期刊
ADVANCED MATERIALS TECHNOLOGIES
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/admt.202300230
关键词
molecular diagnostics; nucleic acid amplification technologies; nucleic acids; point-of-care
The ongoing pandemic and increasing frequency of infectious disease outbreaks have put great focus on nucleic acid amplification-based diagnostic technologies (NAAT). These methods can provide gold standard accuracy and sensitivity, but their availability is limited to centralized facilities, causing distress in times of need. Academic-industrial collaborations can play a major role in developing autonomous and affordable NAAT devices for widespread access to diagnostics in the future.
The ongoing pandemic and increasing frequency of infectious disease outbreaks due to climate change, urbanization, and global human migration have put great focus on nucleic acid amplification-based diagnostic technologies (NAAT). These methods can provide gold standard accuracy and sensitivity, and their widespread availability at the point-of-care is crucial for managing the spread of pathogens in human and animal populations, as well as for environmental surveillance. However, so far the reach of NAAT-based platforms has mostly remained limited to centralized facilities in the hand of trained workers, causing great distress in times of need. In this review, the current state-of-the-art research, as well as, commercial diagnostic products, is highlighted, their performances are discussed, and the role of academic-industrial collaborations in developing the next generation of breakthrough technologies is emphasized. It is envisioned that with these collaborations, the next generation of autonomous, affordable, and mobile NAAT devices can be developed, for a broad range of targets, and for providing truly democratized access to NAAT diagnostics for the global population in the future.
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