On-Chip Fluorescent Sensor for Chemical Vapor Detection

Article Biophysics

Shortened and multivalent aptamers for ultrasensitive and rapid detection of alternariol in wheat using optical waveguide sensors

Shuo Wang et al.

Summary: In this study, the key binding domain of AOH aptamer was identified and successfully designed multivalent aptamer sensors with extremely low detection limits. These sensors can quickly and accurately detect AOH toxins in food products.

BIOSENSORS & BIOELECTRONICS (2022)

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Review Nanoscience & Nanotechnology

Advances and applications of nanophotonic biosensors

Hatice Altug et al.

Summary: This Review presents the progresses in label-free nanophotonic biosensors based on photonic or dielectric surfaces and metasurfaces, and discusses their challenges and benefits in the fields of public health, well-being, and biosafety. Nanophotonic devices can control light and enhance light-matter interactions at subwavelength scales, offering exciting prospects for biosensing applications.

NATURE NANOTECHNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Exploring molecular biology in sequence space: The road to next-generation single-molecule biophysics

Ivo Severins et al.

Summary: Next-generation sequencing techniques combined with biophysical tools enable high-throughput ensemble fluorescence experiments on DNA, RNA, and protein sequences, revealing the relationship between sequence, structure, and function. The next step is to push these experiments to the single-molecule level to directly uncover kinetics and molecular heterogeneity in an unprecedented fashion, leading to new mechanistic insights. The wide range of applications in biology and medicine includes understanding evolutionary pathways and developing new therapeutics.

MOLECULAR CELL (2022)

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Article Nanoscience & Nanotechnology

Fluorescence Brightness, Photostability, and Energy Transfer Enhancement of Immobilized Single Molecules in Zero-Mode Waveguide Nanoapertures

Satyajit Patra et al.

Summary: This study thoroughly investigates the influence of zero-mode waveguide (ZMW) on the fluorescence of single molecules. The results show that the photostability is preserved in ZMW and both fluorescence brightness and total number of emitted photons are increased. Additionally, it is demonstrated that nanophotonics can enhance the FRET process.

ACS PHOTONICS (2022)

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Article Multidisciplinary Sciences

Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device

Brian D. Reed et al.

Summary: This study presents a dynamic approach for single-molecule protein sequencing, where single peptides are probed in real time using a mixture of dye-labeled amino acid recognizers and simultaneously cleaved by aminopeptidases. The peptide sequence is identified by measuring fluorescence intensity, lifetime, and binding kinetics. This method enables discrimination of single amino acid substitutions and posttranslational modifications.

SCIENCE (2022)

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Article Chemistry, Analytical

Detection of SARS-CoV-2 DNA Targets Using Femtoliter Optofluidic Waveguides

Megan Makela et al.

Summary: Chip-scale SARS-CoV-2 testing was demonstrated using silicon nitride nanoslot fluidic waveguides, which significantly enhance optical sensitivity by confining the optical sensing field at the nanoscale. The method provides a low-cost and high throughput platform for real-time virus identification, critical for point-of-care diagnostic applications.

ANALYTICAL CHEMISTRY (2021)

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Article Optics

Extraordinary evanescent field confinement waveguide sensor for mid-infrared trace gas spectroscopy

Marek Vlk et al.

Summary: This study presents a mid-infrared integrated waveguide sensor that addresses some drawbacks of waveguide sensing in air, performing well in terms of optical interaction per unit length and achieving a detection limit of 7 ppm for acetylene.

LIGHT-SCIENCE & APPLICATIONS (2021)

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Article Optics

Single-cell detection by enhancement of fluorescence in waveguides for cancer diagnosis and therapy

Hailang Dai et al.

Summary: The paper introduces a novel fluorescence detection method to aid medical workers in early diagnosis and intervention of malignant tumors, leading to personalized cancer diagnosis and therapy.

PHOTONICS RESEARCH (2021)

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Article Nanoscience & Nanotechnology

Large Field-of-View Super-Resolution Optical Microscopy Based on Planar Polymer Waveguides

Anders Kokkvoll Engdahl et al.

Summary: Planar photonic waveguide chips offer a low-cost and efficient fluorescence microscopy illumination technique for ultrathin samples over a wide field of view, with advantages of high resolution and multicolor fluorescence excitation. These chips are made of standard thickness glass coverslips coated with a high refractive index photoresist polymer, suitable for use with inverted microscopes. Through this technology, high-contrast immunofluorescence and super-resolution imaging with approximately 60 nm resolution can be achieved.

ACS PHOTONICS (2021)

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Review Chemistry, Multidisciplinary

Waveguide Enhanced Raman Spectroscopy for Biosensing: A Review

Mohamed A. Ettabib et al.

Summary: Waveguide enhanced Raman spectroscopy (WERS) utilizes high-index contrast dielectric waveguides to generate a strong evanescent field for direct identification of biochemical species. Advancements in technology have made portable and high sensitivity WERS Raman systems a realistic possibility.

ACS SENSORS (2021)

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Article Chemistry, Analytical

Rapid detection of mozzarella and feta cheese adulteration with cow milk through a silicon photonic immunosensor

Michailia Angelopoulou et al.

Summary: This study utilized a silicon-based photonic immunosensor for the first time to detect adulteration of mozzarella and feta cheeses with bovine milk. The competitive immunoassay method significantly reduced non-specific signals from cheese matrix, enabling quick and accurate detection of bovine milk adulteration at concentrations as low as 0.5%. The reproducible assays with a wide linear dynamic range demonstrated the potential of the proposed immunosensor as a new tool against fraudulent activities in the dairy industry.

ANALYST (2021)

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Review Electrochemistry

Review-Recent Progress in Portable Fluorescence Sensors

Young-Ho Shin et al.

Summary: Portable fluorescence sensors have been developed for various applications such as biochemical detection and water quality monitoring. The integration of modern electronics has enhanced the portability, miniaturization, and sensitivity of these devices. This work reviews the technology, applications, challenges, and future trends in portable fluorescence sensor development.

JOURNAL OF THE ELECTROCHEMICAL SOCIETY (2021)

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Article Chemistry, Applied