4.6 Article

Plasma Sphingomyelin Disturbances: Unveiling Its Dual Role as a Crucial Immunopathological Factor and a Severity Prognostic Biomarker in COVID-19

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Letter Virology

In the age of Omicron variant: Paxlovid raises new hopes of COVID-19 recovery

Zhonglei Wang et al.

JOURNAL OF MEDICAL VIROLOGY (2022)

Editorial Material Medicine, General & Internal

Molnupiravir - A Step toward Orally Bioavailable Therapies for Covid-19

Richard Whitley

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Biotechnology & Applied Microbiology

Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19

Jihoon W. Lee et al.

Summary: The study reveals metabolic changes in immune cells of COVID-19 patients, with increasing disease severity correlating with monocytes bifurcating into two distinct metabolic subsets. The integrated analysis shows a strong interplay between plasma metabolites and cell-type-specific metabolic reprogramming networks associated with disease severity and potential survival prediction.

NATURE BIOTECHNOLOGY (2022)

Article Biochemistry & Molecular Biology

Severity of COVID-19 Patients Predicted by Serum Sphingolipids Signature

Enrica Torretta et al.

Summary: This study found that the imbalance of sphingolipid and glycosphingolipid metabolism in COVID-19 patients is related to disease severity, potentially leading to lipid raft remodeling, inducing cell apoptosis and immune escape.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Physiology

Ceramides in Metabolism: Key Lipotoxic Players

Bhagirath Chaurasia et al.

Summary: The review discusses the impact of lipid metabolites like ceramides on metabolic diseases and the potential therapeutic approaches to combat them.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 83 (2021)

Article Biochemistry & Molecular Biology

Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and influenza virus

Einat B. Vitner et al.

Summary: The study found that the synthetic machinery for glycosphingolipids can serve as a therapeutic target for combating SARS-CoV-2, with two GCS inhibitors inhibiting viral replication. The data suggest that the synthesis of glycosphingolipids is necessary to support viral life cycles.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease

Hridayesh Prakash et al.

Summary: Sphingolipids, including S1P and Ceramide, play a crucial role in respiratory bacterial infections, and potential control of SARSCoV-2 infection may involve targeting S1P signaling and utilizing other sphingolipid derivatives such as Ceramide-1 Phosphate.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2021)

Review Medicine, Research & Experimental

Hematological manifestations and complications of COVID-19

Burak Erdinc et al.

Summary: COVID-19 commonly leads to severe complications such as pneumonia, immunocompromised state, cytokine storm, and acute thrombotic events, requiring close monitoring and early treatment to reduce mortality.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2021)

Article Immunology

Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic Strategies

Murad Abusukhun et al.

Summary: Research has shown that activation of the sphingomyelinase-ceramide pathway in severe COVID-19 patients could be a promising target for future FDA-approved drugs. A significant increase in acid sphingomyelinase activity accurately distinguished between patients in critical condition and healthy controls.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients

Judith Marin-Corral et al.

Summary: Analysis of metabolic pathways in COVID-19 patients revealed associations with disease severity. Factors such as obesity, respiratory rate, and blood pressure were linked to severity, while changes in ceramide metabolism and tryptophan degradation correlated with inflammation. The metabolomic profile could potentially aid in stratifying disease severity and guiding clinical decisions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Pharmacology & Pharmacy

Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19

Vikas P. Sukhatme et al.

Summary: Fluvoxamine, a well-tolerated and widely available selective serotonin reuptake inhibitor, has shown potential in preventing clinical deterioration of COVID-19 patients in a small study. It functions through various mechanisms such as antiviral effects, anti-inflammatory properties, and regulation of coagulopathy.

FRONTIERS IN PHARMACOLOGY (2021)

Article Medicine, Research & Experimental

Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection

Justin Fortune Creeden et al.

Summary: The study suggests that the antidepressant fluoxetine may act as a potential therapy for hyperinflammatory states such as asthma, sepsis, and COVID-19 by targeting IL6ST and NF-kappaB Subunit 1 (NFKB1).

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Cell Biology

Sphingosine 1-phosphate metabolism and insulin signaling

Dominik Wigger et al.

Summary: Insulin, secreted by pancreatic 13-cells, plays a key role in glucose assimilation and storage in muscle and fat cells. Insulin resistance is associated with various metabolic disorders and may lead to the development of diabetes. Certain bioactive lipids and sphingolipid derivatives have been linked to the pathogenesis of insulin resistance.

CELLULAR SIGNALLING (2021)

Article Multidisciplinary Sciences

Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients

Alhaji H. Janneh et al.

Summary: Changes in sphingolipids are closely related to the development of COVID-19, with reduced levels of sphingosine potentially serving as a sensitive biomarker for the early identification of symptomatic and asymptomatic COVID-19 patients.

