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Review
Biochemistry & Molecular Biology
Alberto Nicoletti et al.
Summary: Pancreatic cancer is highly aggressive and has a poor prognosis due to difficulties in detection and limited effectiveness of current treatments. Extracellular vesicles, such as exosomes and microvesicles, may play a crucial role in the progression and resistance to chemotherapy of pancreatic cancer. They also have the potential to be used as biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Junduan Dai et al.
Summary: In this study, a protein-activated magnetic resonance imaging probe was developed, which can directly monitor tumor progression and drug treatment response, as well as screen protease inhibitors in whole-animal models. This study provides an alternative toolkit for cancer diagnosis, treatment response assessment, and anticancer drug screening.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Shuo Ma et al.
Review
Oncology
Xindi Liang et al.
Summary: Lung cancer is a major cause of cancer-related death, and early diagnosis and treatment are crucial for improving the survival rate. MiRNAs have emerged as promising biomarkers for lung cancer due to their high sensitivity and specificity. In the regulation of non-small cell lung cancer, miRNAs play important roles as oncogenic factors, tumor suppressors, and regulators. Dysfunctional miRNAs negatively regulate target genes involved in cell proliferation, invasion, apoptosis, cell cycle disorder, and angiogenesis. This review provides a summary of the biological process and recent advances in the mechanisms of miRNAs in tumor formation and development, with a focus on their potential for early diagnosis of lung cancer through circulating free and extracellular vesicles.
Article
Chemistry, Analytical
Xinyue Zha et al.
Summary: Circulating tumor cells (CTCs) have become a focus of research due to their ability to spread from the primary tumor to other tissues through peripheral blood. Circulating tumor DNA (ctDNA), released by CTCs and other tumor cells, is considered a promising substance for clinical detection. A biocompatible electrochemical biosensor was developed using tetrahedral DNA (TDN) attached to red blood cells and methylene blue (MB) as a signal probe, enabling efficient and rapid detection of ctDNA. The TDN-based biosensor showed linear correlation between current signal and logarithm of ctDNA concentration in the range of 1 fM to 100 pM, with a detection limit of 0.66 fM. This specific and sensitive biosensor can effectively detect ctDNA in real biological environments such as serum, providing potential opportunities for early clinical diagnosis.
Review
Chemistry, Analytical
Anil Gattani et al.
Summary: Parasitic diseases, neglected in both human and animals, particularly in tropical and sub tropical regions, require improved biosensing techniques for early diagnosis and control. Electrochemical biosensors show promising potential in the on-site diagnosis of parasites.
Review
Chemistry, Analytical
Vy Anh Tran et al.
Summary: This paper discusses the structures, synthesis methods, and applications of MXene materials in the field of sensors. It focuses on the recent advancements and future opportunities and challenges in the development of MXene-based sensors.
Review
Chemistry, Multidisciplinary
Goeun Park et al.
Summary: Zika virus (ZIKV) and dengue virus (DENV) infections are becoming more common due to global warming. Accurate diagnosis is essential for controlling these viral infections. Recent research has focused on developing biosensors for the accurate diagnosis of ZIKV and DENV using DNA nanotechnology. These biosensors offer advantages over traditional diagnostic methods, such as PCR and ELISA. DNA can serve as a bioreceptor and be easily modified with functional groups, making it a valuable tool for the development of specific bioreceptors that bind to viral proteins or nucleic acids. This review discusses advances in DNA-nanotechnology-based biosensors for the detection of ZIKV and DENV.
Review
Immunology
Xiangjin Gong et al.
Summary: Ovarian cancer is a highly malignant tumor with a poor prognosis. Current treatments, such as chemotherapy and radiotherapy, yield unsatisfactory results. Exosomes, a type of extracellular vesicle, have shown potential as effective carriers of immunotherapeutic drugs. They play a dual role in inhibiting and promoting tumor development and contain genes that could serve as biomarkers for ovarian cancer diagnosis and prognosis. However, further research is needed to explore the clinical application of exosome-based immunotherapy in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Tiantian Liu et al.
Summary: This article reviews recent mechanistic insights into altered TERT promoter-mediated telomerase activation in urothelial carcinomas (UCs) and discusses potential clinical implications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yifan Zuo et al.
