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Review
Pharmacology & Pharmacy
Yumin Wu et al.
Summary: Cancer vaccine is a promising strategy for personalized immunotherapy, with the efficacy depending on the specificity of tumor antigens. Neoantigens, derived from somatic mutations, have shown the potential to elicit tumor-specific antitumor immune response. However, the delivery of neoantigens to antigen-presenting cells for effective immune response remains a challenge. The development of biomaterials has provided opportunities to construct efficient cancer vaccines with high loading and controlled release capabilities.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Medicine, Research & Experimental
Ziqing Wu et al.
Summary: Biological membrane engineering methods can enhance the functionality of biomembrane-derived nanoparticles for improved drug delivery and treatment. These methods can be applied to various biomembranes and are expected to play a significant role in the treatment and diagnosis of cancer, inflammation, immunological diseases, bone diseases, and Alzheimer's disease.
Article
Chemistry, Multidisciplinary
Mengchi Sun et al.
Summary: This study develops a novel therapeutic strategy for breast cancer by combining immune checkpoint inhibitors with anthracycline and utilizing tumor-derived extracellular vesicles for drug delivery. The experimental results demonstrate that this strategy enhances the immune response and effectively destroys tumors in a TNBC mouse model, providing a solid foundation for clinical treatment.
Review
Instruments & Instrumentation
Hui Liu et al.
Summary: Recently, the use of nanoparticle-based drug delivery systems has become widespread for disease treatment, prevention, and detection. To enhance the targeted delivery ability, a novel concept known as bionic cell membrane coating technology has been developed for nanoparticles. By leveraging the diverse biological functions of cell membrane surface proteins, nanoparticles can achieve immune escape, long circulation time, and targeted delivery. This review focuses on the synthesis, development, and application of this cell membrane coating technology, as well as the function and mechanism of monotypic/hybrid cell membrane-modified nanoparticles. It also discusses the challenges in the clinical application of bionic carriers.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Moon Jung Choi et al.
Summary: Biocompatible theranostic erythrocyte-derived nanoparticles (EDNs) were developed for effective early diagnosis and treatment of triple-negative breast cancer (TNBC). The EDNs encapsulated the anti-cancer drug doxorubicin (DOX) and incorporated diagnostic quantum dots (QDs) for tumor bio-imaging. The surface of the EDNs was conjugated with anti-epidermal growth factor receptor (EGFR) antibody molecules to achieve TNBC targeting. This study demonstrated that the resulting antibody-conjugated EDNs exhibited strong biocompatibility, prolonged blood circulation, and efficient targeting of TNBC, making them potential co-delivery systems for therapeutics and diagnostics.
Article
Engineering, Biomedical
Yongjiang Li et al.
Summary: This study demonstrates the potential of using OMVs as antitumor therapeutics. By co-loading photosensitizer and chemotherapeutic drugs into OMVs and enhancing tumor-targeting ability through macrophage-mediated delivery, a combination of photodynamic therapy, chemotherapy, and immunotherapy can be achieved, effectively eradicating breast tumors and preventing tumor metastasis.
BIOACTIVE MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Aun Raza et al.
Summary: Natural killer (NK) cells are being explored as a major target for cancer immunotherapies, particularly as cellular therapy modalities due to their lower toxicity compared to T lymphocytes. However, there are challenges regarding the activation, genetic engineering resistance, and large-scale expansion of NK cell-based therapy. The use of nanobiomaterials has emerged as a promising solution to address these challenges and enhance the anticancer responses of NK cells for safer and more effective immunotherapy. Smart materials may play a crucial role in activating NK cells as a potential cellular therapy of the future.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qingshuang Tang et al.
Summary: A new nanoplatform combining genetically edited cell membrane and ultrasound responsive BTO has been developed, providing a safe and robust strategy in enhancing immune response against tumor.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhihong Sun et al.
Summary: The success of tumor immunotherapy highlights the potential of harnessing immune system to fight cancer. Strategies for efficient antigen presentation and improving the immunosuppressive microenvironment remain unresolved. This study developed aggregation-induced-emission (AIE) photosensitizer-loaded nano-superartificial dendritic cells (saDC@Fs-NPs) that could directly stimulate T-cell activation and reverse T-cell exhaustion for cancer immunotherapy. The AIE-active photosensitizers induced immunogenic cell death and enhanced T lymphocyte infiltration, promoting the transformation of cold tumors into hot tumors and boosting immunotherapy efficiency.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Nishta Krishnan et al.
Summary: In recent years, researchers have increasingly explored nanoparticles derived from cellular membranes for disease prevention and treatment. These biomimetic nanoparticles, with their flexible design and effective interaction with the surrounding environment, can outperform traditional synthetic nanoparticles. Genetic manipulation has proven to be a robust and flexible method to generate nanoformulations with augmented functionalities. This review provides an overview of genetic engineering approaches to express novel surface proteins and discusses the various biomedical applications of genetically modified cellular nanoparticles.
Article
Oncology
Mangala Hegde et al.
Summary: Metastasis is the main cause of cancer-related deaths, and despite advancements in treatment methods, it remains difficult to treat. Nanotechnology has shown promising applications in the diagnosis and treatment of metastatic cancer, with nanoparticles demonstrating the ability to target specific cells within metastatic regions. This review summarizes the current state of nanotechnology in the field and discusses its potential in various imaging techniques and combination therapies.
Review
Oncology
Ronnie H. Fang et al.
Summary: Cell membrane-coated nanoparticles (CNPs) are emerging nanocarriers that have the potential to improve cancer therapy by overcoming limitations of traditional nanoparticles. CNPs, consisting of a synthetic nanoparticulate core surrounded by a layer of naturally derived cell membranes, offer improved biocompatibility, immune evasion, and tumor targeting. They have been used for drug delivery, phototherapy, and immunotherapy.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Review
Instruments & Instrumentation
Sajad Najafi et al.
Summary: Extracellular vesicles (EVs) are membrane-bound organelles released from eukaryotic cells that can be used as biomarkers for human diseases. EVs have favorable features as ideal drug carriers and vaccines for diseases including cancer.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Xiaoyue Ma et al.
Summary: This study developed an activated mature dendritic cell membrane-coated nanoplatform, aDCM@PLGA/RAPA, which can cross the blood-brain barrier and improve the immune micro-environment, effectively inhibiting glioma growth with great potential for antiglioma immunotherapy.
Article
Engineering, Biomedical
Chunyu Xia et al.
Summary: A sponge-like neutrophil membrane-coated nano-system was developed to inhibit tumor recurrence and metastasis by inhibiting the recruitment and functions of myeloid-derived suppressor cells (MDSCs), which reinforced anti-tumor immunity and also suppressed pulmonary metastasis by inhibiting the formation of pre-metastatic niche (PMN). This nano-system not only showed natural tropism to postoperative inflammatory site but also relieved MDSCs-mediated immunosuppression. Additionally, it suppressed the formation of PMN to inhibit pulmonary metastasis.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Naitik Jain et al.
Summary: Nanocarriers (NCs) have potential in delivering hydrophobic cytotoxic drugs and tumor-specific targeting. However, their clinical translation is limited due to the inability to penetrate the tumor microenvironment and entrapment by macrophages. Immune cell membrane-coated NCs have gained popularity as they can accumulate inside the tumor while remaining unaffected by the immunosuppressive tumor microenvironment. This review discusses the molecular mechanism behind immune cell movement toward the tumor microenvironment, the preparation and characterization of membrane-coated NCs, and the efficacy of immune cell-mimicking NCs in tumor therapy.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Yuchen Xiao et al.
