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The Role of Macrophages in Sarcoma Tumor Microenvironment and Treatment

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Summary: Sarcomas are rare tumors with diverse genetic features and clinical outcomes. This study analyzes over 2000 sarcomas across 45 subtypes and identifies distinct genomic groups that differ from histological subgroups. The complex genetic heterogeneity of sarcomas makes it challenging to identify therapeutic targets and advance patient care. The findings of this study provide valuable insights into subtype-specific genetic alterations and will contribute to the improvement of sarcoma models and further investigations of genetic factors and treatment responses.

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Summary: CSF1 plays a crucial role in regulating TAMs in the inflammatory tumor microenvironment, while PLX3397 serves as an effective inhibitor of CSF1R that can impact the composition of sarcoma tumor microenvironment, suppressing TAMs and improving patient prognosis. By inhibiting the effects of CSF1, PLX3397 reduces M2 polarization and chemotaxis in BMDMs, while also suppressing primary tumor growth and metastasis in a tumor model, enhancing infiltration of CD8(+) T cells in tumor sites.

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