Summary: In this study, an integrated and highly efficient strategy for capturing heterogeneous circulating tumor cells (CTCs) and portable detection was proposed. A cellulose wrinkled hydrogel was used as the biointerface for capturing the CTCs, and a glucometer readout method was introduced for quantifying the captured CTCs. This strategy provides a convenient approach for detecting and analyzing CTCs in non-small-cell lung cancer (NSCLC) patients.
Article
Chemistry, Multidisciplinary
Qi Zhang et al.
Summary: A ratiometric SERS biosensor was developed to detect breast cancer cell-derived exosomes, providing accurate identification of cancer patients and healthy individuals in clinical serum samples.
Article
Oncology
Yung-Yu Hsieh et al.
Summary: Gastric cancer is the fifth most common cancer in the world. The presence of pathogenic microbiota, such as Helicobacter pylori, is an important risk factor for the development of alimentary tract cancers. This study investigated the mutational landscape of F. nucleatum-positive gastric cancer tissues and identified genetic aberrations, including activating mutations of ERBB2, ERBB3, and PIK3CA, disrupted TP53, and high tumor mutational burden, all of which were associated with poor prognosis. These findings suggest that F. nucleatum infection and tumor mutational burden are strong biomarkers for the prognosis of gastric cancer.
Review
Cell Biology
Katarzyna Stefanska et al.
Summary: Exosomes are nanoscale lipid vesicles produced by mammalian cells, playing a crucial role in cell-to-cell communication. In cancer, they contribute to tumor progression and can be used as biomarkers for cancer detection and progression. Their potential application in cancer therapies as drug delivery carriers or diagnostic tools has been suggested. However, they can also transfer drug resistance information, leading to cancer drug resistance. Therefore, understanding the role of exosomes in cancer, drug resistance, and clinical applications is important.
Article
Chemistry, Analytical
Sedighe Khaksari et al.
Summary: This paper presents a novel microfluidic electrochemical aptasensor for the determination of A549 cells. The sensor utilizes a target-induced structure switching mode to selectively and sensitively detect A549 cells. It has a wide linear dynamic range and a low detection limit, making it suitable for analysis in complex matrices.
Review
Oncology
Akhil Pulumati et al.
Summary: Cancer is a disease characterized by the rapid growth and infiltration of malignantly transformed cancer cells into adjacent tissues. It is the leading cause of death worldwide, with millions of new diagnoses and deaths each year. Existing diagnostic techniques have improved early detection rates, but they still have limitations such as inaccurate target definition and high cost. This review discusses various imaging, molecular, and low-cost diagnostic tools and advancements, aiming to improve cancer diagnostics, especially in low- and middle-income countries.
Article
Chemistry, Analytical
Jin Wang et al.
Summary: Researchers have developed a stable and general method for real-time monitoring of microRNA-21 and telomerase in living cells using dual tetrahedral DNA nanostructures. The method enables remarkable signal amplification and has potential applications in biomedical imaging and early precise cancer diagnosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Oncology
Kumiko Umemoto et al.
Summary: This study investigated the prevalence of KRAS mutations and ctDNA fraction in different metastatic organs in PDAC patients. The results showed a higher detection rate and maximum VAF of KRAS mutations in PDAC patients with liver metastasis, highlighting the clinical utility of ctDNA analysis in these cases.
BRITISH JOURNAL OF CANCER
(2023)
Review
Chemistry, Medicinal
Keerti Vishwakarma et al.
Summary: Telomerase is a ribonucleoprotein responsible for maintaining chromosome integrity. It is widely expressed in malignant tumors and prevents telomere shortening in cancer cells, promoting unlimited cell division. The re-activation of telomerase in normal cells suppresses p53 activity, leading to malignancy. This study focuses on anti-telomerase therapies and inhibitors, including chemotherapy, immunotherapy, gene therapy, G-quadruplex stabilizers, and HSP-90 inhibitors, to explore novel strategies for designing anti-telomerase compounds.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Ana-Maria Chiorcea-Paquim
Summary: Breast cancer is a major cause of cancer deaths in women globally and there is a need for the discovery and characterization of diagnostic biomarkers. Circulating cell-free nucleic acids such as miRNAs and BRCA1 can be used for genetic profiling and screening of breast cancer patients. Electrochemical biosensors provide sensitive and cost-effective platforms for detecting breast cancer biomarkers.
