Epigenetic Modifications of MiRNAs in Osteoarthritis: A Systematic Review on Their Methylation Levels and Effects on Chondrocytes, Extracellular Matrix and Joint Inflammation

Article Immunology

Overexpression of FTO alleviates osteoarthritis by regulating the processing of miR-515-5p and the TLR4/MyD88/NF-?B axis

Dongfeng Cai et al.

Summary: This study reveals that FTO is involved in the alleviation of osteoarthritis (OA) through the regulation of the miR-515-5p/TLR4/MyD88/NF-Kappa B axis, which reduces inflammation and cell injury.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Network-based modelling of mechano-inflammatory chondrocyte regulation in early osteoarthritis

Maria Segarra-Queralt et al.

Summary: Osteoarthritis is a joint disease characterized by cartilage degradation, inflammation, and pain. Mechanical loads can induce changes in chondrocyte gene expression through mechanotransduction, leading to either chondroprotection or cartilage degradation. This study develops a network model to simulate the effects of mechanical loads on chondrocyte activity, showing that inflammation and excessive loading have negative effects on chondrocyte metabolism, and anti-inflammatory therapies may be promising for OA management.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

添加到收藏夹

Review Immunology

p38MAPK Signaling Pathway in Osteoarthritis Pathological and Therapeutic Aspects

Zongchao Li et al.

Summary: Osteoarthritis (OA) is an aging-related joint disease. The p38MAPK signaling pathway plays an important role in the pathogenesis and progression of OA, and its inhibition shows potential therapeutic effects.

JOURNAL OF INFLAMMATION RESEARCH (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Overview of Anti-Inflammatory and Anti-Nociceptive Effects of Polyphenols to Halt Osteoarthritis: From Preclinical Studies to New Clinical Insights

Laura Gambari et al.

Summary: Knee osteoarthritis (OA) is a joint disorder characterized by degenerative and inflammatory processes. Bioactive dietary molecules (BDMs), especially polyphenols (PPs), have shown potential in targeting inflammation and pain. However, there are still limitations in terms of biosafety and bioavailability that need to be addressed before their clinical application.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Rheumatology

Senescent skeletal cells cross-talk with synovial cells plays a key role in the pathogenesis of osteoarthritis

Chong-Jie Wu et al.

Summary: This review mainly focuses on the role of senescent skeletal cells in initiating and progressing osteoarthritis, both independently and through cross-talk with macrophages/synovial cells. Current OA-targeted therapies based on eliminating senescent skeletal cells and inhibiting senescence-associated secretory phenotype (SASP) are summarized. The importance of existing animal models for studying OA from the perspective of senescence is highlighted, bridging the gap between basic research and clinical applications.

ARTHRITIS RESEARCH & THERAPY (2022)

添加到收藏夹

Article Orthopedics

Early Addition of Parathyroid Hormone-Related Peptide Regulates the Hypertrophic Differentiation of Mesenchymal Stem Cells

Karthikeyan Rajagopal et al.

Summary: Supplementation of PTHrP from the 4th day of chondrogenic differentiation showed significant reduction in hypertrophic markers and improved expression of cartilage-specific markers in MSC-derived chondrocytes.

CARTILAGE (2021)

添加到收藏夹

Article Immunology

Circ_HECW2 regulates LPS-induced apoptosis of chondrocytes via miR-93 methylation

Jianwei Zuo et al.

Summary: Our study showed that Circ_HECW2 is highly expressed in osteoarthritis and may inhibit miR-93 expression through methylation, affecting LPS-induced chondrocyte apoptosis.

IMMUNITY INFLAMMATION AND DISEASE (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association

Tania L. Jones et al.

Summary: Circulating microRNAs may be associated with age-related fracture/osteoporosis, osteoarthritis, and sarcopenia, with some microRNAs potentially sharing activity between osteoarthritis and osteoporosis. Results from studies were inconsistent, with evidence supporting some microRNAs having dysregulation in these diseases.

BONE (2021)

添加到收藏夹

Article Medicine, Research & Experimental

EZH2 is associated with cartilage degeneration in osteoarthritis by promoting SDC1 expression via histone methylation of the microRNA-138 promoter

Jian Wang et al.

