Integrated Analysis Identifies DPP7 as a Prognostic Biomarker in Colorectal Cancer

Article Respiratory System

Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial

David Cipolla et al.

Summary: The research found that treatment with brensocatib can reduce the activity of NE, PR3, and CatG in sputum in patients with NCFBE, and it has a broad anti-inflammatory effect.

RESPIRATORY RESEARCH (2023)

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Article Pharmacology & Pharmacy

Pharmacokinetic/Pharmacodynamic Evaluation of the Dipeptidyl Peptidase 1 Inhibitor Brensocatib for Non-cystic Fibrosis Bronchiectasis

James D. Chalmers et al.

Summary: Brensocatib, an investigational drug, has shown promise in reducing neutrophil elastase activity in patients with NCFBE. The study found that age and renal function have a moderate effect on brensocatib exposure, but dose adjustments based on these factors are not necessary. Further development of brensocatib for bronchiectasis is supported by the clinically meaningful relationship between suppression of neutrophil elastase activity and reduction in exacerbations.

CLINICAL PHARMACOKINETICS (2022)

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Article Oncology

Clinical Calculator Based on Molecular and Clinicopathologic Characteristics Predicts Recurrence Following Resection of Stage I-III Colon Cancer

Martin R. Weiser et al.

Summary: Clinical calculators and nomograms are recommended by the AJCC for providing individualized and accurate estimates of patient outcome. A third-generation clinical calculator was developed to predict cancer recurrence following resection of stage I-III colon cancer, demonstrating improved discrimination and predictive accuracy by incorporating new variables such as microsatellite genomic phenotype and tumor-infiltrating lymphocytes.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Oncology

Prognostic significance of esterase gene expression in multiple myeloma

Romika Kumari et al.

Summary: This study evaluated the biological significance of esterase expression in multiple myeloma (MM) by analyzing gene expression profiling and genomic variants in patients with newly diagnosed MM (NDMM) or relapsed/refractory MM (RRMM). High or low expression of specific esterases in MM, such as UCHL5, SIAE, ESD, PAFAH1B3, PNPLA4, and PON1, were significantly altered as patients progressed from NDMM to RRMM. Certain esterases, like OVCA2, PAFAH1B3, SIAE, USP4, and PCED1B, were identified as poor prognostic markers, suggesting their potential role in myeloma biology.

BRITISH JOURNAL OF CANCER (2021)

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Article Oncology

Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen

Juho J. Miettinen et al.

Summary: The study identified differential expression of aminopeptidases associated with survival in multiple myeloma patients, highlighted the effectiveness of melflufen in relapsed/refractory cases, and demonstrated the role of specific aminopeptidases in activating the drug.

CANCERS (2021)

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Article Oncology

Hypoxia-Related Gene FUT11 Promotes Pancreatic Cancer Progression by Maintaining the Stability of PDK1

Wenpeng Cao et al.

Summary: The study reveals that FUT11 is significantly increased under hypoxia and predicts poor prognosis in PC patients, while inhibition of FUT11 can significantly reduce proliferation and migration of PC cells. FUT11 promotes proliferation and metastasis of PC by maintaining the stability of PDK1.

FRONTIERS IN ONCOLOGY (2021)

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Article Medicine, General & Internal

Identification of Dipeptidyl Peptidase (DPP) Family Genes in Clinical Breast Cancer Patients via an Integrated Bioinformatics Approach

Tak-Kee Choy et al.

Summary: The study of DPP family in breast cancer revealed that DPP3 and DPP9 had significantly high expression levels in cancer tissues compared to normal tissues, with high expression of DPP3 and DPP4 associated with poor survival in breast cancer patients. On the other hand, high expression levels of DPP6, DPP7, DPP8, and DPP9 were linked to good prognoses in patients. Positive correlations were also found between DPP family genes and various signaling pathways related to cell cycle, TGF-beta, opioid receptors, and immune response.

DIAGNOSTICS (2021)

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Article Oncology

Colorectal cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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Article Oncology

Functional Characterization of POFUT1 Variants Associated with Colorectal Cancer

Marlene Deschuyter et al.

CANCERS (2020)

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Article Medicine, General & Internal

Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis

James D. Chalmers et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Functional protein representations from biological networks enable diverse cross-species inference

Jason Fan et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Multidisciplinary Sciences

Genome-wide expression analysis reveals six contravened targets of EZH2 associated with breast cancer patient survival

Kanchan Kumari et al.

SCIENTIFIC REPORTS (2019)

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Article Multidisciplinary Sciences

Human Sialic acid O-acetyl esterase (SIAE) - mediated changes in sensitivity to etoposide in a medulloblastoma cell line

Rebecca L. Mather et al.

SCIENTIFIC REPORTS (2019)

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Article Biochemistry & Molecular Biology

Identification and Clinical Validation of a Novel 4 Gene-Signature with Prognostic Utility in Colorectal Cancer

Pankaj Ahluwalia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Immunology

Neutrophil Heterogeneity in Cancer: From Biology to Therapies

Pacome Lecot et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

Damian Szklarczyk et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Oncology

HBV Integration-mediated Cell Apoptosis in HepG2.2.15

Xiaoge Hu et al.

JOURNAL OF CANCER (2019)

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Article Biochemistry & Molecular Biology

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

Jianfang Liu et al.

CELL (2018)

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Article Immunology

Unique pattern of neutrophil migration and function during tumor progression

Sima Patel et al.

NATURE IMMUNOLOGY (2018)

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Article Oncology

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

Darshan S. Chandrashekar et al.

NEOPLASIA (2017)

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Article Biochemistry & Molecular Biology

Stem Cell Lineage Infidelity Drives Wound Repair and Cancer

Yejing Ge et al.

CELL (2017)

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Article Endocrinology & Metabolism

Use of an a-Glucosidase Inhibitor and the Risk of Colorectal Cancer in Patients With Diabetes: A Nationwide, Population-Based Cohort Study

Yao-Hsien Tseng et al.

DIABETES CARE (2015)

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Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

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Review Immunology

Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis)

Brice Korkmaz et al.

SEMINARS IN IMMUNOPATHOLOGY (2013)

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Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

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Review Pharmacology & Pharmacy

Peptidomics of the Prolyl Peptidases

Anna Mari Lone et al.

AAPS JOURNAL (2010)

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Article Hematology

Dipeptidyl peptidase 2 apoptosis assay determines the B-cell activation stage and predicts prognosis in chronic lymphocytic leukemia

Alexey V. Danilov et al.

EXPERIMENTAL HEMATOLOGY (2010)

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Article Multidisciplinary Sciences

Association between Acquired Uniparental Disomy and Homozygous Mutations and HER2/ER/PR Status in Breast Cancer

Musaffe Tuna et al.

PLOS ONE (2010)

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Article Oncology

Survival following recurrence in stage II and III colon cancer:: Findings from the ACCENT data set

Michael J. O'Connell et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

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Article Chemistry, Medicinal

Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor

Olga Danilova et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

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Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Hematology

Differential control of G0 programme in chronic lymphocytic leukaemia:: a novel prognostic factor

AV Danilov et al.

BRITISH JOURNAL OF HAEMATOLOGY (2005)

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Integrated Analysis Identifies DPP7 as a Prognostic Biomarker in Colorectal Cancer

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