SCIENTIFIC REPORTS (2021)

Review Cell Biology

Sphingolipids as Modulators of SARS-CoV-2 Infection

Kid Tornquist et al.

Summary: SARS-CoV-2 virus enters cells through binding with ACE2 protein and specific protease priming, while sphingolipids affect the uptake of virus particles. Inhibition of ASM function and S1P levels may be related to disease severity.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemical Research Methods

Evaluation of lipid quantification accuracy using HILIC and RPLC MS on the example of NIST® SRM® 1950 metabolites in human plasma

Mike Lange et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

Article Medicine, General & Internal

Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7)

Pei-Fang Wei

CHINESE MEDICAL JOURNAL (2020)

Editorial Material Medicine, General & Internal

Care for Critically Ill Patients With COVID-19

Srinivas Murthy et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Virology

Clinical features and treatment of COVID-19 patients in northeast Chongqing

Suxin Wan et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Article Microbiology

Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection

Amani Audi et al.

FRONTIERS IN MICROBIOLOGY (2020)

Article Medicine, General & Internal

Mild or Moderate Covid-19

Rajesh T. Gandhi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Biochemistry & Molecular Biology

Role of bioactive sphingolipids in physiology and pathology

Ana Gomez-Larrauri et al.

LIPID MEDIATORS (2020)

Editorial Material Medicine, General & Internal

Cholesterol in Relation to COVID-19: Should We Care about It?

Dina Radenkovic et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Biochemistry & Molecular Biology

Role of cholesterol and sphingolipids in brain development and neurological diseases

Ghulam Hussain et al.

LIPIDS IN HEALTH AND DISEASE (2019)

Article Cell Biology

Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry

Dominik Wigger et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Ceramides as Novel Disease Biomarkers

Jennifer Kurz et al.

TRENDS IN MOLECULAR MEDICINE (2019)

Review Cell Biology

Sphingolipids and their metabolism in physiology and disease

Yusuf A. Hannun et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Sphingolipids in early viral replication and innate immune activation

Judith Bezgovsek et al.

BIOLOGICAL CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

The role of acid sphingomyelinase and modulation of sphingolipid metabolism in bacterial infection

Alexander Simonis et al.

BIOLOGICAL CHEMISTRY (2018)

Review Oncology

Sphingolipid metabolism in cancer signalling and therapy

Besim Ogretmen

NATURE REVIEWS CANCER (2018)

Review Biochemistry & Molecular Biology

Macrophages and Phospholipases at the Intersection between Inflammation and the Pathogenesis of HIV-1 Infection

Francesca Spadaro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Multidisciplinary Sciences

Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver

Ha-Yeun Chung et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region

Takayuki Sassa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

Susan Pyne et al.

PROGRESS IN LIPID RESEARCH (2016)

Article Biochemistry & Molecular Biology

Autophagy in the light of sphingolipid metabolism

Eva Bang Harvald et al.

APOPTOSIS (2015)

Review Biochemistry & Molecular Biology

Sphingolipids in viral infection

Juergen Schneider-Schaulies et al.

BIOLOGICAL CHEMISTRY (2015)

Article Genetics & Heredity

Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis

Huiming Peng et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

Review Cell Biology

Role of Sphingolipids in the Pathobiology of Lung Inflammation

Riccardo Ghidoni et al.

MEDIATORS OF INFLAMMATION (2015)

Review Biochemistry & Molecular Biology

Molecular mechanisms of natural killer cell activation in response to cellular stress

C. J. Chan et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Computer Science, Interdisciplinary Applications

qgraph: Network Visualizations of Relationships in Psychometric Data

Sacha Epskamp et al.

JOURNAL OF STATISTICAL SOFTWARE (2012)

Article Endocrinology & Metabolism

Double-check: validation of diagnostic statistics for PLS-DA models in metabolomics studies

Ewa Szymanska et al.

METABOLOMICS (2012)

Article Biochemistry & Molecular Biology

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers

Rebecca L. Shaner et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Biochemistry & Molecular Biology

Lipid rafts are involved in SARS-CoV entry into Vero E6 cells

Yanning Lu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Biochemical Research Methods

Comprehensive algorithm for quantitative real-time polymerase chain reaction

S Zhao et al.

JOURNAL OF COMPUTATIONAL BIOLOGY (2005)

Article Biotechnology & Applied Microbiology

Bioconductor: open software development for computational biology and bioinformatics

RC Gentleman et al.

GENOME BIOLOGY (2004)

Review Biochemistry & Molecular Biology

Ceramide: second messenger or modulator of membrane structure and dynamics?

WJ van Blitterswijk et al.

BIOCHEMICAL JOURNAL (2003)