4.6 Review

Targeted Protein Degradation: Principles and Applications of the Proteasome

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Advancing targeted protein degradation for metabolic diseases therapy

Qian-Qian Zhou et al.

Summary: The development and application of traditional drugs, especially inhibitors, has become the mainstream drug development. Targeted protein degradation (TPD) technology, based on the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP), has emerged as a promising method to remove specific disease-related proteins. Different TPD strategies, such as PROTAC, MG, LYTAC, CMA-targeting chimeras, AUTAC, ATTEC, and AUTOTAC, can change undruggable protein targets in human cells to druggable, expanding the therapeutic prospect of refractory diseases.

PHARMACOLOGICAL RESEARCH (2023)

Article Biochemistry & Molecular Biology

Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic

Janet M. Sasso et al.

Summary: Targeted protein degradation is an emerging drug discovery strategy that utilizes small molecules to selectively degrade disease-causing proteins, particularly those that are difficult to target. The advent of molecular glue-type protein degraders has simplified and strengthened the connection between E3 ligases and disease-causing proteins, leading to the development of new therapies for unmet medical needs. This paper provides comprehensive insights into targeted protein degraders, with a focus on molecular glues, and discusses their advantages and the advances in drug discovery practices for these degraders.

BIOCHEMISTRY (2023)

Review Chemistry, Multidisciplinary

E3 ligase ligand optimization of Clinical PROTACs

Hanrui Jiang et al.

Summary: Proteolysis targeting chimeras (PROTACs) technology enables the development of drugs for non-druggable targets. However, there is a limited number of E3 ubiquitin ligase ligands available, which limits the design of PROTAC molecules. Most clinical trials on PROTAC molecules are based on CRBN ligands, highlighting the importance of structural optimization of E3 ubiquitin ligase ligands.

FRONTIERS IN CHEMISTRY (2023)

Review Biochemistry & Molecular Biology

The N-degron pathway: From basic science to therapeutic applications

Ah Jung Heo et al.

Summary: The N-degron pathway is a degradative system that regulates protein and biological material half-lives through N-terminal amino acids called N-degrons. N-degrons are recognized by N-recognins, which link them to the ubiquitin-proteasome system (UPS) or autophagy-lysosome system (ALS). The UPS targets N-terminal arginine (Nt-Arg) and other N-degrons for proteasomal proteolysis, while the ALS induces degradation of substrates and various cargoes through N-recognition. This interaction involves reprogramming of the Ub code. Eukaryotic cells have developed diverse mechanisms for targeting all 20 amino acids for degradation. This article discusses the components, regulation, and functions of N-degron pathways, with a focus on Arg/N-degrons and N-recognins' basic mechanisms and therapeutic applications.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2023)

Editorial Material Pharmacology & Pharmacy

Investigating the cell permeability of proteolysis-targeting chimeras (PROTACs)

Hidetomo Yokoo et al.

EXPERT OPINION ON DRUG DISCOVERY (2023)

Article Endocrinology & Metabolism

The role of proteasome activators PA28αβ and PA200 in brown adipocyte differentiation and function

Zeynep Kocberber et al.

Summary: This study investigated the role of proteasome activators in brown adipocytes. Silencing the expression of Psme1 and Psme4 genes did not affect proteasome assembly or activity, and did not impair brown adipocyte differentiation and function.

FRONTIERS IN ENDOCRINOLOGY (2023)

Review Cell Biology

Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective

Bushra Khan et al.

Summary: Mobility is an essential aspect of the animal kingdom that influences evolution and determines animal's biological success. Skeletal muscles play a vital role in voluntary movements and have a significant impact on regulating metabolic homeostasis. Muscle wasting conditions, such as cachexia, have severe effects on muscle function and disrupt normal muscle physiology. This review focuses on the regulatory mechanisms involved in maintaining muscle function and their dysregulation in wasting syndromes, particularly in cancer-induced cachexia. Furthermore, it explores the role of the small ubiquitin-like modifier (SUMO)-mediated pathways and potential treatment strategies for alleviating muscle atrophy.
Review Cell Biology

Protein homeostasis in aging and cancer

Xiao-Qiong Chen et al.

