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Can Bee Venom Be Used as Anticancer Agent in Modern Medicine?

CANCERS (2023)

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Article Pharmacology & Pharmacy

Honey bee venom melittin increases the oxidant activity of cisplatin and kills human glioblastoma cells by stimulating the TRPM2 channel

Kemal Ertilav et al.

Summary: The study found that melittin (MLT) treatment can enhance the cytotoxic effects of cisplatin (CSP) on tumor cells by modulating Ca2+ channels. This enhancement is achieved through the activation of TRPM2 channels, which leads to the accumulation of mitochondrial reactive oxygen species (MitSOX) induced by mitochondrial Ca2+ and Zn2+. The study aimed to investigate the effects of CSP and MLT combination on DBTRG-05MG cells, including cell viability, cell death, apoptosis, and MitSOX levels.

TOXICON (2023)

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Article Biochemistry & Molecular Biology

Determination of the Effects of Bee Venom on Triple Negative Breast Cancer Cells in Vitro

Sedat Sevin et al.

Summary: Honeybees provide bee venom (BV) with potential anti-cancer effects. This study evaluated the cytotoxic and apoptotic effects of BV from Apis mellifera anatoliaca on triple negative breast cancer cells. The results showed that BV can induce apoptotic cell death and may be developed as a potential therapeutic agent for cancer treatment.

CHEMISTRY & BIODIVERSITY (2023)

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Article Biochemistry & Molecular Biology

Apis mellifera anatoliacaVenom Exerted Anti-Inflammatory Activity on LPS-Stimulated Mammalian Macrophages by Reducing the Production of the Inflammatory Cytokines

Sedat Sevin et al.

Summary: The venom of Apis mellifera anatoliaca was characterized and found to have anti-inflammatory potential. The venom demonstrated significant anti-inflammatory effects on LPS-induced macrophages and had no inhibitory effect on glioblastoma cancer cells.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2023)

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Article Integrative & Complementary Medicine

Mellitin peptide quantification in seasonally collected crude bee venom and its anticancer effects on myelogenous K562 human leukaemia cell line

Maher Obeidat et al.

Summary: This study collected Jordanian crude bee venom (JCBV) during different seasons and investigated its in vitro antitumor effects. It was found that JCBV collected during springtime had the highest content of melittin (MEL), which showed apoptotic and cell cycle arrest effects on K562 leukemia cells. The study concludes that the application of bee venom in chemotherapy needs further research and should carefully consider the correlation between bee genotype, collection time, and MEL concentration in JCBV.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2023)

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Article Multidisciplinary Sciences

Evaluating the role of propolis and bee venom on the oxidative stress induced by gamma rays in rats

Eithar K. El Adham et al.

Summary: This study evaluated the protective effects of Egyptian propolis and bee venom against oxidative injury induced by gamma irradiation in rats, and the results suggest that bee products have promising potential as medicinal sources.

SCIENTIFIC REPORTS (2022)

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Article Neurosciences

Bee Venom Effect on Glioblastoma Cells Viability and Gelatinase Secretion

Agata Malek et al.

Summary: This study evaluated the anticancer potential of honey bee venom on glioblastoma cells and found that it exhibited cytotoxic effects on the cells and inhibited the secretion of MMP-2 and MMP-9.

FRONTIERS IN NEUROSCIENCE (2022)

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Article Biochemistry & Molecular Biology

Apis mellifera syriaca Venom: Evaluation of Its Anticoagulant Effect, Proteolytic Activity, and Cytotoxicity along with Its Two Main Compounds-MEL and PLA2-On HeLa Cancer Cells

Carole Yaacoub et al.

Summary: This study found that Apis mellifera syriaca venom has anticoagulant and cytotoxic effects on cancer cells, with its main bioactive molecules being melittin and phospholipase A2. The venom also showed low proteolytic activity on human plasma. Additionally, the crude venom and its components exhibited significant cytotoxicity on HeLa cancer cell lines in vitro.

MOLECULES (2022)

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Article Pharmacology & Pharmacy

Honeybee Venom Synergistically Enhances the Cytotoxic Effect of CNS Drugs in HT-29 Colon and MCF-7 Breast Cancer Cell Lines

Diana Duarte et al.

