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Review
Immunology
Md. Jahirul Islam et al.
Summary: This review compiles comprehensive information on the structural characteristics, virulence mechanisms, binding sites, and potential drug target sites of viral proteins, providing necessary details for virus research and therapeutics.
Article
Pharmacology & Pharmacy
Jessica Gambardella et al.
Summary: We hypothesized that exosomal microRNAs may play a role in the development of thromboembolic complications in COVID-19. We isolated circulating exosomes from COVID-19 patients and categorized them based on D-dimer levels. We found that exosomal miR-145 and miR-885 were significantly correlated with D-dimer levels. Furthermore, human endothelial cells treated with serum from COVID-19 patients showed reduced release of miR-145 and miR-885, increased apoptosis, and impaired angiogenetic properties compared to cells treated with non-COVID-19 serum.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Immunology
Melanie Borrmann et al.
Summary: COVID-19 infection leads to degradation of the endothelial protective glycocalyx layer, resulting in the release of major glycocalyx components. These circulating proteins and their degradation products can feedback on immune and endothelial cells, activating molecular signaling cascades associated with microvascular injury in COVID-19. The study found that plasma concentrations of glycocalyx components were highest in COVID-19 ARDS patients, and the degradation of endothelial glycocalyx components may lead to immune activation and more severe systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medical Laboratory Technology
Selena Mimmi et al.
Summary: In this pilot study, researchers describe a method to characterize the exosome-associated microRNA (exo-miRNA) signature in ACE2-positive and ACE2-negative exosomal populations. The researchers used a sorting protocol with recombinant biotin-conjugated SARS-CoV-2 spike protein to isolate exosomes from plasma samples of six patients. Differential expression of several miRNAs was identified between ExoACE2 and non-ExoACE2.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Virology
Teresa Rito et al.
Summary: Following the emergence of COVID-19 caused by SARS-CoV-2, genomic characterization of the virus and identification of variants have been crucial in containing the disease. This study aims to evaluate the global effort in characterizing SARS-CoV-2 lineages using data from GISAID. Data from major contributing countries over nearly three years were analyzed, including percentage of characterized isolates and time for data processing. The study also assessed early detection of seven major SARS-CoV-2 lineages. While Europe and the USA showed positive results, global efforts were heterogeneous. Monitoring potential variants that evade acquired immunity remains essential.
Article
Immunology
Wout de Mey et al.
Summary: The maturation of dendritic cells (DCs) using TriMix mRNA can induce an antibacterial transcriptional program, while the use of TetraMix mRNA can redirect DCs into an antiviral transcriptional program and induce tumor antigen-specific T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jose Alfredo Samaniego Castruita et al.
Summary: In Denmark, patients with chronic HCV infection were vaccinated against SARS-CoV-2 using mRNA vaccines. The study found traces of mRNA vaccine sequences in the blood of some patients up to 28 days after vaccination, highlighting the importance of further research on the design of lipid nanoparticles and the half-life of mRNA vaccines in humans.
Article
Biochemistry & Molecular Biology
Chiara Papi et al.
Summary: This study aims to investigate the effects of molecules mimicking the activity of pre-miR-145-5p, pre-miR-335-5p, and pre-miR-101-3p on Calu-3 cells and discuss their potential applications in pre-clinical studies. The results show that treatment with agomiR-145-5p effectively inhibits CFTR gene expression and protein production. Therefore, agomiR pre-miR-145-5p should be considered as a therapeutic option for inhibiting CFTR gene expression in various pathological conditions.
Review
Medicine, Research & Experimental
Michael J. Hogan et al.
Summary: This review provides a detailed overview of the development of mRNA vaccines for SARS-CoV-2, discusses and compares preclinical and clinical data, gives a mechanistic overview of immune responses generated by mRNA vaccination, and speculates on the challenges and promising future of this emergent vaccine platform.
ANNUAL REVIEW OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Katharina Roltgen et al.