Summary: Aging is a significant risk factor for cancer, as both aging and cancer are characterized by dysfunction in protein homeostasis. Understanding the mechanisms of proteostasis regulation and its relationship with aging and age-related diseases, including cancer, can contribute to improving the health and quality of life for older individuals. Furthermore, maintaining proteostasis offers potential clinical applications in delaying the aging process and promoting long-term health.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)

Review Biochemistry & Molecular Biology

Pro-apoptotic and anti-apoptotic regulation mediated by deubiquitinating enzymes

Hae-Seul Choi et al.

Summary: Apoptosis is a structured cell death process involving cell morphology and biochemical changes, and the ubiquitin-proteasome system regulates the protein levels. Targeting UPS enzymes and controlling proteasomal degradation of apoptotic proteins could be a unique approach for cancer treatment.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Review Biotechnology & Applied Microbiology

PROTAC targeted protein degraders: the past is prologue

Miklos Bekes et al.

Summary: Targeted protein degradation (TPD) is a new therapeutic modality that can tackle disease-causing proteins which are difficult to target with conventional small molecules. PROTAC molecules, utilizing the ubiquitin-proteasome system to degrade target proteins, has achieved clinical proof-of-concept and attracted significant industry activity. Future directions include identifying target classes suitable for TPD, expanding the use of ubiquitin ligases for precision medicine, and extending the modality beyond oncology.

NATURE REVIEWS DRUG DISCOVERY (2022)

Article Cell Biology

Functional Differences between Proteasome Subtypes

Joanna Abi Habib et al.

Summary: This review focuses on the different subtypes of proteasomes and their roles in maintaining protein homeostasis, protein degradation, and immune response. The mechanisms of ATP- and ubiquitin-dependent protein degradation are described, along with the ATP- and ubiquitin-independent degradation process. The review also discusses the generation of peptides presented by MHC class I molecules and the potential therapeutic application of proteasome modulation in autoimmune diseases.
Review Biochemistry & Molecular Biology

The role of cellular proteostasis in antitumor immunity

Rebecca Mercier et al.

Summary: Immune checkpoint blockade therapy is a significant advancement in cancer treatment. Proteostasis plays a crucial role in maintaining cellular function and regulating gene expression changes. This review focuses on the role of proteostasis in regulating immune responses and determining the immunogenicity of cancer cells.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Recent advances in IAP-based PROTACs (SNIPERs) as potential therapeutic agents

Chao Wang et al.

Summary: PROTACs are effective technology for targeted protein degradation by recruiting the ubiquitin-proteasome system to trigger the polyubiquitination of proteins of interest. IAP-based PROTACs, also known as SNIPERs, have shown promise in degrading target proteins related to diseases, with structures consisting of target protein ligand, E3 ligase ligand, and the linker between them.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Proteolysis-targeting chimeras (PROTACs) in cancer therapy

Xinyi Li et al.

Summary: PROTAC is an engineered technique for targeted protein degradation, which recruits target protein and E3 ubiquitin ligase to trigger the degradation of target protein. It has great potential in cancer therapy and offers advantages over traditional anti-cancer therapies.

MOLECULAR CANCER (2022)

Review Pharmacology & Pharmacy

Molecular glues modulate protein functions by inducing protein aggregation: A promising therapeutic strategy of small molecules for disease treatment

Hongyu Wu et al.

Summary: Molecular glues can induce protein aggregation to modulate biological functions. They have been used as protein degraders and play important roles in complex stabilization, interactome modulation, and transporter inhibition. Discovering and designing molecular glues systematically is important for drug discovery.

ACTA PHARMACEUTICA SINICA B (2022)

Article Cell Biology

Ubiquitination-Proteasome System (UPS) and Autophagy Two Main Protein Degradation Machineries in Response to Cell Stress

Yanan Li et al.

Summary: Cells adapt to environmental stimuli by making changes to combat injury and increase stress tolerance. If the damage is too severe to repair, cells undergo apoptosis to protect the overall population. Protein aggregation can cause serious damage to the cells, but ubiquitin plays a crucial role in clearing these abnormal proteins. Dysregulation of ubiquitin-proteasome system and autophagy can lead to the development of diseases.
Article Cell Biology

The mechanism of action and clinical value of PROTACs: A graphical review

Harriet Graham

CELLULAR SIGNALLING (2022)

Review Biochemistry & Molecular Biology

An overview of PROTACs: a promising drug discovery paradigm

Zi Liu et al.