Summary: In this study, anti-PD-L1 functionalized biomimetic nanoparticles (PDA/GNS@aPD-L1 NPs) were developed for synergistic anti-tumor treatment by combining PD-1/PD-L1 blockade with photothermal ablation. The nanoparticles disrupted PD-1/PD-L1 immunosuppression signaling and delivered photothermal nanoparticles to tumor sites. The photothermal ablation of tumors released tumor-associated antigens and activated anti-tumor immune responses.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Qing You et al.
Summary: Engineered small extracellular vesicles (sEVs) with high CD47 expression and cyclic arginine-glycine-aspartic (c(RGDyC)) modification are developed to deliver short interfering RNA against m(6)A reader YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) for gastric cancer treatment. This nanosystem efficiently depletes YTHDF1 expression, suppresses cancer progression and metastasis, and enhances immune responses. The CD47 expression on the sEVs enhances phagocytosis of tumor cells by tumor-associated macrophages.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yuanke Li et al.
Summary: By genetically engineering antibody-anchored membranes, agonistic antibody-boosted tumor cell nanovaccines were developed to activate costimulatory pathways and improve immune responses against tumors.
ADVANCED MATERIALS
(2023)
Review
Engineering, Biomedical
Biao-Qi Chen et al.
Summary: This article reviews the challenges in nano-immunotherapy related to immune elimination and immunosuppressive microenvironment in cancer treatment. To address these issues, immune-regulating camouflaged nanocomposites have emerged as prevailing strategies. The article discusses the composition, performances, and mechanisms of various immune-regulating nanoplatforms and their applications in cancer immunotherapy and other immunotherapeutic modalities.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Shengyang Liu et al.
Summary: Researchers have developed a nanovaccine that activates the immune system to trigger tumor-specific immune responses, with potential clinical applications in tumor prevention and treatment. The nanovaccine promotes the uptake and maturation of antigens and adjuvants in dendritic cells, leading to an antitumor immune response.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Zhilin Li et al.
Summary: To improve the response rate of immune checkpoint inhibitors in immunosuppressive cancers, a self-amplified biomimetic nanosystem was constructed to induce immunogenic cell death at tumor sites. The nanosystem effectively reverses the immunosuppressive tumor microenvironment, leading to distinctive inhibition of tumor growth and metastasis when combined with immune checkpoint inhibitors.
BIOACTIVE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Na Xie et al.
Summary: Recent advances in neoantigen research have accelerated the development and regulatory approval of tumor immunotherapies, providing emerging targets for personalized cancer immunotherapies and potential predictors for tumor survival prognosis and immune checkpoint blockade responses.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Shuang Bai et al.
Summary: The genetically engineered transferrin-expressing cell membrane nanovesicle encapsulated IR820-dihydroartemisinin nanomedicine (Tf@IR820-DHA) scenario efficiently delivered Fe(III) and IR820-DHA nanoparticles to target tumor locations and induce oxidative stress-associated ICD. This triple stimuli-activated strategy caused high levels of targeted ICD, increasing IFN-gamma-secreting T cell proportions and enhancing a-PD-L1-mediated ICB against primary and distant tumors, representing a promising approach for cancer nanoimmunotherapy.
Review
Chemistry, Multidisciplinary
Jing Liu et al.
Summary: Cancer vaccines aim to stimulate tumor-specific immune responses while sparing normal tissues, with bioinspired materials and technologies playing a role in reshaping the field of cancer nanomedicine. By mimicking desirable properties in nature, bioinspired engineering of cancer vaccine delivery platforms can enhance therapeutic efficacy and safety profiles for clinical translation.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Kuikun Yang et al.
Summary: Nanomedicines, particularly polyprodrug nanomedicines, show promise in cancer therapies due to well-controlled composition and drug loading, presenting significant potential for combating tumors.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Fangyu Zhang et al.
Summary: Cell membrane-functionalized micromotors have attracted considerable interest for biomedical applications due to their biofunctional, versatile, and adaptive capabilities. This new class of micromotors demonstrates enhanced performance in complex biological environments, showing potential in advancing micromotor research.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jiachen Li et al.
Summary: An alternative strategy using photothermal and weak-immunostimulatory porous silicon@Au nanocomposites as particulate cores to prepare a biomimetic nanovaccine is reported. This strategy improves the biosafety and immunotherapeutic efficacy for solid tumors. The nanovaccine efficiently delivers cancer cell membranes into dendritic cells to activate antitumor immunity, resulting in no occurrence of solid tumors and the survival of all immunized mice. Additionally, the nanovaccine synergized with additional immunotherapies can inhibit the growth and metastasis of established solid tumors by initiating antitumor immune responses and reversing immunosuppressive microenvironments.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Dixita Ishani Viswanath et al.
Summary: Landmark successes in oncoimmunology have led to the development of cancer vaccines using biomaterials to enhance the host immune system against tumors. This review focuses on strategies to attract dendritic cells, activate them against tumor-specific antigens, and stimulate T cells in secondary lymphoid organs. Personalized cancer vaccines have the potential to generate long-term systemic immunity against patient- and tumor-specific antigens.
Article
Chemistry, Multidisciplinary
Mariona Estape Senti et al.
Summary: In this study, the consequences and mechanisms of complement activation by anti-PEG antibodies interacting with various types of PEGylated lipid-based nanoparticles were investigated. The activation of complement by anti-PEG antibodies can compromise the integrity of nanoparticles, leading to premature drug release or exposure to serum proteins. The levels of pre-existing anti-PEG IgM antibodies in plasma of healthy donors correlated with the degree of complement activation induced upon exposure to PEGylated liposomes and mRNA LNPs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Yonghui Wang et al.
Summary: Lung cancer is a leading cause of cancer death globally, with abdominal metastasis being particularly difficult to treat. Macrophages are being explored as a promising strategy for cell therapy in oncology. A novel approach using celastrol nanoparticle-containing M1-like macrophages shows potential as a therapeutic system for incurable abdominal metastasis of lung cancer.
Article
Chemistry, Multidisciplinary
Fangjie Chen et al.
Summary: This study utilized cascade cell membrane coating to prepare biomimetic nanoparticles that can manipulate the cross-priming of T cells, leading to strong antitumor immune responses. Combination with clinical anti-programmed death-1 antibodies demonstrated the potential of this approach in enhancing tumor regression and survival rate.
Article
Medicine, Research & Experimental
Qinqin Jiang et al.
Summary: By developing a H2O2 economizer, on-demand O-2 supply and reactive oxygen species production can be achieved during ultrasound activation, alleviating tumor hypoxia limitations and enhancing the efficacy of sonodynamic immunotherapy.
Article
Engineering, Biomedical
Ya-Nan Tan et al.
Summary: The study introduced a new cellular membrane nanovesicles platform for enhancing the efficacy of PD-1/PD-L1 blockade therapy against metastatic tumors. The platform targeted both primary tumors and metastases, promoting T cell infiltration and enhancing antigen presenting ability to inhibit tumor growth and metastasis.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Materials Science, Biomaterials
Nafeesa Khatoon et al.
Summary: Macrophage membrane-coated nanoparticles show promise in enhancing drug delivery and targeting for the treatment of various diseases.
BIOMATERIALS SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Yesi Shi et al.