Summary: During the SARS-CoV-2 pandemic, different vaccines have been used globally. This study compares the antibodies generated by mRNA vaccines, infection, and other types of vaccines. It shows that mRNA vaccines result in a better antibody breadth against viral variants compared to infection. Infection leads to variant-specific antibodies, while mRNA vaccination imprints responses towards the original virus strain. mRNA vaccines also stimulate robust germinal centers in lymph nodes, enhancing the immune response.
Article
Biochemistry & Molecular Biology
Zhen Cui et al.
Summary: The Omicron variant of SARS-CoV-2 is spreading rapidly worldwide due to its increased fitness, with spike structures that maintain stability for receptor recognition but compromise viral fusion efficiency. By altering amino acids and structures, it evades recognition by most antibodies, facilitating immune escape. The research sheds light on conserved regions for the development of broad-spectrum vaccines.
Article
Medicine, General & Internal
Masahiro Yano et al.
Summary: We report a case of acute-onset type 1 diabetes occurring six weeks after receiving a COVID-19 vaccine, suggesting that the vaccine may induce the disease in individuals with a genetic predisposition.
Article
Chemistry, Medicinal
Beibei Wang et al.
Summary: The COVID-19 pandemic has led to a global health crisis and significant societal and economic burden, with SARS-CoV-2 infecting far more people than SARS-CoV. This study used structural data and molecular dynamics simulations to examine the differences in morphology, structure, and dynamics of the envelopes of SARS-CoV and SARS-CoV-2. The models created in this research offer insights into the structure and behavior of the SARS virus envelopes and could be valuable for drug design and membrane fusion and fission processes.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Biochemistry & Molecular Biology
Martina Patone et al.
Summary: The study found that there is an increased risk of myocarditis associated with the first dose of ChAdOx1 and BNT162b2 vaccines, as well as the first and second doses of the mRNA-1273 vaccine in the 1-28 days post-vaccination period. Additionally, individuals with SARS-CoV-2 infection also face a greater risk of myocarditis, pericarditis, and cardiac arrhythmia.
Article
Pharmacology & Pharmacy
Hugo Garcia Tonioli Defendi et al.
Summary: This study investigates the factors promoting the accelerated development of COVID-19 vaccines, focusing on technology and research and development (R&D) strategies. Breakthroughs in biotechnology and molecular biology serve as the foundation for rapid vaccine development, while parallel phases and adaptive clinical trials are key R&D strategies.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Medical Laboratory Technology
Carlota Dobano et al.
Summary: This study evaluates the immunogenicity of the mRNA-1273 (Spykevax) and the BNT162b2 (Comirnaty) vaccines in 445 healthcare workers using multiplex immunoassays. The results show an increase in IgG and IgA levels post-vaccination, with a greater increase observed in individuals vaccinated with Spykevax. Furthermore, the data suggest the induction of cross-reactive antibodies against the nucleocapsid (N CT) region after administering these S-based vaccines.
TRANSLATIONAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Lamiaa El-Shennawy et al.
Summary: El-Shennawy et al. found that circulating extracellular vesicles (evACE2) are associated with COVID-19 severity and have a higher efficacy in inhibiting the infection of SARS-CoV-2 variants compared to soluble ACE2. This study is important for the development of therapeutic approaches against current and future coronavirus infections.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Asier Fernandez-Pato et al.
Summary: COVID-19 deeply affects the plasma miRNome from an early stage, indicating that miRNAs can serve as valuable early predictors of severity and mortality.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Endocrinology & Metabolism
Mikiko Watanabe et al.
Summary: Variables such as increased waist circumference, smoking, hypertension, and longer time elapsed since vaccination were associated with lower antibody titres following COVID-19 mRNA vaccination. This suggests that individuals with central obesity, hypertension, and smoking may benefit from earlier vaccine boosters or different vaccination schedules to ensure adequate immune response.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Harald Bruessow
Summary: The text summarizes the development of high efficacy mRNA vaccines by Pfizer-BioNTech and Moderna against COVID-19, as well as other related studies and data, including vaccine protection effects, impacts on variant viruses, and adverse reactions from vaccination.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Cell Biology
Senlin Zhao et al.
