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Recent Strategies for Cancer Therapy: Polymer Nanoparticles Carrying Medicinally Important Phytochemicals and Their Cellular Targets

PHARMACEUTICS (2023)

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Review Biochemistry & Molecular Biology

Nano-Sized Fucoidan Interpolyelectrolyte Complexes: Recent Advances in Design and Prospects for Biomedical Applications

Natallia V. V. Dubashynskaya et al.

Summary: The marine polysaccharide fucoidan (FUC) shows great potential in pharmaceutical research for developing drug delivery systems with modified release and targeted delivery. The presence of a sulfate group in FUC makes it suitable for forming interpolyelectrolyte complexes (PECs) with various polycations. However, the structural diversity of FUC poses challenges in designing FUC-based nanoformulations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Pharmacology & Pharmacy

Nanoparticles for co-delivery of paclitaxel and curcumin to overcome chemoresistance against breast cancer

Xiangping Lin et al.

Summary: In this study, PTX and CUR were encapsulated into nanoparticles, which showed high encapsulation efficiency and drug loading. The nanoparticles were able to slow down breast cancer cell proliferation and reverse multidrug resistance. Furthermore, compared to single nanoparticle formulations, the co-delivery of PTX and CUR nanoparticles exhibited enhanced tumor suppression and therapeutic outcomes.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2023)

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Review Chemistry, Medicinal

Modulatory properties of curcumin in cancer: A narrative review on the role of interferons

Sajjad Chamani et al.

Summary: The immune system plays a crucial role in maintaining homeostasis and preventing diseases, and curcumin, a compound found in turmeric, has been shown to modulate the immune system and provide various health benefits.

PHYTOTHERAPY RESEARCH (2023)

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Review Oncology

Advanced Phytochemical-Based Nanocarrier Systems for the Treatment of Breast Cancer

Vivek P. Chavda et al.

Summary: This article discusses the application of phytochemical-mediated nanocarriers in breast cancer treatment. Compared with traditional treatment methods, phytochemical-mediated nanocarriers have shown better therapeutic effects and drug delivery, improving patients' quality of life and the healthcare system.

CANCERS (2023)

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Review Materials Science, Biomaterials

Drug-loaded polymeric nanoparticles: a review

Karine Cappuccio de Castro et al.

Summary: Polymeric nanoparticles are widely studied for drug encapsulation in modern medicine. The researchers focus on a formulation that can control drug administration at specific sites. Stimulus-responsive nanoparticles have attracted attention due to their long circulation time, ability to reach disease sites, and improved medication delivery to cells. This review summarizes the trends in drug delivery mechanisms and the impact of internal and external stimulus sources on stimulus-responsive nanocarriers. It also discusses the conventional and emerging methods for synthesizing polymeric nanoparticles.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2022)

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Review Pharmacology & Pharmacy

Genistein: A Review on its Anti-Inflammatory Properties

Yu Xian Goh et al.

Summary: Non-resolving inflammation is a major trigger in various diseases, and patients are seeking natural compounds, such as genistein, as alternative medicine due to the undesirable effects of anti-inflammatory drugs. Previous studies have shown that genistein has strong anti-inflammatory activities by inhibiting various signaling pathways and mediators. However, evidence for its pharmacological effects is still lacking, and further studies are needed.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Development of topical thymoquinone loaded polymer-lipid hybrid vesicular gel: in-vitro and ex-vivo evaluation

Sagar Trivedi et al.

Summary: Thymoquinone-loaded polymer hybrid lipid vesicles were prepared and showed significant inhibition on breast cancer cell lines in vitro, demonstrating high potential for topical anticancer application.

JOURNAL OF LIPOSOME RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Ramesh Kumar Saini et al.

