期刊
CANCERS
卷 15, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/cancers15215117
关键词
RM-1929; photoimmunotherapy; cetuximab-IR700; cetuximab sarotalocan sodium; recurrent head and neck squamous cell carcinoma (HNSCC)
类别
RM-1929 NIR-PIT is an emerging treatment that has been shown to be well-tolerated and clinically meaningful for patients with unresectable and/or recurrent head and neck squamous cell carcinoma.
Simple Summary: RM-1929 near-infrared photoimmunotherapy (NIR-PIT) is an emerging treatment that is currently being investigated under a world-wide Phase III clinical trial and has been conditionally approved for the treatment of unresectable and/or recurrent HNSCC in Japan since 2021. Disease control rates ranged from 66.7 to 100% and overall response rates ranged from 43.3 to 100%. Low-grade postoperative localized pain and edema were the most frequently reported side effects. These preliminary data in real-world use of RM-1929 NIR-PIT show that it is a well-tolerated therapy that has clinically meaningful outcomes for patients with unresectable and/or recurrent HNSCC. Abstract: Head and neck squamous cell carcinoma (HNSCC) contribute to a significant global cancer burden. Developments in current therapeutic approaches have improved patient outcomes but have limited efficacy in patients with unresectable and/or recurrent HNSCC. RM-1929 near-infrared photoimmunotherapy (NIR-PIT) is an emerging treatment that is currently being investigated in a Phase III clinical trial and has been conditionally approved for the treatment of unresectable and/or recurrent HNSCC in Japan. Here, we collect a series of case reports and clinical trial data to assess the efficacy of RM-1929 NIR-PIT. Disease control rates ranged from 66.7 to 100% across these studies, and overall response rates ranged from 43.3 to 100%, suggesting positive clinical outcomes. Low-grade postoperative localized pain and edema were the most frequently reported side effects, and preliminary reports on quality of life and pain levels suggest that RM-1929 NIR-PIT does not significantly decrease quality of life and is manageable with existing pain management strategies, including opioids. These preliminary data in real-world use of RM-1929 NIR-PIT show that it is a well-tolerated therapy that has clinically meaningful outcomes for patients with unresectable and/or recurrent HNSCC.
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