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Research Progress on Stimulus-Responsive Polymer Nanocarriers for Cancer Treatment

PHARMACEUTICS (2023)

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Article Chemistry, Physical

Synthesis of cyclodextrin-based temperature/enzyme-responsive nanoparticles and application in antitumor drug delivery

Jinkui Teng et al.

Summary: Nanocarrier systems with dual stimuli-responsive properties, such as temperature and enzyme, have been prepared for practical and clinical applications. In this study, a temperature/enzyme-responsive nanocarrier was successfully prepared using SA-beta-CD and LCC. The nanocarriers demonstrated efficient trapping and releasing properties for the anti-tumor drug CSL, with a high release rate of 94%. Moreover, cytotoxicity and apoptosis tests confirmed the similar activity of the CSL-trapped nanocarriers to intact CSL on tumor cells. These dual response nanocarriers offer a potential approach for targeted release of anti-cancer drugs.

JOURNAL OF MOLECULAR STRUCTURE (2023)

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Article Biochemistry & Molecular Biology

A Novel NQO1 Enzyme-Responsive Polyurethane Nanocarrier for Redox-Triggered Intracellular Drug Release

Jinhai Xie et al.

Summary: Designing nano-drug delivery vehicles that respond to stimuli from the tumor microenvironment is crucial in cancer therapy. Enzyme-responsive nano-drug delivery systems are particularly effective as they target tumor-specific and highly expressed enzymes, resulting in increased drug release at the target sites and reduced toxicity to normal tissues. NQO1, an important reductase associated with cancer, is overexpressed in certain cancer cells, making the design of nanocarriers with high selectivity and responsiveness to NQO1 significant for tumor diagnosis and treatment.

BIOMACROMOLECULES (2023)

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Article Biochemistry & Molecular Biology

Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer

Mona A. Moustafa et al.

Summary: The study suggests that bioactive polymers-based nanosystems can enhance the anticancer efficacy of FS. Different biopolymers with anticancer activity and targeting ability were selected for nanoparticles preparation, including fucoidan (FU), zein (Zn), and hyaluronic acid (HA). The developed ZFH nanoparticles showed excellent targeting effect on oral cancer cells and regulatory cells, leading to significant cytotoxic action and reduction of tumor biomarkers.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Review Chemistry, Medicinal

Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges

Bhuvi Sachdeva et al.

Summary: Chitin is a biopolymer derived from marine crustaceans and organisms like bacteria, fungi, and algae, which offers biodegradability and biocompatibility properties suitable for biomedical applications. Its deacetylated derivative, chitosan, also possesses similar properties and can be used as a support material in biomedical applications. Additionally, both chitin and chitosan have intrinsic material properties such as antioxidant, antibacterial, and antitumor activities. This paper focuses on the use of chitin and chitosan biopolymers in drug delivery strategies for cancer treatment.

MARINE DRUGS (2023)

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Article Chemistry, Physical

Curcumin encapsulation in functional PLGA nanoparticles: A promising strategy for cancer therapies

Felipe da Silva Feltrin et al.

Summary: Nanoparticles have shown promise as drug delivery systems for various diseases. Encapsulating curcumin in PLGA nanoparticles can overcome its limitations and improve its anticancer effects. This article summarizes recent strategies for delivering curcumin to different cancer cells using PLGA nanoparticles, discusses targeting strategies and improvements for each cancer cell analyzed, and explores encapsulation techniques.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2022)

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Article Biophysics

Acid-sensitive charge-reversal co-assembled polyurethane nanomicelles as drug delivery carriers

Jingyi Liu et al.

Summary: Two amphiphilic polyurethanes with opposite charges were successfully synthesized by introducing carboxyl groups and tertiary amine groups, which exhibited good stability in blood and high cellular uptake efficiency for drug delivery carriers. The co-assembled nanomicelles prepared by electrostatic interaction between these polyurethanes showed acid-sensitive property and pH-dependent charge-reversal behavior, leading to enhanced cellular uptake efficiency and lower cytotoxicity. Additionally, the polyurethane-based micelles demonstrated controlled drug release behavior with minimal burst release in physiological pH and improved antitumor activity.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Pharmacology & Pharmacy

GSH-responsive poly-resveratrol based nanoparticles for effective drug delivery and reversing multidrug resistance

Yang Liping et al.

