☆ 4.7 Article

Polymorphism and Multi-Component Crystal Formation of GABA and Gabapentin

PHARMACEUTICS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Multidisciplinary

Conformational Selectivity and Evolution Affected by the Desolvation Process

Yue Liu et al.

Summary: The conformation and polymorph selectivity of gabapentin were investigated in this study. The structural differences between conformers in solution and crystal states were analyzed, and the effects of solute-solvent interactions on conformational selectivity were explored. Additionally, a possible mechanism for selective polymorph crystallization was proposed and analyzed.

CRYSTAL GROWTH & DESIGN (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

How Many Cocrystals Are We Missing? Assessing Two Crystal Engineering Approaches to Pharmaceutical Cocrystal Screening

Davey Chiara Cappuccino et al.

Summary: Drug development may involve extensive screening for crystalline forms of active pharmaceutical ingredients. Crystal engineering, although aiming to simplify this task, may overlook potentially interesting compounds. This study compares the effectiveness of a knowledge-based approach to a systematic crystallization screening and finds that computational methods perform better in identifying successful cocrystallization.

CRYSTAL GROWTH & DESIGN (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

GABA-Controlled Synthesis of the Metastable Polymorphic Form and Crystallization Behavior with a Chiral Malic Acid

Laura Lamkowski et al.

Summary: This study describes the successful synthesis of the pharmaceutical interesting metastable polymorph H of the API gamma-aminobutyric acid (GABA) using a controlled pH-based crystallization approach with acetic acid, a method previously accessible only through sublimation. It also presents the synthesis and single crystal characterization of a nonhydrated chiral [GABA-H] [malate] compound.

CRYSTAL GROWTH & DESIGN (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Polymorphism in the 1/1 Pterostilbene/Picolinic Acid Cocrystal

Rafael Barbas et al.

Summary: The crystal structures of two new polymorphs of the 1/1 pterostilbene/picolinic acid cocrystal have been analyzed, characterized, and explained in terms of energetics and bioavailability, with a focus on the supramolecular synthons formed by picolinic acid.

CRYSTAL GROWTH & DESIGN (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Keywords: γ-Aminobutyric acid Pyridoxalkinase Glutamate decarboxylase Whole-cell bioconversion Pyridoxal 5′-phosphate

Sion Ham et al.

Summary: Gamma-aminobutyric acid (GABA) is a crucial neurotransmitter inhibitor in the mammalian nervous system and can also be used for bioplastics synthesis. Current whole-cell bioconversion systems for GABA production require a costly cofactor PLP. This study introduces a new GABA producing system that can achieve competitive level production without additional PLP supply.

ENZYME AND MICROBIAL TECHNOLOGY (2022)

添加到收藏夹

Article Chemistry, Physical

Study of the crystal structure, H-bonding and noncovalent interactions of novel cocrystal by systematic computational search approach

B. S. Chethan et al.

Summary: A novel cocrystal based on hydrogen bonding interactions was designed and characterized using experimental and theoretical methods. The results showed that intramolecular charge transfer stabilizes the crystal structure, and weak noncovalent interactions play an important role in the crystal structure.

JOURNAL OF MOLECULAR STRUCTURE (2022)

添加到收藏夹

Article Crystallography

A Lection in Humbleness: Crystallization of Chiral and Zwitterionic APIs Baclofen and Phenibut

Marco Herbst et al.

Summary: This study discusses the crystallization and multicomponent crystal formation of active pharmaceutical ingredients with dicarboxylic acid co-formers. The research elucidates the crystallization process of several crystalline entities and investigates the factors influencing the outcome.

CRYSTALS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Co-crystals of zwitterionic GABA API's pregabalin and phenibut: properties and application

Daniel Komisarek et al.

Summary: Several multicomponent crystalline species formed by zwitterionic GABA analogues pregabalin and phenibut are presented in this study. The compounds are evaluated based on their crystal structure and properties such as melting behaviour, solubility, and lattice energies. Furthermore, the major property distinctions between a homo- and heterochiral co-crystalline system and how they enable enantiopurification of pregabalin are discussed.

CRYSTENGCOMM (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Assessment of Effects of Solvents on Cocrystallization by Computational Simulation Approach

Manami Dhibar et al.

Summary: This study aimed to improve the solubility and dissolution of telmisartan through cocrystallization technique and computational simulation approach. Results showed that telmisartan-oxalic acid cocrystals significantly increased solubility and dissolution rate compared to pure telmisartan.

CURRENT DRUG DELIVERY (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Recent Development of Mn-based Oxides as Zinc-Ion Battery Cathode

Wen Shi et al.

Summary: This article systematically summarizes the recent progress of Mn-based oxides as ZIB cathodes, including the classification based on different oxidation states, the respective polymorphs used as ZIB cathodes, commonly employed modification strategies to enhance performance, and the effects of these strategies on performance enhancement.

