4.7 Article

Selection of Excipients for the Preparation of Vancomycin-Loaded Poly(D,L-lactide-co-glycolide) Microparticles with Extended Release by Emulsion Spray Drying

期刊

PHARMACEUTICS
卷 15, 期 10, 页码 -

出版社

MDPI
DOI: 10.3390/pharmaceutics15102438

关键词

PLGA; microparticles; emulsions; spray drying; stabilisers

向作者/读者索取更多资源

The aim of this study was to investigate the relationship between the composition of the W/O emulsion used in the spray-drying process and the quality of the dry polymer particles obtained. It was found that emulsions containing Poloxamer (R) 407 and sorbitan monooleate released the drug rapidly, while emulsions without additives or with chitosan released the drug slowly.
The aim of this study was to relate the composition of the W/O emulsion used as a starting fluid in the spray-drying process to the quality of the dry polymer particles obtained in terms of physical-chemical properties, compatibility and drug release performance. Four W/O emulsions containing vancomycin hydrochloride (VAN), an encapsulating PLGA polymer and Poloxamer (R) 407, chitosan and/or sorbitan monooleate as stabilisers were spray-dried using an ultrasonic atomising nozzle. The microparticles obtained were micron-sized, with a volume mean diameter between 43.2 +/- 0.3 and 64.0 +/- 12.6 mu m, and spherical with a mostly smooth, non-porous surface and with high drug loading (between 14.5 +/- 0.6 and 17.1 +/- 1.9% w/w). All formulations showed a prolonged and biphasic VAN release profile, with diffusion being the primary release mechanism. Microparticles prepared from the emulsions with Poloxamer (R) 407 and sorbitan monooleate released VAN rapidly and completely within one day. The release of VAN from microparticles prepared from the emulsion without additives or with chitosan in the inner aqueous phase was significantly decreased; after four days, a cumulative release of 65% and 61%, respectively, was achieved. Microparticles with encapsulated chitosan had the largest mean particle diameter and the slowest release of VAN.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据