Review
Biochemical Research Methods
Patrick Severin Sfragano et al.
Summary: In order to address cancer-related issues, the biosensing field is constantly searching for new biomarkers that can be non-invasively analyzed. Extracellular vesicles (EVs) have emerged as promising biomarkers that can provide direct information on diseases. However, there is a lack of practical and effective quantitative procedures for EV detection due to difficulties in the pre-analytical and analytical phases. This review aims to provide a comprehensive overview of recent progress in EV detection using electrochemical and photoelectrochemical biosensors.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Medicine, General & Internal
Awadhesh Kumar Verma et al.
Summary: FRET-based biosensors detect and quantify biomolecules by measuring changes in fluorescence intensity. They utilize non-radiative energy transfer from an excited donor fluorophore to a nearby acceptor fluorophore. FRET-based biosensors have diverse applications in biochemistry, cell biology, and drug discovery.
Article
Biophysics
Shanni Hong et al.
Summary: This study presents a fluorescence aptamer sensor that can monitor the rapid leaching kinetics of quantum dots and the concentration of ions in living cells in real time. The sensor shows high specificity and can be used to study the biosafety and cytotoxicity mechanisms of various cadmium-based quantum dots.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Oncology
Rebecca L. Siegel et al.
Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Review
Chemistry, Analytical
Seungah Lee et al.
Summary: Fluorescence can be enhanced or quenched depending on the distance between the metal nanoparticle surface and the fluorophore molecule. Metal-enhanced fluorescence (MEF) has promising potential in fluorescence-based biological sensing. MEF-based biosensor systems can be categorized into two platforms: two/three-dimensional scaffolds or colloidal suspensions. This review summarizes the applications of wavelength-dependent carbon dots (UV-VIS), noble metals (VIS), and upconversion nanoparticles (NIR to VIS), which contribute to the enhancement of fluorescence through resonance energy transfer modulation, and provides a perspective on this topic.
Article
Nanoscience & Nanotechnology
Yisha Wang et al.
Summary: In this study, a simple and effective endogenous strategy of post-synthesis-modified Zn2+ was proposed to enhance electrochemiluminescence (ECL) emissions of nonmetal porphyrin-based metal-organic frameworks (MOFs). The enhanced ECL signal of Zn-TCPP/UiO-66-NH2 nanoluminophores was utilized to develop a label-free ECL biosensor for detecting nanoscale exosomes, which exhibited good sensitivity and a wide detection range. This work provides inspiration for exploring strategies to enhance ECL efficiencies of porphyrin-based MOFs, which has important application prospects in sensitive bioassays.
ACS APPLIED NANO MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Dan Yang et al.
Summary: Silicon nanomaterials, especially silicon quantum dots (Si QDs), have emerged as promising biomedical materials due to their natural reserves, biocompatibility, and optical properties. This review summarizes the recent advances in the rational design and modification methods of Si QDs, providing insights into the exploration of modified Si QDs for biomedical applications. The review also highlights the current research hotspots of Si QDs in areas such as disease diagnosis/therapeutics, bioanalyte sensing, and tissue engineering.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Peng Miao et al.
Summary: This study presents a concept of DNA bipedal walking nanomachine for direct nucleic acid assay. The DNA nanostructures transitions and pH-assisted detachable intermolecular design are utilized for the construction and regeneration of electrochemical biosensor. The feasibility of detecting ctDNA and SARS-CoV-2 RNA in clinical samples has been demonstrated.
Article
Biochemical Research Methods
Mohamad Mahani et al.
Summary: A novel oligosensor using Si quantum dots (SiQDs) was designed and developed for the detection of miRNAs. This sensor showed high selectivity and sensitivity, and demonstrated good recovery rates in human fluid samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Hua Chai et al.
Summary: This study presents a ratiometric electrochemical biosensor for the detection of circulating tumor DNA (ctDNA). The sensor utilizes DNA probes and DNAzyme activation to achieve detection. The results show high sensitivity and selectivity, and the method holds great potential for widespread application in biological sample analysis.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Jing Su et al.
Summary: A sensitive and portable electrochemical biosensor in combination with smartphones was developed for quantitative analysis of exosomes. The biosensor could detect extremely low concentrations of exosomes in microliter-level serum and cell culture supernatant. It also showed great potential for early diagnosis of prostate disease and monitoring of exosome secretion during drug therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Shah Zada et al.
