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Neuroimmune Interactions in Fetal Alcohol Spectrum Disorders: Potential Therapeutic Targets and Intervention Strategies

CELLS (2023)

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Summary: Prenatal alcohol exposure can lead to fetal alcohol spectrum disorders (FASD), which include developmental abnormalities in the eyes, face, and brain, as well as neurobehavioral deficits. However, these abnormalities cannot be detected early in pregnancy using current imaging techniques. This study found that the levels of certain markers, particularly myelin basic protein (MBP), in fetal brain-derived exosomes (FB-E) in maternal blood were highly correlated with morphological abnormalities associated with alcohol exposure. These findings suggest that FB-E markers, such as MBP, may be used as predictors of FASD.

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ERK1/2 Signalling Pathway Regulates Tubulin-Binding Cofactor B Expression and Affects Astrocyte Process Formation after Acute Foetal Alcohol Exposure

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The maternal-placental-fetal interface: Adaptations of the HPA axis and immune mediators following maternal stress and prenatal alcohol exposure

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Summary: Ethanol exposure to the developing fetus can result in fetal alcohol spectrum disorders (FASD), which vary in severity and can affect multiple organ systems, leading to lifelong disabilities. Damage to the CNS is common in FASD, altering behavior and cognition, with no cures currently available. Alcohol can directly alter neuron function in the CNS and also affect glial cell function, potentially leading to neuroinflammation and contributing to FASD pathology.

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