Summary: This study reports the synthesis of a GSH-responsive polymer that exhibits anti-cancer effects, high drug loading capacity, and the ability to overcome multidrug resistance. The polymer is capable of self-assembling into nanoparticles for efficient drug delivery. In vitro and in vivo experiments demonstrate the potential of this system for cancer treatment.

DRUG DELIVERY (2022)

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Article Polymer Science

Synthesis and Study of Thermoresponsive Amphiphilic Copolymers via RAFT Polymerization

Marija Kavaliauskaite et al.

Summary: The synthesis and study of well-defined thermoresponsive amphiphilic copolymers with various compositions have been reported. The kinetics of the reversible addition-fragmentation chain transfer (RAFT) (co)polymerization and the thermoresponsive properties of the copolymers in aqueous solutions were investigated.

POLYMERS (2022)

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Review Nanoscience & Nanotechnology

Bioenzyme-based nanomedicines for enhanced cancer therapy

Mengbin Ding et al.

Summary: Bioenzyme-based nanomedicines have shown great potential in improving the efficacy of cancer therapies by modulating the tumor microenvironment and increasing the penetration and retention of nanoparticles in deep tumors. These nanomedicines can enhance chemotherapy, phototherapy, and immunotherapy for cancer treatment.

NANO CONVERGENCE (2022)

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Article Biochemistry & Molecular Biology

Tumor-targeted delivery of honokiol via polysialic acid modified zein nanoparticles prevents breast cancer progression and metastasis

Qi Zhang et al.

Summary: Polysialic acid (PSA) modified zein nanoparticles were developed for targeted delivery of honokiol (HNK) to enhance drug delivery efficiency and specific biodistribution at tumor sites. Animal experiments confirmed the favorable antitumor efficacy and biosafety of PSA-Zein-HNK, suggesting its potential as an efficient tumor-targeted drug delivery strategy for breast cancer treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Nanoscience & Nanotechnology

pH-Responsive Hyaluronic Acid Nanoparticles for Enhanced Triple Negative Breast Cancer Therapy

Xiangle Zeng et al.

Summary: This study developed a nanomicelle formulation (HDO-NPs) by combining dasatinib and olaparib, which exhibited synergistic effects on triple negative breast cancer by inducing DNA damage and inhibiting DNA damage repair. HDO-NPs were able to effectively target tumor tissues, improve drug bioavailability, and demonstrate excellent therapeutic effects both in vitro and in vivo.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Chemistry, Physical

Hyaluronic acid-based dual-responsive nanomicelles mediated mutually synergistic photothermal and molecular targeting therapies

Liangliang Cai et al.

Summary: Nanomicelles combining nanotechnology-assisted photothermal therapy (PTT) and a novel HSP90 inhibitor AT13387 can achieve mutually synergistic PTT/molecularly targeted therapy (MTT) for the precise treatment of triple-negative breast cancer (TNBC).

NANO RESEARCH (2022)

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Article Pharmacology & Pharmacy

Dual Responsive poly(vinyl caprolactam)-Based Nanogels for Tunable Intracellular Doxorubicin Delivery in Cancer Cells

Kummara Madhusudana Rao et al.

Summary: This study developed Dox-encapsulated nanogels that can release the drug under dual stimuli conditions, showing potential for effective cancer treatment.

PHARMACEUTICS (2022)

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Article Chemistry, Applied

Dual-pH responsive chitosan nanoparticles for improving in vivo drugs delivery and chemoresistance in breast cancer

Qiang Chen et al.

Summary: Efficient dual-pH responsive chitosan nanoparticles were fabricated to treat MDR tumors, showing high toxicity and strong antitumor efficiency in vivo.

CARBOHYDRATE POLYMERS (2022)

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Review Pharmacology & Pharmacy

The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia

Bernard Gallez

Summary: Hypoxia is a common feature of solid tumors and plays a role in tumor progression and resistance to therapy. Despite various approaches to target hypoxia, their translation into clinical practice has been disappointing. Companion diagnostics may help in matching patients with specific interventions.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Chemistry, Multidisciplinary

Hypoxia-Activated PEGylated Paclitaxel Prodrug Nanoparticles for Potentiated Chemotherapy

Dengyuan Hao et al.