Summary: The study evaluated the anti-cancer efficacy of honeybee venom in combination with chemotherapeutic or CNS drugs in colon and breast cancer cells. The results showed that the combination of honeybee venom with these drugs can improve their anti-cancer activity, especially at lower concentrations.

PHARMACEUTICS (2022)

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Article Oncology

Bee venom protects against pancreatic cancer via inducing cell cycle arrest and apoptosis with suppression of cell migration

Jing Zhao et al.

Summary: Bee venom can inhibit the proliferation of pancreatic cancer cells by inducing cell cycle arrest and apoptosis, and impede cell migration.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2022)

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Article Multidisciplinary Sciences

Apitherapy combination improvement of blood pressure, cardiovascular protection, and antioxidant and anti-inflammatory responses in dexamethasone model hypertensive rats

Fatma El-Zahraa Abd El-Hakam et al.

Summary: This study evaluates the antihypertensive effects of combinations of natural apitherapy compounds in the treatment of hypertension. The results demonstrate that this combination therapy effectively lowers blood pressure, improves ECG changes, regulates angiotensin-II, endothelin-1, and tumor growth factor beta levels, improves histopathological structure, and reduces NF-kB and oxidative stress biomarkers in hypertensive rats.

SCIENTIFIC REPORTS (2022)

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Article Food Science & Technology

The Pharmacological Potential of Novel Melittin Variants from the Honeybee and Solitary Bees against Inflammation and Cancer

Pelin Erkoc et al.

Summary: The venom of honeybees, specifically melittin peptides, has shown potential therapeutic effects on inflammation and cancer. This study explores the pharmacological activities of known and newly discovered melittin variants from honeybees and older solitary bees in the context of cancer and inflammation. The findings suggest that some ancestral variants from solitary bees have promising therapeutic potential in modulating inflammatory processes and inhibiting cancer cell viability/proliferation, including aggressive breast cancers.

TOXINS (2022)

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Article Oncology

Bee Venom Triggers Autophagy-Induced Apoptosis in Human Lung Cancer Cells via the mTOR Signaling Pathway

Ji Eun Yu et al.

Summary: Bee venom has been used in oriental medicine to treat inflammatory diseases, and recent studies have shown its potential in treating cancer. It inhibits cell growth and induces apoptotic cell death in lung cancer cells. Additionally, bee venom induces autophagy by inhibiting the mTOR signaling pathway, which further promotes apoptosis. This suggests that bee venom could be a new approach to cancer treatment.

JOURNAL OF ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Melittin induces ferroptosis and ER stress-CHOP-mediated apoptosis in A549 cells

Xuan Li et al.

Summary: Melittin in bee venom induces cell death in lung cancer cells through the mechanisms of ferroptosis and ER stress-CHOP signaling.

FREE RADICAL RESEARCH (2022)

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Article Integrative & Complementary Medicine

Dual Cytotoxic Responses Induced by Treatment of A549 Human Lung Cancer Cells with Sweet Bee Venom in a Dose-Dependent Manner

Yu-Na Hwang et al.

Summary: The pharmacological effect of sweet bee venom (sBV) treatment on A549 human lung cancer cells was investigated. The results showed that sBV induced cell death in A549 cells at pharmacological concentrations, while causing hemolytic cell death at high concentrations.

JOURNAL OF PHARMACOPUNCTURE (2022)

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Article Toxicology

A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin

Mackson Martins Rocha et al.

Summary: This study investigated the effects of melittin on bone metastasis in colorectal cancer and found that melittin could inhibit metastasis growth, induce necrosis and inflammatory processes, and had no significant side effects. This suggests that melittin may be a promising agent for reducing skeletal-related impact in colorectal cancer patients with bone metastasis.

JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES (2022)

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Review Chemistry, Medicinal

Bee products as a source of promising therapeutic and chemoprophylaxis strategies againstCOVID-19 (SARS-CoV-2)

William G. Lima et al.

Summary: The emergence of the novel coronavirus has become a major international concern, with no specific antivirals available. Apitherapy offers promise as a potential source of treatment or prevention for COVID-19.

PHYTOTHERAPY RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Bee venom and its active component Melittin synergistically potentiate the anticancer effect of Sorafenib against HepG2 cells

Ghada H. Mansour et al.