Summary: In this paper, recent advancements in bioinspired membrane-coated nanoplatform for systemic protection against immune-related diseases, including autoimmune and infectious diseases, are summarized. The challenges and limitations in the progress of therapeutic nanoplatform are also discussed, and the further application of nanomodulators in translational medicine for combating immune-related diseases is explored.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Yongrong Yao et al.
Summary: A synergistic antitumor platform was constructed using cancer cell biomimetic nanoparticles to combine chemotherapy drugs and PD-1/PD-L1 blockade inhibitors, resulting in enhanced antitumor immunity and improved therapeutic efficacy.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Multidisciplinary Sciences
Chengli Yang et al.
Summary: This study combines chemotherapy with protein tyrosine phosphatase nonreceptor type 2 (Ptpn2)-based immunotherapy to improve the efficacy of melanoma treatment. The prepared nanoparticles effectively evade the reticuloendothelial system and accumulate in tumor sites. The multifunctional nanoparticles directly kill tumor cells, stimulate immunogenic cell death, and promote immune cell activation.
Article
Engineering, Biomedical
Tingting Wang et al.
Summary: This study demonstrates the significant improvement of immunotherapy efficacy for glioblastoma (GBM) by modulating the tumor immunosuppressive microenvironment (TIME) through novel all-in-one biomimetic nanoparticles. By remodeling the TIME, these nanoparticles activate immune responses, decrease tumor infiltration, and reduce the expression of PD-L1 on tumor cells. Modulating the TIME shows potential as a significant strategy to enhance immunotherapy for GBM and other cold tumors.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Liwen Fu et al.
Summary: This study developed a novel nanoparticle platform loaded with Rh2 drug for the effective treatment of osteosarcoma, capable of triggering immunogenic cell death, enhancing immune responses, and inhibiting tumor growth.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Xing Chen et al.
Summary: The cytomembrane-derived delivery platform is a promising biomimetic strategy for oncotherapy. By fusing mature dendrosomes with redox-responsive nanoparticles, durable and reliable tumor inhibition can be achieved, along with enhanced immunogenicity and immunocyte differentiation. Combination with aPD-L1 further enhances the antitumor effect.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Xiaoxi Wang et al.
Summary: An intelligent bionic nanoplatform combining targeted therapy with immunotherapy was developed to treat triple-negative breast cancer. In vitro and in vivo experiments demonstrated that this nanoplatform effectively inhibited the growth and metastasis of breast cancer and triggered an anti-tumor immune response.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Shuya Zang et al.
Summary: The study presents a biomimetic nanocarrier for targeted blockade of metabolic support between cancer cells and cancer-associated fibroblasts (CAFs). The nanocarrier effectively increases chemosensitivity of cancer cells, inhibits tumor growth, and reduces lactate production in the tumor microenvironment, leading to enhanced immune response and tumor suppression.
ACTA BIOMATERIALIA
(2022)
Review
Pharmacology & Pharmacy
Zhouqi Meng et al.
Summary: This review article explores the recent research progress of cell-derived biomimetic nanovaccines for cancer immunotherapy, and discusses the perspectives and challenges associated with the future clinical translation of these emerging vaccine platforms.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Nishta Krishnan et al.
Summary: Vaccines have been successful in managing many diseases, but there are still diseases without approved vaccine formulations. Bacterial membrane vesicles (BMVs) have gained attention as a versatile vaccine platform due to their immunostimulatory properties, nanoscale size, and ability to be modified for different diseases. This article provides an overview of the interactions between BMVs and immune cells, as well as their applications in bacterial infections, viral infections, and cancer.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Jing Yan et al.
Summary: This study demonstrates a synergistic approach using self-adaptive platelet pharmacytes for cascaded delivery of exosome-inhibiting siRNA and anti-PD-L1 to enhance antitumor immunity.
ADVANCED MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Huijie Han et al.
Summary: The development of cell membrane-modified biomimetic nanoparticles, specifically platelet membrane-coated nanoparticles, has shown great potential in the field of nanomedicine for targeted therapy. These nanoparticles can mimic the functions of primary cells and successfully deliver drugs to the targeted sites, enhancing therapeutic responses and reducing side effects. Platelet membrane-coated nanoparticles possess the characteristics of platelets, including immune system evasion and interaction with pathogens, making them an ideal drug delivery system.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Namdev Dhas et al.
Summary: The idea of using natural cell membranes as a coating for nanoparticles is a promising approach that gives man-made vectors natural capabilities and advantages. These biomimetic nanoparticles retain the physicochemical properties of the nanoparticles while also having the functionality of source cell membranes. They have been used for drug delivery, immune evasion, imaging, cancer-targeting, and phototherapy sensitivity. Various methods have been reported for reengineering the surface of nanoparticles using biological membranes, and cell-membrane-based biohybrid delivery systems have gained interest as therapeutic delivery systems due to their low immunogenicity and biomimetic properties.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Oncology
Qinghua Wu et al.
Summary: Hypoxia in the tumor microenvironment weakens cytotoxic T cell function and promotes recruitment of regulatory T cells, thereby reducing tumor immunogenicity. Hypoxia-inducible factors (HIFs), especially HIF1A and HIF2A, play important roles in tumor immune escape through various mechanisms. Understanding these mechanisms can lead to the development of targeted therapies for tumor treatment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Tan Li et al.
Summary: Recent breakthroughs in cell membrane-fabricated nanovaccine have provided innovative therapeutic options for preventing tumor metastasis and recurrence. However, the immunosuppressive tumor microenvironment makes personalized treatment of solid tumors challenging. In this study, a personalized photothermal nanovaccine was developed based on surgical-loaded mesoporous polydopamine nanoparticles, which showed outstanding imaging-guided photothermal immunotherapy efficacy and inhibited metastasis tumors by inducing antitumor immunities, especially in combination with aPD-L1 therapy. Prophylactic testing results confirmed that the photothermal nanovaccine can prevent rechallenge of 4T1 cells by 100% in a postsurgical tumor model. This work demonstrates the potential of personalized photothermal nanovaccine for tumor-specific treatment and prevention of postoperative tumor recurrence.
Article
Nanoscience & Nanotechnology
Chao Liu et al.
Summary: This study presents a genetically engineered cell membrane nanovesicle for cancer immunotherapy. The nanovaccine, named ASPIRE, can improve antigen delivery to lymphoid organs and generate broad-spectrum T-cell responses that eliminate established tumors. This work provides a powerful vaccine formula that can directly activate both native T cells and exhausted T cells, suggesting a general strategy for personalized cancer immunotherapy.
NATURE NANOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Shaobo Ruan et al.
Summary: Cancer immunotherapy has shown benefits in recent years, but novel targeting approaches and modulators are needed for broader patient populations. Extracellular vesicles (EVs) offer targeted immunity modulation and improved efficacy, with unique properties like surface markers and immunomodulatory functions. Future potential lies in EVs as a cancer immunotherapeutic biomaterial through reprogramming strategies and addressing unique challenges.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Shan Liu et al.
Summary: Extracellular vesicles (EVs) are important carriers in cell-to-cell communication, transferring substances such as DNA and RNA to recipient cells. EVs, with excellent biocompatibility and stability, can be used as therapeutic carriers for signal transduction, immunoregulation, and other therapeutic effects. This review summarizes the classification, isolation, and characterization strategies of EVs, and highlights recent advances in the application of EV therapeutics in in vitro research, in vivo animal models, and clinical settings.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Yingping Zeng et al.