Summary: Developing controlled drug-release systems is crucial for increasing therapeutic efficacy. In this study, we synthesized hypoxia-responsive PEGylated paclitaxel prodrugs, which could release the drug and exert cytotoxicity in the tumor hypoxia microenvironment.

ACS NANO (2022)

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Article Materials Science, Multidisciplinary

Thermo-responsive PNIPAAm-b-PLA amphiphilic block copolymer micelle as nanoplatform for docetaxel drug release

Soheila Ghasemi et al.

Summary: In this study, a thermo-responsive smart amphiphilic block copolymer was synthesized through controlled polymerization method and self-assembled into stable nanomicelles for efficient loading and sustained release of an anti-cancer drug DTX. Results showed that the DTX-loaded polymeric micelles exhibited comparable toxicity to free drugs and could potentially serve as an effective intracellular drug delivery system in chemotherapy.

JOURNAL OF MATERIALS SCIENCE (2022)

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Review Chemistry, Multidisciplinary

Redox-Responsive Drug Delivery Systems: A Chemical Perspective

Heba F. Abed et al.

Summary: This paper explores the physiological and biochemical basis of redox-responsive drug delivery systems as a potential cancer treatment, and reviews recent advances in the chemical composition and design of these systems. It discusses five main redox-responsive chemical entities, focusing on the most commonly used disulfide bonds and their incorporation into liposomes, polymeric micelles, and nanogels.

NANOMATERIALS (2022)

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Review Medicine, General & Internal

Polymeric biomaterials in the treatment of posterior segment diseases

Ivan Seah et al.

Summary: Polymeric biomaterials have great potential in the treatment of eye diseases, especially retinal conditions. They can serve as both endotamponade agents to prevent intraocular scarring and drug delivery platforms for treating retinal diseases. They can also be used as scaffolds for cellular products and provide non-viral gene delivery solutions to the retina.

FRONTIERS IN MEDICINE (2022)

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Article Materials Science, Biomaterials

Phosphorylcholine zwitterionic shell-detachable mixed micelles for enhanced cancerous cellular uptakes and increased DOX release

Haimei Cao et al.

Summary: In this study, mixed micelles were fabricated using two amphiphilic copolymers P(DMAEMA-co-MaPCL) and PCL-SS-PMPC to enhance cancerous cellular uptakes and increase drug release. The mixed micelles exhibited prolonged circulation time in a physiological environment and aggregated in a tumor microenvironment, leading to enhanced cancerous cellular penetration and increased drug release.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Review Polymer Science

Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering

Shuai Chang et al.

Summary: Bone defects are a pressing issue in orthopedic clinics, attracting attention from the biomedical community and society. Stimulus-responsive hydrogels, as a smart biomaterial, have advantages in sensing external stimuli and providing cell adhesion, proliferation, and differentiation for precise bone defect repair.

GELS (2022)

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Review Chemistry, Multidisciplinary

Lanthanide-Doped Near-Infrared Nanoparticles for Biophotonics

Hui Li et al.

Summary: Light in the near-infrared (NIR) spectral region is increasingly used in bioapplications due to its deeper penetration in biological tissues. Lanthanide-doped luminescent nanoparticles with excitation and/or emission in the NIR range are gaining attention for noninvasive biological applications, offering unique optical properties such as large Stokes shift, sharp luminescence emissions, long lifetimes, and photostability. Advanced strategies for enhancing the luminescence brightness of these nanoparticles have been introduced, along with a review of their superior biophotonic applications in high-resolution imaging, single-nanoparticle-level detection, and tissue-penetrating diagnostics and therapeutics.

ADVANCED MATERIALS (2021)

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Article Pharmacology & Pharmacy

Photothermal/matrix metalloproteinase-2 dual-responsive gelatin nanoparticles for breast cancer treatment

Xiaojie Chen et al.

Summary: In this study, nanoparticles with dual-responsive, tumor targeting characteristics were designed for the treatment of breast cancer through the combination of photothermal therapy and chemotherapy. The variability in nanoparticle size and characteristics enhanced drug release and therapeutic efficacy against breast cancer.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Oncology

Polymers Based on Phenyl Boric Acid in Tumor-Targeted Therapy

Dexia Luo et al.

