☆ 4.6 Article

How Toll-like Receptor 9 Plays a Key Role in the Development of Gastric Cancer and Is Linked to Epstein-Barr Virus Infection

CANCERS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

Hereditary Diffuse Gastric Cancer: Molecular Genetics, Biological Mechanisms and Current Therapeutic Approaches

Lidia-Sabina Cosma et al.

Summary: This article presents an overview of the genetic characteristics and current treatment approaches of hereditary diffuse gastric cancer (HDGC). It highlights the importance of the CTNNA1 gene, among others, in relation to this disease, and emphasizes the need for risk management in diagnosing patients through genetic testing.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Pediatrics

Increased expression of the TLR7/9 signaling pathways in chronic active EBV infection

Luyao Liu et al.

Summary: This study aimed to investigate the immunological mechanisms of Toll-like receptor (TLR) signaling pathways in different types of Epstein-Barr virus (EBV) infection. The results showed that there was an increased expression of TLR7/TLR9 in EBV-infected patients, leading to increased downstream signaling mediators such as MyD88 and NF-κB. Particularly, in patients with chronic active EBV infection, the TLR7/TLR9 pathway was overactivated, resulting in enhanced inflammation which might be relevant to poor prognosis.

FRONTIERS IN PEDIATRICS (2022)

添加到收藏夹

Review Oncology

Gastric Cancer and the Immune System: The Key to Improving Outcomes?

Sara H. Keshavjee et al.

Summary: Gastric cancer is a lethal form of cancer usually arising from the inner mucosa layer of the stomach. Surgery and chemotherapy are the primary treatments, but immunologic therapies have shown promise in the treatment of gastric cancer. This review summarizes the role of the immune system in gastric cancer formation and growth, as well as the current research on immunologic therapies.

CANCERS (2022)

添加到收藏夹

Article Medicine, General & Internal

Epstein-Barr Virus is Associated with Gastric Cancer Precursor: Atrophic Gastritis

Kai Zhao et al.

Summary: EBV infection is significantly associated with atrophic gastritis, particularly in H. pylori-negative patients. EBV infection also influences gastric function by decreasing the PG I/PG II ratio. Co-infection of EBV and H. pylori does not increase the risk of atrophic gastritis.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2022)

添加到收藏夹

Review Oncology

The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy

Vincenzo Salemme et al.

Summary: The progression of breast cancer is influenced by genetic and epigenetic factors that involve interactions between tumor cells and the tumor microenvironment, particularly immune cells. Immune cells in the tumor microenvironment can have dual roles in cancer onset and progression, affecting both tumor suppression and promotion. Understanding the complex interplay between cancer and immune cells, as well as therapeutic strategies targeting this interaction, is crucial for developing effective combination treatments to overcome tumor immune evasion mechanisms and maximize the clinical benefits of current immunotherapies.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Review Immunology

Epstein-Barr Virus Epithelial Cancers-A Comprehensive Understanding to Drive Novel Therapies

Shuting Han et al.

Summary: The text discusses the similarities and differences of EBV-associated epithelial cancers (such as NPC, LELC, and EBVaGC), providing a comprehensive description of their clinical, pathological, and molecular characteristics. It emphasizes the importance of research in uncovering targets for future drug development and resistance to immunotherapy.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines

Rossella Sartorius et al.

Summary: Toll-like receptors (TLRs) are transmembrane proteins that serve as sensors of invading pathogens by recognizing pathogen-associated molecular patterns, and trigger signaling pathways leading to upregulation of immune defense genes. Understanding viral sensing and signaling mechanisms triggered by these receptors can aid in the development of vaccines, and exploring the TLR/virus interplay may guide the design of innovative vaccine platforms.

NPJ VACCINES (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Tumor microenvironment as a therapeutic target in cancer

Yi Xiao et al.

Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.

PHARMACOLOGY & THERAPEUTICS (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility

Aga Syed Sameer et al.

Summary: Toll-like receptors (TLRs) play important roles in gut inflammatory pathways and have a significant impact on the risk of colorectal cancer. This review comprehensively discusses the structure, functions, signaling of TLRs, and their role in CRC susceptibility.