Summary: Increasing consumption of fruits, vegetables, and whole grains reduces the risk of metabolic syndrome-related diseases, such as neurodegenerative diseases, cardiovascular disease, diabetes, and cancer. Citrus fruits, rich in carotenoids, flavonoids, terpenes, limonoids, and other bioactive compounds, have been shown to have health benefits in preventing metabolic syndrome. Citrus essential oil, containing limonoids and terpenes, also has antioxidant, antimicrobial, and flavoring properties. This review provides a comprehensive overview of the composition and health benefits of citrus bioactives.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

The Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review

Elena Ferrari et al.

Summary: This review presents evidence of autophagy modulation and anti-cancer effects induced by epigallocatechin gallate (EGCG) treatment in experimental cancer models. The study found that EGCG promotes cytotoxic autophagy through the inactivation of the PI3K/Akt/mTOR pathway, leading to apoptosis induction. Furthermore, EGCG inhibits drug-induced pro-survival autophagy and is considered a valuable agent in cancer chemoprevention.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Pharmacology & Pharmacy

Evaluation of novel conjugated resveratrol polymeric nanoparticles in reduction of plasma degradation, hepatic metabolism and its augmentation of anticancer activity in vitro and in vivo

Yan Jing Yee et al.

Summary: This study aimed to develop an effective delivery system for Resveratrol (RSV), a natural product with anticancer properties. The strategy involved chemical modification and nanoparticle formulation to enhance the stability and reduce the metabolism rate of RSV. The results showed that the conjugated RSV nanoparticles had better tumor suppression effect compared to other formulations.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Microscopy

Trainable segmentation for transmission electron microscope images of inorganic nanoparticles

Cameron G. Bell et al.

Summary: This study presents a trainable segmentation method for accurately segmenting inorganic nanoparticles from transmission electron microscope images. The method achieves a balance between accuracy and training time, outperforming global and local thresholding methods and neural networks. The study also quantitatively investigates the effectiveness of the components of the trainable segmentation method, namely filter kernels and classifiers, and identifies the most accurate classifiers for different data types in ParticleSpy.

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Review Nutrition & Dietetics

Naringenin induces intrinsic and extrinsic apoptotic signaling pathways in cancer cells: A systematic review and meta-analysis of in vitro and in vivo data

Fatemeh Faramarzi et al.

Summary: Various reports indicate that naringenin has a beneficial effect on the development of cancer. This systematic review and meta-analysis reveal that naringenin inhibits cancer cells by activating apoptotic pathways and altering apoptotic factors in vitro and in vivo. The findings highlight the potential therapeutic effects of naringenin in cancer inhibition through caspases cascade.

NUTRITION RESEARCH (2022)

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Review Chemistry, Medicinal

Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases

Faheem Hyder Pottoo et al.

Summary: Thymoquinone (TQ) possesses various properties such as anticonvulsant, antianxiety, antidepressant, and antipsychotic. It protects brain cells from oxidative stress and neurotoxicity, prevents neurodegenerative disorders, and reduces inflammation. TQ inhibits mitochondrial malfunction, reduces glutamate-induced apoptosis, and suppresses inflammatory mediators. It has shown positive outcomes and fewer side effects compared to other drugs in clinical studies.

PHARMACEUTICALS (2022)

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Article Engineering, Biomedical

Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects

Mia Karam et al.

Summary: Myocardial infarction (MI) is a major global disease, and early diagnosis and treatment still face limitations. Polymeric nanoparticles provide a new solution as noninvasive drug delivery systems. This review summarizes the recent advances in polymeric nanoparticle-based diagnostics and therapeutics for MI, as well as their application in cardiac regenerative therapy.

MATERIALS TODAY BIO (2022)

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Review Nutrition & Dietetics

The Role of Catechins in Regulating Diabetes: An Update Review

Lianghua Wen et al.

Summary: This paper summarizes the important role of catechins in alleviating diabetes and its underlying mechanisms, providing scientific direction for future research on catechin alleviating diabetes.