Summary: Proteolysis targeting chimeras (PROTACs) technology has emerged as a novel therapeutic paradigm that degrades target proteins. Unlike traditional small molecule inhibitors, PROTACs can inhibit the entire biological function of the target protein. Currently, diverse proteins have been successfully degraded by PROTACs, and they have shown promising efficacy in clinical trials. However, identifying appropriate targets for PROTAC technology and designing efficient PROTACs remain challenges.

MOLECULAR BIOMEDICINE (2022)

Review Biochemistry & Molecular Biology

Targeted protein degradation: mechanisms, strategies and application

Lin Zhao et al.

Summary: Traditional drug discovery focuses on direct regulation of protein activity. However, the emerging targeted protein degradation (TPD) technologies, such as PROTAC, provide potential approaches to remove disease-associated proteins by utilizing cells' degradation machinery. These TPD strategies, including molecular glue, LYTAC, and AbTAC, expand the scope of TPD and offer fresh insights into drug discovery.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Biochemistry & Molecular Biology

Bassoon inhibits proteasome activity via interaction with PSMB4

Carolina Montenegro-Venegas et al.

Summary: This study reveals a novel interaction between presynaptic scaffolding protein bassoon and the beta subunit of the 20S core proteasome, PSMB4, which regulates proteasomal activity at the presynapse. The findings offer a mechanistic explanation for the link of bassoon to human diseases associated with pathological protein aggregation.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Editorial Material Biochemistry & Molecular Biology

The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities

Rune Busk Damgaard

CELL DEATH AND DIFFERENTIATION (2021)

Review Biochemistry & Molecular Biology

Proteasome interaction with ubiquitinated substrates: from mechanisms to therapies

Xiang Chen et al.

Summary: The 26S proteasome is responsible for regulated proteolysis in eukaryotic cells, with substrates targeted to it through post-translational modification with ubiquitin. Deubiquitinating enzymes (DUBs) play a crucial role in catalyzing ubiquitin chain hydrolysis, coupling deubiquitination to substrate unfolding and degradation. This intricate machinery of proteasomes and ubiquitin-modified substrates remains an active area of investigation, with potential for therapeutic targeting.

FEBS JOURNAL (2021)

Review Chemistry, Multidisciplinary

The Functional Deubiquitinating Enzymes in Control of Innate Antiviral Immunity

Zhi Zong et al.

Summary: Innate antiviral immunity is the first line of defense against viral pathogens, relying on pattern recognition receptors to recognize pathogen-associated molecular patterns and initiate signaling cascades producing proinflammatory cytokines and IFN-I. The ubiquitin system, specifically DUBs, plays crucial roles in regulating immune responses, with viral DUBs counteracting host immunity. The potential of utilizing DUBs as therapeutic targets for infectious diseases is discussed, along with the challenges.

ADVANCED SCIENCE (2021)

Article Multidisciplinary Sciences

The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag

Indrajit Sahu et al.

Summary: The study demonstrates that 20S proteasomes can degrade not only the ubiquitin tag but also the conjugated substrate, leading to the identification of ubiquitin remnants on branched peptide products. Peptidomics reveals proteasome-trapped ubiquitin-derived peptides and potential 20S substrates in different cellular conditions, indicating the potential involvement of elevated levels of 20S proteasomes in cell survival under stress.

NATURE COMMUNICATIONS (2021)

Review Cell Biology

Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine

Tomomi Sato et al.

Summary: CRBN plays a crucial role in neural stem cell proliferation, suggesting potential applications in regenerative medicine.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Cell Biology

On the Role of the Immunoproteasome in Protein Homeostasis

Michael Basler et al.

Summary: The immunoproteasome is a special type of proteasome induced under inflammatory conditions, contributing to protein homeostasis in cells and involved in immune response, T cell expansion, and inflammatory diseases. Targeting the immunoproteasome has shown therapeutic effectiveness in cancer, autoimmune diseases, and transplantation in preclinical animal models.
Editorial Material Biochemistry & Molecular Biology

How to build a proteasome

Edward P. Morris et al.

Summary: The biogenesis of eukaryotic 20S proteasomes requires the accurate assembly of 14 closely related protein subunits and occurs in a complex series of chaperone-dependent steps. Important insights into this pathway are now provided by the high-resolution cryo-EM structures of two 20S proteasome assembly intermediates.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

Review Pharmacology & Pharmacy

PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy

Si-Min Qi et al.

