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Smart Delivery Systems Responsive to Cathepsin B Activity for Cancer Treatment

PHARMACEUTICS (2023)

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Article Biochemistry & Molecular Biology

A cathepsin B/GSH dual-responsive fluorinated peptide for effective siRNA delivery to cancer cells

Zhen Shi et al.

Summary: In this study, a novel redox- and enzyme-responsive fluorinated polyarginine (PFC-PR) was developed as an anti-cancer siRNA carrier. The PFC-PR showed efficient binding with siRNA and enhanced stability, serum tolerance, cellular uptake, and endosome escape. It also exhibited responsiveness to cancer cell-specific conditions, leading to enhanced siRNA release and cancer-targeting ability. Overall, the PFC-PR demonstrated good biocompatibility and high gene silencing efficiency, making it a potential candidate for anti-cancer gene therapy applications.

BIOORGANIC CHEMISTRY (2023)

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Article Biochemistry & Molecular Biology

Proteolytic Resistance Determines Albumin Nanoparticle Drug Delivery Properties and Increases Cathepsin B, D, and G Expression

Ekaterina P. Kolesova et al.

Summary: Proteolytic activity plays a crucial role in cell homeostasis and function, with implications in cancer progression and treatment response. Endosomes, which are often the final destination of internalized nanoparticles, are major sites of cellular proteolytic activity. However, little is known about the impact of nanoparticles on endosomal biology. In this study, we generated albumin nanoparticles with varying resistance to proteolysis and demonstrated a relationship between their sensitivity to proteases and drug delivery properties, irrespective of the degree of proteolytic degradation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Pharmacology & Pharmacy

Targeted delivery and apoptosis induction activity of peptide-transferrin targeted mesoporous silica encapsulated resveratrol in MCF-7 cells

Dongning Li et al.

Summary: In this study, transferrin-cathepsin B cleavable peptide modified mesoporous silica nanoparticle encapsulated Res was synthesized, which improved the drug release performance of Res in breast cancer cells and significantly decreased cell viability while increasing cell apoptosis.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2023)

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Article Chemistry, Medicinal

Isolation of Nocuolin A and Synthesis of New Oxadiazine Derivatives. Design, Synthesis, Molecular Docking, Apoptotic Evaluation, and Cathepsin B Inhibition

Victor Tena Perez et al.

Summary: Nocuolin A, an oxadiazine, was isolated from the cyanobacterium Nostoc sp. Its chemical structure was determined using NMR and mass spectrometry. Two new oxadiazines were synthesized from this compound, and their structures were elucidated by NMR and MS analysis. Compound 3 exhibited cytotoxicity against ACHN and Hepa-1c1c7 tumor cell lines and significantly inhibited cathepsin B activity in these cell lines. Furthermore, compound 3 showed low in vivo toxicity in a murine model.

MARINE DRUGS (2023)

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Review Cell Biology

Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways

Zhen Xie et al.

Summary: Cathepsin B (CatB), a cysteine protease, is primarily located in the subcellular endosomal and lysosomal compartments and is involved in the degradation of intracellular and extracellular proteins. It plays diverse roles in physiological and pathological processes, including programmed cell death (PCD). However, CatB-mediated PCD can lead to disease progression under pathological conditions. This review provides an overview of the critical roles and regulatory pathways of CatB in different types of PCD, and discusses its potential as a therapeutic target in multiple diseases. Current gaps in understanding CatB's involvement in PCD are also highlighted to guide future research directions.

CELL DEATH & DISEASE (2023)

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Article Pharmacology & Pharmacy

Development of a Peptide-Based Nano-Sized Cathepsin B Inhibitor for Anticancer Therapy

So-Hyeon Park et al.

Summary: A novel peptide and drug conjugate (PDC) called RR-BA was developed using a cathepsin-B-specific peptide (RR) and bile acid (BA), which could self-assemble in an aqueous solution to form stable nanoparticles. The nano-sized RR-BA conjugate exhibited significant inhibitory effects on cathepsin B and showed anticancer effects against mouse colorectal cancer cells (CT26). In vivo experiments in CT26 tumor-bearing mice also confirmed its therapeutic effect and low toxicity. Therefore, the RR-BA conjugate holds promise as an effective anticancer drug candidate for targeting cathepsin B in cancer therapy.

PHARMACEUTICS (2023)

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Article Medicine, Research & Experimental

Tumor protease-activated theranostic nanoparticles for MRI-guided glioblastoma therapy

Ching-Hsin Huang et al.

