4.6 Article

Evening Primrose Extract Modulates TYMS Expression via SP1 Transcription Factor in Malignant Pleural Mesothelioma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

FOXM1-induced TYMS upregulation promotes the progression of hepatocellular carcinoma

Liang Wang et al.

Summary: TYMS was found to be upregulated in HCC cells and patient samples. High expression of TYMS was associated with an unfavorable prognosis in HCC patients. TYMS promoted the proliferation and invasion of HCC cells and inhibited apoptosis. TYMS is a downstream target of FOXM1. TYMS knockdown reversed the 5-FU resistance caused by FOXM1 overexpression and re-sensitized HCC cells to 5-FU treatment.

CANCER CELL INTERNATIONAL (2022)

Article Biochemistry & Molecular Biology

Sp1 Plays a Key Role in Vasculogenic Mimicry of Human Prostate Cancer Cells

Deok-Soo Han et al.

Summary: This study investigated the crucial role of Sp1 in the process of vasculogenic mimicry (VM) in human prostate cancer cells. The results demonstrated that Sp1 mediates VM formation through interacting with the twist/VE-cadherin/AKT pathway in human PCa cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Oncology

Combinations of Phytochemicals More Efficiently than Single Components Activate Nrf2 and Induce the Expression of Antioxidant Enzymes in Pancreatic Cancer Cells

Marta Cykowiak et al.

Summary: Cancer prevention related to aging can be improved by using combinations of phytochemicals. The study found that XAN and PEITC mixture is the most effective modulator of the Nrf2 pathway, inducing cell cycle arrest and increasing apoptosis markers.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2022)

Article Biochemistry & Molecular Biology

Thymidylate Synthase Overexpression Drives the Invasive Phenotype in Colon Cancer Cells

Wojciech M. Ciszewski et al.

Summary: This study found a close correlation between TYMS and invasion ability in colon cancer cells, as well as its crucial role in EMT regulation. It suggests that chemotherapeutics targeting TYMS expression may enhance the effectiveness of colon cancer treatment, especially in the metastatic stage.

BIOMEDICINES (2022)

Review Food Science & Technology

Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials

Saad Bakrim et al.

Summary: Phenolic compounds show significant protective and therapeutic effects against different types of human cancers, with various anti-cancer mechanisms and clinical evidence supporting their potential.
Article Oncology

Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer

Mohammad Aarif Siddiqui et al.

Summary: The study identified a functional correlation between thymidylate synthase (TS), EMT, chemotherapy and metastasis in non-small cell lung cancer (NSCLC), establishing TS as a potential therapeutic marker. Further experiments revealed that TS may influence the occurrence and development of NSCLC by regulating EMT transcription factors and effectors.

BRITISH JOURNAL OF CANCER (2021)

Article Pharmacology & Pharmacy

Diagnostic and prognostic value of thymidylate synthase expression in breast cancer

Shaoran Song et al.

Summary: TYMS expression in breast cancer is associated with tumor progression and prognosis, with higher expression indicating poorer prognosis. TYMS expression levels are closely related to the clinical characteristics of breast cancer.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2021)

Review Pathology

Pleural mesothelioma classification update

Mary Beth Beasley et al.

Summary: The 2015 WHO classification of pleural mesotheliomas includes three major histologic subtypes, but recent data supports the need for a more granular classification. Diagnostic immunohistochemical work up is essential in establishing the final diagnosis, and the forthcoming WHO classification will include mesothelioma in situ as a diagnostic category.

VIRCHOWS ARCHIV (2021)

Article Pharmacology & Pharmacy

Upregulation of Thymidylate Synthase Induces Pemetrexed Resistance in Malignant Pleural Mesothelioma

Yuzo Sato et al.

Summary: The study revealed that TYMS expression is elevated in drug-resistant cell lines compared to parental cell lines, knocking down TYMS can reduce drug resistance, while overexpression can increase resistance. Higher levels of dTMP in resistant cells suggest the importance of the nucleic acid-biosynthetic pathway for the efficacy of PMX.

FRONTIERS IN PHARMACOLOGY (2021)

Article Oncology

Identification and Validation of TYMS as a Potential Biomarker for Risk of Metastasis Development in Hepatocellular Carcinoma

Shuai Li et al.