Summary: PROTAC technology is an effective method for degrading target proteins through the ubiquitin-proteasome system, with promising applications in cancer treatment. The first oral PROTACs have shown encouraging results in clinical trials, sparking greater enthusiasm for PROTAC research.

FRONTIERS IN PHARMACOLOGY (2021)

Review Immunology

The Role of Proteasomes in the Thymus

Melina Frantzeskakis et al.

Summary: The thymus provides a microenvironment for T cell generation and selection, with cTECs expressing thymoproteasomes for optimal CD8(+) T cell positive selection, and mTECs expressing immunoproteasomes for self-tolerance in T cells.

FRONTIERS IN IMMUNOLOGY (2021)

Review Chemistry, Multidisciplinary

From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation

Carlotta Cecchini et al.

Summary: PROTACs are heterobifunctional degraders that eliminate targeted proteins by utilizing the UPS system, showing potential as an appealing technology in drug discovery. However, their poor cellular permeability due to high molecular weight and large polar surface area poses challenges, requiring strategies and biological tools to enhance cellular uptake.

FRONTIERS IN CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response

Nathan A. Snyder et al.

Summary: Ubiquitin signaling is a dynamic process that impacts protein activity, localization, or stability. Deubiquitinating enzymes counteract this process by removing ubiquitin, playing a crucial role in physiological pathways. DUB activity is tightly regulated in dynamic environments and plays a significant role in oxidative stress conditions.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

A novel recognition site for polyubiquitin and ubiquitin-like signals in an unexpected region of proteasomal subunit Rpn1

Andrew J. Boughton et al.

Summary: The Rpn1 receptor in the ubiquitin-proteasome system contains a known binding site and a newly discovered recognition site, shedding further light on the mechanism of signal recognition processes.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

A proteomic platform to identify off-target proteins associated with therapeutic modalities that induce protein degradation or gene silencing

Xin Liu et al.

Summary: A proteomics-based platform was developed to assess the abundance of off-target proteins, with 2813 proteins selected as the off-target proteome (SOTP) based on genetics and pharmacology evidence. Mass spectrometry was then used to identify 1828 proteins from the SOTP in 4 human cell lines.

SCIENTIFIC REPORTS (2021)

Review Cell Biology

Opportunities and Challenges of Small Molecule Induced Targeted Protein Degradation

Ming He et al.

Summary: PROTAC is a new technology for inducing protein degradation using small molecules, which shows advantages in overcoming tumor resistance, affecting non-enzymatic functions of target proteins, degrading undruggable targets, and providing rapid and reversible chemical knockout tools. However, it also faces challenges and issues as a rapidly developing new chemical biology technology.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Out of Control: The Role of the Ubiquitin Proteasome System in Skeletal Muscle during Inflammation

Stefanie Haberecht-Mueller et al.

Summary: The majority of critically ill ICU patients with severe sepsis develop ICU-acquired weakness characterized by loss of muscle mass, reduction in myofiber size and decreased muscle strength. This phenotype results from dysregulated protein homeostasis, with UPS being the predominant protein-degrading system in muscle under various conditions causing muscle atrophy. The regulation and target-specificity of E3 ubiquitin ligases in muscle atrophy, as well as the function of standard and immunoproteasome in inflammation-induced muscle atrophy and the potential treatment strategies, are discussed in this review.

BIOMOLECULES (2021)

Review Biochemistry & Molecular Biology

E3 ubiquitin ligases: styles, structures and functions

Quan Yang et al.

Summary: E3 ubiquitin ligases are key enzymes in the ubiquitination process, playing a crucial role in transferring ubiquitin protein to the lysine site of targeted substrates. Their importance in regulating cellular activities and responding to cancer development is increasingly recognized.

MOLECULAR BIOMEDICINE (2021)

Review Pharmacology & Pharmacy

Degradation of proteins by PROTACs and other strategies

Yang Wang et al.

ACTA PHARMACEUTICA SINICA B (2020)

Article Biochemistry & Molecular Biology

Regulation of the 20S Proteasome by a Novel Family of Inhibitory Proteins

Maya A. Olshina et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Multidisciplinary Sciences

The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates

Kirby Martinez-Fonts et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies

Nikolaos Antoniou et al.

CANCERS (2020)

Review Cell Biology

How to Inactivate Human Ubiquitin E3 Ligases by Mutation

Cristina Garcia-Barcena et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System

Weigang Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond

Jun Hamazaki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Chemistry, Multidisciplinary

Linear Ubiquitin Chains: Cellular Functions and Strategies for Detection and Quantification

Gunnar Dittmar et al.

