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What's in a Name? An Overview of the Proliferating Nomenclature in the Field of Phage Lysins

期刊

CELLS
卷 12, 期 15, 页码 -

出版社

MDPI
DOI: 10.3390/cells12152016

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bacteriophage; lysins; phage lysins; enzymes; antimicrobials; nomenclature

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In recent years, the research on phage lysins as alternative antimicrobials has grown significantly, resulting in diverse naming customs among research groups. While this diversity showcases the vitality of the topic, it also creates confusion and lack of comparability. This article aims to clarify the ambiguities by examining the historical naming customs, providing a semantic classification, and proposing a standardized nomenclature for the lysin community.
In the last few years, the volume of research produced on phage lysins has grown spectacularly due to the interest in using them as alternative antimicrobials. As a result, a plethora of naming customs has sprouted among the different research groups devoted to them. While the naming diversity accounts for the vitality of the topic, on too many occasions it also creates some confusion and lack of comparability between different works. This article aims at clarifying the ambiguities found among names referring to phage lysins. We do so by tackling the naming customs historically, framing their original adoption, and employing a semantic classification to facilitate their discussion. We propose a periodization of phage lysin research that begins at the discovery era, in the early 20th century, enriches with a strong molecular biology period, and grows into a current time of markedly applied research. During these different periods, names referring to the general concepts surrounding lysins have been created and adopted, as well as other more specific terms related to their structure and function or, finally, names that have been coined for the antimicrobial application and engineering of phage lysins. Thus, this article means to serve as an invitation to the global lysin community to take action and discuss a widely supported, standardized nomenclature.

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