☆ 4.7 Review

Research Progress on the Mechanism of Nanoparticles Crossing the Intestinal Epithelial Cell Membrane

PHARMACEUTICS (2023)

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Summary: This study presents a selenium-based strategy to optimize the structure of liposomes, enhancing their stability and bioavailability. The selenized liposomes exhibited improved gastrointestinal stability and sustained drug release compared to conventional liposomes. Although the selenium modification did not significantly improve drug absorption, it provides an alternative option for stabilizing liposomes for oral delivery of unstable and poorly absorbed drugs.

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Rui Liu et al.

Summary: Decades have passed since the approval of the first nanoparticles-based medicine for human cancer treatment, and research and development in nanoparticles for drug delivery have been continuing. Today, there have been significant advancements in nanoparticles, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines, and nano-antibodies. These nanoparticles have shown great potential in the treatment and diagnosis of challenging diseases such as cancer and neurodegenerative diseases, making them promising drug carriers and therapeutic agents in the future.

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Summary: The oral route is considered the most ideal method for drug administration. Food protein nanoparticles show potential for oral drug delivery, offering improved safety and cost-effectiveness compared to polymeric nanoparticles. These nanoparticles have the ability to enhance oral bioavailability of a wide range of drugs, from small molecules to biomacromolecules, due to the variety of food proteins available and their easy surface modification capabilities. Despite being in its early stages, food protein nanoparticles hold promise for the development of oral drug delivery systems.

JOURNAL OF CONTROLLED RELEASE (2023)

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Enhancing oral bioavailability of andrographolide via sodium dodecyl sulfate and D-α-Tocopherol polyethylene glycol 1000 succinate copolymer modified nanocrystals

Wan Liu et al.

Summary: Nanocrystal technology is commonly used to improve the oral bioavailability of poorly-soluble drugs. This study focused on enhancing oral absorption through nanocrystals and utilized SDS-TPGS to modify andrographolide nanocrystals (S-TANs). The results showed that the particle sizes of modified nanocrystals were larger than that of physical mixtures, and nanocrystals improved the solubility and absorption of andrographolide. Additionally, the copolymer modified nanocrystals exhibited higher enhancing ability than physical mixtures. Overall, functional stabilizer modification is an efficient strategy to enhance the oral bioavailability of nanocrystals.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2023)

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Interactive mechanisms between caveolin-1 and actin filaments or vimentin intermediate filaments instruct cell mechanosensing and migration

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Lipid-based nanoparticles: Enhanced cellular uptake via surface thiolation

Patrick Knoll et al.

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Selenized Polymer-Lipid Hybrid Nanoparticles for Oral Delivery of Tripterine with Ameliorative Oral Anti-Enteritis Activity and Bioavailability

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Cellular Uptake Pathways of Nanoparticles: Process of Endocytosis and Factors Affecting their Fate

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Revealing macropinocytosis using nanoparticles

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Transport mechanism of hydroxy-propyl-beta-cyclodextrin modified solid lipid nanoparticles across human epithelial cells for the oral absorption of antileishmanial drugs

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Summary: This study investigated the transport mechanism of modified solid lipid nanoparticles in a human colonic adenocarcinoma cell line and found that the modified nanoparticles were biocompatible and suitable for delivering hydrophobic and hydrophilic drugs to the gastrointestinal system for the treatment of visceral leishmania.

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CHINESE CHEMICAL LETTERS (2022)

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Curcumin-loaded zein/pectin nanoparticles: Caco-2 cellular uptake and the effects on cell cycle arrest and apoptosis of human hepatoma cells (HepG2)

Yaqi Peng et al.

Summary: Curcumin is a natural plant component with significant in vitro anticancer effects. However, its bioavailability is limited. This study investigates the transportation mechanism of Curcumin-loaded zein-pectin core/shell nanoparticles (En-CUR) into Caco-2 cells and the inhibitory effects of En-CUR on HepG2 cell proliferation. The results show that En-CUR is taken up by Caco-2 cells through multiple endocytic pathways. En-CUR treatment leads to increased apoptosis, cell cycle arrest, and mitochondrial dysfunction in HepG2 cells. These findings suggest that En-CUR is a promising delivery system for Curcumin and exhibits superior anticancer effects.

