相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth
Xin Li et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)
Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL
Yinan Yuan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease
Shenyou Nie et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
De novo acute myeloid leukemia: A population- based study of outcome in the United States based on the Surveillance, Epidemiology, and End Results (SEER) database, 1980 to 2017
Koji Sasaki et al.
CANCER (2021)
Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins
Xin Li et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)
Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth
Fangrui Wu et al.
THERANOSTICS (2021)
MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)-Current Treatment Options. Is There a Role for CAR-T Cell Therapy?
Oliver Britten et al.
CELLS (2019)
Peptidomimetics for Targeting Protein-Protein Interactions between DOT1 L and MLL Oncofusion Proteins AF9 and ENL
Lei Du et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia
Liling Wan et al.
NATURE (2017)
MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches
Amanda C. Winters et al.
FRONTIERS IN PEDIATRICS (2017)
Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways
Rolf Marschalek
ANNALS OF LABORATORY MEDICINE (2016)
Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential
Aravinda Kuntimaddi et al.
CELL REPORTS (2015)
Leukemia Fusion Target AF9 Is an Intrinsically Disordered Transcriptional Regulator that Recruits Multiple Partners via Coupled Folding and Binding
Benjamin I. Leach et al.
STRUCTURE (2013)
c-Myc and Cancer Metabolism
Donald M. Miller et al.
CLINICAL CANCER RESEARCH (2012)
Synthesis and Structure-Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L
Justin L. Anglin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
Scott R. Daigle et al.
CANCER CELL (2011)
MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia
Sara C. Monroe et al.
EXPERIMENTAL HEMATOLOGY (2011)
A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription
Akihiko Yokoyama et al.
CANCER CELL (2010)
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)
Man Mohan et al.
GENES & DEVELOPMENT (2010)
AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia
Chengqi Lin et al.
MOLECULAR CELL (2010)
11q23/MLL Acute Leukemia : Update of Clinical Aspects
Hayato Tamai et al.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY (2010)
H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias
Andrei V. Krivtsov et al.
CANCER CELL (2008)
Outcome of risk-based therapy for infant acute lymphoblastic leukemia with or without an MLL gene rearrangement, with emphasis on late effects: A final report of two consecutive studies, MLL96 and MLL98, of the Japan Infant Leukemia Study Group
D. Tomizawa et al.
LEUKEMIA (2007)
MLL translocations, histone modifications and leukaemia stem-cell development
Andrei V. Krivtsov et al.
NATURE REVIEWS CANCER (2007)
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
Emmanuelle Bitoun et al.
HUMAN MOLECULAR GENETICS (2007)
Analysis of prognostic factors of acute lymphoblastic leukemia in infants: report on CCG 1953 from the Children's Oncology Group
Joanne M. Hilden et al.
BLOOD (2006)
Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement
LY Shih et al.
LEUKEMIA (2006)
MLL fusion partners AF4 and AF9 interact at subnuclear foci
F Erfurth et al.
LEUKEMIA (2004)
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization
BB Zeisig et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region
CH Pui et al.
LANCET (2002)
分享论文