Summary: This paper summarized and analyzed the characteristics and influencing factors of tumor targeted therapy, as well as the application of phenyl boric acid modified polymers in different types of tumors. The results show that tumor-targeted therapy has great clinical application prospects, and PBA is a beneficial member of drug loading systems.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

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Article Biophysics

pH-sensitive and tumor-targeting nanogels based on ortho ester-modified PEG for improving the in vivo anti-tumor efficiency of doxorubicin

Xin Wang et al.

Summary: By copolymerizing various components, a pH-sensitive and tumor-targeting nanogel was developed, showing a spherical structure and excellent stability. In vitro and in vivo experiments demonstrated good drug delivery and antitumor effects of the multifunctional nanogels.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Biochemistry & Molecular Biology

Temperature and Photo Dual-Stimuli Responsive Block Copolymer Self-Assembly Micelles for Cellular Controlled Drug Release

Zi-Hao Zhou et al.

Summary: A novel temperature responsive lateral chain photosensitive block copolymer was synthesized, showing apparent light and temperature dual responsiveness, making it a potential drug controlled release carrier for cancer therapy.

MACROMOLECULAR BIOSCIENCE (2021)

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Article Materials Science, Biomaterials

Dual pH-responsive-charge-reversal micelle platform for enhanced anticancer therapy

Jianhong Liao et al.

Summary: A novel nanodrug delivery system based on PDPP block copolymers was developed to enhance in vitro cellular uptake and anticancer efficacy. The charge-reversal of micelles from negative to positive at pH 6.5 significantly enhanced cellular uptake and anticancer efficacy.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Biochemistry & Molecular Biology

Anticancer nano-delivery systems based on bovine serum albumin nanoparticles: A critical review

Raghu Solanki et al.

Summary: Bovine serum albumin nanoparticles (BSA NPs) are promising for efficient anti-cancer drug delivery due to their non-toxicity, non-immunogenicity, biodegradability, biocompatibility, and high drug-binding capacity. Understanding the structural/physicochemical features of BSA molecule and its derived nanovehicles, as well as effective variables in delivery mechanism, is essential for leveraging the potential of this carrier in cancer therapy. The review highlights recent advances in using BSA NPs for delivering anti-cancer agents and discusses the factors influencing the efficiency of therapeutics in nano-delivery systems.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Polymer Science

Light-Responsive Polymeric Micellar Nanoparticles with Enhanced Formulation Stability

Kyoung Nan Kim et al.

Summary: Light-sensitive polymeric micelles have been developed as promising drug delivery systems, with the ability to release drugs under UV light. The diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles show high stability and hydrophobicity.

POLYMERS (2021)

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Article Biotechnology & Applied Microbiology

An improved method in fabrication of smart dual-responsive nanogels for controlled release of doxorubicin and curcumin in HT-29 colon cancer cells

Fatemeh Abedi et al.

Summary: The proposed combination therapy using smart responsive nanogels can achieve a synergistic effect for cancer treatment, reduce drug dosage, and improve efficacy.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Hyaluronidase and pH Dual-Responsive Nanoparticles for Targeted Breast Cancer Stem Cells

Weinan Li et al.

Summary: The pH-responsive and CD44 receptor-mediated targeted nanoparticles loaded with Thioridazine showed great potential in eliminating cancer stem cells. In vitro release studies demonstrated effective drug release in acidic pH conditions. Cellular uptake studies confirmed efficient uptake of the nanoparticles in mammospheres, and in vivo distribution studies showed prolonged retention at tumor sites and improved tumor-suppressing effects.

FRONTIERS IN ONCOLOGY (2021)

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Review Chemistry, Multidisciplinary

Recent advances of redox-responsive nanoplatforms for tumor theranostics

Miaomiao Chen et al.

Summary: Nano-biotechnologies integrating diagnosis with therapy offer a promising prospect for cancer theranostics. Developing "smart" theranostic nanoplatforms with specific targeting, precise cargoes release, and non-invasive therapeutics for cancers is crucial in personalized medicine. Exploiting redox-responsive theranostic nanoplatforms to modulate intracellular redox homeostasis, especially in tumor microenvironment characterized by high levels of H2O2 and GSH, has shown significant progress in recent studies.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Materials Science, Biomaterials

Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy

Liuhui Zhang et al.

