期刊
CANCERS
卷 15, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/cancers15164167
关键词
cancer; gene regulatory networks; network biology
类别
Using a network biology framework, we identified cancer type-specific gene regulatory networks for 17 types of cancer, and elucidated core transcription factors and regulatory networks for multiple cancer types. By comparing normal tissues and cells to cancer type-specific networks, we found that the expression of key network-influencing factors can serve as a prognostic indicator for cancer patients.
Identifying cancer type-specific genes that define cell states is important to develop effective therapies for patients and methods for detection, early diagnosis, and prevention. While molecular mechanisms that drive malignancy have been identified for various cancers, the identification of cell-type defining transcription factors (TFs) that distinguish normal cells from cancer cells has not been fully elucidated. Here, we utilized a network biology framework, which assesses the fidelity of cell fate conversions, to identify cancer type-specific gene regulatory networks (GRN) for 17 types of cancer. Through an integrative analysis of a compendium of expression data, we elucidated core TFs and GRNs for multiple cancer types. Moreover, by comparing normal tissues and cells to cancer type-specific GRNs, we found that the expression of key network-influencing TFs can be utilized as a survival prognostic indicator for a diverse cohort of cancer patients. These findings offer a valuable resource for exploring cancer type-specific networks across a broad range of cancer types.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据