Summary: Novel and target-specific theranostic nanoparticles (TNPs) were synthesized to release potent toxin monomethyl auristatin E (MMAE), with the aim of improving therapy for Glioblastoma (GBM). The TNPs showed promising anti-tumor effects and synergistic effects with radiation therapy in a mouse model.

THERANOSTICS (2023)

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Review Instruments & Instrumentation

Exploring the role of mesoporous silica nanoparticle in the development of novel drug delivery systems

Senitta Stephen et al.

Summary: Mesoporous silica nanoparticles (MSN) offer advantages such as high drug loading efficiency and suitability for functionalization, making them attractive for delivering therapeutic agents in the treatment of various diseases. Recent research has expanded their application to deliver a range of compounds, from small chemicals to large peptides or proteins, for combating complex diseases.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Review Clinical Neurology

Extralysosomal cathepsin B in central nervous system: Mechanisms and therapeutic implications

Junjun Ni et al.

Summary: This review summarizes the physiological and pathological functions of CatB in the central nervous system and discusses its potential therapeutic applications.

BRAIN PATHOLOGY (2022)

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Review Pharmacology & Pharmacy

Clinical Combinatorial Treatments Based on Cancer Vaccines: Combination with Checkpoint Inhibitors and Beyond

Mojdeh Soltani et al.

Summary: The efficacy of cancer vaccines can be influenced by various factors, with the immunosuppressive tumor microenvironment being a crucial one. Combining cancer vaccines with other immunotherapies or conventional treatments can enhance their effectiveness by increasing immune surveillance, tumor immunogenicity, and modulating immune escape in the tumor microenvironment. In particular, immune checkpoint inhibitors have shown promising results in enhancing the therapeutic effects of cancer vaccines, despite their initially low clinical efficacy. Furthermore, these combination therapies have acceptable safety profiles and minimal additional toxicity compared to using single-agent cancer vaccines or immune checkpoint inhibitors alone.

CURRENT DRUG TARGETS (2022)

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Article Pharmacology & Pharmacy

Disitamab vedotin: a novel antibody-drug conjugates for cancer therapy

Fan Shi et al.

Summary: This paper provides a general insight and summary of the mechanism of action and the current clinical studies of RC-48, an HER2-targeted ADC drug, in HER2-positive solid tumors.

DRUG DELIVERY (2022)

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Article Pharmacology & Pharmacy

pH/enzyme dual sensitive and nucleus-targeting dendrimer nanoparticles to enhance the antitumour activity of doxorubicin

Zi-Yan Wu et al.

Summary: In this study, a pH/enzyme dual sensitive nanocarrier was developed for direct drug delivery into the nucleus. The nanocarrier demonstrated controlled drug release and exhibited promising anticancer effects both in vitro and in vivo.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2022)

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Article Biochemical Research Methods

Linkers: A synergistic way for the synthesis of chimeric proteins

Dharti Keyur Patel et al.

Summary: In cells, protein domains are linked by short oligopeptides known as linker peptides, which assist in domain-domain interaction and protein folding in specific conformations. Linkers allow for controlled movement of protein domains in the dynamic cell environment, and recent advances in recombinant DNA technology have enabled the construction of multiple gene constructs with open reading frames. Incorporating bridge sequences (linkers) into independent domains is gaining momentum, with the flexibility to space the bridging partner as needed for cellular function.

PROTEIN EXPRESSION AND PURIFICATION (2022)

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Article Multidisciplinary Sciences

CTSB is a negative prognostic biomarker and therapeutic target associated with immune cells infiltration and immunosuppression in gliomas

Kaiming Ma et al.

Summary: This study systematically explored the biological features and clinical significance of CTSB in gliomas. The results showed that CTSB was highly expressed in certain malignant subtypes of gliomas and was an independent hazard associated with poor survival. Additionally, CTSB was found to be involved in immunoreaction and inflammation response in gliomas. The expression of CTSB was positively correlated with inflammatory metagenes and the levels of glioma-infiltrating immune cells, suggesting its potential as a biomarker and therapeutic target for gliomas.

SCIENTIFIC REPORTS (2022)

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Review Pharmacology & Pharmacy

Beyond basic research: the contribution of cathepsin B to cancer development, diagnosis and therapy

Andrey A. Zamyatnin Jr et al.

Summary: In this article, the importance of Cathepsin B (CtsB) in cancer progression is reviewed, highlighting its complex molecular involvement with various regulatory processes. The article details the development of CtsB-specific Activity-Based Probes, the evolution of these towards a new generation of Prodrugs, and the evaluation of their therapeutic potential as anti-cancer agents in the clinic.