Summary: EVs rich in miR-181a-5p released by highly metastatic CRC cells can activate HCCs and remodel the TME, thereby facilitating liver metastasis in CRC patients.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Public, Environmental & Occupational Health
Maylis Layan et al.
Summary: This study evaluated the impact of isolation and vaccination on the transmission of SARS-CoV-2 within Israeli households. The results showed that vaccination reduced the risk of infection and transmission, while isolation also led to important reductions in transmission risk.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Oncology
A. L. Schmidt et al.
Summary: This study analyzes the clinical features of cancer patients who develop symptomatic COVID-19 after vaccination. It finds that these patients often have comorbidities and can experience severe and even lethal infections. Hematologic malignancy patients are over-represented among the vaccinated cancer patients who develop symptomatic COVID-19. Therefore, while vaccination remains crucial in protecting vulnerable populations, including cancer patients, those who develop breakthrough infections despite full vaccination still face the risk of severe outcomes.
ANNALS OF ONCOLOGY
(2022)
Review
Oncology
Erna Jia et al.
Summary: EV biomarkers show promising diagnostic potential for pancreatic cancer, especially in early-stage diagnosis. However, limitations in EV isolation and detection technologies exist.
Article
Oncology
Wenyu Wang et al.
Summary: This study aimed to identify EV miRNA biomarkers for ovarian cancer diagnosis and metastasis regulation, resulting in a panel of eight dysregulated miRNAs. The OCEM signature developed based on these eight miRNAs demonstrated high diagnostic accuracy across diverse clinical samples.
Article
Biochemistry & Molecular Biology
Zeli Zhang et al.
Summary: Multiple COVID-19 vaccines have successfully protected against symptomatic cases and deaths. Comparisons of T cell, B cell, and antibody responses to different vaccines can provide insights into protective immunity against COVID-19, particularly immune memory. mRNA vaccines and Ad26.COV2.S induced strong T cell responses, while mRNA vaccines showed substantial declines in antibodies.
Article
Public, Environmental & Occupational Health
Raju S. R. Adduri et al.
Summary: This study identified novel biomarkers associated with beryllium exposure using extracellular vesicles derived from blood plasma. The biomarkers successfully differentiated between exposed and unexposed subjects, with high predictive accuracy. These biomarkers could be used for beryllium exposure assessment in resource-limited settings.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2022)
Article
Virology
Rachid Essalmani et al.
Summary: The spike protein of SARS-CoV-2 plays a crucial role in infecting the lungs and other tissues by binding to the ACE2 receptor. Cleavage of the spike protein at S1/S2 and S2' sites is important for viral entry and fusion. This study identifies the fusion activation site S2' as KPSKR815 down arrow and demonstrates that its cleavage is enhanced by ACE2 engagement. The combination of furin and TMPRSS2 inhibitors shows promise as potent antivirals against SARS-CoV-2.
JOURNAL OF VIROLOGY
(2022)
Editorial Material
Medicine, General & Internal
Halane Vaillant-Roussel et al.
EXERCER-LA REVUE FRANCOPHONE DE MEDECINE GENERALE
(2022)
Article
Cell Biology
Marjorie C. Pontelli et al.
Summary: SARS-CoV-2 infection can lead to lymphocytopenia and infect immune cells such as monocytes, B cells, and T cells, resulting in T cell apoptosis. Additionally, SARS-CoV-2 is frequently detected in monocytes and B cells from COVID-19 patients.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Fanglei Zuo et al.
Summary: This study demonstrates that an mRNA vaccine booster in individuals vaccinated with inactivated vaccines can significantly increase the humoral and cellular immune responses against the virus, including the Omicron variant.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Sergi Marti et al.