NUTRIENTS (2022)

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Article Pharmacology & Pharmacy

Anti-cancer activity of naringenin loaded smart polymeric nanoparticles in breast cancer

Metin Yildirim et al.

Summary: This study prepared pH and thermo sensitive smart polymeric nanoparticles carrying a promising anticancer agent, naringenin, to improve its bioavailability and therapeutic efficacy against breast cancer. The newly prepared nanoparticles showed stability, bioactivity, and no toxicity against human epithelia cells.

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Article Nanoscience & Nanotechnology

Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading

Agnes -Valencia Weiss et al.

Summary: This study presents a method for determining the elasticity of gelatin nanoparticles and explores the possibility of tuning their elastic properties through crosslinking. The results show that loading drugs significantly affects the mechanical properties of nanoparticles, while crosslinkable macromolecules do not. Furthermore, the study found that the nanoparticles exhibit good cell compatibility.

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Article Pharmacology & Pharmacy

PLGA-Quercetin Nano-Formulation Inhibits Cancer Progression via Mitochondrial Dependent Caspase-3,7 and Independent FoxO1 Activation with Concomitant PI3K/AKT Suppression

Neera Yadav et al.

Summary: This study demonstrates the potential of PLGA-QNPs in anticancer therapy. PLGA-QNPs significantly reduce the viability of cervical and breast cancer cells, induce apoptosis, and suppress cancer progression through regulation of gene expression and signaling pathways. In a mammary adenocarcinoma rat model, PLGA-QNPs also reduce tumor burden and prolong tumor latency. Therefore, PLGA-QNPs may serve as an effective drug delivery system for anticancer therapy.

PHARMACEUTICS (2022)

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Review Biochemistry & Molecular Biology

Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities

Jolita Stabrauskiene et al.

Summary: Naringin and naringenin, the main bioactive polyphenols in citrus fruits, have antioxidant and anticancer properties. They can suppress cancer development, modulate cellular signaling pathways, and have the potential to improve the condition of cancer patients.

BIOMEDICINES (2022)

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Article Biotechnology & Applied Microbiology

Folate receptor-targeted PLGA-PEG nanoparticles for enhancing the activity of genistein in ovarian cancer

Arjun Patra et al.

Summary: In this study, folate receptor-targeted and PEGylated poly(lactide-co-glycolide) nanoparticles containing GEN were successfully developed for targeted delivery to ovarian cancer cells. These nanoparticles showed improved water solubility, sustained release of GEN, and increased cellular uptake in folate receptor-overexpressing ovarian cancer cells. The GEN-containing nanoparticles exhibited superior anticancer activity compared to non-targeted nanoparticles.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2022)

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Review Chemistry, Medicinal

Potential Pharmaceutical Applications of Quercetin in Cardiovascular Diseases

Paraskevi Papakyriakopoulou et al.

Summary: This comprehensive literature review critically evaluates the pathophysiological mechanisms of quercetin in relation to cardiovascular risk factors and atherosclerosis, and assesses its potential application in cardiovascular diseases. Experimental studies suggest that quercetin has multiple effects, including antihypertensive, hypolipidemic, hypoglycemic, anti-atherosclerotic, and cardioprotective effects. Clinical studies have shown beneficial effects of quercetin on glycemic and lipid parameters, but inconsistent effects on other cardiometabolic risk factors. The design of clinical trials and the lack of pharmacokinetic/pharmacodynamic tests prior to the studies may contribute to this inconsistency. Further well-designed preclinical and clinical studies are needed to examine the therapeutic mechanisms and efficacy of quercetin in cardiovascular diseases.

PHARMACEUTICALS (2022)

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Article Chemistry, Multidisciplinary

Development of (-)-epigallocatechin-3-gallate-loaded folate receptor-targeted nanoparticles for prostate cancer treatment

Read F. Alserihi et al.