EXPERT OPINION ON THERAPEUTIC TARGETS (2022)

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Article Chemistry, Medicinal

Cathepsin B-Cleavable Polymeric Photosensitizer Prodrug for Selective Photodynamic Therapy: In Vitro Studies

Manish Jain et al.

Summary: Cathepsin B plays an important role in cancer, atherosclerosis, and other inflammatory diseases. A cathepsin B-cleavable polymeric photosensitizer prodrug was synthesized for photodynamic therapy (PDT) of cancer, which showed potential for selective destruction of cells with high cathepsin B activity.

PHARMACEUTICALS (2022)

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Review Pharmacology & Pharmacy

Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders

Gregory Hook et al.

Summary: This review evaluates the effects of deleting the CTSB gene on brain dysfunctions in neurological diseases and aging animal models. The findings suggest that CTSB gene knockout improves behavioral deficits, neuropathology, and biomarkers, supporting CTSB as a rational drug target for treating neurologic disorders.

PHARMACOLOGICAL REVIEWS (2022)

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Article Engineering, Biomedical

Comparative study of cathepsin B-cleavable linkers for the optimal design of cathepsin B-specific doxorubicin prodrug nanoparticles for targeted cancer therapy

Nayeon Shim et al.

Summary: Carrier-free prodrug nanoparticles have shown potential as a cancer therapy approach, with enhanced tumor targeting and reduced toxicity to normal cells.

BIOMATERIALS (2022)

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Review Chemistry, Multidisciplinary

Stimulus-responsive self-assembled prodrugs in cancer therapy

Xiao Dong et al.

Summary: This review summarizes the application of self-assembled prodrugs in cancer drug development. Self-assembled prodrugs can improve the physicochemical properties of drugs and achieve controlled release at tumor sites, thus showing potential for clinical applications.

CHEMICAL SCIENCE (2022)

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Article Pharmacology & Pharmacy

Tisotumab Vedotin: First Approval

Anthony Markham

Summary: Tisotumab vedotin, an antibody-drug conjugate targeting tissue factor expressing tumors, has received accelerated approval in the US for the treatment of cervical cancer. This approval marks a significant milestone in its development.

DRUGS (2021)

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Article Nanoscience & Nanotechnology

Design and Preparation of corn-like SPIONs@DFK-SBP-M13 Assembly for Improvement of Effective Internalization

Na Zhang et al.

Summary: By designing recombinant M13 phage, more internalization of SPIONs was achieved, enhancing targeted delivery and smart release efficiency, which opens up possibilities for designing and optimizing new nanomaterials with special functions.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Medicine, General & Internal

Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma

April Nettesheim et al.

Summary: The deposition of extracellular matrix (ECM) in the trabecular meshwork (TM) is a hallmark of glaucoma. Previous research has identified the enzyme cathepsin B (CTSB) as playing a role in regulating ECM remodeling and outflow physiology in TM cells, suggesting it as a potential therapeutic target for attenuating fibrosis and ECM deposition in the glaucomatous outflow pathway.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Biochemistry & Molecular Biology

An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy

Juliana T. W. Tong et al.

Summary: The emergence of a large number of antibody-drug conjugates (ADCs) for cancer therapy has attracted significant attention globally, with 11 ADCs granted FDA approval as of September 2021, 8 of which have been approved since 2017. Despite challenges, optimism for this therapeutic approach remains high, as evidenced by a landmark year for deals and partnerships in the ADC arena in 2020.

MOLECULES (2021)

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Article Medicine, General & Internal

Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma

Thomas Powles et al.

Summary: Enfortumab vedotin significantly prolonged survival compared with standard chemotherapy in patients with advanced urothelial carcinoma who had previously received platinum-based treatment and a PD-1 or PD-L1 inhibitor, as well as showing better progression-free survival outcomes.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Nanoscience & Nanotechnology

EGFR Targeted Cetuximab-Valine-Citrulline (vc)-Doxorubicin Immunoconjugates-Loaded Bovine Serum Albumin (BSA) Nanoparticles for Colorectal Tumor Therapy

Zixuan Ye et al.

Summary: The study successfully synthesized cetuximab-vc-DOX-NPs targeting EGFR-overexpressing tumor cells using bovine serum albumin nanoparticles, showing strong cytotoxicity and tumor inhibition efficacy with low systemic toxicity. In vitro and in vivo studies demonstrated the promising potential of cetuximab-vc-DOX-NPs as a targeted drug delivery system.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Engineering, Biomedical

Recent trends in bioresponsive linker technologies of Prodrug-Based Self-Assembling nanomaterials

Anne Nguyen et al.

