期刊
CELLS
卷 12, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/cells12212553
关键词
Drosophila; wrapping glia; axon; myelin; receptor tyrosine kinase signaling; cell-cell adhesion
类别
The rapid transmission of action potentials is crucial for efficient communication in the nervous system. Glial cells play a role in regulating conduction velocity by controlling axonal diameter. Understanding the mechanisms of glial wrapping in Drosophila can provide insights into the development of complex structures like myelin in mammals.
The rapid transmission of action potentials is an important ability that enables efficient communication within the nervous system. Glial cells influence conduction velocity along axons by regulating the radial axonal diameter, providing electrical insulation as well as affecting the distribution of voltage-gated ion channels. Differentiation of these wrapping glial cells requires a complex set of neuron-glia interactions involving three basic mechanistic features. The glia must recognize the axon, grow around it, and eventually arrest its growth to form single or multiple axon wraps. This likely depends on the integration of numerous evolutionary conserved signaling and adhesion systems. Here, we summarize the mechanisms and underlying signaling pathways that control glial wrapping in Drosophila and compare those to the mechanisms that control glial differentiation in mammals. This analysis shows that Drosophila is a beneficial model to study the development of even complex structures like myelin.
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