Summary: The study developed an amplified imaging platform for intracellular miRNAs based on Mo2B nanosheets, which combined fluorescence quenching and hybridization chain reaction technologies for sensitive detection and imaging of miRNAs. This platform demonstrated excellent performance in distinguishing cancer cells from normal cells and monitoring miRNA expression changes in cancer cells.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Dongwei Feng et al.
Summary: A novel dual selective fluorescent nanosensor for detecting cancerous exosomes was developed. The sensor exhibited outstanding selectivity, high detection sensitivity, simplicity, and low cost, making it significant for clinical diagnosis of known or unknown targets.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Medical Laboratory Technology
Anushree Gade et al.
Summary: Cancer is the second leading cause of death worldwide, mostly due to delayed detection. Utilizing biomarker-based detection tools can help in early recognition of cancer. This review examines the use of SPR-based sensors in cancer diagnosis.
CLINICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Yuchan Meng et al.
Summary: ZnSe nanodisks:Ti3C2 MXene complex was prepared and applied to develop a photoelectrochemical biosensor for the sensitive detection of an non-small-cell cancer biomarker ctDNA KRAS G12D. The composite showed remarkable photoelectrochemical performance and, when combined with signal amplification, enabled accurate detection of KRAS G12D.
Article
Chemistry, Analytical
Yamin Xiong et al.
Summary: The study proposed a novel strategy for highly specific detection of tumor-derived exosomes based on FRET technology, which combines detection of multiple exosomal surface markers. This method shows potential for clinical cancer diagnosis, effectively diagnosing non-small cell lung cancer.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Biomedical
Robert C. McDonald
Summary: Tumor biopsies play a crucial role in oncology for guiding medical treatment and evaluating disease progression. However, accessing reliable tumor tissue pathology is challenging due to the heterogeneous nature of tumors. Oxygen levels in tumor tissue provide valuable information, but there is a risk of acquiring non-diagnostic cells if the biopsy needle is placed in normal tissue. A pO(2)-guided biopsy needle has been developed to determine oxygen levels and fluctuations in highly resolved tumor regions, aiding in determining the optimal region for cell sampling and treatment options.
JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME
(2022)
Article
Materials Science, Biomaterials
Ling Yang et al.
Summary: In this study, we successfully synthesized core-shell quantum dot nanocrystals and magnetic nanoparticles, and applied the ctDNA-triggered hybridization chain reaction for the detection of CYFRA21-1 DNA associated with lung cancer. Compared to conventional methods, this new approach offers improved sensitivity and accuracy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Materials Science, Biomaterials
Fereshteh Vajhadin et al.
Summary: Blood analysis is a well-established method for monitoring various diseases, including cancer. In recent years, the focus has shifted to the detection of circulating tumor cells (CTCs), which can provide valuable information about the cancer status. Optical cytosensors, such as colorimetry and fluorescence, have shown promising results in detecting CTCs. However, further research is needed to fully exploit their potential in cancer diagnostics and monitoring.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Medicine, Research & Experimental
Jiang Min et al.
Summary: Circulating tumor DNA (ctDNA) is cell-free DNA released by tumor cells and can provide comprehensive genomic information. Noninvasive ctDNA assays have been widely used in cancer diagnosis and monitoring, but there is still room for improvement in the early diagnosis of esophageal cancer.
MEDICAL SCIENCE MONITOR
(2022)
Article
Chemistry, Multidisciplinary
Fei Liu et al.
Summary: This study demonstrates fast DNA fluorescence detection on the confined surface of hydrogel particles by tailoring the pore size and surface charge. A fluorescence-on DNA sensor based on hydrogel particle array is fabricated using graphene oxide's fluorescence quenching property and its different adsorption behaviors towards single-strand DNA or double-strand DNA. The study shows great potential in DNA diagnostics, gene analysis, and liquid biopsy.
Review
Biochemistry & Molecular Biology
Lu Chang et al.
Summary: Liquid biopsy, as an innovative method for early cancer diagnosis, has the potential to be a promising biomarker for non-invasive detection, especially for the early detection of NSCLC. It allows for the extraction of malignant features from body fluids that are not present in primary tumors, reducing the need for invasive treatments.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Biochemical Research Methods
Jeong Ah Park et al.