CHEMSUSCHEM (2021)

添加到收藏夹

Review Engineering, Chemical

Crystallization control via membrane distillation-crystallization: A review

Marie-Charlotte Sparenberg et al.

Summary: Membrane distillation-crystallization is a promising method that may outperform conventional crystallization processes in terms of crystallization control and product quality. This review provides a comprehensive overview of the current research on membrane distillation-crystallization, focusing on the impact of different parameters on crystal morphology and quality, as well as discussing control of crystal habit, polymorphism, and other factors.

DESALINATION (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Glycine: The Gift that Keeps on Giving

Elena Boldyreva

Summary: Despite its small size and achirality, glycine exhibits diverse behaviors across different phenomena. Research on glycine highlights the critical importance of phenomena at interfaces in areas such as crystal growth, dissolution, and physical properties.

ISRAEL JOURNAL OF CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Solid-State Overview of R-Baclofen: Relative Stability of Forms A, B and C and Characterization of a New Heterosolvate

Nicolas Couvrat et al.

Summary: A new polymorphic form (Form C) of enantiopure Baclofen was isolated and characterized in this study. The relative stability of three forms was proposed based on structural data and thermal analyses, with the experiments indicating different stability orders at different temperatures. Additionally, a new heterosolvate of the molecule was observed in a N,N-DMF/water mixture, providing a new pathway to isolate pure R-Baclofen Form B.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

添加到收藏夹

Review Engineering, Chemical

Review of melt crystallization in the pharmaceutical field, towards crystal engineering and continuous process development

Shengzhe Jia et al.

Summary: The paper reviews the application of melt crystallization in the pharmaceutical field, focusing on the developments in polymorph screening, additive effects, spherical crystal formation, co-crystal formation, and production of high purity drug intermediates. It also discusses the challenges and strategies in continuous melt crystallization development.

CHEMICAL ENGINEERING RESEARCH & DESIGN (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Review of Liquid-Liquid Phase Separation in Crystallization: From Fundamentals to Application

Shijie Xu et al.

Summary: In the field of industrial crystallization, liquid-liquid phase separation (LLPS) poses a significant challenge in controlling the crystallization process effectively. By studying the influence of LLPS on nucleation mechanisms and kinetics, researchers aim to understand the reasons behind LLPS and make breakthroughs in regulating crystal morphology.

CRYSTAL GROWTH & DESIGN (2021)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

Crystal Structure and Thermal Properties of Phenibut, Phenibut H2O and Phenibut HCl: a Case for Phase Stability Based on Structural Considerations

D. Komisarek et al.

Summary: Phenibut, an anxiolytic drug approved in many eastern European states, has been studied for its crystal structures and thermal properties. By analyzing crystal packing, IR spectra, and molecular interaction energies, the stability of different forms of Phenibut was compared.

ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Development and Evolution of Energetic Cocrystals

Jonathan C. Bennion et al.

Summary: This article discusses the impact of cocrystallization on the performance, sensitivity to external stimuli, and manufacturability of energetic materials, as well as the motivating effect of cocrystallization on the exploration of novel materials. Cocrystallization combines widely used energetic materials with nonenergetic coformers to alter key properties.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Insight into the Formation of Cocrystals of Flavonoids and 4,4′-Vinylenedipyridine: Heteromolecular Hydrogen Bonds, Molar Ratio, and Structural Analysis

Yanhong Zhang et al.

Summary: Cocrystals offer a way to modify the properties of active pharmaceutical ingredients, with heterogeneous hydrogen bonds playing a crucial role in their prediction and formation. This study synthesized and characterized ten cocrystals of flavonoids and VDP, successfully predicting the presence of heteromolecular hydrogen bonds based on computational data and experimental results. It was found that the predicted outcomes align well with the actual situations in cocrystals, particularly when the number of intermolecular hydrogen-bond donors in the flavonoids is limited to two.

CRYSTAL GROWTH & DESIGN (2021)

添加到收藏夹

Article Chemistry, Physical

2-Amino-6-methylpyridine based co-crystal salt formation using succinic acid: Single-crystal analysis and computational exploration

Akbar Ali et al.

Summary: The study reports the formation methodology, single-crystal characterization, and computational study of the co-crystal between 2-amino-6methylpyridine and succinic acid. The molecules are interconnected by hydrogen bonds to form a 2D network in the crystal structure, with weak interactions contributing to further strengthening. Computational analysis supports the presence of strong hydrogen bonds and the molecular orbital analysis suggests stability and noticeable nonlinear optical properties of the title complex.

JOURNAL OF MOLECULAR STRUCTURE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

1-Ethyluracil, a New Scaffold for Preparing Multicomponent Forms: Synthesis, Characterization, and Computational Studies

Yannick Rosello et al.