Summary: This study proposed a unique ROS and GSH dual responsive nanocarrier (PCL-SS) for DTX delivery to improve the efficacy of chemotherapy for prostate cancer. The nanocarrier was found to enhance drug accumulation at tumor sites and minimize systemic side effects.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Applied

A multiple environment-sensitive prodrug nanomicelle strategy based on chitosan graftomer for enhanced tumor therapy of gambogic acid

Qian Du et al.

Summary: This study developed a novel multiple environment-sensitive polymeric prodrug of gambogic acid (GA) with high loading capacity and targeted tumor accumulation for improving the anticancer effectiveness. The amphiphilic prodrug exhibited potential in both in vivo and in vitro due to its responsiveness to multiple tumor microenvironments and high drug-loading capacity.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Multidisciplinary

NIR-activated self-sensitized polymeric micelles for enhanced cancer chemo-photothermal therapy

Lijun Yang et al.

Summary: NIR-activated therapies using light-responsive drug delivery systems offer a promising approach for precise cancer therapy. The developed polymeric micelles showed enhanced resistance to photobleaching, increased photothermal conversion efficiency, NIR-controlled drug release, good biocompatibility, and excellent tumor accumulation. The chemo-photothermal synergistic therapy achieved a high tumor inhibition rate with minimal side effects.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Mitochondria-targeted ROS- and GSH-responsive diselenide-crosslinked polymer dots for programmable paclitaxel release

Seul Gi Kim et al.

Summary: The design of ROS- and GSH-responsive PTX-loaded polymer dot with mitochondria-targeting capability allows for selective release of PTX in cancer cells, leading to enhanced apoptosis and reduced effects on normal cells.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2021)

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Article Pharmacology & Pharmacy

Light-Responsive Micelles Loaded With Doxorubicin for Osteosarcoma Suppression

Jiayi Chen et al.

Summary: The study synthesized a light-responsive doxorubicin-conjugated polymer that can self-assemble into polymeric micelles, enhancing tumor targeting and reducing cardiotoxicity. After ultraviolet irradiation, the drug delivery system showed increased cellular uptake, potentially promising for targeted therapy for osteosarcoma.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Chemistry, Multidisciplinary

Spiropyran-Based Drug Delivery Systems

Andrew Fagan et al.

Summary: Nanocarriers are increasingly popular in drug delivery, offering advantages in encapsulating and distributing poorly soluble drugs while minimizing adverse effects. Spiropyrans have emerged as potential nanocarriers due to their responsiveness to stimuli and biocompatibility, showing promise in drug delivery systems.

FRONTIERS IN CHEMISTRY (2021)

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Review Nanoscience & Nanotechnology

Smart materials for drug delivery and cancer therapy

Yao Yang et al.

Summary: Smart materials play a crucial role in drug delivery, with endogenous/exogenous responsive materials possessing properties such as controlled drug release and enhanced diagnostic accuracy. Significant research advancements have been made in the development of smart materials responsive to various triggers.

VIEW (2021)

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Review Materials Science, Biomaterials

Recent progress of redox-responsive polymeric nanomaterials for controlled release

Peng-Hao Hsu et al.

Summary: Redox-responsive polymeric nanomaterials (PNMs) can target various redox molecules and release encapsulated payloads upon stimulation by installing appropriate responsive moieties within the polymer structure.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Applied

Anisamide-functionalized pH-responsive amphiphilic chitosan-based paclitaxel micelles for sigma-1 receptor targeted prostate cancer treatment

Ding Qu et al.

CARBOHYDRATE POLYMERS (2020)

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Article Chemistry, Physical

Functionalized polymeric nanogels with pH-sensitive benzoic-imine cross-linkages designed as vehicles for indocyanine green delivery

Shu-Chiao Liao et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2020)

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Article Engineering, Chemical

Thermo-responsive adsorption-desorption of perfluoroorganics from water using PNIPAm hydrogels and pore functionalized membranes

Anthony Saad et al.

JOURNAL OF MEMBRANE SCIENCE (2020)

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Article Engineering, Biomedical

Acetal-linked polymeric prodrug micelles based on aliphatic polycarbonates for paclitaxel delivery: preparation, characterization,in vitrorelease and anti-proliferation effects

Shiya Zhou et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2020)

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Review Pharmacology & Pharmacy

Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery

Son H. Pham et al.