Summary: Polymeric epigallocatechin 3-gallate (EGCG)-loaded nanoparticles (NPs) coupled with folic acid (FA) were developed to target human folate receptor alpha (FOLR1) and prostate-specific membrane antigen (PSMA(+)) in prostate cancer (PCa) model. The targeted NPs showed significant reduction in spheroid size and enhanced anticancer activity against PCa cell lines.

NANOTECHNOLOGY REVIEWS (2022)

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Article Chemistry, Multidisciplinary

Effect of thymoquinone-loaded lipid-polymer nanoparticles as an oral delivery system on anticancer efficiency of doxorubicin

Faezeh Abbaspour Moghaddam et al.

Summary: The study demonstrated that LPNPs containing TQ released more in simulated intestinal fluid and PLGA-PC-TQ NPs improved the anticancer activity of DOX, with significantly increased uptake through Caco-2 cells. In addition, PLGA-PC-TQ NPs showed a significant reduction in cancer cell migration.

JOURNAL OF NANOSTRUCTURE IN CHEMISTRY (2022)

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Review Medicine, Research & Experimental

Resveratrol (RV): A pharmacological review and call for further research

Li-Xue Zhang et al.

Summary: Resveratrol (RV) is a polyphenolic compound found in various plants known for its association with health benefits such as anti-obesity, cardioprotective, neuroprotective, antitumor, antidiabetic, antioxidants, anti-age effects, and glucose metabolism. It has therapeutic properties in cancer, neurodegeneration, and atherosclerosis, and also shows antibacterial effects.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Naringenin inhibits human breast cancer cells (MDA-MB-231) by inducing programmed cell death, caspase stimulation, G2/M phase cell cycle arrest and suppresses cancer metastasis

Zhaozhen Qi et al.

Summary: The study revealed significant anticancer potential of naringenin against breast cancer MDA-MB-231 cells, inhibiting cell proliferation, inducing apoptosis, causing cell cycle arrest, and reducing cell migration and invasion tendency.

CELLULAR AND MOLECULAR BIOLOGY (2021)

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Article Materials Science, Multidisciplinary

Effect of Chitosan Coating on PLGA Nanoparticles for Oral Delivery of Thymoquinone: In Vitro, Ex Vivo, and Cancer Cell Line Assessments

Sultan Alshehri et al.

Summary: The study successfully formulated thymoquinone-encapsulated chitosan-coated nanoparticles using the emulsion evaporation method for improved efficacy against breast cancer. The optimized nanoparticles showed enhanced antioxidant potential and cytotoxicity, demonstrating great potential for breast cancer management.

COATINGS (2021)

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Article Pharmacology & Pharmacy

Development and in vitro evaluation of pH-sensitive naringenin@ZIF-8 polymeric micelles mediated by aptamer

Zhangjie Wang et al.

Summary: This study successfully synthesized a pH-sensitive and aptamer-modified drug-loading polymer micelles, demonstrating superior tumor targeting and pH-sensitive drug release abilities. In vitro experiments showed significant inhibitory effects and clear targeting of AP-(NAR@ZIF-8)/PMs on human lung cancer and breast cancer cells.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Genistein and Temozolomide-Loaded Polymeric Nanoparticles: A Synergistic Approach For Improved Anti-Tumor Efficacy Against Glioblastoma

Irem Meteoglu et al.

Summary: The study developed dual-drug-loaded nanoparticles (Gen-TMZ-NPs) to enhance anti-tumor activity in U87MG glioblastoma cells, showing effective inhibition of cell migration and proliferation, as well as promotion of apoptosis.

PROCESS BIOCHEMISTRY (2021)

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Review Environmental Sciences

A review of dietary phytochemicals and their relation to oxidative stress and human diseases

Ruirui Guan et al.

Summary: Phytochemicals found in plant-based diets have beneficial effects on reducing oxidative stress and preventing various diseases, suggesting a diet rich in fruits, vegetables, and grains.