Summary: Metastasis is a major cause of HCC mortality, and effective biomarkers for HCC metastasis are lacking. This study identified potential key genes for HCC metastasis, highlighting the significant association of TYMS gene with HCC development and metastasis. Further research on TYMS may provide new insights into HCC progression and potential targets for prognosis.

FRONTIERS IN ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

Phytochemicals in Malignant Pleural Mesothelioma Treatment-Review on the Current Trends of Therapies

Malgorzata Chmielewska-Kassassir et al.

Summary: Malignant pleural mesothelioma (MPM) is a rare yet highly aggressive tumor caused by exposure to asbestos fibers. Current studies focus on developing new treatment strategies for MPM by exploring natural compounds and plant extracts.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

The Role of E-Cadherin and microRNA on FAK Inhibitor Response in Malignant Pleural Mesothelioma (MPM)

Man Lee Yuen et al.

Summary: Research on the role of E-cadherin and microRNA in the efficacy of FAK inhibitors in MPM revealed that MPM cells with high CDH1 mRNA levels exhibited resistance to the FAK inhibitor PND-1186. Additionally, PND-1186 induced cell cycle disruption by inducing the G2/M arrest of MPM cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Plant Sciences

Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action

Srimanta Patra et al.

Summary: Dietary polyphenols demonstrate chemopreventive activity by modulating key molecular targets and pathways to limit cancer initiation and progression. Combining polyphenols with existing anticancer drugs enhances anticancer activity and offers promising perspectives for clinical applications.

PHYTOMEDICINE (2021)

Article Nutrition & Dietetics

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo

Marta Cykowiak et al.

Summary: The study found that combinations of phytochemicals can enhance the activation and expression of Nrf2 and NF-κappa B, reduce NF-κappa B activity, and induce apoptosis in HCC cells. In a mouse model, X and PEITC or their combination were observed to reduce tumor burden.

NUTRIENTS (2021)

Article Biochemistry & Molecular Biology

The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial-Mesenchymal Transition

Katarzyna Sobierajska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Oncology

Implications of ABCC4-Mediated cAMP Efflux for CRC Migration

Jakub Kryczka et al.

CANCERS (2020)

Article Biochemistry & Molecular Biology

Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers

Aarif Siddiqui et al.

CELL DEATH AND DIFFERENTIATION (2019)

Review Nutrition & Dietetics

The Immunomodulatory and Anti-Inflammatory Role of Polyphenols

Nour Yahfoufi et al.

NUTRIENTS (2018)

Review Oncology

Multiple biological functions of Twist1 in various cancers

Zhixiang Zhao et al.

ONCOTARGET (2017)

Review Nutrition & Dietetics

Natural Polyphenols for Prevention and Treatment of Cancer

Yue Zhou et al.

NUTRIENTS (2016)

Review Biochemistry & Molecular Biology

Role of phytochemicals in the inhibition of epithelial-mesenchymal transition in cancer metastasis

Eun-Kyung Kim et al.

FOOD & FUNCTION (2016)

Article Cell Biology

Protective Effect of Spironolactone on Endothelial-to-Mesenchymal Transition in HUVECs via Notch Pathway

Xiao Chen et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)

Review Biochemistry & Molecular Biology

In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment

Massimo Fantini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Medicine, Research & Experimental

Influence of polyphenol extract from evening primrose (Oenothera paradoxa) seeds on human prostate and breast cancer cell lines

Urszula Lewandowska et al.

POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ (2014)

Article Immunology

Expression of snail, twist, and Zeb1 in malignant mesothelioma

Heta Merikallio et al.

Article Agriculture, Multidisciplinary

Polyphenols from Evening Primrose (Oenothera paradoxa) Defatted Seeds Induce Apoptosis in Human Colon Cancer Caco-2 Cells

Sylwia Gorlach et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

Article Anatomy & Morphology

The role of Sp1 and Sp3 in normal and cancer cell biology

Lin Li et al.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2010)

Article Biochemistry & Molecular Biology

Interaction of Sp1 zinc finger with transport factor in the nuclear localization of transcription factor Sp1

Tatsuo Ito et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Review Biochemistry & Molecular Biology

Sp1: Emerging roles - Beyond constitutive activation of TATA-less housekeeping genes

Inken Wierstra

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Urology & Nephrology

Clinical significance of thymidylate synthase expression in bladder cancer

T Nomura et al.

INTERNATIONAL JOURNAL OF UROLOGY (2002)