期刊
CELLS
卷 12, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/cells12182249
关键词
microgravity; oligodendrocyte progenitors; global metabolomics; oligodendrocyte progenitor energetics
类别
This study investigates the impact of space microgravity on the metabolomics profile of oligodendrocyte progenitors (OLPs) and reveals increased glutamate and energy metabolism during the OLPs' stay in space. The study also shows significantly increased mitochondrial respiration and glycolysis in OLPs after space flight. These findings provide valuable information about the energetic state of OLPs in space and suggest potential therapeutic targets for long-term space missions.
Intracranial hypertension (ICP) and visual impairment intracranial pressure (VIIP) are some of the sequels of long-term space missions. Here we sought to determine how space microgravity (mu G) impacts the metabolomics profile of oligodendrocyte progenitors (OLPs), the myelin-forming cells in the central nervous system. We report increased glutamate and energy metabolism while the OLPs were in space for 26 days. We also show that after space flight, OLPs (SPC OLPs) display significantly increased mitochondrial respiration and glycolysis. These data are in agreement with our previous work using simulated microgravity. In addition, our global metabolomics approach allowed for the discovery of endogenous metabolites secreted by OLPs while in space that are significantly modulated by microgravity. Our results provide, for the first time, relevant information about the energetic state of OLPs while in space and after space flight. The functional and molecular relevance of these specific pathways are promising targets for therapeutic intervention for humans in long-term space missions to the moon, Mars and beyond.
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