna International PostDoctoral Program for Molecular Life Sciences (VIPS)
- University of Vienna Initiativkolleg [I059-N]
- European Research Council (ERC) [337011] Funding Source: European Research Council (ERC)
Organisms use endogenous clocks to anticipate regular environmental cycles, such as days and tides. Natural variants resulting in differently timed behaviour or physiology, known as chronotypes in humans, have not been well characterized at the molecular level. We sequenced the genome of Clunio marinus, a marine midge whose reproduction is timed by circadian and circalunar clocks. Midges from different locations show strain-specific genetic timing adaptations. We examined genetic variation in five C. marinus strains from different locations and mapped quantitative trait loci for circalunar and circadian chronotypes. The region most strongly associated with circadian chronotypes generates strain-specific differences in the abundance of calcium/calmodulin-dependent kinase II.1 (CaMKII. 1) splice variants. As equivalent variants were shown to alter CaMKII activity in Drosophila melanogaster, and C. marinus (Cma)-CaMKII.1 increases the transcriptional activity of the dimer of the circadian proteins Cma-CLOCK and Cma-CYCLE, we suggest that modulation of alternative splicing is a mechanism for natural adaptation in circadian timing.
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