Summary: Cancer immunotherapy effectively inhibits cancer progression by activating the autoimmune system. Cell membrane-coated nanoparticles have unique functions that allow for precise drug delivery and improved cancer immunotherapy effectiveness.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Hongmei Cao et al.
Summary: A strategy is developed to generate DEV-AIE nanoparticles by using DCs as a cell reactor, enabling synergistic photodynamic immunotherapy for effective tumor treatment and inhibition of cancer stem cells.
Review
Pharmacology & Pharmacy
Qiong Long et al.
Summary: Bacterial membrane vesicles (BMVs) have emerged as promising platforms for the development of vaccines and immunotherapeutic strategies. They are highly immunogenic due to the rich microbe-associated molecular patterns and can be modified for additional functions. This article reviews the immunological characteristics, production and modification techniques, and applications of BMVs as vaccines or vaccine carriers.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Xiu Zhao et al.
Summary: By mimicking the structure and infection processes of herpesvirus, a herpesvirus-mimicking nanoparticle named Vir-ZM@TD has been engineered for effective tumor therapy, showing promising results in inducing innate immunity and enhancing the survival time of tumor-bearing mice.
ADVANCED MATERIALS
(2022)
Review
Immunology
Samuele Notarbartolo et al.
Summary: CD4(+) and CD8(+) T-RM cells play a crucial role in the adaptive immune response against tumors. However, tumors can evade the surveillance of T-RM cells, leading to clinical manifestation. The generation and maintenance of T-RM cells, as well as their role in antitumor immunity and immunotherapy, are still areas of ongoing research.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Review
Biophysics
Jianing Zhao et al.
Summary: Cell membrane-based DDSs are promising drug delivery systems for cancer therapy, which can enhance delivery efficiency by combining different cell membrane sources and artificial nanocarriers. This review presents the recent advances in CDDSs and their functional mechanisms. A future perspective highlights the limitations of CDDSs and possible resolutions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Neda Khosravi et al.
Summary: Nanomedicine research has made significant progress, but encounters obstacles such as low drug concentration and rapid drug elimination. Stem cell membranes and stem cell-derived exosomes have emerged as promising therapeutic carriers. Combining synthetic nanoparticles with stem cell membranes enhances drug delivery. Utilizing stem cell-derived exosome membranes improves the therapeutic capability of engineered drug delivery vehicles.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Cell Biology
Fanqiang Meng et al.
Summary: Genetically engineered bacteria were used to synthesize fusion neoantigens and prepare personalized therapeutic vaccines, which effectively enhanced anti-tumor immune response.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Cell Biology
Dokyung Jung et al.
Summary: IL2-sEVs are potential cancer immunotherapeutic agents that regulate both immune and cancer cells by reprogramming miRNA levels, and improve anti-cancer efficacy by decreasing PD-L1 expression.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Nanoscience & Nanotechnology
Yu-Yang Huo et al.
Summary: The incorporation of thermosensitive lipid membrane into red blood cell and MCF-7 cancer cell hybrid membrane vesicles enhances chemo-/photothermal combined tumor therapy. Double-layer coating shows better antileakage and higher NIR-responsivity. The nanodrug can be efficiently and specifically taken up by MCF-7 cells.
ACS APPLIED BIO MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Wen-lu Yan et al.
Summary: Despite the clinical benefits of immune activation in cancer treatment, the immunosuppressive tumor microenvironment (ITME) poses a major challenge. This review explores strategies using nanosized drug delivery systems (NDDSs) to modulate ITME, including triggering immunogenetic cell death, utilizing tumor vaccines, and directly regulating intratumoral immune components. The contributions and future directions in this field are also discussed.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Pharmacology & Pharmacy
Suhaila O. Alhaj-Suliman et al.
Summary: In the past two decades, there has been increasing interdisciplinary research on the development of nanoparticles for medical applications. However, nanoparticles still face biological barriers and biodistribution challenges, limiting their overall clinical potential. To overcome these limitations, innovative modifications have been made to nanoparticle formulations designed for cancer imaging and treatment, aiming to enhance specificity and target diseased tissues. Recent advancements in technology and chemistry have been employed to modify the surface and characteristics of nanoparticles, in combination with identifying critical biomarkers, providing new strategies for improving nanoparticle specificity in cancer diagnosis and therapy. This review discusses the latest advances in nanoparticle design and engineering, and outlines future directions for the development of next-generation nanomedicines.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Yunqi Guo et al.
Summary: Reported is a nanomedicine formulation based on nanoparticles, which can release drugs on the surface of tumors, effectively inhibit tumor growth, and enhance the function of immune cells.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Pei Pan et al.
Summary: This study developed a hybrid nanoplatform combining radiosensitization and enhanced antitumor immune response. The platform utilized a high-Z element to produce reactive oxygen species (ROS) and induce immunogenic death in cancer cells under X-ray irradiation. Furthermore, the fusion of tumor cell and bacterial membranes amplified the immune response. The synergistic therapy achieved significant tumor inhibition and has potential as a clinical alternative treatment.
Article
Chemistry, Multidisciplinary
Chunping Liu et al.
Summary: Extracellular vesicles (EVs) are membranous vesicles secreted by living cells, serving as intermediaries for intercellular communication and molecular transfer. Recent studies have shown that EVs can regulate tumor occurrence and development by transferring molecules and have broad application prospects in immunotherapy. The breakthrough of nanotechnology promotes the development and exploration of engineered EVs for immune-targeted therapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Cong-Shan Yuan et al.
Summary: In this study, cancer cell membrane-camouflaged gelatin nanoparticles were used to co-deliver oxygen-generating agent and siRNA to improve tumor hypoxic microenvironment and enhance immune cell activity. The results demonstrated that this approach significantly suppressed tumor growth and enhanced cytotoxic T cell activity.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Mohamed Ibrahim et al.
Summary: Polyethylene glycol (PEG) is widely used as an additive in foods and cosmetics, and as a carrier in PEGylated therapeutics. However, there is mounting evidence that PEG causes immunogenic responses when conjugated with other materials, resulting in the production of anti-PEG antibodies. These antibodies can negatively impact the therapeutic efficacy of PEGylated formulations and hypersensitivity reactions to PEGylated products can be a significant barrier to their utility.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Wen Li et al.
Summary: This study presents a hybrid nanovaccine that can enhance T-cell immune responses by promoting antigen presentation and achieve effective cancer therapy through near-infrared light activation.
Article
Chemistry, Multidisciplinary
Zhixiang Lu et al.
Summary: Researchers have investigated sono-responsive nanoparticles coated with DC-targeted antibody chimeric cancer cell membrane for multimodal therapy. These nanoparticles can directly target and activate DCs, promote tumor antigen cross-presentation, and generate a T cell immune response. By producing reactive oxygen species through sonication, this sono-immunotherapy can also directly kill cancer cells.
Review
Immunology
Qi Jiang et al.
Summary: CCNPs have enormous potential in cancer immunotherapy, but there are challenges in translating their effects in vitro to the clinical setting. These challenges can be addressed in the future with a focus on individualized treatment with CCNPs and CCNPs combined with other effective treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Chelsea Peterson et al.
Summary: Immunotherapy has made significant advances in recent years, revolutionizing the field of oncology. This review discusses the successes and challenges of cancer immunotherapy, as well as recent advancements in tumor immunology that can help overcome treatment resistance.
Article
Nanoscience & Nanotechnology
Xiaoxia Song et al.
Summary: Researchers have developed a macrophage membrane-coated nanocomplex that can target and modulate the immune system for tumor therapy. The nanocomplex utilizes photoacoustic imaging and magnetic guidance, resulting in synergistic therapeutic effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Materials Science, Biomaterials
Mengling Shen et al.