FRONTIERS IN CHEMISTRY (2020)

Review Oncology

APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis

Morgan S. Schrock et al.

SEMINARS IN CANCER BIOLOGY (2020)

Article Multidisciplinary Sciences

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution

T. Ukmar-Godec et al.

SCIENCE ADVANCES (2020)

Review Oncology

Novel immunomodulatory drugs and neo-substrates

Shaobing Gao et al.

BIOMARKER RESEARCH (2020)

Article Cell Biology

Transcriptomic Landscape of Cisplatin-Resistant Neuroblastoma Cells

Miguel Angel Merlos Rodrigo et al.

Article Multidisciplinary Sciences

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling

Qing Yin et al.

NATURE COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Advances in targeted degradation of endogenous proteins

Sascha Roth et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Article Developmental Biology

Proteasome Expression in Ovarian Heterotopic Allografts of Wistar and August Rats under Induction of Donor-Specific Tolerance

T. M. Astakhova et al.

RUSSIAN JOURNAL OF DEVELOPMENTAL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Cellular functions and molecular mechanisms of non-lysine ubiquitination

Amie J. McClellan et al.

OPEN BIOLOGY (2019)

Review Oncology

Proteasomes and Several Aspects of Their Heterogeneity Relevant to Cancer

Alexey Morozov et al.

FRONTIERS IN ONCOLOGY (2019)

Review Chemistry, Multidisciplinary

Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs

Mikihiko Naito et al.

FRONTIERS IN CHEMISTRY (2019)

Review Biotechnology & Applied Microbiology

Deubiquitylating enzymes and drug discovery: emerging opportunities

Jeanine A. Harrigan et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Multidisciplinary Sciences

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

Tiffany A. Thibaudeau et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 2

Noriyuki Murai et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

DNA damage-induced replication stress results in PA200-proteasome-mediated degradation of acetylated histones

Imke K. Mandemaker et al.

EMBO REPORTS (2018)

Article Multidisciplinary Sciences

ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation

Donghoon Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Oncology

Regulation of Protein Degradation by Proteasomes in Cancer

Ho Hee Jang

JOURNAL OF CANCER PREVENTION (2018)

Review Chemistry, Multidisciplinary

Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism

Laurent Cappadocia et al.

CHEMICAL REVIEWS (2018)

Article Biochemistry & Molecular Biology

The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis

Hyoung Tae Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

Xiaorong Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Cell Biology

Shaping proteostasis at the cellular, tissue, and organismal level

Ambre J. Sala et al.

JOURNAL OF CELL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Proteasome Structure and Assembly

Lauren Budenholzer et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

Article Biochemistry & Molecular Biology

An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome

Evan J. Worden et al.

MOLECULAR CELL (2017)

Article Biochemistry & Molecular Biology

The Mammalian Proteasome Activator PA28 Forms an Asymmetric α4β3 Complex

Eva M. Huber et al.

STRUCTURE (2017)

Review Biochemistry & Molecular Biology

The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

Yong Tae Kwon et al.

TRENDS IN BIOCHEMICAL SCIENCES (2017)

Review Oncology

Proteasome expression and activity in cancer and cancer stem cells

Ioannis A. Voutsadakis

TUMOR BIOLOGY (2017)

Article Chemistry, Multidisciplinary

The Proteasome in Modern Drug Discovery: Second Life of a Highly Valuable Drug Target

Philipp M. Cromm et al.

ACS CENTRAL SCIENCE (2017)

Review Biochemistry & Molecular Biology

AAA-ATPases in Protein Degradation

Ravikiran S. Yedidi et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2017)

Review Biochemistry & Molecular Biology

The Logic of the 26S Proteasome

Galen Andrew Collins et al.

Article Biochemistry & Molecular Biology

Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination

Toshiyuki Takasugi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

RING finger protein 31 promotes p53 degradation in breast cancer cells

J. Zhu et al.

ONCOGENE (2016)

Article Oncology

Cancer Stem-like Properties in Colorectal Cancer Cells with Low Proteasome Activity

Koji Munakata et al.

CLINICAL CANCER RESEARCH (2016)

Review Cell Biology

Emerging role of immunoproteasomes in pathophysiology

Gagandeep Kaur et al.