PHARMACEUTICS (2020)

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Article Biochemistry & Molecular Biology

Photo- and pH-Responsive Polycarbonate Block Copolymer Prodrug Nanomicelles for Controlled Release of Doxorubicin

Nagendra Kalva et al.

MACROMOLECULAR BIOSCIENCE (2020)

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Review Polymer Science

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Alexandra Zamboulis et al.

POLYMERS (2020)

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Article Biochemistry & Molecular Biology

Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications

Wanting Hou et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

pH-responsive polymeric micelles self-assembled from benzoic-imine-containing alkyl-modified PEGylated chitosan for delivery of amphiphilic drugs

Ching-Wei Hsu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Pharmacology & Pharmacy

Co-delivery of doxorubicin and paclitaxel by reduction/pH dual responsive nanocarriers for osteosarcoma therapy

Yongshuang Li et al.

DRUG DELIVERY (2020)

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Article Chemistry, Multidisciplinary

Amino acid-modified PAMAM dendritic nanocarriers as effective chemotherapeutic drug vehicles in cancer treatment: a study using zebrafish as a cancer model

Szu-Yuan Wu et al.

RSC ADVANCES (2020)

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Article Materials Science, Biomaterials

Co-assembly of curcumin and a cystine bridged peptide to construct tumor-responsive nano-micelles for efficient chemotherapy

Yemei Dai et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Materials Science, Biomaterials

Reactive oxygen species (ROS)-responsive ferrocene-polymer-based nanoparticles for controlled release of drugs

Yoonhee Na et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Medicine, Research & Experimental

Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics

Peng Mi

THERANOSTICS (2020)

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Article Engineering, Biomedical

Integrated block copolymer prodrug nanoparticles for combination of tumor oxidative stress amplification and ROS-responsive drug release

Wei Yin et al.

BIOMATERIALS (2019)

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Article Chemistry, Applied

A photo-controlled hyaluronan-based drug delivery nanosystem for cancer therapy

Feifei Sun et al.

CARBOHYDRATE POLYMERS (2019)

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Article Biophysics

PEG-b-poly (carbonate)-derived nanocarrier platform with pH-responsive properties for pancreatic cancer combination therapy

Priyanka Ray et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Chemistry, Multidisciplinary

ROS-responsive thioether-based nanocarriers for efficient pro-oxidant cancer therapy

Yoon-Seok Kim et al.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2019)

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Article Pharmacology & Pharmacy

A Smart pH-Sensitive Delivery System for Enhanced Anticancer Efficacy via Paclitaxel Endosomal Escape

Yihua Yang et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Engineering, Biomedical

A polymeric micelle with an endosomal pH-sensitivity for intracellular delivery and enhanced antitumor efficacy of hydroxycamptothecin

Xiaohui Pu et al.

ACTA BIOMATERIALIA (2019)

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Review Pharmacology & Pharmacy

Stimulus-responsive nanoscale delivery systems triggered by the enzymes in the tumor microenvironment

Zhen-Tao Zhang et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Article Biochemistry & Molecular Biology

Enzyme and pH dual-responsive hyaluronic acid nanoparticles mediated combination of photodynamic therapy and chemotherapy

Qian Ren et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Chemistry, Multidisciplinary

Direct Nucleus-Targeted Drug Delivery Using Cascade pHe/Photo Dual-Sensitive Polymeric Nanocarrier for Cancer Therapy

Ziyang Cao et al.

SMALL (2019)

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Review Chemistry, Multidisciplinary

Enzyme responsive drug delivery systems in cancer treatment

Mahsa Shahriari et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Materials Science, Biomaterials

Thermo-responsive polymers: Applications of smart materials in drug delivery and tissue engineering

Mattia Sponchioni et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Biotechnology & Applied Microbiology

A chitosan-based cascade-responsive drug delivery system for triple-negative breast cancer therapy

Shiwei Niu et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Chemistry, Applied

pH-sensitive amphiphilic chitosan-quercetin conjugate for intracellular delivery of doxorubicin enhancement

Yuzhi Mu et al.

CARBOHYDRATE POLYMERS (2019)

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Article Biophysics

A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy

Shujuan Xiong et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Biochemistry & Molecular Biology

Drug release and kinetic models of anticancer drug (BTZ) from a pH-responsive alginate polydopamine hydrogel: Towards cancer chemotherapy

Abdelrahman I. Rezk et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Chemistry, Multidisciplinary

Biodegradable Micelles for NIR/GSH-Triggered Chemophototherapy of Cancer

Chuan Zhang et al.

