4.8 Article

Structural basis of Smoothened regulation by its extracellular domains

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome

Robert Blassberg et al.

HUMAN MOLECULAR GENETICS (2016)

Article Biochemistry & Molecular Biology

Regulation of the oncoprotein Smoothened by small molecules

Hayley J. Sharpe et al.

NATURE CHEMICAL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes

Phillip J. Stansfeld et al.

STRUCTURE (2015)

Article Chemistry, Multidisciplinary

Extension and Validation of the GROMOS 53A6GLYC Parameter Set for Glycoproteins

Laercio Pol-Fachin et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2014)

Review Biochemistry & Molecular Biology

Amphipols for Each Season

Manuela Zoonens et al.

JOURNAL OF MEMBRANE BIOLOGY (2014)

Article Multidisciplinary Sciences

Crystal structure of a human GABAA receptor

Paul S. Miller et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Deciphering key features in protein structures with the new ENDscript server

Xavier Robert et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Chemistry, Multidisciplinary

New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish

Paulina Ciepla et al.

CHEMICAL SCIENCE (2014)

Article Multidisciplinary Sciences

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

Uwe Weierstall et al.

NATURE COMMUNICATIONS (2014)

Article Biochemical Research Methods

How good are my data and what is the resolution?

Philip R. Evans et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2013)

Review Pharmacology & Pharmacy

Structure-Function of the G Protein-Coupled Receptor Superfamily

Vsevolod Katritch et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 (2013)

Article Chemistry, Physical

Improved Parameters for the Martini Coarse-Grained Protein Force Field

Djurre H. de Jong et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)

Article Multidisciplinary Sciences

Structure of the human smoothened receptor bound to an antitumour agent

Chong Wang et al.

NATURE (2013)

Review Multidisciplinary Sciences

Molecular signatures of G-protein-coupled receptors

A. J. Venkatakrishnan et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

Daniel Nedelcu et al.

NATURE CHEMICAL BIOLOGY (2013)

Review Cell Biology

The mechanisms of Hedgehog signalling and its roles in development and disease

James Briscoe et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling

Rajashree Rana et al.

NATURE COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Oxysterols are allosteric activators of the oncoprotein Smoothened

Sigrid Nachtergaele et al.

NATURE CHEMICAL BIOLOGY (2012)

Article Multidisciplinary Sciences

Structural Basis of Wnt Recognition by Frizzled

Claudia Y. Janda et al.

SCIENCE (2012)

Article Multidisciplinary Sciences

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

Wei Liu et al.

SCIENCE (2012)

Article Multidisciplinary Sciences

Linking Crystallographic Model and Data Quality

P. Andrew Karplus et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors

Eugene Chun et al.

STRUCTURE (2012)

Article Biochemical Research Methods

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

Eva Chovancova et al.

PLOS COMPUTATIONAL BIOLOGY (2012)

Article Biochemical Research Methods

Overview of the CCP4 suite and current developments

Martyn D. Winn et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Structural insights into agonist-induced activation of G-protein-coupled receptors

Xavier Deupi et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)

Article Chemistry, Physical

Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of pKa Values

Chresten R. Sondergaard et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2011)

Article Chemistry, Physical

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKa Predictions

Mats H. M. Olsson et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2011)

Review Biochemistry & Molecular Biology

Molecular Simulation Approaches to Membrane Proteins

Phillip J. Stansfeld et al.

STRUCTURE (2011)

Article Biochemical Research Methods

MolProbity: all-atom structure validation for macromolecular crystallography

Vincent B. Chen et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Article Biochemical Research Methods

Recent developments in classical density modification

Kevin Cowtan

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

XDS

Wolfgang Kabsch

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Article Chemistry, Multidisciplinary

xia2: an expert system for macromolecular crystallography data reduction

G. Winter

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2010)

Article Biochemistry & Molecular Biology

NADPH oxidase activator P67(phox) behaves in solution as a multidomain protein with semi-flexible linkers

Dominique Durand et al.

JOURNAL OF STRUCTURAL BIOLOGY (2010)

Article Chemistry, Medicinal

GDC-0449-A potent inhibitor of the hedgehog pathway

Kirk D. Robarge et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Letter Biochemistry & Molecular Biology

Structural Ties between Cholesterol Transport and Morphogen Signaling

J. Fernando Bazan et al.

Review Chemistry, Physical

Combining an Elastic Network With a Coarse-Grained Molecular Force Field: Structure, Dynamics, and Intermolecular Recognition

Xavier Periole et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2009)

Article Biochemical Research Methods

Crystallizing membrane proteins using lipidic mesophases

Martin Caffrey et al.

NATURE PROTOCOLS (2009)

Article Multidisciplinary Sciences

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

Rajat Rohatgi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

Robert L. Yauch et al.

SCIENCE (2009)

Article Biophysics

Bacteriorhodopsin/amphipol complexes: Structural and functional properties

Yann Gohon et al.

BIOPHYSICAL JOURNAL (2008)

Article Chemistry, Physical

GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation

Berk Hess et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2008)

Article Biochemistry & Molecular Biology

Coarse-grained MD simulations of membrane protein-bilayer self-assembly

Kathryn A. Scott et al.

STRUCTURE (2008)

Review Biochemistry & Molecular Biology

Inference of macromolecular assemblies from crystalline state

Evgeny Krissinel et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Chemistry, Multidisciplinary

Phaser crystallographic software

Airlie J. McCoy et al.

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)

Article Multidisciplinary Sciences

Patched1 regulates Hedgehog signaling at the primary cilium

Rajat Rohatgi et al.

SCIENCE (2007)

Article Chemistry, Physical

The MARTINI force field: Coarse grained model for biomolecular simulations

Siewert J. Marrink et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2007)

Article Biochemistry & Molecular Biology

Oxysterols pathway in are novel activators of the hedgehog pluripotent mesenchymal cells

Jennifer R. Dwyer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Chemistry, Physical

Canonical sampling through velocity rescaling

Giovanni Bussi et al.

JOURNAL OF CHEMICAL PHYSICS (2007)

Article Biochemical Research Methods

A time- and cost-efficient system for high-level protein production in mammalian cells

A. Radu Aricescu et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2006)

Article Biochemical Research Methods

The Buccaneer software for automated model building.: 1.: Tracing protein chains

Kevin Cowtan

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2006)

Article Multidisciplinary Sciences

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

Ryan B. Corcoran et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemical Research Methods

Coot:: model-building tools for molecular graphics

P Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)

Article Genetics & Heredity

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

MK Cooper et al.

NATURE GENETICS (2003)

Article Multidisciplinary Sciences

Small molecule modulation of Smoothened activity

JK Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts

EC Bailey et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells

DA Zacharias et al.

SCIENCE (2002)

Article Biotechnology & Applied Microbiology

A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

T Nagai et al.

NATURE BIOTECHNOLOGY (2002)

Article Multidisciplinary Sciences

Electrostatics of nanosystems: Application to microtubules and the ribosome

NA Baker et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)