期刊
PHARMACEUTICS
卷 15, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics15102507
关键词
mesoporous silicon nanoparticles; bisphosphonates; cancer cell membrane coating; radiolabeling; doxorubicin; triple-negative breast cancer
Mesoporous silicon nanoparticles (PSi NPs) are a promising nanomedicine platform with the ability of radiolabeling, drug loading, and cancer targeting. The functionalized NPs showed good radiochemical and colloidal stability, and exhibited enhanced cellular uptake and improved chemotherapy in vitro.
Mesoporous silicon nanoparticles (PSi NPs) are promising platforms of nanomedicine because of their good compatibility, high payload capacities of anticancer drugs, and easy chemical modification. Here, PSi surfaces were functionalized with bisphosphonates (BP) for radiolabeling, loaded with doxorubicin (DOX) for chemotherapy, and the NPs were coated with cancer cell membrane (CCm) for homotypic cancer targeting. To enhance the CCm coating, the NP surfaces were covered with polyethylene glycol prior to the CCm coating. The effects of the BP amount and pH conditions on the radiolabeling efficacy were studied. The maximum BP was (2.27 wt%) on the PSi surfaces, and higher radiochemical yields were obtained for 99mTc (97% +/- 2%) and 68Ga (94.6% +/- 0.2%) under optimized pH conditions (pH = 5). The biomimetic NPs exhibited a good radiochemical and colloidal stability in phosphate-buffered saline and cell medium. In vitro studies demonstrated that the biomimetic NPs exhibited an enhanced cellular uptake and increased delivery of DOX to cancer cells, resulting in better chemotherapy than free DOX or pure NPs. Altogether, these findings indicate the potential of the developed platform for cancer treatment and diagnosis.
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