Summary: Biological membrane-based nanomaterials have significant advantages in cancer therapy, providing efficient tumor treatment. This review summarizes the applications of different biological membrane-based nanomaterials and identifies areas for further improvement, offering systematic knowledge and optimization strategies in this field.
BIOMATERIALS SCIENCE
(2022)
Review
Medicine, Research & Experimental
Aparna Shukla et al.
Summary: Nanomedicine is a powerful tool for developing innovative drug carriers with greater efficacy and fewer side effects in cancer treatment. This review discusses different nanocarriers, their routes of administration, and the effect of dimensional properties on chemotherapy. It also highlights emerging therapies, such as photothermal, photodynamic, immunotherapy, chemodynamic, and gas therapy, and their advantages compared to conventional molecular anticancer therapies.
Review
Immunology
Jii Bum Lee et al.
Summary: Targeting immune evasion through immune checkpoint pathways has revolutionized cancer treatment. This review discusses the historical discovery of CTLA-4 and PD-1 and their potential as anti-cancer therapeutics. It also explores the clinical utility of immune checkpoint inhibitors, particularly in non-small cell lung cancer, and the ongoing research on combination therapy and novel ICIs.
Review
Pharmacology & Pharmacy
Flavia Castro et al.
Summary: Erythrocyte-mimicking nanovehicles (EM-NVs) have been extensively studied as biomimetic coating on artificial nanocarriers due to their upgraded biocompatibility, biodegradability, non-immunogenicity, and long-term blood circulation. These EM-NVs have a wide range of applications in drug delivery, imaging, phototherapy, and other areas, showing great potential for therapeutic and diagnostic applications in various diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Oncology
Hans Raskov et al.
Summary: The functions and interactions between the innate and adaptive immune systems play a crucial role in anticancer immunity. Cytotoxic T cells with CD8 as the most effective effectors in the anticancer immune response form the basis of successful cancer immunotherapies. Advancements in genetically modified or synthetic receptors on cytotoxic T cells are being developed for future cancer treatment. Combinatory regimens may optimize treatment effects and reduce adverse events in cancer therapy.
BRITISH JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Fernanda G. Kugeratski et al.
Summary: Exosomes play crucial roles in cancer by either promoting tumor development or inhibiting tumor immune suppression. They deliver signals that affect immune regulation of lymphoid and myeloid cell populations in tumors.
Article
Nanoscience & Nanotechnology
Yao Lu et al.
Summary: In this study, biomimetic artificial antigen-presenting cells (aAPCs) were developed using ultrathin MnOx nanoparticles functionalized with T-cell activators and tumor cell membranes to enhance lung metastasis immunotherapy. These aAPCs efficiently expanded and activated intratumoral CD8(+) T cells and dendritic cells, while regulating the tumor microenvironment (TME) to facilitate T-cell survival.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Jordi Llop et al.
Summary: Nanoparticles with surface-modified esterase-cleavable radionuclide anchors can reduce retention in liver and spleen, leading to enhanced accumulation and imaging contrast in tumors. These advances have potential applications in early cancer detection, diagnosis, and radionuclide therapy.
Article
Engineering, Biomedical
Zhihong Sun et al.
Summary: The study introduced a new potential anti-tumor immunotherapy method called intelligent DCs (iDCs), which utilize nanoparticles loaded with photothermal agents and coated with mature DC membrane technology. iDCs can stimulate T cells, reduce the expression of heat shock proteins in tumor cells, and induce immunogenic cell death through mild photothermal therapy, achieving a synergistic anti-tumor effect.
Article
Chemistry, Multidisciplinary
Adrija Jha et al.
Summary: This article discusses the advantages of biomimetic nanoparticles as drug delivery systems, such as biocompatibility and targeting ability, and explores their applications in cancer treatment and diagnosis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Oncology
Eryn Blass et al.
Summary: Immunotherapy has revolutionized cancer treatment with the development of immune-checkpoint inhibitors and personalized neoantigen vaccines. These vaccines trigger specific T cell responses against individual patient's tumors, showing promising tumor-specific immunogenicity and antitumor activity.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Review
Oncology
Ping Gong et al.
Summary: Cancer immunotherapy, such as CAR-T and PD-1, is a breakthrough in cancer treatment, but still faces challenges. Cell membrane-coated nanomaterials have shown promise in improving the effectiveness and safety of tumor immunotherapy. The use of immunocyte membranes as a natural barrier for nanocarriers is a rapidly developing field in recent years.
Article
Chemistry, Multidisciplinary
Cheng Xu et al.
Summary: SPNE is a polymer multicellular nanoengager that combines an NIR-II absorbing polymer core with fused membranes from immunologically engineered tumor cells and DCs for synergistic second-NIR-II photothermal immunotherapy. It enables effective interactions among tumor cells, DCs, and T cells by high accumulation in lymph nodes and tumors, leading to enhanced T cell activation.
ADVANCED MATERIALS
(2021)
Review
Engineering, Biomedical
Peipei Wu et al.
Summary: Extracellular vesicles play a crucial role in disease treatment and diagnosis, with engineered design enhancing their therapeutic capability and diagnostic imaging potential.
Article
Engineering, Biomedical
Haimei Zhou et al.
Summary: The study utilized slow-release Poly I: C-encapsulated nanoparticles and biomimetic system MPLP to effectively inhibit tumor growth and metastasis by activating bone marrow-derived macrophages' tumor-specific immune response.
Article
Nanoscience & Nanotechnology
Dan Wu et al.
Summary: This study introduces a novel approach using cell membrane-encapsulated magnetic nanoparticles to activate NK cells and enhance their anti-tumor effects.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Fatemeh Oroojalian et al.
Summary: Nanotechnology offers promising opportunities for cancer management, particularly through biomimetic approaches using immune cell membranes to coat nanoparticles for improved stability and targeting; the surface proteins from immune cells can provide various functionalities to nanoparticles, enhancing their efficacy and reducing toxicity.
Article
Chemistry, Multidisciplinary
Liang Gong et al.
Summary: The study proposes a glycoengineering approach to decorate NK cells with nanobodies such as 7D12, which enhances the affinity and specificity of NK cells to tumor cells overexpressing EGFR. The modified NK cells showed increased cytokine secretion and effective killing of EGFR-positive tumor cells, indicating a potential novel method for cancer-targeted immunotherapy.
Review
Engineering, Biomedical
Faisal Raza et al.
Summary: Immunotherapy in cancer treatment is being significantly impacted by advancements in biomimetic nanotechnology. The challenges surrounding cancer nanomedicine have led to a push for innovative approaches, such as biomimetic nanoparticles, to improve the delivery and effectiveness of immunotherapeutics for cancer. These strategies show promise in addressing issues related to the tumor microenvironment, patient heterogeneity, and immunotoxicity.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Jun Dai et al.
Summary: The study presents a novel strategy for tumor photodynamic-immunotherapy using red blood cell-mimicking nanoparticles, combining photodynamic therapy and immunotherapy properties to achieve synergistic immune system activation for anti-tumor activity. The nanoparticles demonstrated significant anti-tumor efficacy in a tumor-bearing mouse model, showing promising potential in enhancing tumor immunotherapy.
NATIONAL SCIENCE REVIEW
(2021)
Review
Pharmacology & Pharmacy
Quoc-Viet Le et al.