CHEMOSPHERE (2021)

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Article Chemistry, Medicinal

EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses

Dinoop Ravindran Menon et al.

Summary: This study demonstrates that EGCG enhances anti-tumor immune responses by inhibiting JAK-STAT signaling in melanoma. It could be used as an alternative treatment strategy to target the PD-L1/PD-L2-PD-1 axis in cancers.

PHARMACEUTICALS (2021)

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Article Medicine, Research & Experimental

Apigenin-Loaded PLGA-DMSA Nanoparticles: A Novel Strategy to Treat Melanoma Lung Metastasis

Ramkrishna Sen et al.

Summary: Apigenin nanoparticles have shown potential anticancer effects in the treatment of melanoma, particularly in preventing lung metastasis. These nanoparticles, when surface-functionalized with meso-2,3-dimercaptosuccinic acid (DMSA), exhibited enhanced bioavailability and antitumor efficacy when administered orally. Additionally, DMSA-conjugated apigenin nanoparticles demonstrated increased cellular internalization and cytotoxicity, suggesting a promising approach for the treatment of melanoma lung metastasis.

MOLECULAR PHARMACEUTICS (2021)

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Review Oncology

Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways

Haijun Wang et al.

Summary: Curcumin, a natural polyphenol derived from turmeric, demonstrates anti-inflammatory, antioxidant, and especially anti-tumor activities through multiple biological signaling pathways. Additionally, it inhibits tumor proliferation, angiogenesis, EMT, invasion, and metastasis by regulating tumor-related ncRNA expression. The cross regulatory relationship between ncRNA and signaling pathways illustrates the anti-tumor mechanism of curcumin.

FRONTIERS IN ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Formulation, Characterization and Cytotoxicity Effects of Novel Thymoquinone-PLGA-PF68 Nanoparticles

Nurul Shahfiza Noor et al.

Summary: Thymoquinone has anti-cancer properties but limited clinical application due to its volatile characteristics. A polymeric nanoformulation with PLGA-PEG and Pluronics F68 was developed to conserve thymoquinone's biological activity. The encapsulation showed promising anti-cancer effects against breast cancer cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Applied

Co-delivery of quercetin and caffeic-acid phenethyl ester by polymeric nanoparticles for improved antitumor efficacy in colon cancer cells

Reyhan Dilsu Colpan et al.

Summary: This study synthesized quercetin-caffeic-acid phenethyl ester co-loaded PLGA nanoparticles and demonstrated their improved anti-cancer activity on human colorectal carcinoma cells, indicating promising potential for cancer treatment.

JOURNAL OF MICROENCAPSULATION (2021)

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Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Ankur Sharma et al.

Summary: The study demonstrated the significant antitumor effect of curcumin-loaded PLGA nanoparticles on MDA-MB231 human breast cancer cells, showing high encapsulation efficiency and sustained payload release.

NANOMEDICINE (2021)

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Review Pharmacology & Pharmacy

Neuropharmacological Effects of Quercetin: A Literature-Based Review

Md. Shahazul Islam et al.

Summary: Quercetin, as a natural bioactive flavonoid, has demonstrated neuroprotective effects in neurodegenerative brain disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, making it a potential candidate for complementary medicine in preventing and treating various neurodegenerative diseases.

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Review Biochemistry & Molecular Biology

Genistein: A Potent Anti-Breast Cancer Agent

Smitha S. Bhat et al.