Summary: Prodrugs are designed to improve the pharmaceutical properties of potent compounds and represent a central approach in drug development. The success of prodrug strategy relies on reversible linkages for controlled release of the parent drug. While prodrug approaches enhance pharmacokinetic properties over their parent drugs, challenges still exist in absorption, distribution, metabolism, elimination, and toxicity.

BIOMATERIALS (2021)

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Article Pharmacology & Pharmacy

Loncastuximab Tesirine: First Approval

Arnold Lee

Summary: Loncastuximab tesirine is an antibody-drug conjugate developed for the treatment of B cell lymphomas, currently approved in the US for specific types of lymphoma treatment while being researched for treatments of other types of lymphoma.

DRUGS (2021)

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Article Hematology

Camidanlumab tesirine in patients with relapsed or refractory lymphoma: a phase 1, open-label, multicentre, dose-escalation, dose-expansion study

Mehdi Hamadani et al.

Lancet Haematology (2021)

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Article Medicine, General & Internal

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer

Shanu Modi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Chemistry, Multidisciplinary

Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors

Yanan Li et al.

CHINESE CHEMICAL LETTERS (2020)

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Article Oncology

Cysteine Cathepsins Inhibition Affects Their Expression and Human Renal Cancer Cell Phenotype

Magdalena Rudzinska et al.

CANCERS (2020)

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Article Medicine, General & Internal

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer

Kohei Shitara et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Antibody-Drug Conjugates: The New Frontier of Chemotherapy

Sara Ponziani et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Chemistry, Medicinal

Antibody-Drug Conjugates: The Last Decade

Nicolas Joubert et al.

PHARMACEUTICALS (2020)

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Article Engineering, Biomedical

Cancer-specific drug-drug nanoparticles of pro-apoptotic and cathepsin B-cleavable peptide-conjugated doxorubicin for drug-resistant cancer therapy

Man Kyu Shim et al.

BIOMATERIALS (2020)

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Article Geriatrics & Gerontology

Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins

Jie Meng et al.

NEUROBIOLOGY OF AGING (2020)

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Review Cell Biology

Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment

Eva Vidak et al.

CELLS (2019)

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Review Oncology

Cathepsin B: A sellsword of cancer progression

Olja Mijanovic et al.

CANCER LETTERS (2019)

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Article Pharmacology & Pharmacy

Polatuzumab Vedotin: First Global Approval

Emma D. Deeks

DRUGS (2019)

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Review Biochemistry & Molecular Biology

The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance

Magdalena Rudzinska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Oncology

A Phase I Study of ADCT-402 (Loncastuximab Tesirine), a Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma

Brad S. Kahl et al.

CLINICAL CANCER RESEARCH (2019)

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Article Chemistry, Physical

PDMS-PMOXA-Nanoparticles Featuring a Cathepsin B-Triggered Release Mechanism

Daniel Ehrsam et al.

MATERIALS (2019)

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Article Cell Biology

Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice

Junjun Ni et al.

AGING CELL (2019)

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Review Biochemistry & Molecular Biology

Cathepsin B: Active site mapping with peptidic substrates and inhibitors

Janina Schmitz et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2019)

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Article Oncology

A phase 1 trial of SGN-CD70A in patients with CD70-positive, metastatic renal cell carcinoma

Sumanta K. Pal et al.

CANCER (2019)

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Review Chemistry, Multidisciplinary

Nanocarriers for drug delivery applications

Munusamy Chamundeeswari et al.

ENVIRONMENTAL CHEMISTRY LETTERS (2019)

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Article Gastroenterology & Hepatology

Glypican-3-Specific Antibody Drug Conjugates Targeting Hepatocellular Carcinoma

Ying Fu et al.

HEPATOLOGY (2019)

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Article Cell Biology

Targeting the lysosome by an aminomethylated Riccardin D triggers DNA damage through cathepsin B-mediated degradation of BRCA1

Yanyan Wang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Materials Science, Biomaterials

Improved tumor targeting and penetration by a dual-functional poly(amidoamine) dendrimer for the therapy of triple-negative breast cancer

Changliang Liu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Review Chemistry, Multidisciplinary

Cleavable linkers in antibody-drug conjugates

Jonathan D. Bargh et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Article Nanoscience & Nanotechnology

Gold Nanorods Functionalized with Cathepsin B Targeting Peptide and Doxorubicin for Combinatorial Therapy against Multidrug Resistance

Xiaomin Zhi et al.

