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Optimizing Absorption for Intranasal Delivery of Drugs Targeting the Central Nervous System Using Alkylsaccharide Permeation Enhancers

PHARMACEUTICS (2023)

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Review Pharmacology & Pharmacy

Improvement of Intranasal Drug Delivery with Intravail(R) Alkylsaccharide Excipient as a Mucosal Absorption Enhancer Aiding in the Treatment of Conditions of the Central Nervous System

Adrian L. Rabinowicz et al.

Summary: Intranasal drug administration is a common route for therapeutic formulations, but challenges such as poor absorption and mucosal tissue damage exist. Potential absorption enhancers like alkylsaccharides have been investigated to address these issues, improving absorption of therapeutic agents across mucosal membranes and applicable to a wide range of molecules. Alkylsaccharide excipients, such as dodecyl maltoside, have shown to be nonirritating and effective in enhancing systemic bioavailability, and are used in FDA-approved intranasal formulations for migraine and epilepsy patients.

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Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers

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HEADACHE (2016)

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AAPS PHARMSCITECH (2015)

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Article Pharmacology & Pharmacy

Analytical Challenges and Regulatory Requirements for Nasal Drug Products in Europe and the U.S.

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A pilot study assessing the bioavailability and pharmacokinetics of diazepam after intranasal and intravenous administration in healthy volunteers

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EPILEPSY RESEARCH (2013)

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Review Instruments & Instrumentation

High efficiency intranasal drug delivery using Intravail® alkylsaccharide absorption enhancers

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DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2013)

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Review Pharmacology & Pharmacy

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Article Chemistry, Medicinal

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Zolmitriptan nasal spray exhibits good long-term safety and tolerability in migraine: Results of the INDEX trial

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