BIOMED RESEARCH INTERNATIONAL (2021)

添加到收藏夹

Article Oncology

Prognostic value of modified Lauren classification in gastric cancer

Fei-Long Ning et al.

Summary: This study assessed the prognostic performances of three pathological classifications in gastric cancer patients and developed a novel prognostic nomogram for individually predicting overall survival (OS). The results showed that the modified Lauren classification demonstrated superior predictive ability for OS, and the new prognostic nomogram incorporating this classification outperformed the American Joint Committee on Cancer 8th edition tumor-nodemetastasis classification in terms of discriminative ability, model fitting performance, and net benefits.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies

Julita Machlowska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Toll-Like Receptor 9 Agonists in Cancer

Lilit Karapetyan et al.

ONCOTARGETS AND THERAPY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma

Nabanita Roy Chattopadhyay et al.

ISCIENCE (2020)

添加到收藏夹

Review Gastroenterology & Hepatology

Diffuse gastric cancer: histologic, molecular, and genetic basis of disease

Pritish Iyer et al.

TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

添加到收藏夹

Article Virology

Endosomal Toll-Like Receptors Mediate Enhancement of Interleukin-17A Production Triggered by Epstein-Barr Virus DNA in Mice

Marwa Shehab et al.

JOURNAL OF VIROLOGY (2019)

添加到收藏夹

Article Oncology

TLR9 acts as a sensor for tumor-released DNA to modulate anti-tumor immunity after chemotherapy

Tae Heung Kang et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

添加到收藏夹

Article Oncology

A novel TNM staging system for gastric cancer based on the metro-ticket paradigm: a comparative study with the AJCC-TNM staging system

Jun Lu et al.

GASTRIC CANCER (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

Epidemiology of gastric cancer: global trends, risk factors and prevention

Prashanth Rawla et al.

GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY (2019)

添加到收藏夹

Article Hematology

Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells

Eleonora Fonte et al.

HAEMATOLOGICA (2017)

添加到收藏夹

Review Medicine, Research & Experimental

Heterogeneity of Toll-like receptor 9 signaling in B cell malignancies and its potential therapeutic application

Ling Bai et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

添加到收藏夹

Review Biology

Epstein-Barr virus infection and nasopharyngeal carcinoma

Sai Wah Tsao et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2017)

添加到收藏夹

Article

A common molecular signature of intestinal-type gastric carcinoma indicates processes related to gastric carcinogenesis

Renata Binato et al.

Oncotarget (2017)

添加到收藏夹

Article Hematology

Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells

Eleonora Fonte et al.

HAEMATOLOGICA (2017)

添加到收藏夹

Article Rheumatology

Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes

Antonella Farina et al.

ARTHRITIS RESEARCH & THERAPY (2017)

添加到收藏夹

Review Immunology

Toll-like receptor 9 in breast cancer

Jouko Sandholm et al.

FRONTIERS IN IMMUNOLOGY (2014)

添加到收藏夹

Review Immunology

Toll-like receptor signaling pathways

Takumi Kawasaki et al.

FRONTIERS IN IMMUNOLOGY (2014)

添加到收藏夹

Article Oncology

TLR9 Signaling in the Tumor Microenvironment Initiates Cancer Recurrence after Radiotherapy

Chan Gao et al.

CANCER RESEARCH (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Understanding TLR9 action in Epstein-Barr virus infection

Ludwig Zauner et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2012)

添加到收藏夹

Review Oncology

Immune Microenvironment in Tumor Progression: Characteristics and Challenges for Therapy

Valerie Chew et al.

JOURNAL OF ONCOLOGY (2012)

添加到收藏夹

Review Immunology

Immune responses to Epstein-Barr virus: molecular interactions in the virus evasion of CD8(+) T cell immunity

Martin Rowe et al.

MICROBES AND INFECTION (2010)

添加到收藏夹

Article Immunology

Activation of Toll-like receptor 9 by DNA from different bacterial species

A Dalpke et al.

INFECTION AND IMMUNITY (2006)

添加到收藏夹

Article Immunology

Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells

J Lund et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.