Summary: The effectiveness of noninvasive respiratory support in severe COVID-19 patients is still controversial. This study compared different treatment methods and found that noninvasive ventilation resulted in higher intubation or death rate within 28 days for COVID-19 patients.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Ainsley Ryan Yan Bin Lee et al.
Summary: This systematic review and meta-analysis compared the efficacy of covid-19 vaccines between immunocompromised and immunocompetent individuals. The results showed that immunocompromised patients, especially organ transplant recipients, had significantly lower rates of seroconversion after covid-19 vaccination. A second dose of the vaccine consistently improved seroconversion in all patient groups, although the improvement was smaller for organ transplant recipients. Targeted interventions, including a third dose (booster) of the vaccine, should be performed for immunocompromised patients.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Biology
Noah J. Silverstein et al.
Summary: This study suggests that the abundance of specific lymphoid cell types is associated with the severity and recovery of COVID-19. Innate lymphoid cells (ILCs) decrease in number with age and in males, and their decreased abundance is seen in COVID-19 patients and children with MIS-C. However, the numbers of ILCs gradually recover in children with MIS-C. These results indicate that the abundance of lymphoid cell subsets plays a significant role in COVID-19 severity and recovery, potentially contributing to disease tolerance and tissue homeostasis.
Article
Genetics & Heredity
Shuya Ji et al.
Summary: The downregulation of miR-145-5p in prostate cancer is associated with poor prognosis and low differentiation. Experimental results show that the downregulation of miR-145-5p promotes neuroendocrine differentiation and proliferation of prostate cancer cells. SOX11 is a direct target of miR-145-5p, and it regulates MYCN to mediate neuroendocrine differentiation and proliferation of prostate cancer cells.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Michel Obeid et al.
Summary: After vaccination with mRNA vaccines, the neutralizing antibody responses in immunocompromised patients and healthy controls have shown a decline at 6 months. These findings may provide insights for the development of optimal booster vaccination schedules, especially for immunocompromised patients.
Article
Cell Biology
Ioanna Dagla et al.
Summary: Vaccination is highly effective in mitigating the COVID-19 pandemic. However, individual immune responses to mRNA vaccines vary significantly. Metabolomics analysis reveals distinct plasma metabolic profiles associated with immune response levels, indicating the potential of certain metabolites as predictive markers for vaccine response.
Review
Cell Biology
Tania R. Dias et al.
Summary: This article discusses miRNAs related to SARS-CoV-2 that are dysregulated in cancer and may impact the immune response to vaccines. The authors propose seven potential miRNAs as prognostic biomarkers for stratifying cancer patients, aiding in personalized treatment.
Article
Cell Biology
Andrea Latini et al.
Summary: This study reveals a low expression of hsa-let7b-5p in naso-oropharyngeal swabs of COVID-19 patients and demonstrates its functional role in regulating ACE2 and DPP4 levels, suggesting its potential as a therapeutic target for COVID-19.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Yizhuo Wang et al.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Immunology
Mohamed J. Saadh et al.
Summary: This study aimed to evaluate the relative effectiveness of three approved vaccines against COVID-19 in a sample of the Jordanian population. The results showed that receiving two doses of a vaccine was associated with lower odds of mortality and hospitalization but higher odds of infection. More research is needed to evaluate the safety and efficacy of vaccines against SARS-CoV-2.
MICROBIAL PATHOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Krystal L. Ching et al.
Summary: Extracellular vesicles called exosomes have been found to play a crucial role in intercellular communication and tissue homeostasis. Recent studies have shown that a subset of exosomes, called defensosomes, are mobilized during bacterial infection and may also contribute to the antiviral response against SARS-CoV-2, the virus responsible for COVID-19.
Article
Cell Biology
Francois Berry et al.
Summary: This study reveals that small extracellular vesicles (sEVs) present in nasal mucus play an important role in SARS-CoV-2 infection. These sEVs, produced by uninfected nasal epithelial cells, contain the virus receptor and an activated protease that facilitate viral entry into target cells. This suggests that nasal mucus is not a protective barrier against SARS-CoV-2 infection but instead promotes it.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Yangying Hu et al.