Summary: This work successfully prepared a series of cocrystals of the modified nucleobase 1-ethyluracil with different coformers and investigated the influence of hydroxyl substituents on cocrystal formation. Characterization and computational studies revealed the structural motifs and energies associated with H-bonding interactions in the cocrystals.

CRYSTAL GROWTH & DESIGN (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Challenges and Progress in Nonsteroidal Anti-Inflammatory Drugs Co-Crystal Development

Ilma Nugrahani et al.

Summary: Co-crystal innovation presents opportunities for discovering novel patent drugs, with challenges such as the difficulty in selecting co-formers. However, over time, developments in NSAID co-crystals continue to address these challenges.

MOLECULES (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Interaction Region Indicator: A Simple Real Space Function Clearly Revealing Both Chemical Bonds and Weak Interactions

Tian Lu et al.

Summary: A new real space function IRI was proposed, which can equally well reveal chemical bonding and weak interaction regions, serving as a more complete and efficient tool compared to RDG.

CHEMISTRYMETHODS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multicomponent crystals of baclofen with acids and bases-conformational flexibility and synthon versatility

Ramokone Junia Malapile et al.

Summary: Baclofen was used to form multicomponent crystals with coformers of different acidic strength and molecular size, resulting in a variety of MCCs with similarities in crystal packing arrangements. This structural feature can be utilized for crystal engineering purposes in the design of Baclofen MCCs.

CRYSTENGCOMM (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Gabapentin-saccharin co-crystals with enhanced physicochemical properties and in vivo absorption formulated as oro-dispersible tablets

Iman I. Soliman et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Manipulating the Ultralong Organic Phosphorescence of Small Molecular Crystals

Wenyong Jia et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

The Polymorphism of Drugs: New Approaches to the Synthesis of Nanostructured Polymorphs

Dmitry Chistyakov et al.

PHARMACEUTICS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Polymorphic Transition in Traditional Energetic Materials: Influencing Factors and Effects on Structure, Property, and Performance

Rupeng Bu et al.

CRYSTAL GROWTH & DESIGN (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Mercury 4.0: from visualization to analysis, design and prediction

Clare F. Macrae et al.

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2020)

添加到收藏夹

Article Chemistry, Physical

Quantum ESPRESSO toward the exascale

Paolo Giannozzi et al.

JOURNAL OF CHEMICAL PHYSICS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Green Mechanochemical Strategy for the Discovery and Selective Preparation of Polymorphs of Active Pharmaceutical Ingredient γ-Aminobutyric Acid (GABA)

Lingyu Wang et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Plasticity in zwitterionic drugs: the bending properties of Pregabalin and Gabapentin and their hydrates

U. B. Rao Khandavilli et al.

IUCRJ (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Surprising Effect of Carbon Chain Length on Inducing Ability of Additives: Elusive Form-II of γ-Aminobutyric Acid (GABA) Induced by Sodium Carboxylate Additives

Lingyu Wang et al.

CRYSTAL GROWTH & DESIGN (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Solution versus Crystal Hydration: The Case of gamma-Amino Acid Pregabalin

Rene R. E. Steendam et al.

CRYSTAL GROWTH & DESIGN (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Resolution of Baclofenium Hydrogenomaleate By Using Preferential Crystallization. A First Case of Complete Solid Solution at High Temperature and a Large Miscibility Gap in the Solid State

Francois-Xavier Gendron et al.

CRYSTAL GROWTH & DESIGN (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Exploring Nature and Predicting Strength of Hydrogen Bonds: A Correlation Analysis Between Atoms-in-Molecules Descriptors, Binding Energies, and Energy Components of Symmetry-Adapted Perturbation Theory

Saeedreza Emamian et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2019)

添加到收藏夹

Review Chemistry, Applied

Application of Selective Crystallization Methods To Isolate the Metastable Polymorphs of Paracetamol: A Review

Patricia C. Cruz et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Diastereomeric Salt Formation by the gamma-Amino Acid RS-Baclofen and L-Malic Acid: Stabilization by Strong Heterosynthons Based on Hydrogen Bonds between RNH3+ and COOH/COO- Groups

Elva Nettzayeet Cordova-Villanueva et al.

CRYSTAL GROWTH & DESIGN (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Recent progress of structural study of polymorphic pharmaceutical drugs

Kenjirou Higashi et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Understanding Polymorphic Control of Pharmaceuticals Using lmidazolium-Based Ionic Liquid Mixtures as Crystallization Directing Agents

Ines C. B. Martins et al.