Summary: Genistein, an isoflavonoid found in high quantities in soybeans, has a wide range of bioactives and is extensively studied for its tumoricidal effects. It affects cancer cell proliferation through various pathways, but the observed activities are time- and dose-dependent, and show varying results in women depending on physiological parameters such as menopausal states.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2021)

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Review Nanoscience & Nanotechnology

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Review Oncology

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Doxorubicin loaded on chitosan-protamine nanoparticles triggers apoptosis via downregulating Bcl-2 in breast cancer cells

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Naringenin exerts anticancer effects by inducing tumor cell death and inhibiting angiogenesis in malignant melanoma

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RSC ADVANCES (2020)

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Review Biochemistry & Molecular Biology

The Effects of Resveratrol in Patients with Cardiovascular Disease and Heart Failure: A Narrative Review

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

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In vitro and in vivo characterization of pharmaceutical nanocarriers used for drug delivery

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Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways

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Article Pharmacology & Pharmacy

pH-sensitive polymeric nanoparticles of quercetin as a potential colon cancer-targeted nanomedicine

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Article Oncology

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The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production

Hana Alkhalidy et al.

MOLECULES (2018)

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Article Biochemistry & Molecular Biology

Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin

Anita Umerska et al.

ANTIOXIDANTS (2018)

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Editorial Material Oncology

Naringenin: an analgesic and anti-inflammatory citrus flavanone

Marilia F. Manchope et al.

ONCOTARGET (2017)

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Article Food Science & Technology

Naringenin causes ASK1-induced apoptosis via reactive oxygen species in human pancreatic cancer cells

Hyun Jin Park et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

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Review Biochemistry & Molecular Biology

The Role of Resveratrol in Cancer Therapy

Jeong-Hyeon Ko et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Oncology

Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells

Ke-Wei Ren et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2017)

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Article Biochemistry & Molecular Biology

Naringenin-Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K/AKT and MAPK Signaling Pathways

Whasun Lim et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

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Article Oncology

Curcumin induces G2/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM/Chk2/p53-dependent pathway

An Hu et al.

ONCOTARGET (2017)

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Review Oncology

Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

Md Asaduzzaman Khan et al.

ONCOTARGET (2017)

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Review Food Science & Technology

Curcumin: A Review of Its Effects on Human Health

Susan J. Hewlings et al.

FOODS (2017)

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Review Oncology

The therapeutic potential of resveratrol: a review of clinical trials

Adi Y. Berman et al.

NPJ PRECISION ONCOLOGY (2017)

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Article Pharmacology & Pharmacy

Cholesterol-conjugated poly(D, L-lactide)-based micelles as a nanocarrier system for effective delivery of curcumin in cancer therapy

Preeti Kumari et al.

DRUG DELIVERY (2017)

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Article Biochemistry & Molecular Biology

Naringenin-Mediated ATF3 Expression Contributes to Apoptosis in Human Colon Cancer

Hun Min Song et al.

BIOMOLECULES & THERAPEUTICS (2016)

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Article Chemistry, Multidisciplinary

Resveratrol loaded PLGA: D-alpha-tocopheryl polyethylene glycol 1000 succinate blend nanoparticles for brain cancer therapy

Mahalingam Rajamanickam Vijayakumar et al.

RSC ADVANCES (2016)

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Article Integrative & Complementary Medicine

Thymoquinone Protects against Myocardial Ischemic Injury by Mitigating Oxidative Stress and Inflammation

Shreesh Ojha et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

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Article Biochemistry & Molecular Biology

Antioxidant studies of chitosan nanoparticles containing naringenin and their cytotoxicity effects in lung cancer cells

Sekar Praveen Kumar et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

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Article Pharmacology & Pharmacy

Resveratrol-loaded polymeric nanoparticles suppress glucose metabolism and tumor growth in vitro and in vivo

Kyung-Ho Jung et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

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Review Biochemistry & Molecular Biology

Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases

Yu-Jie Zhang et al.

MOLECULES (2015)

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Review Nutrition & Dietetics

Epigallocatechin Gallate: A Review of Its Beneficial Properties to Prevent Metabolic Syndrome

Samuel Legeay et al.

NUTRIENTS (2015)

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Review Polymer Science

A Review on Preparation, Properties and Applications of Polymeric Nanoparticle-Based Materials

Amara Nasir et al.

