Biomimetic Inorganic Nanovectors as Tumor-Targeting Theranostic Platform against Triple-Negative Breast Cancer

Article Chemistry, Multidisciplinary

Targeted Therapy of Oral Squamous Cell Carcinoma with Cancer Cell Membrane Coated Co-Fc Nanoparticles Via Autophagy Inhibition

Jiaqi Chen et al.

Summary: In this study, a novel nanoparticle Co-Fc@HCQ was successfully synthesized, which achieved targeted therapy for oral squamous cell carcinoma by inhibiting autophagy and enhancing the generation of reactive oxygen species.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Engineering, Biomedical

Microenvironment-driven sequential ferroptosis, photodynamic therapy, and chemotherapy for targeted breast cancer therapy by a cancer-cell-membrane-coated nanoscale metal-organic framework

Wei-Lun Pan et al.

Summary: In this study, a nanomedicine based on the tumor microenvironment (TME) was designed and developed for effective cancer treatment. The nanocomposite with a cancer cell membrane (CM) coating can evade the immune clearance and accumulate at the tumor site. Activation of the nanocomposite in the TME triggers a series of reactions, promoting cancer cell death and enhancing photodynamic therapy (PDT) efficacy. This sequential synergistic therapy has demonstrated the ability to inhibit cancer cell proliferation effectively.

BIOMATERIALS (2022)

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Article Materials Science, Multidisciplinary

Combination of photothermal, prodrug and tumor cell camouflage technologies for triple-negative breast cancer treatment

Lirong Zhang et al.

Summary: This study successfully constructed a nanoplatform for triple-negative breast cancer treatment by combining photothermal therapy, prodrug design, and tumor cell camouflage formulation, achieving effective therapeutic effects against TNBC. The nanoparticles demonstrated excellent drug release performance and enhanced targeting ability to tumor cells.

MATERIALS TODAY ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Live Macrophage-Delivered Doxorubicin-Loaded Liposomes Effectively Treat Triple-Negative Breast Cancer

Lan Yang et al.

Summary: This study demonstrates a system for treating triple-negative breast cancer by utilizing the tumor-targeting capabilities of macrophages. By loading doxorubicin-carrying liposomes on the surfaces of macrophages, the system significantly enhances drug accumulation at tumor sites, penetrates deeper into tumor tissue, and enhances the anti-tumor immune response, leading to improved survival rates in mice.

ACS NANO (2022)

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Article Pharmacology & Pharmacy

A robust approach to make inorganic nanovectors biotraceable

Huang Wen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Multidisciplinary Sciences

Systematic design of cell membrane coating to improve tumor targeting of nanoparticles

Lizhi Liu et al.

Summary: The mechanism underlying partial coating in cell membrane (CM) coating technology has been revealed to be the adsorption of CM fragments or vesicles, which can eventually be ruptured under external force. Partial coating is difficult to self-repair due to limited membrane fluidity. Introducing external phospholipids as a helper can increase CM fluidity and promote the final fusion of lipid patches.

NATURE COMMUNICATIONS (2022)

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Article Nanoscience & Nanotechnology

Modified Bovine Milk Exosomes for Doxorubicin Delivery to Triple-Negative Breast Cancer Cells

Jessica Pullan et al.

Summary: This study describes the use of chemical modifications to incorporate a targeting peptide and a hypoxia-responsive lipid into bovine milk exosomes for drug delivery. The results show that these modified exosomes can effectively kill triple-negative breast cancer cells.

ACS APPLIED BIO MATERIALS (2022)

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Review Biochemistry & Molecular Biology

Cellular pathways influenced by protein arginine methylation: Implications for cancer

Jian Xu et al.

Summary: Arginine methylation is a crucial post-translational modification that influences protein function and has significant implications for cancer therapy. Protein arginine methyltransferases (PRMTs) have been implicated in various cellular processes and are being explored as potential drug targets for cancer treatment, with some inhibitors already in clinical trials.

MOLECULAR CELL (2021)

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Article Chemistry, Multidisciplinary

Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles

Liang Jia et al.

Summary: This study presents a facile strategy to prepare cell membrane-coated nanoclusters with pH-responsiveness, which can target tumors and release drugs effectively.

NANO TODAY (2021)

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Article Multidisciplinary Sciences

Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

Lizhi Liu et al.