Summary: The study found that Bee Venom and its active component, Melittin, when combined with Sorafenib, have a synergistic anticancer effect on HepG2 cells, potentially representing a new enhancing strategy for HCC treatment.

BIOORGANIC CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Melittin Increases Cisplatin Sensitivity and Kills KM-H2 and L-428 Hodgkin Lymphoma Cells

Teresa Kreinest et al.

Summary: Melittin from bee venom showed high toxicity for HL cell lines KM-H2 and L-428, as well as increased cisplatin sensitivity in chemo-resistant L-428 cells. However, melittin did not reduce ABC transporter activity. These findings suggest that melittin or its analogs could be promising agents for treating HL patients with resistant disease in the future.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Bee Venom Melittin Disintegrates the Respiration of Mitochondria in Healthy Cells and Lymphoblasts, and Induces the Formation of Non-Bilayer Structures in Model Inner Mitochondrial Membranes

Edward Gasanoff et al.

Summary: The study showed that melittin is three times more cytotoxic to Jurkat cells than to HHL, but O-2 consumption and RCI values of mitochondria from both cell types were equally affected by melittin. The decline of mitochondrial bioenergetics induced by melittin primarily contributes to cell death.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Antioxidant Activity in Bee Products: A Review

Marianna Martinello et al.

Summary: Bee products have been traditionally used for their nutritional and therapeutic purposes, with a focus on their potential as natural antioxidants. However, the complex composition and variable nature of these products, along with diverse analytical methods, have resulted in a wide range of reported results, highlighting the need for standardized evaluation methods.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Neuroprotective Activity of Melittin-The Main Component of Bee Venom-Against Oxidative Stress Induced by Aβ25-35 in In Vitro and In Vivo Models

Cong Duc Nguyen et al.

Summary: Melittin, the main component of honeybee venom, has been found to exhibit neuroprotective actions by alleviating oxidative stress and memory impairment in both in vitro and in vivo models. It effectively protects neuronal cells by regulating reactive oxygen species and apoptosis-related factors, while enhancing antioxidant defense pathways. Melittin also activates neurogenesis pathways and improves cognitive deficits, suggesting its potential as a therapeutic agent for neurodegenerative disorders.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

The Cytotoxic Effect of Apis mellifera Venom with a Synergistic Potential of Its Two Main Components-Melittin and PLA2-On Colon Cancer HCT116 Cell Lines

Carole Yaacoub et al.

Summary: The study found that bee venom has a strong cytotoxic effect on colon cancer cells, and when the biopeptides MEL and PLA2 in bee venom are used together, they exhibit synergistic activity, potentially inducing membrane disruption in cancer cells.

MOLECULES (2021)

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Review Oncology

Intratumoural administration and tumour tissue targeting of cancer immunotherapies

Ignacio Melero et al.

Summary: Immunotherapies such as immune-checkpoint inhibitors and CAR T cells are transforming oncology and hematology, but systemic distribution poses safety concerns. Intratumoural delivery and tumour tissue-targeted compounds show promise in enhancing the efficacy of immunotherapies, with potential to induce abscopal or anenestic effects in preclinical models. Clinical trials evaluating these strategies face challenges related to administration methodology, pharmacokinetics, and response assessments.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Review Food Science & Technology

Bee Venom Components as Therapeutic Tools against Prostate Cancer

Jasmin Katrin Badawi

Summary: Prostate cancer is one of the most common cancers in men, with challenges in disease progression and resistance of cancer cells to available therapeutic agents. Further therapeutic agents are needed, and bee venom components have shown promising anticancer effects, particularly melittin.

TOXINS (2021)

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Article Biochemistry & Molecular Biology

Molecular characterization of the anticancer properties associated with bee venom and its components in glioblastoma multiforme

Andrea A. Lebel et al.

Summary: Glioblastoma multiforme (GBM) is a common form of malignant glioma with limited treatment options, highlighting the importance of developing new therapeutic approaches. This study found that bee venom and its components exhibit anti-cancer activities in human glioma cells by impacting apoptosis, necrosis, and the expression levels of certain genes, suggesting potential value in the treatment of GBM.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Review Biochemistry & Molecular Biology

Bee Venom: From Venom to Drug

Abdelwahab Khalil et al.