Summary: The study demonstrates that EZH2 inhibits miR-138 expression by promoting histone methylation of its promoter, leading to cartilage degeneration in osteoarthritis models through upregulating SDC1 expression. This suggests a novel mechanistic strategy for future osteoarthritis treatments.

LABORATORY INVESTIGATION (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

DNA methyltransferase 3 beta mediates the methylation of the microRNA-34a promoter and enhances chondrocyte viability in osteoarthritis

Shouliang Xiong et al.

Summary: The study demonstrated that silencing miR-34a by targeting MCL1 and mediating the downstream PI3K/AKT pathway through DNMT3B could effectively reduce ECM degradation and inflammatory response in chondrocytes of OA mice. The miR-34a inhibitor also showed potential in suppressing inflammatory response in cartilage tissues.

BIOENGINEERED (2021)

添加到收藏夹

Article Oncology

Cryptotanshinone interferes with chondrocyte apoptosis in osteoarthritis by inhibiting the expression of miR-574-5p

Songtao Yue et al.

Summary: The study showed that CTS can downregulate the expression of miR-574-5p by regulating its methylation, leading to improved YAF2 expression and affecting chondrocyte apoptosis.

MOLECULAR MEDICINE REPORTS (2021)

添加到收藏夹

Review Medicine, General & Internal

Osteoarthritis: Novel Molecular Mechanisms Increase Our Understanding of the Disease Pathology

Susanne Graessel et al.

Summary: Osteoarthritis is a common musculoskeletal condition that causes significant health and social problems worldwide, with its exact etiology still unclear. With an aging and increasingly obese population, the prevalence of the disease is increasing. Understanding the molecular mechanisms underlying the disease is crucial for future therapeutic approaches.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Article Geriatrics & Gerontology

CircFADS2 is downregulated in osteoarthritis and suppresses LPS-induced apoptosis of chondrocytes by regulating miR-195-5p methylation

Hanwen Zhang et al.

Summary: The study found that circFADS2 is downregulated in OA and negatively correlated with miR-195-5p. In chondrocytes, overexpression of circFADS2 and downregulation of miR-195-5p were observed after LPS treatment. Overexpression of circFADS2 reduced the apoptosis of chondrocytes under LPS treatment by downregulating miR-195-5p through methylation.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Osteoarthritis-Related Inflammation Blocks TGF-β's Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region

Nathalie Thielen et al.

Summary: Inflammation in OA can inhibit TGF-beta signaling in chondrocytes through modifications of SMAD2/3 linker region, suggesting a potential new therapeutic target for the disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Rheumatology

Exploring views of orthopaedic surgeons, rheumatologists and general practitioners about osteoarthritis management

Jason A. Wallis et al.

Summary: This study aimed to explore the views of medical professionals on the management of hip and knee OA. The results showed that medical professionals generally recognized the importance of nonsurgical treatment and agreed that joint replacement surgery should be a last resort. There is room for improvement in patient education and the use of validated outcome measures in routine medical practice.

MUSCULOSKELETAL CARE (2021)

添加到收藏夹

Review Orthopedics

The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review

K. Sun et al.

OSTEOARTHRITIS AND CARTILAGE (2020)

添加到收藏夹

Article Rheumatology

Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017

Saeid Safiri et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

添加到收藏夹

Article Orthopedics

LncRNA SNHG9 is downregulated in osteoarthritis and inhibits chondrocyte apoptosis by downregulating miR-34a through methylation

Hongfei Zhang et al.

BMC MUSCULOSKELETAL DISORDERS (2020)

添加到收藏夹

Article Immunology

Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments

Linda R. Watkins et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

添加到收藏夹

Article Cell Biology

Curcumin reinforces MSC-derived exosomes in attenuating osteoarthritis via modulating the miR-124/NF-kB and miR-143/ROCK1/TLR9 signalling pathways

Bo Qiu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

添加到收藏夹

Review Cell & Tissue Engineering

Degenerative osteoarthritis a reversible chronic disease

V Di Nicola

REGENERATIVE THERAPY (2020)

添加到收藏夹

Review Medicine, General & Internal

MicroRNA in osteoarthritis: physiopathology, diagnosis and therapeutic challenge

Antonio Oliviero et al.