Summary: This review discusses the continued development of neurotoxin biosensors based on electrochemistry and optics. Cyanobacteria that cause algal blooms are widely distributed worldwide and pose a serious threat to human health. Traditional analytical techniques for detecting neurotoxins have limitations, but the introduction of biosensors can overcome these limitations.
Article
Biophysics
Jiaju Shi et al.
Summary: This article discusses the advantages and disadvantages of label-free and label-based methods commonly used in the isolation of CTCs, and systematically reviews the most recent advances in the combination of microfluidic chips and biosensing for the enrichment of circulating tumor cells, proposing the current barriers and developmental trends in CTCs research.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Piaopiao Chen et al.
Summary: The study introduces a new method for tumor detection using folate receptor as a marker for circulating tumor cells. It combines fluorescence and color-distance detection modes to detect liver cancer cells. The method utilizes enzyme-assisted amplification strategy and CdTe QDs and Cu NPs for improved detection. The results of clinical samples validation show good agreement with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Myoungro Lee et al.
Summary: In this study, a capacitance-based electrical biosensor was developed to detect exosomes in undiluted serum samples without pretreatment. The biosensor utilized a DNA aptamer for CD63 protein detection and MoS2 nanoparticles to enhance the electrical sensitivity. The interdigitated micro-gap electrode system efficiently amplified the electrical signal for exosome detection, offering high selectivity and sensitivity. The biosensor exhibited linearity between the capacitance signal and exosome concentration in serum, with a detection limit of 2192.6 exosomes/mL.
BIOSENSORS & BIOELECTRONICS
(2022)
Editorial Material
Oncology
Amaia Fernandez-Uriarte et al.
Summary: Cancer screening has been an important field of research. Traditional biomarkers are not suitable for population screening. Circulating tumor DNA has emerged as a promising new marker for cancer, but there are still challenges and the accuracy of new screening tests needs further definition.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Biochemistry & Molecular Biology
Maria F. Arisi et al.
Summary: ctDNA, a component of cfDNA shed by malignant tumors, offers a non-invasive and real-time method to evaluate the genomic profile of a patient's tumor. Though not yet implemented in clinical practice, ongoing studies are exploring its potential as a tool in cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Pai-Chi Teng et al.
Summary: Serum alpha-fetoprotein and radiologic imaging are commonly used tests for early diagnosis and treatment monitoring of hepatocellular carcinoma (HCC), but their accuracy is limited. Developing novel HCC biomarkers reflecting tumor biology is an unmet need. Circulating tumor cells (CTCs) have potential as a noninvasive biomarker for HCC, offering molecular and functional data that can reflect the underlying tumor.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Engineering, Biomedical
Lianyu Yu et al.
Summary: In this study, an integrative DNA tetrahedral nanomachine was self-assembled for the sensitive detection and negative feedback regulation of intracellular miRNAs. The nanomachine exhibited excellent sensitivity and specificity, and demonstrated the ability to synchronously regulate target cells. It has promising applications in the early diagnosis and tailored management of cancers.
MATERIALS TODAY BIO
(2022)
Review
Chemistry, Inorganic & Nuclear
Anees A. A. Ansari et al.
Summary: This review summarizes the application of nanomaterials in latent fingerprint imaging, with a focus on luminescent Ln(3+)-NPs/UCNPs and their advantages in producing high-quality images on porous and non-porous surfaces. The review also discusses the use of conventional techniques, such as physical, chemical, and instrumental methods, for fingerprint detection, highlighting their limitations. Furthermore, the review emphasizes the need for further research in developing efficient, high-performance, surface-functionalized, biocompatible, and nontoxic Ln(3+) NPs/UCNPs for recognizing latent fingerprints on different surfaces.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Urology & Nephrology
Ikenna Madueke et al.
UROLOGIC CLINICS OF NORTH AMERICA
(2022)
Article
Medicine, General & Internal
Anine Larsen Ottestad et al.
Journal of Personalized Medicine
(2022)
Article
Biophysics
Jie Wang et al.
Summary: This study designed a nanoprobe based on a cascade-amplification-reaction for the detection of intracellular telomerase. The method demonstrated fast response and strong fluorescence signals, allowing convenient monitoring of telomerase activity and changes in different types of tumor cells.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Inorganic & Nuclear
Tianxun Gong et al.