IMMUNOLOGY AND CELL BIOLOGY (2016)

Review Cell Biology

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

Lori Buetow et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

CHK2 stability is regulated by the E3 ubiquitin ligase SIAH2

C. Garcia-Limones et al.

ONCOGENE (2016)

Article Multidisciplinary Sciences

Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility

Lin Huang et al.

SCIENTIFIC REPORTS (2016)

Article Microbiology

Fundamental Characteristics of AAA plus Protein Family Structure and Function

JustinM. Miller et al.

ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL (2016)

Article Biochemistry & Molecular Biology

KPC1-Mediated Ubiquitination and Proteasomal Processing of NF-κB1 p105 to p50 Restricts Tumor Growth

Yelena Kravtsova-Ivantsiv et al.

Article Biochemistry & Molecular Biology

A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation

Zhengyu Zha et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

The Parkinson's-associated protein DJ-1 regulates the 20S proteasome

Oren Moscovitz et al.

NATURE COMMUNICATIONS (2015)

Article Microbiology

The immunoproteasome and viral infection: a complex regulator of inflammation

Mary K. McCarthy et al.

FRONTIERS IN MICROBIOLOGY (2015)

Article Cell Biology

Isg15 controls p53 stability and functions

Yi-Fu Huang et al.

CELL CYCLE (2014)

Review Chemistry, Multidisciplinary

Classification of Intrinsically Disordered Regions and Proteins

Robin van der Lee et al.

CHEMICAL REVIEWS (2014)

Article Biochemistry & Molecular Biology

PA28αβ Reduces Size and Increases Hydrophilicity of 20S Immunoproteasome Peptide Products

Mary Raule et al.

CHEMISTRY & BIOLOGY (2014)

Article Biochemistry & Molecular Biology

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

Isabel Saez et al.

CURRENT GENOMICS (2014)

Article Biochemistry & Molecular Biology

Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to Regulate Stress Responses

Takeshi Maruyama et al.

SCIENCE SIGNALING (2014)

Review Biochemistry & Molecular Biology

Regulating the 20S Proteasome Ubiquitin-Independent Degradation Pathway

Gili Ben-Nissan et al.

BIOMOLECULES (2014)

Article Biochemistry & Molecular Biology

Proteasome Regulation by ADP-Ribosylation

Park F. Cho-Park et al.

Review Biochemistry & Molecular Biology

The proteasome and the degradation of oxidized proteins: Part I-structure of proteasomes

Tobias Jung et al.

REDOX BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

Harald W. Platta et al.

BIOCHEMICAL JOURNAL (2012)

Article Gastroenterology & Hepatology

Identification of Pancreatic Cancer Stem Cells and Selective Toxicity of Chemotherapeutic Agents

Rama Adikrisna et al.

GASTROENTEROLOGY (2012)

Article Biochemistry & Molecular Biology

A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1

Oren Moscovitz et al.

MOLECULAR CELL (2012)

Article Multidisciplinary Sciences

Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy

Eri Sakata et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Endocrinology & Metabolism

Radioresistance of prostate cancer cells with low proteasome activity

Lorenza Della Donna et al.

PROSTATE (2012)

Article Biotechnology & Applied Microbiology

Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast

Laura Gatti et al.

BMC GENOMICS (2011)

Review Biochemical Research Methods

Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes

Min Jae Lee et al.

MOLECULAR & CELLULAR PROTEOMICS (2011)

Review Biotechnology & Applied Microbiology

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets

Lynn Bedford et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Article Biochemistry & Molecular Biology

The Ski protein negatively regulates Siah2-mediated HDAC3 degradation

Hong-Ling Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Review Biochemistry & Molecular Biology

Ubiquitin-independent p53 proteasomal degradation

P. Tsvetkov et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Biochemistry & Molecular Biology

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12

Christiane Riedinger et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Sven Geisler et al.

NATURE CELL BIOLOGY (2010)

Article Multidisciplinary Sciences

Mdm2 facilitates the association of p53 with the proteasome

Roman Kulikov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules

Benoit Guillaume et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Immunology

Proteasomes in immune cells: more than peptide producers?

Marcus Groettrup et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Article Biochemistry & Molecular Biology

Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L

Gunter Schmidtke et al.

FEBS LETTERS (2009)

Article Biochemistry & Molecular Biology

Susceptibility of p53 Unstructured N Terminus to 20 S Proteasomal Degradation Programs the Stress Response

Peter Tsvetkov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Oncology

In Vivo Imaging, Tracking, and Targeting of Cancer Stem Cells

Erina Vlashi et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2009)

Article Biochemistry & Molecular Biology

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

Dung-Fang Lee et al.