Summary: Cell membrane-derived vesicles, with their unique multicomponent feature, have the potential to overcome various obstacles encountered in vivo and have created a new category of drug delivery systems. This technology has significant potential applications in the field of drug delivery.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Nanoscience & Nanotechnology
Zhaowei Li et al.
Summary: The study developed a versatile biomimetic nanoplatform for the synergism of photothermal/starvation/immunotherapy, demonstrating effective inhibition of primary tumors and metastasis, induction of immune memory effect, paving the way for high-performance tumor ablation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Cell Biology
Lingxiao Ye et al.
Summary: The binding of PD-L1 with its receptor PD-1 can deactivate cytotoxic T lymphocytes, facilitating immune escape of tumors. Exosomal PD-L1 derived from tumor cells is implicated in drug resistance. The potential of circulating exosomal PD-L1 as a clinical indicator and therapeutic targeting strategies are discussed, including inhibiting exosome biogenesis or secretion.
Review
Chemistry, Multidisciplinary
Zahid Hussain et al.
Summary: Cell-membrane camouflaged nanomedicines have emerged as a promising approach to address limitations in cancer treatment, improving drug delivery and therapeutic outcomes. These biomimetic nanomedicines optimize drug delivery by enhancing circulation time, permeation into the cancerous microenvironment, minimizing immunogenicity, and enabling cell-cell communication.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Jaehyun Kim et al.
Summary: Cancer immunotherapy has greatly improved the standard of care for solid tumors, with immune checkpoint blockade targeting immunosuppressive mechanisms. However, the overall response rate to immune checkpoint blockades is low, with some patients experiencing severe immune-related adverse events. The failure of immune checkpoint blockades is primarily attributed to the tumor microenvironment, leading to current research focusing on targeting and suppressing the immunosuppressive characteristics within the tumor microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Tao Zhang et al.
Summary: A biomimetic nanoplatform was developed for efficient co-loading and targeted delivery of photo/chemotherapeutic agents for TNBC combination treatment, showing excellent TNBC-targeting ability and high PTT/PDT performances both in vitro and in vivo. This platform exhibited synergistic cytotoxicity and apoptosis-inducing activity in TNBC cells, effectively suppressing tumor growth and recurrence through tumor ablation and antiangiogenesis.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Baicheng Wei et al.
Summary: A new cancer treatment strategy has been developed, where tumor-associated macrophage polarization therapy combined with ICD induced by low-dose chemotherapy drugs can significantly enhance the efficacy of immunotherapy.
Review
Immunology
Carolyn Marar et al.
Summary: Extracellular vesicles play a crucial role in regulating the immune response during tumor progression, serving as mediators of communication between cancer and immune cells. Their diverse molecular cargo can shed light on tumor progression mechanisms, offering diagnostic and prognostic tools for immunologists.
Article
Chemistry, Multidisciplinary
Xiaoqiang Zheng et al.
Summary: The research developed a new class of cell-mimicking nanomedicine using oligomeric Au(I)-peptide complex to create erythrocyte-mimicking nano-cells, which effectively restored p53 and p73 and augmented antitumor immunity. This study suggests that MDM2/MDMX degradation is a potential therapeutic paradigm to synergize anti-PD1 immunotherapy for LUAD, and cell-mimicking nanoparticles with bionic skeletons hold promise in revolutionizing nanomedicine for various human diseases.
Article
Chemistry, Multidisciplinary
Chengyun Chen et al.
Summary: The thiolated and Mn2+ coordinated cyclic dinucleotide nanovaccine (Mn-cGAMP NVs) enhances the stability of cGAMP and activation of STING, promoting antitumor immune response through direct cytosolic delivery and avoiding degradation.
Article
Multidisciplinary Sciences
Baharak Bahmani et al.
Summary: This study explores the potential of using platelet membrane-coated nanoparticles for localized delivery of TLR agonists in tumor immunotherapy. The results demonstrate enhanced local immune activation, complete tumor regression in colorectal tumor models, and protection against tumor re-challenges. Moreover, intratumoral delivery of TLR agonists also shows efficacy in delaying tumor growth and inhibiting metastasis in aggressive breast cancer models.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Jie Li et al.
Summary: The study introduced the use of natural product Solamargine to design cell-mimicking core-shell nanoparticles with acid-responsive off-coating properties, which showed superior antitumor efficacy in tumor-targeted therapy. This off-coating strategy provides a new perspective for optimizing CM-NPs and highlights the application value of natural product medicines and excipients.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Oncology
Hans-Ake Fabricius et al.
Summary: Platelets, as the smallest cells in the blood stream, play crucial roles in hemostasis, inflammation, immunity, and tissue repair. In malignancies, platelets are also involved in promoting metastasis and resistance to anti-tumor treatment. The complex interaction between platelets and cancer cells is still not fully understood, although various surface molecules and transduction mechanisms have been identified.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Ao Chen et al.
Summary: A nanoplatform was constructed to reverse tumor acidosis and hypoxia through alkali and oxygen generation triggered by tumor acidosis, polarizing tumor-associated macrophages to anti-tumor M1 phenotype macrophages and enhancing tumor immune response. Furthermore, under regional light irradiation, reactive oxygen species produced by photosensitizers in the nanoplatform could increase the immunogenicity of tumors, transitioning tumors from immunosuppressive cold tumors to immunogenic hot tumors and amplifying the effect of immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yale Yue et al.
Summary: The complete regression of residual tumors after photothermal therapy depends on the activation and recognition of the immune system. This study explored biomimetic nanoparticles carrying repolarization agent of TAMs to remodel the post-PTT inflammatory microenvironment. In a breast tumor model, these nanoparticles significantly elevated the levels of M1-like TAMs, resulting in an increased tumor-elimination rate.
Article
Engineering, Biomedical
Shichuan Hu et al.
Summary: In this study, fibroblast activation protein-alpha (FAP) gene-engineered tumor cell-derived exosome-like vesicle vaccines (eNVs-FAP) were developed as a candidate tumor vaccine targeting both the tumor parenchyma and the stroma. The eNVs-FAP vaccine showed excellent antitumor effects by inducing strong and specific CTL immune responses against tumor cells and FAP +CAFs, and reprogramming the immunosuppressive TME in various cancer models. The mechanistic analysis revealed that eNVs-FAP promoted DC maturation, increased effector T cell infiltration, and reduced immunosuppressive cell populations in the TME, leading to enhanced tumor cell ferroptosis.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Xueqin Huang et al.
Summary: Creating a biomimetic nanoplatform by coating homologous cancer cell membranes onto mesoporous polydopamine nanoparticles encapsulating the autophagy inhibitor chloroquine allows for synergistic manipulation of photothermal therapy and autophagy to achieve enhanced anticancer efficiency with high tumor targeting and penetration abilities against prostate cancer.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Yi Liu et al.
Summary: Camouflaged cell-membrane-based nanoparticles loaded with therapeutic miRNAs show promise in improving treatment outcomes for breast cancer. This strategy has the potential for clinical translation to enhance personalized therapy for breast cancer and other malignancies, by sensitizing tumor cells to chemotherapy and demonstrating site-specific accumulation at tumor sites.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yupeng Wang et al.
Summary: An engineered biomimetic nano-RBC system utilizing hemoglobin is developed to deliver chemotherapy drugs and oxygen, effectively reprogramming the tumor immunosuppressive microenvironment. This strategy targets tumor-associated macrophages and alleviates tumor hypoxia, enhancing the antitumor immune response and inhibiting tumor metastasis and recurrence.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jihye Hong et al.