NANOMATERIALS (2019)

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Article Medicine, Research & Experimental

Stimuli-responsive nanodrug self-assembled from amphiphilic drug-inhibitor conjugate for overcoming multidrug resistance in cancer treatment

Ping Huang et al.

THERANOSTICS (2019)

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Article Engineering, Biomedical

Camptothecin prodrug nanomicelle based on a boronate ester-linked diblock copolymer as the carrier of doxorubicin with enhanced cellular uptake

Ya Gao et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2018)

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Article Nanoscience & Nanotechnology

Dual pH-Responsive Shell-Cleavable Polycarbonate Micellar Nanoparticles for in Vivo Anticancer Drug Delivery

Shaoqiong Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Dual pH-responsive multifunctional nanoparticles for targeted treatment of breast cancer by combining immunotherapy and chemotherapy

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Dual Intratumoral Redox/Enzyme-Responsive NO-Releasing Nanomedicine for the Specific, High-Efficacy, and Low-Toxic Cancer Therapy

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Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents

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A glutathione-responsive sulfur dioxide polymer prodrug as a nanocarrier for combating drug-resistance in cancer chemotherapy

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Chitosan-based polymer hybrids for thermo-responsive nanogel delivery of curcumin

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Development of endogenous enzyme-responsive nanomaterials for theranostics

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Polyacrylamide-b-copolypeptide hybrid copolymer as pH-responsive carrier for delivery of paclitaxel: Effects of copolymer composition on nanomicelles properties, loading efficiency and hemocompatibility

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L-Peptide functionalized dual-responsive nanoparticles for controlled paclitaxel release and enhanced apoptosis in breast cancer cells

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Sericin nanomicelles with enhanced cellular uptake and pH-triggered release of doxorubicin reverse cancer drug resistance

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Mitochondrial Targeted Doxorubicin-Triphenylphosphonium Delivered by Hyaluronic Acid Modified and pH Responsive Nanocarriers to Breast Tumor: in Vitro and in Vivo Studies

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Hydrazone-Containing Triblock Copolymeric Micelles for pH-Controlled Drug Delivery

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Reduction-sensitive mixed micelles for selective intracellular drug delivery to tumor cells and reversal of multidrug resistance

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Hydrazone linkages in pH responsive drug delivery systems

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Successful in vivo hyperthermal therapy toward breast cancer by Chinese medicine shikonin-loaded thermosensitive micelle

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PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application

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Synthesis of novel amphiphilic poly(N-isopropylacrylamide)-b-poly(aspartic acid) nanomicelles for potential targeted chemotherapy in ovarian cancer

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pH and redox dual-responsive biodegradable polymeric micelles with high drug loading for effective anticancer drug delivery

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Dual temperature- and pH-responsive polymeric micelle for selective and efficient two-step doxorubicin delivery

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mPEGylated solanesol micelles as redox-responsive nanocarriers with synergistic anticancer effect

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Tailored design of multifunctional and programmable pH-responsive self-assembling polypeptides as drug delivery nanocarrier for cancer therapy

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Specifically Increased Paclitaxel Release in Tumor and Synergetic Therapy by a Hyaluronic Acid-Tocopherol Nanomicelle

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Multi-responsive graft copolymer micelles comprising acetal and disulfide linkages for stimuli-triggered drug delivery

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Redox-Responsive Nanoparticles from the Single Disulfide Bond-Bridged Block Copolymer as Drug Carriers for Overcoming Multidrug Resistance in Cancer Cells

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Dysregulated pH: a perfect storm for cancer progression

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Crystal structures of Saturn-like C50Cl10 and pineapple-shaped C64Cl4: Geometric implications of double- and triple-pentagon-fused chlorofullerenes

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Temperature, pH, and ionic strength induced changes of the swelling behavior of PNIPAM-poly(allylacetic acid) copolymer microgels

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Cross-linking of poly(N-vinyl pyrrolidone) films by electron beam irradiation

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Hypoxia in cancer: significance and impact on clinical outcome

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Molecular recognition of sialic acid end groups by phenylboronates

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New functions for the matrix metalloproteinases in cancer progression

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NATURE REVIEWS CANCER (2002)

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The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors

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