The Role of Supporting Cell Populations in Satellite Cell Mediated Muscle Repair

Skeletal muscle has a high capacity to repair and remodel in response to damage, largely through the action of resident muscle stem cells, termed satellite cells. Satellite cells are required for the proper repair of skeletal muscle through a process known as myogenesis. Recent investigations have observed relationships between satellite cells and other cell types and structures within the muscle microenvironment. These findings suggest that the crosstalk between inflammatory cells, fibrogenic cells, bone-marrow-derived cells, satellite cells, and the vasculature is essential for the restoration of muscle homeostasis. This review will discuss the influence of the cells and structures within the muscle microenvironment on satellite cell function and muscle repair.

Automated summary

Skeletal muscle has a remarkable ability to repair and remodel itself, which is mainly achieved through the action of satellite cells. Recent studies have shown the relationships between satellite cells and other cell types and structures in the muscle microenvironment. These findings highlight the essential role of crosstalk between inflammatory cells, fibrogenic cells, bone-marrow-derived cells, satellite cells, and the vasculature in muscle homeostasis restoration.