Summary: While T-cell therapy is a significant breakthrough in cancer immunotherapy, its efficacy against solid tumors is limited due to T-cell exhaustion caused by immunosuppressive mechanisms. T-cell-derived nanovesicles (TCNVs) produced by extrusion through membranes with micro/nanosized pores show promising anti-tumoral activity in the immunosuppressive tumor microenvironment. TCNVs express programmed cell death protein 1 and TGF-beta receptor on their surface, which helps block PD-L1 on cancer cells and scavenge TGF-beta in the TME, preventing T-cell exhaustion and directly killing cancer cells. These findings suggest TCNVs as an effective strategy for cancer immunotherapy to overcome tumor's immunosuppressive mechanisms.
ADVANCED MATERIALS
(2021)
Review
Microbiology
Mariana G. Sartorio et al.
Summary: Production of extracellular vesicles in bacteria, particularly outer membrane vesicles (OMVs) in gram-negative bacteria, is a well-documented but poorly understood process. Besides their roles in pathogenesis, cell-to-cell communication, and stress responses, OMVs also play important roles in immunomodulation and balancing the gut microbiota. The review discusses the various roles of OMVs and the current understanding of their biogenesis, as well as the expanding biotechnological applications of OMVs.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021
(2021)
Review
Pharmacology & Pharmacy
Yukiya Takayama et al.
Summary: Although numerous preclinical studies have shown significant anti-tumor effects of MSC-based cancer therapy, several clinical trials have failed to demonstrate consistent results, indicating limited therapeutic effects. In order to achieve successful clinical outcomes with MSC-based cancer therapy, it is important to address interdonor heterogeneity of administered MSCs, improve tumor-homing efficiency, and optimize drug delivery from MSCs to cancer cells.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Hematology
Alexander Biederstaedt et al.
Summary: Cellular immunotherapy, particularly CAR-NK therapy, has shown promising efficacy in treating hematologic malignancies. Research is focused on enhancing CAR-NK cell potency and translating successful strategies to solid tumor treatments.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiang Xiong et al.
Summary: A novel nanovaccine containing a cell membrane antigen induced by immunogenic cell death was reported, providing a complete antigen array and avoiding severe chemotherapy toxicity. The nanovaccine codelivers adjuvant R837 and membrane antigen, triggering personalized immune responses, enhancing antitumor effects, and providing long-term protection. The surface-exposed calcinetin on the nanovaccine actively uptakes dendritic cells, enhancing antitumor effects, and activating immune memory cells.
Article
Chemistry, Multidisciplinary
Cailing Chen et al.
Summary: Cell-membrane-coated nanoparticles, particularly those derived from tumor-associated macrophages (TAMM), show promise as an antitumor therapeutic strategy. TAMM exhibit unique antigen-homing affinity capacity and immune compatibility, with potential to enhance antitumor immunity efficiency via activation of antigen-presenting cells and production of tumor-specific effector T cells in metastatic tumors. TAM-membrane-based photodynamic immunotherapy offers a new personalized approach to tumor therapy.
Review
Nanoscience & Nanotechnology
Inge Katrin Herrmann et al.
Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.
NATURE NANOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yujie Shi et al.
Summary: The development of long-acting parenteral formulations (LAPFs) aims to improve drug pharmacokinetics and therapeutic efficacy in treating chronic diseases. LAPFs have been shown to extend therapeutic half-life and enhance patient adherence, leading to positive treatment outcomes. Despite progress in designing effective LAPFs, challenges and prospects remain in manipulation of in vivo clearance and drug release to achieve long-acting effects.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Oncology
Celine Pisibon et al.
Summary: Immune checkpoint therapies have revolutionized cancer treatment by reactivating the patient's immune system. Despite clear benefits observed in patients, many still fail to respond or develop resistance to these treatments. Understanding the mechanisms of immune checkpoints is essential for overcoming resistance and improving clinical outcomes.
Article
Chemistry, Multidisciplinary
Songbo Zhao et al.
Summary: A novel immunotherapy approach utilizing NK cells conjugated with magnetic nanoparticles has been developed for treating solid tumors, demonstrating improved tumor targeting and inhibition capabilities through magnetic field guidance.
Article
Oncology
Peter M. K. Westcott et al.
Summary: The study reveals that despite low TMB, tumors from patients with microsatellite stable colorectal cancer still express predicted neoantigens, although at lower levels compared to those in colorectal cancer with microsatellite instability. Low expression of neoantigens may lead to immediate T-cell dysfunction, but it can be controlled by restoring priming in tumors with low neoantigen expression.
Review
Biochemistry & Molecular Biology
Li Chen et al.
Summary: Biomimetic nanoparticles (BNPs) integrate biological vectors with functional agents for targeted drug delivery. Natural vectors are deliberately modified to enhance permeability, loading capability, and specificity, making them more effective for delivering contrast agents, chemotherapy drugs, nucleic acids, and genes to target sites.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Nanoscience & Nanotechnology
Maya Holay et al.
Summary: The field of nanomedicine has accelerated significantly in the past decade by drawing inspiration and materials from the natural world. Bacteria-inspired nanomedicines, with their motility, immune modulation, and dynamic interactions, have opened up exciting avenues of research and proven successful in combatting cancer and infectious disease.
ACS APPLIED BIO MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Jiacheng Huang et al.
Summary: The extracellular matrix (ECM) is a key component of tumors, playing roles in mechanical support, microenvironment modulation, and signaling. Interactions between cancer cells and the tumor microenvironment can lead to ECM stiffness changes and contribute to malignant transformation. Understanding ECM dysregulation in the TME is essential for identifying therapeutic targets for cancer treatment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Medicine, Research & Experimental
Liyan Li et al.
Summary: By overexpressing CD64 on cell membrane nanovesicles and encapsulating PD-L1 antibody and chemotherapeutic agent CP, the CD64-NVs-aPD-L1-CP can simultaneously disrupt the immunosuppressive effect of PD-L1, decrease the inhibition of Tregs, enhance the tumor elimination by T cells, suppress tumor growth, and extend survival time, making them charismatic carriers for combined cancer immunotherapy.
Article
Chemistry, Multidisciplinary
Xupeng Mu et al.
Summary: Combination therapy using PD-L1 blockade, PD-L1 siRNA, and DOX shows great potential for treating prostate cancer bone metastasis through synergistic chemoimmunotherapy. Stem cell membrane-camouflaged nanoparticles can enhance blood retention and tumor accumulation, improving therapeutic efficacy.
Article
Materials Science, Biomaterials
Ying Long et al.
Summary: The newly developed pH-responsive liposome loaded with multiple drugs showed enhanced anti-tumor activity against gastric cancer by inducing apoptosis, autophagy, pyroptosis, and inhibiting tumor invasion and metastasis through the VEGFR2/STAT3 pathway. The naturally-derived hybrid cell membrane coating improved the biointerfacing of nanocomplexes, leading to prolonged circulation time and enhanced targeting ability.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Wonchan Park et al.
Summary: A study developed a method to deliver drugs to the skin through microneedles, stimulating the immune system using tumor cell membrane proteins as specific antigens and a TLR7 agonist to inhibit cancer cell growth. In vivo experiments showed that microneedles loaded with F127-R837@M NPs significantly inhibited cancer cell growth.
Article
Materials Science, Biomaterials
Xiaochen Pei et al.