Computational and Mathematical Methods in Medicine
(2022)
Review
Cell Biology
Wei-Yu Chi et al.
Summary: This review provides an up-to-date summary of current COVID-19 vaccines, discusses the biological basis and clinical impact of SARS-CoV-2 variants and subvariants, analyzes the effectiveness of different vaccine booster regimens against various SARS-CoV-2 strains, reviews potential mechanisms of vaccine-induced severe adverse events, summarizes current studies on immune correlates of protection, and finally discusses the development of next-generation vaccines.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Daniel R. Feikin et al.
Summary: This study systematically reviewed the duration of protection provided by COVID-19 vaccines against various clinical outcomes. The findings indicate that the effectiveness or efficacy of the vaccines decreased from 1 to 6 months after full vaccination, but remained high against severe disease. Evaluating the effectiveness or efficacy of vaccines beyond 6 months is crucial for updating vaccine policies.
Article
Oncology
Karla A. Lee et al.
Summary: A study showed that cancer patients are at higher risk of COVID-19 infection compared to non-cancer patients, especially those undergoing chemotherapy or immunotherapy. The association between cancer and COVID-19 infection was stronger in older individuals over 65 years and males. Further research is needed to identify specific subgroups at higher risk for COVID-19 infection and adverse outcomes based on tumor types and treatment regimens.
Editorial Material
Oncology
Raphaelle Fanciullino et al.
Summary: Although cancer patients may benefit from COVID-19 vaccination using mRNA encapsulated into lipid carriers, the extent to which solid tumors can uptake the vaccine dose is still unknown, calling for a careful evaluation for optimal protection of this specific and frail population.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Ankita Garg et al.
Summary: Elevated levels of cardiovascular and inflammatory microRNAs were observed in critically ill COVID-19 patients, suggesting a specific response and cardiac involvement of COVID-19. MiR profiles showed potential for differentiating between severe COVID-19 and Influenza-ARDS patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Oncology
Vincenzo Di Noia et al.
Summary: The study demonstrated that the BNT162b2 vaccine is immunogenic and safe in cancer patients. The second dose is necessary for achieving a satisfactory humoral response.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Xavier Ruiz-Plazas et al.
Summary: The study demonstrates that liquid biopsy detection of TWEAK-regulated exo-oncomiRNAs in semen can improve prognosis prediction for prostate cancer (PCa), opening up new avenues for diagnosis and treatment. Liquid biopsy-based biomarkers, including microRNAs packaged within extracellular vesicles, are promising tools for managing PCa patients. This research identifies potential semen biomarkers and targets regulated by TWEAK that could improve PCa prognosis.
Article
Immunology
Sandhya Bansal et al.
Summary: After vaccination, circulating exosomes rapidly induce expression of SARS-CoV-2 spike protein, with antibodies peaking 14 days after the second dose. Increasing levels of spike protein in exosomes following booster doses demonstrate their important role in effective immunization post mRNA vaccination.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Biochemical Research Methods
Angelica Ramos et al.
Summary: The study shows that before the second dose, 95.3% of vaccinated healthcare workers already had antibodies, indicating a potential for a sufficient immune response with a single dose. Further research is needed to assess the impact of different vaccination strategies on immune response and follow-up studies will help in understanding post-vaccination immunity.
JOURNAL OF VIROLOGICAL METHODS
(2021)
Article
Cell Biology
Qin Zhang et al.
Summary: Supermeres are a distinct type of extracellular nanoparticles that exhibit unique biological and functional properties, with a different protein and RNA composition from small extracellular vesicles and exomeres. They are enriched with cargo involved in multiple cancers, Alzheimer's disease, and cardiovascular disease, and have specific functions in vivo, suggesting their potential as circulating biomarkers and therapeutic targets.