Summary: Cell membrane coated nanoparticles have unique properties that make them attractive for nanomedical applications, but it has been found that most nanoparticles are only partially coated. This partial coating can impact the biological fate of the nanoparticles.

NATURE COMMUNICATIONS (2021)

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Article Engineering, Biomedical

Leukocyte/platelet hybrid membrane-camouflaged dendritic large pore mesoporous silica nanoparticles co-loaded with photo/chemotherapeutic agents for triple negative breast cancer combination treatment

Tao Zhang et al.

Summary: A biomimetic nanoplatform was developed for efficient co-loading and targeted delivery of photo/chemotherapeutic agents for TNBC combination treatment, showing excellent TNBC-targeting ability and high PTT/PDT performances both in vitro and in vivo. This platform exhibited synergistic cytotoxicity and apoptosis-inducing activity in TNBC cells, effectively suppressing tumor growth and recurrence through tumor ablation and antiangiogenesis.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Chemical

Recovery of uranium with bisphosphonate modified mesoporous silicon

Rinez Thapa et al.

Summary: A novel nanostructured adsorbent was successfully employed to selectively remove uranium from tailing produced by processing real ore samples, demonstrating high selectivity towards uranium and stability in repeated adsorption/desorption cycles. The adsorbent, consisting of bisphosphonate ligands grafted on stable carbonized surfaces of mesoporous silicon, showed potential for industrial applications with the ability to capture and release uranium efficiently.

SEPARATION AND PURIFICATION TECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Comparison between Fluorescence Imaging and Elemental Analysis to Determine Biodistribution of Inorganic Nanoparticles with Strong Light Absorption

Konstantin Tamarov et al.

Summary: The biodistribution of PEGylated BPSi NPs with different sizes was investigated in mice, revealing that these nanoparticles mainly accumulated in the liver and spleen after intravenous injection. The smallest 140 nm particles showed the highest accumulation in tumors, producing sufficient heat for cancer PTT. Other techniques besides optical imaging should be considered to study the organ biodistribution of light-absorbing NPs.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Medicine, Research & Experimental

Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management

Pushkar Singh Rawat et al.

Summary: Doxorubicin, a commonly used anti-cancer drug, exerts its activity through DNA intercalation and inhibition of topoisomerase II enzyme. However, its use is limited by its dose-dependent cardiotoxicity, which is believed to involve oxidative stress, apoptosis, and various other mechanisms. Pharmacological strategies have been explored to mitigate Doxorubicin-induced cardiotoxicity.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Targeted doxorubicin delivery and release within breast cancer environment using PEGylated chitosan nanoparticles labeled with monoclonal antibodies

Omar Helmi et al.

Summary: Breast cancer is a top chronic and life-threatening disease worldwide. Nano-drug therapeutic systems using biodegradable chitosan nanoparticles (CSNPs) have shown efficacy in providing selective and sustained release of drugs within the breast tumor microenvironment. Functionalizing CSNPs with breast cancer-specific monoclonal antibodies (mAb) has demonstrated high cytotoxicity against cancer cells.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Dual Functions of Riboflavin-functionalized Poly(lactic-co-glycolic acid) Nanoparticles for Enhanced Drug Delivery Efficiency and Photodynamic Therapy in Triple-negative Breast Cancer Cells

Wid Mekseriwattana et al.

Summary: This study demonstrated the use of modified PLGA-CSRf nanoparticles as both drug delivery ligands and photodynamic therapy agents for TNBC cells. The biocompatibility of the nanoparticles was confirmed in both breast cancer and normal breast cells, with a significant increase in cellular uptake in cancer cells compared to normal cells. The results suggest that riboflavin can enhance the delivery of PLGA nanoparticles to TNBC cells and improve the therapeutic effects of combined drug delivery and photodynamic therapy.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2021)

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Article Oncology

Ultrasound-Mediated Cavitation Enhances EGFR-Targeting PLGA-PEG Nano-Micelle Delivery for Triple-Negative Breast Cancer Treatment

Libin Chen et al.

Summary: The study explores the therapeutic effect of EGFR-targeting nano-micelles combined with ultrasound-mediated cavitation in treating TNBC, which significantly increases drug accumulation in tumor regions, reduces toxicity, and enhances therapeutic efficacy. Compared to standalone nano-micelle treatment, the combination with UMC is better at suppressing tumor growth.

CANCERS (2021)

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Article Chemistry, Multidisciplinary