Summary: Insects of the order Hymenoptera, such as honeybees, have venom containing various bioactive compounds that have potential therapeutic applications. Research suggests that bee venom and its components exhibit multiple biological activities, including anti-microbial, anti-inflammatory, and anti-cancer properties. There is ongoing exploration of utilizing bee venom as a drug delivery vehicle and discussing its molecular mechanisms for potential medical benefits.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Melittin suppresses epithelial-mesenchymal transition and metastasis in human gastric cancer AGS cells via regulating Wnt/BMP associated pathway

Jye-Yu Huang et al.

Summary: Melittin, a component extracted from bee venom, has been shown to inhibit migration and invasion of human gastric cancer cells through multiple signaling pathways, potentially providing a treatment option for metastasized gastric cancers in the future.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Bee Products in Dermatology and Skin Care

Anna Kurek-Gorecka et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

Melittin-A Natural Peptide from Bee Venom Which Induces Apoptosis in Human Leukaemia Cells

Michal Ceremuga et al.

BIOMOLECULES (2020)

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Article Food Science & Technology

Extending Metabolomic Studies of Apis mellifera Venom: LC-MS-Based Targeted Analysis of Organic Acids

Magdalena Pawlak et al.

TOXINS (2020)

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Article Food Science & Technology

Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease

Hyemin Gu et al.

Toxins (2020)

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Review Food Science & Technology

Antimicrobial Properties ofApis mellifera's Bee Venom

Hesham El-Seedi et al.

TOXINS (2020)

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Article Infectious Diseases

Melittin fromApis floreaVenom as a Promising Therapeutic Agent for Skin Cancer Treatment

Sirikwan Sangboonruang et al.

ANTIBIOTICS-BASEL (2020)

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Review Public, Environmental & Occupational Health

Bee Venom-A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections

Keneth Iceland Kasozi et al.

FRONTIERS IN PUBLIC HEALTH (2020)

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Article Integrative & Complementary Medicine

Cytotoxic Effect of Bee (A. mellifera) Venom on Cancer Cell Lines

Sima Khalilifard Borojeni et al.

JOURNAL OF PHARMACOPUNCTURE (2020)

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Review Nutrition & Dietetics

Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

Maria Carpena et al.

NUTRIENTS (2020)

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Article Biochemistry & Molecular Biology

Bee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner

Da-Hyun Kim et al.

BMB REPORTS (2020)

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Article Oncology

Role of Bee Venom and Melittin on Restraining Angiogenesis and Metastasis in γ-Irradiated Solid Ehrlich Carcinoma-Bearing Mice

Nermeen M. El Bakary et al.

INTEGRATIVE CANCER THERAPIES (2020)

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Article Biochemistry & Molecular Biology

Bee Venom and Its Peptide Component Melittin Suppress Growth and Migration of Melanoma Cells via Inhibition of PI3K/AKT/mTOR and MAPK Pathways

Haet Nim Lim et al.

MOLECULES (2019)

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Article Food Science & Technology

Bee Venom Alleviates Atopic Dermatitis Symptoms through the Upregulation of Decay-Accelerating Factor (DAF/CD55)

Yenny Kim et al.

TOXINS (2019)

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Article Food Science & Technology

First Characterization of The Venom from Apis mellifera syriaca, A Honeybee from The Middle East Region

Jacinthe Frangieh et al.

TOXINS (2019)

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Review Biochemistry & Molecular Biology

Antiviral peptides as promising therapeutic drugs

Liana Costa Pereira Vilas Boas et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests

Rim Wehbe et al.

MOLECULES (2019)

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Review Immunology

Bee Updated: Current Knowledge on Bee Venom and Bee Envenoming Therapy

Manuela B. Pucca et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

Synergistic Effects of Melittin and Plasma Treatment: A Promising Approach for Cancer Therapy

Priyanka Shaw et al.

CANCERS (2019)

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Article Multidisciplinary Sciences

The membrane effects of melittin on gastric and colorectal cancer

Caroline Soliman et al.