NATURE CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rachna T. Shroff et al.
Summary: Cancer patients showed diminished immune responses to the BNT162b2 mRNA vaccine compared to the control group, but a third dose of the vaccine was found to be safe and significantly improved humoral immunity against SARS-CoV-2.
Article
Multidisciplinary Sciences
Rishi R. Goel et al.
Summary: This study found that immune memory to SARS-CoV-2 and its variants remains robust for at least 6 months after mRNA vaccination, with antibodies declining but still detectable in most individuals. mRNA vaccines also induced functional memory B cells and antigen-specific T cells, with recall responses primarily increasing antibody levels in individuals with preexisting immunity.
Article
Virology
Federico Gobbi et al.
Summary: Individuals who previously contracted SARS-CoV-2 are expected to have a more rapid and sustained immune response to COVID-19 vaccines, with markedly higher titers of neutralizing antibodies compared to natural infection. A single dose of the vaccine may be sufficient to induce an effective response in previously infected individuals.
Article
Immunology
Pilar Vizcarra et al.
Summary: The study showed that pre-existing SARS-CoV-2-specific cellular immunity can affect the reactogenicity of the BNT162b2 mRNA COVID-19 vaccine, with different reactions observed in various groups after vaccination.
Review
Immunology
Marton Olbei et al.
Summary: The hyper-induction of pro-inflammatory cytokines, also known as a cytokine storm or CRS, is a key aspect of the current SARS-CoV-2 pandemic, contributing to mortality in certain COVID-19 patients. By analyzing cytokine responses to various viral infections, it was found that SARS-CoV-2 induces a unique dysregulation in the type-I interferon response compared to other respiratory viruses. This study's findings could potentially aid specialists in identifying interventions to alleviate CRS in various diseases and evaluate their applicability in COVID-19 cases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Meredith Packer et al.
Summary: The study identified interactions between lipid impurities and mRNA through LNP delivery systems, resulting in impurities that cannot be translated, reducing vaccine efficiency.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Georgia Mandolesi et al.
Summary: The study found that levels of let-7b-5p in cerebrospinal fluid of MS patients are correlated with various microRNAs and inflammation-related protein factors, showing specific expression patterns. Additionally, reduced CSF let-7b-5p levels were associated with progressive MS and negatively correlated with hallmark processes of the disease phases, indicating potential use as a biomarker for MS course.
Article
Immunology
Agnes S. Meidert et al.
Summary: The study found differential expression of miRNAs in EVs of patients with COVID-19 pneumonia and severe COVID-19, some of which are related to immunologic processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kimberly J. Hassett et al.
Summary: The size of LNP particles was found to affect the immunogenicity of vaccines in mice, with smaller diameter LNPs being less immunogenic; however, all particle sizes tested yielded robust immune responses in non-human primates (NHP).
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Medicine, Research & Experimental
Suhas Sureshchandra et al.
Summary: mRNA vaccines for SARS-CoV-2 have shown strong protection against severe disease, enhancing spike-specific B cells and robust CD4(+) T cell responses. However, CD8(+) T cell responses following vaccination were relatively weak and variable, with clonally expanded CD8(+) T cells observed.
Article
Immunology
Ritu Mishra et al.
Summary: The novel coronavirus infection, SARS-CoV-2, has been found to be associated with neurological anomalies in patients, even after viral load declines. The Spike gene of SARS-CoV-2 can modify host exosomes and trigger neuroinflammation in the Central Nervous System. This study provides novel insights into the impact of Spike gene on host microRNA shuttling via exosomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Shuo Wang et al.
Summary: The study revealed that in hepatocellular carcinoma, miR-145-5p negatively regulates cell proliferation, migration, invasion, and apoptosis by targeting ARF6, and is significantly associated with patient prognosis. These findings provide insights into key factors of HCC metastasis.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Virology
Qutaiba A. Al Khames Aga et al.