ACS APPLIED BIO MATERIALS (2019)

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Article Chemistry, Medicinal

Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity

BinQing Wei et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

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Article Oncology

Characterization of SGN-CD123A, APotent CD123-Directed Antibody-Drug Conjugate for Acute Myeloid Leukemia

Fu Li et al.

MOLECULAR CANCER THERAPEUTICS (2018)

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Article Biochemical Research Methods

Multifunctional Tumor-Targeting Cathepsin B-Sensitive Gemcitabine Prodrug Covalently Targets Albumin in Situ and Improves Cancer Therapy

Huicong Zhang et al.

BIOCONJUGATE CHEMISTRY (2018)

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Article Biochemistry & Molecular Biology

Cathepsin B-mediated CD18 shedding regulates leukocyte recruitment from angiogenic vessels

Shintaro Nakao et al.

FASEB JOURNAL (2018)

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Article Multidisciplinary Sciences

Glutamic acid-valine-citrulline linkers ensure stability and efficacy of antibody-drug conjugates in mice

Yasuaki Anami et al.

NATURE COMMUNICATIONS (2018)

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Article Medicine, Research & Experimental

Docetaxel-Loaded Hyaluronic Acid-Cathepsin B-Cleavable-Peptide-Gold Nanoparticles for the Treatment of Cancer

Oyuntuya Gotov et al.

MOLECULAR PHARMACEUTICS (2018)

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Article Cell Biology

Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells

Ana Mitrovic et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2017)

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Review Nanoscience & Nanotechnology

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Fakhar Ud Din et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Chemistry, Multidisciplinary

Cathepsin nanofiber substrates as potential agents for targeted drug delivery

Yael Ben-Nun et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Dermatology

Rapid visualization of nonmelanoma skin cancer

Ethan Walker et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

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Article Medicine, Research & Experimental

Backbone Degradable N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates with Gemcitabine and Paclitaxel: Impact of Molecular Weight on Activity toward Human Ovarian Carcinoma Xenografts

Jiyuan Yang et al.

MOLECULAR PHARMACEUTICS (2017)

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Article Oncology

Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates

Nina G. Caculitan et al.

CANCER RESEARCH (2017)

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Review Chemistry, Multidisciplinary

Peptide dendrimers: drug/gene delivery and other approaches

S. S. Santos et al.

CANADIAN JOURNAL OF CHEMISTRY (2017)

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Article Biochemistry & Molecular Biology

Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients

Jian Ruan et al.

MOLECULAR CANCER (2016)

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Article Oncology

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

Magdalena Dorywalska et al.

MOLECULAR CANCER THERAPEUTICS (2016)

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Review Oncology

Mechanisms of Resistance to Antibody-Drug Conjugates

Frank Loganzo et al.

MOLECULAR CANCER THERAPEUTICS (2016)

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Article Multidisciplinary Sciences

In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics

Xiangzhao Ai et al.

NATURE COMMUNICATIONS (2016)

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Review Biochemistry & Molecular Biology

A Bright Future for Precision Medicine: Advances in Fluorescent Chemical Probe Design and Their Clinical Application

Megan Garland et al.

CELL CHEMICAL BIOLOGY (2016)

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Article Nanoscience & Nanotechnology

Enzyme-Induced and Tumor-Targeted Drug Delivery System Based on Multifunctional Mesoporous Silica Nanoparticles

Yin-Jia Cheng et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Engineering, Biomedical

Synthesis of a novel, sequentially active-targeted drug delivery nanoplatform for breast cancer therapy

Arpan Satsangi et al.

BIOMATERIALS (2015)

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Article Biophysics

RGD peptide-modified multifunctional dendrimer platform for drug encapsulation and targeted inhibition of cancer cells

Xuedan He et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2015)

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Review Chemistry, Multidisciplinary

Current ADC Linker Chemistry

Nareshkumar Jain et al.

PHARMACEUTICAL RESEARCH (2015)

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Article Chemistry, Physical

Self-Assembly of Phenylalanine-Based Molecules

Helen W. German et al.

JOURNAL OF PHYSICAL CHEMISTRY A (2015)

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Review Oncology

Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response

Oakley C. Olson et al.

NATURE REVIEWS CANCER (2015)

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Probing Quantum Plasmon Coupling Using Gold Nanoparticle Dimers with Tunable Interparticle Distances Down to the Subnanometer Range

Hoon Cha et al.

