4.6 Article

In Vivo and In Vitro Evidence for an Interplay between the Glucocorticoid Receptor and the Vitamin D Receptor Signaling

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells

Daniel Chauss et al.

Summary: Research suggests that Vitamin D plays a crucial role in regulating the transcriptional response of T cells, leading to the transition from pro-inflammatory to suppressive cells. In patients with severe COVID-19, disruptions in Vitamin D signaling may be responsible for dysregulation of the immune system, resulting in increased inflammation.

NATURE IMMUNOLOGY (2022)

Article Immunology

Physiological levels of 25-hydroxyvitamin D3 induce a suppressive CD4+T cell phenotype not reflected in the epigenetic landscape

Carina Matos et al.

Summary: Vitamin D3 and its metabolites have significant effects on the differentiation and function of human CD4(+)T cells. 25(OH)D-3 is converted to its active form 1,25(OH)(2)D-3 by T cells, leading to the upregulation of FOXP3, CD25, and CTLA-4 expression and the inhibition of IFN-gamma production. The combination of 25(OH)D-3 or 1,25(OH)(2)D-3 with TGF-beta further enhances the expression of CD25 and CTLA-4, as well as the secretion of soluble CTLA-4 and IL-10, while decreasing IFN-gamma expression.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2022)

Article Immunology

Improving Glucocorticoid Sensitivity of Brain-Homing CD4+ T Helper Cells by Steroid Hormone Crosstalk

Steven C. Koetzier et al.

Summary: The study demonstrates that glucocorticoid sensitivity of Th17.1 cells can be enhanced through treatment with calcitriol and further improved with progesterone. This finding opens up a new therapeutic avenue for Th17.1-associated inflammatory diseases, including multiple sclerosis.

FRONTIERS IN IMMUNOLOGY (2022)

Article Medicine, Research & Experimental

Calcitriol Inhibits Proliferation and Potentially Induces Apoptosis in B16-F10 Cells

Eva Krishna Sutedja et al.

Summary: Calcitriol inhibits cell proliferation and induces apoptosis in B16-F10 cells.

MEDICAL SCIENCE MONITOR BASIC RESEARCH (2022)

Review Clinical Neurology

Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications

Manon Galoppin et al.

Summary: Vitamin D plays an important role in multiple sclerosis by modulating the immune system, reducing disease activity and progression. It affects the differentiation of immune cells, regulates innate immune cells, and reduces immune cell trafficking at the blood-brain barrier. Additionally, Vitamin D reduces activation of glial cells within the central nervous system, potentially providing neuroprotective effects.

BRAIN COMMUNICATIONS (2022)

Article Immunology

A flow cytometric approach to study glucocorticoid receptor expression in immune cell subpopulations of genetically engineered mice

Sybille D. Reichardt et al.

Summary: Studies using genetically engineered mice have provided insights into the mechanisms of glucocorticoids (GCs) in controlling the immune system by targeting deletions of the GC receptor (GR) gene in specific cell types. Flow cytometric analysis showed efficient and highly selective depletion of GR protein in immune cell subpopulations with T cells or myeloid cells, consistent with the expected cellular specificity of the promoters used. Flow cytometry is a powerful tool for defining GR protein content at a single cell level when studying the function of GCs in the immune system, showing quicker results compared to mRNA expression analysis.

IMMUNOLOGY LETTERS (2021)

Review Immunology

A Brief Review of the Effects of Vitamin D on Multiple Sclerosis

Andrei Miclea et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Pharmacology & Pharmacy

Glucocorticoid-Induced Leucine Zipper: A Novel Anti-inflammatory Molecule

Oxana Bereshchenko et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Immunology

Immune regulation by glucocorticoids

Derek W. Cain et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Cell Biology

A simple solution for antibody signal enhancement in immunofluorescence and triple immunogold assays

Abraham Rosas-Arellano et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2016)

Article Cell Biology

1, 25(OH)2D3 protects β cell against high glucose-induced apoptosis through mTOR suppressing

Zesong Yang et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2015)

Review Biochemistry & Molecular Biology

Vitamin D receptor signaling mechanisms: Integrated actions of a well-defined transcription factor

Carsten Carlberg et al.

STEROIDS (2013)

Review Microbiology

MECHANISMS UNDERLYING EFFECTS OF 1,25-DIHYDROXYVITAMIN D3 ON THE TH17 CELLS

Hong Zhang et al.

EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY (2013)

Article Endocrinology & Metabolism

The History of the Discovery of Vitamin D and Its Daughter Steroid Hormone

Anthony W. Norman

ANNALS OF NUTRITION AND METABOLISM (2012)

Review Cell Biology

On the Trail of the Glucocorticoid Receptor: Into the Nucleus and Back

Sofie Vandevyver et al.

TRAFFIC (2012)

Article Biochemistry & Molecular Biology

Dexamethasone Enhances 1α,25-Dihydroxyvitamin D3 Effects by Increasing Vitamin D Receptor Transcription

Alejandro A. Hidalgo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Endocrinology & Metabolism

1α, 25-dihydroxyvitamin D and corticosteroid regulate adipocyte nuclear vitamin D receptor

X. Sun et al.

INTERNATIONAL JOURNAL OF OBESITY (2008)

Letter Medicine, General & Internal

Are statins analogues of vitamin D?

Trevor G. Marshall

LANCET (2006)

Article Genetics & Heredity

Glucocorticoid receptor-dependent gene regulatory networks

PP Le et al.

PLOS GENETICS (2005)

Review Biochemistry & Molecular Biology

Gene regulation by the glucocorticoid receptor:: Structure:function relationship

R Kumar et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Vitamin D: A millenium perspective

MF Holick

JOURNAL OF CELLULAR BIOCHEMISTRY (2003)