Summary: This study investigated the adverse effects associated with three different COVID-19 vaccines and found that local reactions were more common with Pfizer and AstraZeneca vaccines, while systemic events were more prevalent with AstraZeneca and Pfizer vaccines. There was no correlation between age or gender and the duration of adverse effects, and some participants reported unusual symptoms like swelling of eyelids and severe allergic reactions. Overall, Pfizer, AstraZeneca, and Sinopharm vaccines were deemed safe, with Sinopharm showing lower prevalence of adverse effects compared to the others.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Valerie Oberhardt et al.
Summary: After vaccination, CD8(+) T cells become important effector cells in providing early protection, being effectively mobilized one week after primary vaccination and maintaining stability after booster vaccination. Compared with natural infection, vaccine-induced CD8(+) T cells exhibit similar functional capacities but with a different subset distribution.
Article
Multidisciplinary Sciences
Mathilde Mathieu et al.
Summary: This study tracks the intracellular trafficking of two proteins before their secretion in EVs, reporting the biogenesis and protein markers of EV subtypes: ectosomes budding from the plasma membrane as well as exosomes from late endosomes.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Jae Hyun Park et al.
Summary: Extracellular vesicles are nanometer-scaled, membrane-bound materials released by cells, containing diverse contents such as proteins and nucleic acids. These vesicles have shown potential as therapeutic agents for SARS-CoV-2 infection by inhibiting viral replication and mediating anti-viral responses through miRNAs.
Article
Public, Environmental & Occupational Health
Wei-Xi Shen et al.
Summary: A practical model has been developed to identify the features of cytokine storm in COVID-19, revealing the pathogenesis of the disease and providing new insights for precision treatment.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Yanbo Wang et al.
Summary: The study found that miRNA in serum can directly inhibit SARS-CoV-2 replication, and there are differences in the response to COVID-19 between young people and the elderly or people with comorbidities.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Junsong Zhang et al.
Summary: The study found that hACE2 in exosomes can block the entry of SARS-CoV-2 into cells, thereby inhibiting its replication. This suggests that viral receptors on exosomes could serve as a potential antiviral strategy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Medicine, Research & Experimental
Byoung Kwon Park et al.
Summary: This study identified a direct interaction between the S protein and the N protein of MERS-CoV during virus assembly in infected cells, and demonstrated that Spike CD peptides of MERS-CoV inhibit this interaction. Additionally, cell penetration by synthetic Spike CD peptides inhibits viral plaque formation in MERS-CoV-infected cells.
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Roujian Lu et al.
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Bhagyashree S. Joshi et al.
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Biochemistry & Molecular Biology
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Biochemistry & Molecular Biology
Alexandra C. Walls et al.
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Tina B. McKay et al.
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Yuan Huang et al.
ACTA PHARMACOLOGICA SINICA
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Na-Na Zhang et al.
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Zunlong Ke et al.
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Biochemistry & Molecular Biology
He Wang et al.
BIOSCIENCE REPORTS
(2020)
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Immunology
Katlyn Lederer et al.
Article
Multidisciplinary Sciences
Steffen Klein et al.
NATURE COMMUNICATIONS
(2020)
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Cell Biology
Federico Cocozza et al.
JOURNAL OF EXTRACELLULAR VESICLES
(2020)
Article
Oncology
Noemi Garcia-Magallanes et al.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2020)
Letter
Biochemistry & Molecular Biology
Zhiying Gao et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
Article
Medicine, Research & Experimental
Kimberly J. Hassett et al.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Article
Biochemistry & Molecular Biology
Liang Yan et al.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Review
Cell Biology
Guillaume van Niel et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2018)
Article
Alireza Khodadadi-Jamayran et al.
Article
Oncology
Dominique Thuringer et al.
Article
Oncology
Kangping Lu et al.
Review
Biochemistry & Molecular Biology
Thomas Schlake et al.
Article
Medical Laboratory Technology
Omar F. Laterza et al.
CLINICAL CHEMISTRY
(2009)