ACS NANO (2014)

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Article Chemistry, Multidisciplinary

Cathepsin-B Induced Controlled Release from Peptide-Capped Mesoporous Silica Nanoparticles

Cristina de la Torre et al.

CHEMISTRY-A EUROPEAN JOURNAL (2014)

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Controlled release of free doxorubicin from peptide-drug conjugates by drug loading

Zhipeng Chen et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Enhanced Cellular Entry and Efficacy of Tat Conjugates by Rational Design of the Auxiliary Segment

Pengcheng Zhang et al.

MOLECULAR PHARMACEUTICS (2014)

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Arpan Satsangi et al.

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Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression

F. Bengsch et al.

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Enzyme-Responsive Cell-Penetrating Peptide Conjugated Mesoporous Silica Quantum Dot Nanocarriers for Controlled Release of Nucleus-Targeted Drug Molecules and Real-Time Intracellular Fluorescence Imaging of Tumor Cells

Jinming Li et al.

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Review Pharmacology & Pharmacy

Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor

Qi Yin et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

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Article Oncology

Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer

Nimali P. Withana et al.

CANCER RESEARCH (2012)

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Article Biochemistry & Molecular Biology

Soluble E-cadherin: more than a symptom of disease

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Article Biotechnology & Applied Microbiology

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

Peter D. Senter et al.

NATURE BIOTECHNOLOGY (2012)

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Review Engineering, Biomedical

Stimuli-Sensitive Synthetic Polypeptide-Based Materials for Drug and Gene Delivery

Chaoliang He et al.

ADVANCED HEALTHCARE MATERIALS (2012)

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Article Chemistry, Multidisciplinary

Dual Enzyme-Triggered Controlled Release on Capped Nanometric Silica Mesoporous Supports

Alessandro Agostini et al.

CHEMISTRYOPEN (2012)

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Article Biotechnology & Applied Microbiology

Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma

R. R. Malla et al.

CANCER GENE THERAPY (2011)

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Article Chemistry, Multidisciplinary

Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release

Neetu Singh et al.

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Targeting MMP-9, uPAR, and cathepsin B inhibits invasion, migration and activates apoptosis in prostate cancer cells

A. K. Nalla et al.

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Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors

Eva Kolwijck et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2010)

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Article Biochemical Research Methods

HPMA Polymer-Based Site-Specific Delivery of Oligonucleotides to Hepatic Stellate Cells

Ningning Yang et al.

BIOCONJUGATE CHEMISTRY (2009)

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Granulysin Induces Cathepsin B Release from Lysosomes of Target Tumor Cells to Attack Mitochondria through Processing of Bid Leading to Necroptosis

Honglian Zhang et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Biochemistry & Molecular Biology

Cysteine cathepsins trigger caspase-dependent cell death through cleavage of Bid and antiapoptotic Bcl-2 homologues

Gabriela Droga-Mazovec et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Biochemistry & Molecular Biology

Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice

O. Vasiljeva et al.

ONCOGENE (2008)

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Article Pathology

The cathepsin family and their role in colorectal cancer

Doerthe Kuester et al.

PATHOLOGY RESEARCH AND PRACTICE (2008)

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Article Multidisciplinary Sciences

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters

Elena A. Dubikovskaya et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems

Twan Lammers et al.

JOURNAL OF CONTROLLED RELEASE (2007)

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Article Oncology

RNA interference-mediated simultaneous down-regulation of urokinase-type plasminogen activator receptor and cathepsin B induces caspase-8-mediated apoptosis in SNB19 human glioma cells

Christopher S. Gondi et al.

MOLECULAR CANCER THERAPEUTICS (2006)

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Article Multidisciplinary Sciences

A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

Cameron C. Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Biochemical Research Methods

Overexpression of cathepsin B in gastric cancer identified by proteorne analysis

MPA Ebert et al.

PROTEOMICS (2005)

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Article Oncology

Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas

CS Gondi et al.

CANCER RESEARCH (2004)

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Article Cell Biology

Trafficking of lysosomal cathepsin B-green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment

M Linke et al.

JOURNAL OF CELL SCIENCE (2002)

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Article Biochemistry & Molecular Biology

CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells

M Montaser et al.

BIOLOGICAL CHEMISTRY (2002)

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Article Biochemistry & Molecular Biology

Cathepsin B activity regulation - Heparin-like glycosaminoglycans protect human cathepsin B from alkaline pH-induced inactivation

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