CRYSTAL GROWTH & DESIGN (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Disappearing Polymorphs Revisited

Dejan-Kresimir Bucar et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Crystal structure refinement with SHELXL

George M. Sheldrick

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Conformation versus cohesion in the relative stabilities of gabapentin polymorphs

Sean P. Delaney et al.

RSC ADVANCES (2014)

添加到收藏夹

Article Pharmacology & Pharmacy

Investigating Gabapentin Polymorphism Using Solid-State NMR Spectroscopy

Kassibla E. Dempah et al.

AAPS PHARMSCITECH (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Cocrystals of gabapentin with C-alkylresorcin[4]arenes

Harshita Kumari et al.

CRYSTENGCOMM (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multiwfn: A multifunctional wavefunction analyzer

Tian Lu et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2012)

添加到收藏夹

Article Chemistry, Physical

Conformational preferences of γ-aminobutyric acid in the gas phase and in water

Il Keun Song et al.

JOURNAL OF MOLECULAR STRUCTURE (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

On the Track of New Multicomponent Gabapentin Crystal Forms: Synthon Competition and pH Stability

Vania Andre et al.

CRYSTAL GROWTH & DESIGN (2011)

添加到收藏夹

Article Chemistry, Multidisciplinary

Polymorphism control of nanosized glycine crystals on engineered surfaces

Kitae Kim et al.

CRYSTENGCOMM (2011)

添加到收藏夹

Article Pharmacology & Pharmacy

Solid-state transformation of different gabapentin polymorphs upon milling and co-milling

Shan-Yang Lin et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

添加到收藏夹

Software Review Chemistry, Multidisciplinary

OLEX2: a complete structure solution, refinement and analysis program

Oleg V. Dolomanov et al.

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2009)

添加到收藏夹

Article Chemistry, Medicinal

Engineering a GABA endowed with pharmacological CNS activity when given by an extracerebral route

Joseph Vamecq et al.

MEDICINAL CHEMISTRY RESEARCH (2009)

添加到收藏夹

Article Chemistry, Multidisciplinary

Polymorphs of gabapenitin

Hayley A. Reece et al.

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS (2008)

添加到收藏夹

Article Chemistry, Multidisciplinary

An alternate crystal form of gabapentin: A cocrystal with oxalic acid

Mazal Wenger et al.

CRYSTAL GROWTH & DESIGN (2008)

添加到收藏夹

Article Crystallography

Crystal growth of α and γ glycine polymorphs and their polymorphic phase transformations

K. Srinivasan

JOURNAL OF CRYSTAL GROWTH (2008)

添加到收藏夹

Article Chemistry, Multidisciplinary

A short history of SHELX

George M. Sheldrick

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (2008)

添加到收藏夹

Article Crystallography

1:1 Cocrystal of (S)-3-(ammoniomethyl)-5-methylhexanoate and (S)-mandelic acid

Brian Samas et al.

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE (2007)

添加到收藏夹

Article Chemistry, Medicinal

Solid-state properties and relationship between anhydrate and monohydrate of Baclofen

Sabiruddin Mirza et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2007)

添加到收藏夹

Article Chemistry, Multidisciplinary

(S)-3-(Ammoniomethyl)-5-methylhexanoate (pregabalin)

Nalivela Venu et al.

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS (2007)

添加到收藏夹

Review Psychology, Clinical

Role of GABA in anxiety and depression

Allan V. Kalueff et al.

DEPRESSION AND ANXIETY (2007)

添加到收藏夹

Review Pharmacology & Pharmacy

Mechanisms of the antinociceptive action of gabapentin

Jen-Kun Cheng et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2006)

添加到收藏夹

Article Chemistry, Multidisciplinary

Effect of high pressure on the crystal structures of polymorphs of glycine

A Dawson et al.

CRYSTAL GROWTH & DESIGN (2005)

添加到收藏夹

Review Plant Sciences

GABA in plants:: just a metabolite?

N Bouché et al.

TRENDS IN PLANT SCIENCE (2004)

添加到收藏夹

Article Chemistry, Multidisciplinary

Impact of molecular speciation on crystal nucleation in polymorphic systems:: The conundrum of γ glycine and molecular 'self poisoning'

CS Towler et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

添加到收藏夹

Review Health Care Sciences & Services

Gabapentin in the treatment of neuropathic pain

MI Bennett et al.

PALLIATIVE MEDICINE (2004)

添加到收藏夹

Article Chemistry, Multidisciplinary

Single-crystal structure validation with the program PLATON

AL Spek

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2003)

添加到收藏夹

Article Crystallography

Growth of nonlinear optical gamma-glycine crystals

MN Bhat et al.

JOURNAL OF CRYSTAL GROWTH (2002)

添加到收藏夹

Review Clinical Neurology

Gabapentin use in neuropathic pain syndromes

B Nicholson

ACTA NEUROLOGICA SCANDINAVICA (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.