Summary: Recent advances in surface-enhanced Raman scattering (SERS) have led to the development of SERS tags, which offer significant promise for sensitive and selective detection in medical applications. These tags utilize electromagnetic and chemical enhancement mechanisms to amplify signals, providing high sensitivity, low detection limits, and good selectivity.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Analytical
Myoungro Lee et al.
Summary: Exosomes have gained attention as potential biomarkers for early cancer diagnosis and have advantages over current tissue biopsies. However, accurate quantification methods for exosome concentration still need to be determined through further clinical trials. Recent developments in nanomaterial and biomaterial hybrid-based biosensors have shown promise in improving the sensitivity and selectivity for detecting exosomal biomarkers.
Article
Chemistry, Analytical
Ke Wang et al.
Summary: This article discusses the application of electrochemical biosensors in ctDNA detection. They offer advantages such as high sensitivity, high specificity, low cost, and good portability. The article summarizes the choices and performance of different types of ctDNA sensors, and analyzes their development in the areas of Internet of Things, point-of-care testing, big data, and big health.
Review
Biochemical Research Methods
Minchuan Luo et al.
Summary: Semiconductor quantum dots (QDs) are sensitive probes that play an important role in cytologic diagnoses, biosensing, and bioimaging. Microfluidic technology provides a rapid platform for disease marker tracing. In vivo fluorescence imaging based on QDs has become popular for analyzing complex biological processes.
Article
Materials Science, Biomaterials
Yanping Xu et al.
Summary: In this study, a TiO2-based surface-enhanced Raman scattering (SERS) bioprobe was developed for the detection of circulating tumor cells (CTCs). The bioprobe showed outstanding ultrasensitive specificity, signal stability, and biocompatibility. It was able to effectively detect multiple types of cancer cells and achieve precise targeting using fluorescence imaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Analytical
Shuainan Li et al.
Summary: The development of a designer nanoprobe called TDFM was described in this study for efficient fluorescence imaging of tumor-related miRNA-214 in living cells. The nanoprobe demonstrated sensitive detection and good specificity in cell-free experiments, and showed strong fluorescence signal in living cells. It has the potential to be applied in the development of DNA nanodevices for improved fluorescence imaging of miRNAs in living cells.
Review
Gastroenterology & Hepatology
Joseph C. Ahn et al.
Summary: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related morbidity and mortality worldwide, and current tests like alpha-fetoprotein have limited accuracy. Liver biopsy, while informative, is not routinely used due to invasiveness, leading to a need for new biomarkers. Liquid biopsy, specifically detection of circulating tumor cells (CTCs), offers potential for early detection and personalized treatment management in HCC patients. Quantitative analysis of CTCs can predict disease prognosis and treatment response, highlighting the importance of developing CTC detection platforms for clinical use.
Review
Chemistry, Analytical
Zhi-Fang Sun et al.
Summary: This review summarizes the recent development of nanomaterials-based optical and electrochemical analytical techniques for CTCs detection, aiming at amplifying the signal and enhancing the sensitivity.
Article
Biophysics
Min Wu et al.
Summary: This study introduces a novel fluorescent biosensor for one-step sensitive quantification of salivary exosomes, offering high sensitivity and a low limit of detection.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Wenxi Xia et al.
Summary: By introducing antibodies and MLP into magnetic nanobeads, we have successfully increased the capture efficiency of HCC-CTCs while maintaining cell viability. This new strategy holds great promise for achieving real-time identification and monitoring of CTCs in clinical settings.
Article
Chemistry, Physical
Xi Zhou et al.
Summary: In this study, hierarchical structures of PtNPs decorated with hyperbranched PdRu nanospines were synthesized for efficient detection of CTCs. Multiplexed signal amplification significantly improved the analytical performance of the biosensor, with a detection limit for CTCs of 2 cells mL(-1).
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Biophysics
Juan Cai et al.
Summary: The newly developed cytosensor utilizes a dual recognition strategy and excellent electrocatalytic materials to achieve accurate detection of CTCs. The sensor has a wide linear range and low detection limit, allowing for detection of CTCs in clinical blood samples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biophysics
Mei Chen et al.