MOLECULAR CELL (2009)

Article Cell Biology

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

Fuminori Tokunaga et al.

NATURE CELL BIOLOGY (2009)

Review Cell Biology

Molecular mechanisms of proteasome assembly

Shigeo Murata et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Review Multidisciplinary Sciences

The proteasome: Overview of structure and functions

Keiji Tanaka

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2009)

Article Multidisciplinary Sciences

E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1

Da-Qiang Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-inked polyubiquitin chains

Abdallah K. Al-Hakim et al.

BIOCHEMICAL JOURNAL (2008)

Review Biochemistry & Molecular Biology

Unconventional serine proteases: Variations on the catalytic Ser/His/Asp triad configuration

Ozlem Dogan Ekici et al.

PROTEIN SCIENCE (2008)

Review Biochemistry & Molecular Biology

Role of the ubiquitin proteasome system in renal cell carcinoma

Paul G. Corn

BMC BIOCHEMISTRY (2007)

Review Biochemistry & Molecular Biology

Role of proteasomes in disease

Burkhardt Dahlmann

BMC BIOCHEMISTRY (2007)

Article Cardiac & Cardiovascular Systems

Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase

Tian Xia et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Article Biochemistry & Molecular Biology

Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A

S. K. Lim et al.

ONCOGENE (2007)

Article Multidisciplinary Sciences

Structure and function of the yeast U-box-containing ubiquitin ligase Ufd2p

Daqi Tu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Cell Biology

ROS as signalling molecules:: mechanisms that generate specificity in ROS homeostasis

Benoit D'Autreaux et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Biotechnology & Applied Microbiology

Chaperone-based procedure to increase yields of soluble recombinant proteins produced in E-coli

Ario de Marco et al.

BMC BIOTECHNOLOGY (2007)

Article Multidisciplinary Sciences

Regulation of CD8+ T cell development by thymus-specific proteasomes

Shigeo Murata et al.

SCIENCE (2007)

Review Cell Biology

The ubiquitination code: a signalling problem

Tanja Woelk et al.

CELL DIVISION (2007)

Article Biochemistry & Molecular Biology

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

Patricia Chastagner et al.

EMBO REPORTS (2006)

Article Biochemistry & Molecular Biology

A ubiquitin ligase complex assembles linear polyubiquitin chains

Takayoshi Kirisako et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes

Jun Hamazaki et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase

MMO Peña et al.

BIOCHEMICAL JOURNAL (2006)

Article Biochemistry & Molecular Biology

Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells

CS Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein

P Sdek et al.

MOLECULAR CELL (2005)

Article Multidisciplinary Sciences

The discovery of ubiquitin-dependent proteolysis

KD Wilkinson

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Mechanism of direct degradation of IκBα by 20S proteasome

B Alvarez-Castelao et al.

FEBS LETTERS (2005)

Article Biochemistry & Molecular Biology

20S proteasomal degradation of ornithine decarboxylase is regulated by NQ01

G Asher et al.

MOLECULAR CELL (2005)

Review Cell Biology

Roles of molecular chaperones in protein misfolding diseases

JM Barral et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2004)

Review Biochemistry & Molecular Biology

Mechanism and function of deubiquitinating enzymes

AY Amerik et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)

Article Multidisciplinary Sciences

Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein

RF Kalejta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

Close identity of a pressure-stabilized intermediate with a kinetic intermediate in protein folding

R Kitahara et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Characterization of the mouse gene for the U-box-type ubiquitin lipase UFD2a

C Kaneko et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Article Biochemistry & Molecular Biology

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins

LGGC Verhoef et al.

HUMAN MOLECULAR GENETICS (2002)

Article Biochemistry & Molecular Biology

PA200, a nuclear proteasome activator involved in DNA repair

V Ustrell et al.

EMBO JOURNAL (2002)

Article Multidisciplinary Sciences

NQ01 stabilizes p53 through a distinct pathway

G Asher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Immunoproteasome assembly and antigen presentation in mice lacking both PA28α and PA28β

S Murata et al.

EMBO JOURNAL (2001)

Article Multidisciplinary Sciences

Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

KM Sakamoto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome

SL McCutchen-Maloney et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)