Summary: A multiple-unit nanocluster was developed by randomly reuniting multiple PAMAM core units with cell membrane fragments, showing promising potential for tumor homotypic targeting and anti-metastasis treatment.
BIOMATERIALS SCIENCE
(2021)
Review
Materials Science, Biomaterials
Mian Wang et al.
Summary: MSC membrane-coated nanoparticles are an effective method for selective targeting and enhancing therapeutic efficacy. Combining bioengineered cell membranes with synthesized nanoparticles offers a wide range of possibilities for the development of targeted drug delivery.
BIOMATERIALS SCIENCE
(2021)
Review
Materials Science, Biomaterials
Xuerui Chen et al.
Summary: Personalized cancer therapy is becoming increasingly important, and the use of cell membrane-coated nanoparticles allows for individualized treatment, improving the efficacy of anticancer therapy.
BIOMATERIALS SCIENCE
(2021)
Review
Engineering, Biomedical
Cheng-Hui Xu et al.
ACTA BIOMATERIALIA
(2020)
Review
Engineering, Biomedical
Hong-Ying Chen et al.
ACTA BIOMATERIALIA
(2020)
Article
Chemistry, Multidisciplinary
Shanshan Cheng et al.
Article
Chemistry, Multidisciplinary
Qin Jiang et al.
Article
Chemistry, Multidisciplinary
Qianhua Feng et al.
Review
Pharmacology & Pharmacy
Gergely Tibor Kozma et al.
ADVANCED DRUG DELIVERY REVIEWS
(2020)
Article
Chemistry, Multidisciplinary
Yao Jiang et al.
ADVANCED MATERIALS
(2020)
Article
Engineering, Biomedical
Huaiji Wang et al.
Review
Cell Biology
Luo-Qin Fu et al.
CELLULAR IMMUNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Serkan Yaman et al.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Min Li et al.
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Nanoscience & Nanotechnology
Dongdong Wang et al.
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Mikyung Kang et al.
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Lang Rao et al.
ADVANCED MATERIALS
(2020)
Article
Engineering, Biomedical
Pengfei Zhao et al.
Article
Engineering, Biomedical
Chuan Hu et al.
Article
Cell Biology
Mengze Lv et al.
Article
Chemistry, Multidisciplinary
Lingqiao Liu et al.
Review
Pharmacology & Pharmacy
Yuefei Zhu et al.
ACTA PHARMACEUTICA SINICA B
(2020)
Article
Chemistry, Multidisciplinary
Yao Li et al.
Review
Oncology
Sonam Mittal et al.
Article
Chemistry, Multidisciplinary
Yuanyuan Cheng et al.
Review
Chemistry, Multidisciplinary
Pratigyan Dash et al.
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Chemistry, Multidisciplinary
Dan Shao et al.
ADVANCED MATERIALS
(2020)
Review
Oncology
Wei Yan et al.
Article
Nanoscience & Nanotechnology
Anil Parsram Bidkar et al.
ACS APPLIED NANO MATERIALS
(2020)
Review
Pharmacology & Pharmacy
Qing Xia et al.
ACTA PHARMACEUTICA SINICA B
(2019)
Review
Immunology
Robert E. Hollingsworth et al.
Article
Biochemistry & Molecular Biology
Ali Masjedi et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Multidisciplinary Sciences
Wen-Long Liu et al.
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Ravi B. Patel et al.
ADVANCED MATERIALS
(2019)
Review
Oncology
Tao Jiang et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Qian Chen et al.
ADVANCED MATERIALS
(2019)
Review
Immunology
Jitka Fucikova et al.
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Oncology
Jenna C. Harris et al.
Review
Cell Biology
Bagher Farhood et al.
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Chemistry, Multidisciplinary
Hong-Hui Wu et al.
JOURNAL OF CONTROLLED RELEASE
(2019)
Review
Biotechnology & Applied Microbiology
Xueman Chen et al.
NATURE REVIEWS DRUG DISCOVERY
(2019)
Editorial Material
Oncology
Jacques Banchereau et al.
NATURE REVIEWS CLINICAL ONCOLOGY
(2018)
Review
Chemistry, Multidisciplinary
Yiming Zhou et al.
CHEMISTRY-AN ASIAN JOURNAL
(2018)
Review
Immunology
Samanta C. Funes et al.
Review
Oncology
Robert D. Leone et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2018)
Review
Pharmacology & Pharmacy
Ruixiang Li et al.
ACTA PHARMACEUTICA SINICA B
(2018)
Article
Medicine, Research & Experimental
Jordan Gauthier et al.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2018)
Editorial Material
Engineering, Biomedical
Mansi Saxena et al.
NATURE BIOMEDICAL ENGINEERING
(2018)
Review
Oncology
Si-Qi Qiu et al.
CANCER TREATMENT REVIEWS
(2018)
Article
Multidisciplinary Sciences
Gang Chen et al.
Article
Immunology
Bin Han et al.
JOURNAL OF IMMUNOLOGY RESEARCH
(2018)
Review
Medicine, Research & Experimental
Aldo Pezzuto et al.
CURRENT MOLECULAR MEDICINE
(2018)
Review
Chemistry, Multidisciplinary
Rui Zhang et al.
JOURNAL OF CONTROLLED RELEASE
(2018)
Review
Immunology
Zhuting Hu et al.
NATURE REVIEWS IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Yupeng Wang et al.
Review
Biochemistry & Molecular Biology
Jianjin Shi et al.
TRENDS IN BIOCHEMICAL SCIENCES
(2017)
Review
Cell Biology
Costas A. Lyssiotis et al.
TRENDS IN CELL BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Guangbao Yang et al.
NATURE COMMUNICATIONS
(2017)
Article
Chemistry, Multidisciplinary
Hao Tian et al.
ADVANCED FUNCTIONAL MATERIALS
(2017)
Article
Chemistry, Multidisciplinary
Lang Rao et al.
Article
Chemistry, Multidisciplinary
Ze Chen et al.
Article
Chemistry, Multidisciplinary
Huiping Sun et al.
ADVANCED MATERIALS
(2016)
Article
Chemistry, Multidisciplinary
Jing-Yi Zhu et al.
Review
Immunology
Hergen Spits et al.
Article
Chemistry, Multidisciplinary
Quanyin Hu et al.
ADVANCED MATERIALS
(2015)
Editorial Material
Medicine, Research & Experimental
Yiping Yang
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Article
Chemistry, Multidisciplinary
Weiwei Gao et al.
Article
Multidisciplinary Sciences
Che-Ming J. Hu et al.
Article
Multidisciplinary Sciences
Jarno Drost et al.
Article
Multidisciplinary Sciences
A. Phillip West et al.
Article
Chemistry, Multidisciplinary
Jianhua Zhang et al.
Article
Oncology
Ivraym B. Barsoum et al.
Article
Chemistry, Multidisciplinary
Brian T. Luk et al.
News Item
Biotechnology & Applied Microbiology
Laura DeFrancesco
NATURE BIOTECHNOLOGY
(2014)
Review
Oncology
Ubaldo E. Martinez-Outschoorn et al.
SEMINARS IN CANCER BIOLOGY
(2014)
Article
Oncology
Michail V. Sitkovsky et al.
CANCER IMMUNOLOGY RESEARCH
(2014)
Article
Oncology
Esra A. Akbay et al.
Article
Multidisciplinary Sciences
Che-Ming J. Hu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Engineering, Biomedical
Xiao-Shan Yue et al.
Article
Oncology
WA Osta et al.
Review
Multidisciplinary Sciences
LM Coussens et al.