PLOS ONE (2019)

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Article Pharmacology & Pharmacy

Antimutagenic and Synergistic Cytotoxic Effect of Cisplatin and Honey Bee Venom on 4T1 Invasive Mammary Carcinoma Cell Line

Faranak Shiassi Arani et al.

ADVANCES IN PHARMACOLOGICAL SCIENCES (2019)

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Article Integrative & Complementary Medicine

Bee Venom Suppresses EGF-Induced Epithelial-Mesenchymal Transition and Tumor Invasion in Lung Cancer Cells

Yun-Jeong Jeong et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2019)

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Apoptotic Effect of Melittin Purified from Iranian Honey Bee Venom on Human Cervical Cancer HeLa Cell Line

Hannaneh Zarrinnahad et al.

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS (2018)

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Editorial Material Allergy

Death due to Live Bee Acupuncture Apitherapy

P. Vazquez-Revuelta et al.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2018)

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Article Medicine, Research & Experimental

Hesperidin, piperine and bee venom synergistically potentiate the anticancer effect of tamoxifen against breast cancer cells

Abeer A. A. Khamis et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Biochemistry & Molecular Biology

Anti-Inflammatory Effect of Melittin on Porphyromonas Gingivalis LPS-Stimulated Human Keratinocytes

Woon-Hae Kim et al.

MOLECULES (2018)

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Review Pharmacology & Pharmacy

Bee venom therapy: Potential mechanisms and therapeutic applications

Shuai Zhang et al.

TOXICON (2018)

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Multiple bee stings, multiple organs involved: a case report

Luana Ferreira Martins de Toledo et al.

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL (2018)

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To bee or not to bee: The potential efficacy and safety of bee venom acupuncture in humans

E. Paul Cherniack et al.

TOXICON (2018)

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Anti-cancer effect of bee venom on human MDA-MB-231 breast cancer cells using Raman spectroscopy

Gyeong Bok Jung et al.

BIOMEDICAL OPTICS EXPRESS (2018)

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Venom allergy, risk factors for systemic reactions and the knowledge levels among Turkish beekeepers

Dane Ediger et al.

ASIA PACIFIC ALLERGY (2018)

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Melittin inhibits the invasion of MCF-7 cells by downregulating CD147 and MMP-9 expression

Jianjun Wang et al.

ONCOLOGY LETTERS (2017)

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Key Issues in Hymenoptera Venom Allergy: An Update

T. Alfaya Arias et al.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2017)

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Antiviral activity of animal venom peptides and related compounds

Elida Cleyse Gomes da Mata et al.

JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES (2017)

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Article Oncology

Melittin exerts an antitumor effect on non-small cell lung cancer cells

Su-Fang Zhang et al.

MOLECULAR MEDICINE REPORTS (2017)

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Article Oncology

Melittin suppresses tumor progression by regulating tumor-associated macrophages in a Lewis lung carcinoma mouse model

Chanju Lee et al.

ONCOTARGET (2017)

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Article Infectious Diseases

Antimicrobial Activity of Bee Venom and Melittin against Borrelia burgdorferi

Kayla M. Socarras et al.

ANTIBIOTICS-BASEL (2017)

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Review Oncology

Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy

Islam Rady et al.

CANCER LETTERS (2017)

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Article Biochemistry & Molecular Biology

Metabolomic Profiling of the Synergistic Effects of Melittin in Combination with Cisplatin on Ovarian Cancer Cells

Sanad Alonezi et al.

METABOLITES (2017)

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Article Integrative & Complementary Medicine

Bee Venom Acupuncture Reduces Interleukin-6, Increases Interleukin-10, and Induces Locomotor Recovery in a Model of Spinal Cord Compression

Raquel Nascimento de Souza et al.

JOURNAL OF ACUPUNCTURE AND MERIDIAN STUDIES (2017)

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Article Biotechnology & Applied Microbiology

Antitumour action on human glioblastoma A1235 cells through cooperation of bee venom and cisplatin

Goran Gajski et al.

CYTOTECHNOLOGY (2016)

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Article Food Science & Technology

Chemical characterization, antioxidant, anti-inflammatory and cytotoxic properties of bee venom collected in Northeast Portugal

Filipa Sobral et al.