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING (2015)

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Article Pharmacology & Pharmacy

Curcumin loaded poly(2-hydroxyethyl methacrylate) nanoparticles from gelled ionic liquid - In vitro cytotoxicity and anti-cancer activity in SKOV-3 cells

Sathish Sundar Dhilip Kumar et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

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Article Biochemistry & Molecular Biology

Intracellular Drug Release from Curcumin-Loaded PLGA Nanoparticles Induces G2/M Block in Breast Cancer Cells

Paolo Verderio et al.

BIOMACROMOLECULES (2013)

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Review Chemistry, Applied

A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention

Allen Y. Chen et al.

FOOD CHEMISTRY (2013)

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Article Oncology

Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells

Zhiyu Zhang et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2013)

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Article Medicine, Research & Experimental

Resveratrol-Loaded Nanoparticles Based on Poly(epsilon-caprolactone) and Poly(D,L-lactic-co-glycolic acid)-Poly(ethylene glycol) Blend for Prostate Cancer Treatment

Vanna Sanna et al.

MOLECULAR PHARMACEUTICS (2013)

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Review Chemistry, Physical

Stimuli-responsive nanocarriers for drug delivery

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NATURE MATERIALS (2013)

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Article Oncology

Naringenin (Citrus Flavonone) Induces Growth Inhibition, Cell Cycle Arrest and Apoptosis in Human Hepatocellular Carcinoma Cells

Duraikannu Arul et al.

PATHOLOGY & ONCOLOGY RESEARCH (2013)

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Review Pharmacology & Pharmacy

Quercetin: a flavonoid with the potential to treat asthma

Laila Rigolin Fortunato et al.

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

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Article Oncology

Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers

Masashi Kanai et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2012)

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Article Biochemistry & Molecular Biology

The Bone-Protective Effect of Genistein in the Animal Model of Bilateral Ovariectomy: Roles of Phytoestrogens and PTH/PTHR1 Against Post-Menopausal Osteoporosis

Qing Miao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

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Article Chemistry, Physical

Temperature-Dependent Spectroscopic Evidences of Curcumin in Aqueous Medium: A Mechanistic Study of Its Solubility and Stability

Ramya Jagannathan et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2012)

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Article Chemistry, Applied

Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway

Haitao Luo et al.

FOOD CHEMISTRY (2011)

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Article Nanoscience & Nanotechnology

Doxorubicin-incorporated polymeric micelles composed of dextran-b- poly(DL-lactide-co-glycolide) copolymer

Young-Il Jeong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2011)

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Article Chemistry, Applied

The manufacturing techniques of drug-loaded polymeric nanoparticles from preformed polymers

Pegi Ahlin Grabnar et al.

JOURNAL OF MICROENCAPSULATION (2011)

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Article Obstetrics & Gynecology

Genistein, a phytoestrogen, improves total cholesterol, and Synergy, a prebiotic, improves calcium utilization, but there were no synergistic effects

LeeCole L. Legette et al.

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2011)

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Article Multidisciplinary Sciences

Involvement of Both Extrinsic and Intrinsic Apoptotic Pathways in Apoptosis Induced by Genistein in Human Cervical Cancer Cells

Su-Hyeon Kim et al.

NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS (2009)

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Review Chemistry, Multidisciplinary

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

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PHARMACEUTICAL RESEARCH (2009)

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Review Nanoscience & Nanotechnology

Nanocarriers as an emerging platform for cancer therapy

Dan Peer et al.

NATURE NANOTECHNOLOGY (2007)

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Article Cell Biology

Kaempferol-induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK

TTT Nguyen et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2003)

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Article Biochemistry & Molecular Biology

Effect of EGCG on lipid absorption and plasma lipid levels in rats

DG Raederstorff et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2003)

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Article Endocrinology & Metabolism

Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: A randomized double-blind placebo-controlled study

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JOURNAL OF BONE AND MINERAL RESEARCH (2002)

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