BRITISH MEDICAL BULLETIN (2019)

添加到收藏夹

Review Orthopedics

Epigenetics as a New Frontier in Orthopedic Regenerative Medicine and Oncology

Andre J. van Wijnen et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2019)

添加到收藏夹

Review Rheumatology

Therapeutic options for targeting inflammatory osteoarthritis pain

Philip G. Conaghan et al.

NATURE REVIEWS RHEUMATOLOGY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

DNA methylation regulates miR-140-5p and miR-146a expression in osteoarthritis

Ioanna Papathanasiou et al.

LIFE SCIENCES (2019)

添加到收藏夹

Review Cell Biology

Wnt signaling: a promising target for osteoarthritis therapy

Yudan Wang et al.

CELL COMMUNICATION AND SIGNALING (2019)

添加到收藏夹

Review Cell Biology

Epigenetics in osteoarthritis: Novel spotlight

Anwar Fathollahi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

A dietary polysaccharide from Eucheuma cottonii downregulates proinflammatory cytokines and ameliorates osteoarthritis-associated cartilage degradation in obese rats

Sabri Sudirman et al.

FOOD & FUNCTION (2019)

添加到收藏夹

Review Genetics & Heredity

microRNA single polynucleotide polymorphism influences on microRNA biogenesis and mRNA target specificity

Jaroslaw Kroliczewski et al.

GENE (2018)

添加到收藏夹

Article Cell Biology

Studying microRNAs in osteoarthritis: Critical overview of different analytical approaches

Varvara Trachana et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2018)

添加到收藏夹

Article Cell Biology

MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12

Wei-Shiung Lian et al.

CELL DEATH & DISEASE (2018)

添加到收藏夹

Article Rheumatology

The Epigenomic Landscape in Osteoarthritis

Tommie C. Simon et al.

CURRENT RHEUMATOLOGY REPORTS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes

Atsushi Takahashi et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Sport Sciences

Basic Science of Articular Cartilage

Camila B. Carballo et al.

CLINICS IN SPORTS MEDICINE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

MicroRNA-23a-3p promotes the development of osteoarthritis by directly targeting SMAD3 in chondrocytes

Liang Kang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

添加到收藏夹

Review Orthopedics

MicroRNAs: exploring new horizons in osteoarthritis

M. Nugent

OSTEOARTHRITIS AND CARTILAGE (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

Hyun Sook Hwang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

添加到收藏夹

Review Cell Biology

Regulation of microRNA biogenesis

Minju Ha et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

添加到收藏夹

Article Cell Biology

Inflammaging: disturbed interplay between autophagy and inflammasomes

Antero Salminen et al.

AGING-US (2012)

添加到收藏夹

Article Orthopedics

Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes

Silvia Diaz-Prado et al.

BMC MUSCULOSKELETAL DISORDERS (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis

Meina Wang et al.

SKELETAL BIOLOGY AND MEDICINE II: BONE AND CARTILAGE HOMEOSTASIS AND BONE DISEASE (2011)

添加到收藏夹

Review Rheumatology

Inflammation in osteoarthritis

Mary B. Goldring et al.

CURRENT OPINION IN RHEUMATOLOGY (2011)

添加到收藏夹

Review Physiology

MICRORNAS IN DEVELOPMENT AND DISEASE

Danish Sayed et al.

PHYSIOLOGICAL REVIEWS (2011)

添加到收藏夹

Article Rheumatology

Genetic Variation in the SMAD3 Gene Is Associated With Hip and Knee Osteoarthritis

Ana M. Valdes et al.

ARTHRITIS AND RHEUMATISM (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization

Simon R. Tew et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

添加到收藏夹

Review Biochemistry & Molecular Biology

MicroRNAs: Genomics, biogenesis, mechanism, and function

DP Bartel

CELL (2004)

添加到收藏夹

Article Cell Biology

TGF-β/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

X Yang et al.

JOURNAL OF CELL BIOLOGY (2001)

添加到收藏夹

Epigenetic Modifications of MiRNAs in Osteoarthritis: A Systematic Review on Their Methylation Levels and Effects on Chondrocytes, Extracellular Matrix and Joint Inflammation

相关参考文献

导出引文

分享论文