FOOD AND CHEMICAL TOXICOLOGY (2016)

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Article Microbiology

Inhibitory effects of bee venom and its components against viruses in vitro and in vivo

Md Bashir Uddin et al.

JOURNAL OF MICROBIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology

Sanad Alonezi et al.

METABOLITES (2016)

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Article Allergy

Bee venom enhances the differentiation of human regulatory T cells

I. Caramalho et al.

ALLERGY (2015)

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Article Medicine, General & Internal

First report on the isolation of melittin from Iranian honey bee venom and evaluation of its toxicity on gastric cancer AGS cells

Amir Mahmoodzadeh et al.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2015)

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Article Oncology

Honeybee venom possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer cell line

Yong-Wan Kim et al.

ONCOLOGY REPORTS (2015)

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Article Oncology

Bee venom inhibits growth of human cervical tumors in mice

Hye Lim Lee et al.

ONCOTARGET (2015)

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Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B

Jie Zheng et al.

ONCOTARGET (2015)

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Review Food Science & Technology

The Protective Effect of Bee Venom on Fibrosis Causing Inflammatory Diseases

Woo-Ram Lee et al.

TOXINS (2015)

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Article Biochemistry & Molecular Biology

Melittin peptides exhibit different activity on different cells and model membranes

Elaheh Jamasbi et al.

AMINO ACIDS (2014)

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Article Chemistry, Medicinal

Co-culture with NK-92MI cells enhanced the anti-cancer effect of bee venom on NSCLC cells by inactivation of NF-κB

Pushpa Saranya Kollipara et al.

ARCHIVES OF PHARMACAL RESEARCH (2014)

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Article Food Science & Technology

Melittin suppresses EGF-induced cell motility and invasion by inhibiting PI3K/Akt/mTOR signaling pathway in breast cancer cells

Yun-Jeong Jeong et al.

FOOD AND CHEMICAL TOXICOLOGY (2014)

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Anti-genotoxicity and anti-mutagenicity of Apis mellifera venom

Marcia Miyuki Hoshina et al.

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Melittin Restores PTEN Expression by Down-Regulating HDAC2 in Human Hepatocelluar Carcinoma HepG2 Cells

Hui Zhang et al.

PLOS ONE (2014)

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Article Public, Environmental & Occupational Health

Myocardial injury following multiple bee stings

Balasingam Nisahan et al.

TROPICAL DOCTOR (2014)

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Article Oncology

Melittin radiosensitizes esophageal squamous cell carcinoma with induction of apoptosis in vitro and in vivo

Hongcheng Zhu et al.

TUMOR BIOLOGY (2014)

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Cancer Cell Growth Inhibitory Effect of Bee Venom via Increase of Death Receptor 3 Expression and Inactivation of NF-kappa B in NSCLC Cells

Kyung Eun Choi et al.

TOXINS (2014)

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Review Environmental Sciences

Melittin: A lytic peptide with anticancer properties

Goran Gajski et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2013)

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Review Biochemistry & Molecular Biology

Peptide inhibitors against herpes simplex virus infections

Stefania Galdiero et al.

JOURNAL OF PEPTIDE SCIENCE (2013)

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Article Toxicology

Potentiation of a novel palladium (II) complex lethality with bee venom on the human T-cell acute lymphoblastic leukemia cell line (MOLT-4)

Zahra Safaeinejad et al.

JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES (2013)

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Article Multidisciplinary Sciences

Melittin Suppresses HIF-1α/VEGF Expression through Inhibition of ERK and mTOR/p70S6K Pathway in Human Cervical Carcinoma Cells

Jae-Moon Shin et al.

PLOS ONE (2013)

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Article Food Science & Technology

Interactions of PLA2-s from Vipera lebetina, Vipera berus berus and Naja naja oxiana Venom with Platelets, Bacterial and Cancer Cells

Mari Samel et al.

TOXINS (2013)

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Article Oncology

In vitro activities of antimicrobial cationic peptides; melittin and nisin, alone or in combination with antibiotics against Gram-positive bacteria

Sibel Dosler et al.

JOURNAL OF CHEMOTHERAPY (2012)

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Review Astronomy & Astrophysics

Ionizing Radiation and Life

Lewis R. Dartnell

ASTROBIOLOGY (2011)

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