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Rod-like mesoporous silica nanoparticles facilitate oral drug delivery via enhanced permeation and retention effect in mucus

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Wei Wu et al.

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Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling

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Multi-functional chitosan copolymer modified nanocrystals as oral andrographolide delivery systems for enhanced bioavailability and anti-inflammatory efficacy

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Jiao Liu et al.

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The intragastrointestinal fate of paclitaxel-loaded micelles: Implications on oral drug delivery

Iqbal Zoya et al.

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CHINESE CHEMICAL LETTERS (2021)

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Nanotechnology for delivery of natural therapeutic substances: a review

Raju Saka et al.

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Macropinocytosis as a cell entry route for peptide-functionalized and bystander nanoparticles

Yue-Xuan Li et al.

Summary: The endocytic pathways are crucial for the uptake of nanoparticles into cells and subcellular compartments. Macropinocytosis stands out for its unique ability to engulf large cargo, though its molecular mechanisms and role in nanoparticle uptake are not well understood. This review focuses on the macropinocytic machinery and its involvement in nanoparticle internalization, highlighting the synergistic effect between ligand-functionalized and unfunctionalized nanoparticles. The regulation of nanoparticle uptake efficiency by extracellular amino acids and the interconnectedness of macropinocytosis, metabolism, and nanomedicine are also discussed to inspire future research.

JOURNAL OF CONTROLLED RELEASE (2021)

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Specialised endocytic proteins regulate diverse internalisation mechanisms and signalling outputs in physiology and cancer

Giovanni Giangreco et al.

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Imran Khan et al.

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Curcumin Nanoparticles Inhibiting Ferroptosis for the Enhanced Treatment of Intracerebral Hemorrhage

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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A common strategy to improve transmembrane transport in polarized epithelial cells based on sorting signals: Guiding nanocarriers to TGN rather than to the basolateral plasma membrane directly

Runyu Zhang et al.

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CHINESE CHEMICAL LETTERS (2021)

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Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo

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PHARMACEUTICAL RESEARCH (2021)

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Nanocrystals for Improving Oral Bioavailability of Drugs: Intestinal Transport Mechanisms and Influencing Factors

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AAPS PHARMSCITECH (2021)

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Yuhao Zhou et al.

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Eun-Young Shin et al.

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Henri-Francois Renard et al.

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CURRENT OPINION IN CELL BIOLOGY (2021)

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Maria J. Iraburu et al.

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Natural Nano-Drug Delivery System in Coptidis Rhizoma Extract with Modified Berberine Hydrochloride Pharmacokinetics

Jing Zhao et al.

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Dynamin-dependent vesicle twist at the final stage of clathrin-mediated endocytosis

Xiaodong Cheng et al.

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Lisa Redlingshofer et al.

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Xi Liu et al.

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Interaction of cruciferin-based nanoparticles with Caco-2 cells and Caco-2/HT29-MTX co-cultures

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Mechanisms of transport of polymeric and lipidic nanoparticles across the intestinal barrier

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Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

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Separation of monodisperse alginate nanoparticles and effect of particle size on transport of vitamin E

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Efficient Peroral Delivery of Insulin via Vitamin B12 Modified Trimethyl Chitosan Nanoparticles

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Divalent Folate Modification on PEG: An Effective Strategy for Improving the Cellular Uptake and Targetability of PEGylated Polyamidoamine-Polyethylenimine Copolymer

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Intestinal Uptake and Transport of Vitamin B12-loaded Soy Protein Nanoparticles

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Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules

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Transferrin receptor specific nanocarriers conjugated with functional 7peptide for oral drug delivery

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JOURNAL OF BIOCHEMISTRY (2013)

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In vitro uptake evaluation in Caco-2 cells and in vivo results in diabetic rats of insulin-loaded PLGA nanoparticles

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Intracellular fate of octaarginine-modified liposomes in polarized MDCK cells

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Bioavailability of nanoparticles in nutrient and nutraceutical delivery

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Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?

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