Summary: A novel 3D GR/AuPtPd nanoflower sensing platform based on CRISPR/Cas9 cleavage-triggered entropy-driven strand displacement reaction (ESDR) was developed for effective detection of ctDNA. This method allows for low levels of ctDNA detection without requiring complicated operation procedures and stringent reaction conditions.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Crystallography
Omnia Samy et al.
Summary: Molybdenum disulfide (MoS2) is a compound with outstanding features and wide applications, playing important roles in electronics and energy, as well as significant effects in detecting diseases like cancer and Alzheimer's.
Article
Chemistry, Multidisciplinary
Piaopiao Chen et al.
Summary: The study describes a method using quantum dots as signal reporters for homogeneous visual and fluorescent detection of lung cancer cells, achieving successful detection and quantitative analysis. The levels of CTCs detected in clinical samples were consistent with other testing methods and correlated with radiologic and pathological findings.
Article
Chemistry, Analytical
Xiaokun Wang et al.
Summary: A fluorescence assay based on immunomagnetic separation and a two-step signal amplification strategy has been developed for sensitive and selective detection of exosomes. The method allows for the isolation and quantitative analysis of exosomes in biological fluids with satisfactory recovery rates, providing a sensitive and anti-interference platform for exosome isolation and detection.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Xiaojuan Liu et al.
Summary: The combination of a metal-organic framework-functionalized paper and a screen-printed electrode has enabled the development of a simple and cost-efficient electrochemical biosensor for detecting cancer-derived exosomes with high sensitivity and a low detection limit. This label-free paper-based biosensor offers advantages such as low cost, ease of operation, and high sensitivity, making it suitable for point-of-care diagnosis in resource-limited settings.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Ayemeh Bagheri Hashkavayi et al.
Summary: An electrochemical aptasensor based on rolling circle amplification (RCA) and the catalytic ability of the hemin/G-quadruplex complex was developed for highly sensitive and selective detection of circulating tumor cells (CTCs). This strategy allows for the sensitive determination of target cancer cells down to a single cell with high selectivity even in human serum. The proposed platform with dual signal amplification shows promise for simple and ultrasensitive detection of CTCs, as well as other cancer cells and biomarkers in different clinical and biological samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Biochemistry & Molecular Biology
Jin-Ha Choi et al.
Summary: Nucleic acids, including DNA and RNA, are promising biomarkers for cancer diagnosis. Nanomaterial-based FRET and MEF biosensors offer accurate and sensitive detection of cancer-related nucleic acids, contributing to early cancer diagnosis.
Article
Engineering, Biomedical
Mara A. Pop et al.
Summary: While miRNAs are known to be involved in specific cellular processes or pathologies, their dosage-dependent effects remain largely unexplored. Studying the effects of incremental miRNA dosage is important, but current delivery methods cannot control the amount of miRNA entering cells.
ADVANCED NANOBIOMED RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Dongfei Chen et al.
Summary: An ultrasensitive electrochemical biosensor based on DNA-Au@MNPs has been developed for rapid detection of ctDNA in whole blood, with an ultralow detection limit and broad dynamic range. This sensor provides a promising method for achieving a 20-minute response time and minimally invasive early cancer diagnosis.
Article
Chemistry, Multidisciplinary
Chao Xing et al.
Summary: In this study, an accelerated DNA tetrahedron based molecular beacon was developed for efficient detection and imaging of miRNA in living cells. The research provides an improved strategy for fluorescence amplified RNA imaging in early clinical diagnosis.
CHEMICAL COMMUNICATIONS
(2021)
Article
Materials Science, Biomaterials
Nanhang Zhu et al.
Summary: In this study, a FRET magnetic aptamer-sensor was developed for rapid and efficient detection of exosomes, with a detection limit of 13 particles per mL and 100% accuracy in screening a specific cancer antigen. This system shows promising potential for liquid biopsy in lung cancer detection.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Ruiyuan Zhang et al.
Summary: The study reports the in situ analysis of human telomerase using a multicolor DNA tetrahedron nanoprobe, enabling imaging, real-time monitoring, and determination of product length distribution in living cells. It detects multiple information of intracellular telomerase and provides deeper insights into the function of telomerase.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
YiFang Huang et al.
ANALYTICA CHIMICA ACTA
(2020)
Article
Chemistry, Analytical
Huiting Lu et al.
ANALYTICAL CHEMISTRY
(2020)
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