4.6 Article

Multi-omics Characterization of Response to PD-1 Inhibitors in Advanced Melanoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Absent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells

Beatriz Lozano-Ruiz et al.

Summary: This study demonstrates that AIM2 is not only important in innate immune cells but also plays a crucial role in CD4(+) T cells, specifically in the differentiation and function of regulatory T cells (Tregs).

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Oncology

Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma

Jedd D. Wolchok et al.

Summary: The 6.5-year results of the CheckMate 067 trial demonstrate durable clinical benefits with nivolumab plus ipilimumab or nivolumab monotherapy compared to ipilimumab alone in patients with advanced melanoma.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

Yasset Perez-Riverol et al.

Summary: PRIDE is the largest data repository of mass spectrometry-based proteomics data in the world, with around 500 datasets submitted per month. In addition to continuous improvements in data pipelines and infrastructure, PRIDE has developed the Spectra Archive and MAGE-TAB file format to enhance sample metadata annotation and access to mass spectra.

NUCLEIC ACIDS RESEARCH (2022)

Article Oncology

Clinical Proteomics of Metastatic Melanoma Reveals Profiles of Organ Specificity and Treatment Resistance

Lir Beck et al.

Summary: The study identified associations between the proteomic profiles of metastatic melanoma patients and clinical information such as survival and immunotherapy response, particularly highlighting the correlation between lung metastases and better immunotherapy response. Analysis of BRAF status and treatment history provided insights into the impact on immunotherapy response and suggested potential for improved treatment efficacy through combination therapy.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

Risks and benefits of reinduction ipilimumab/nivolumab in melanoma patients previously treated with ipilimumab/nivolumab

Paul B. Chapman et al.

Summary: In melanoma patients who have received prior ipilimumab/nivolumab combination immunotherapy, reinduction with ipi/nivo may lead to less favorable outcomes compared to the initial course, and the response to reinduction is not necessarily correlated with response to the initial treatment. Additionally, reinduction with ipi/nivo is associated with frequent immune-related adverse events, although less frequent than after the initial course.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of beta-catenin and PD-L1

Yihui Ma et al.

Summary: The study revealed that PDIA6 plays a crucial role in the progression of pancreatic cancer, with its overexpression promoting malignant characteristics of the cancer cells, while its knockdown leads to a reduction in these traits. Additionally, PDIA6 interacts with CSN5 and influences the deubiquitination of beta-catenin and PD-L1, suggesting PDIA6 as a potential target for pancreatic cancer treatment.

NEOPLASIA (2021)

Article Biochemistry & Molecular Biology

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

Michal Harel et al.

Article Oncology

Calnexin Impairs the Antitumor Immunity of CD4+ and CD8+ T Cells

Yichen Chen et al.

CANCER IMMUNOLOGY RESEARCH (2019)

Article Oncology

Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden

Carl Morrison et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

Article Multidisciplinary Sciences

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

Moshe Sade-Feldman et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Functional proteomics outlines the complexity of breast cancer molecular subtypes

Angelo Gamez-Pozo et al.

SCIENTIFIC REPORTS (2017)

Article Medicine, General & Internal

Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma

Antoni Ribas et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Article Biochemical Research Methods

The Perseus computational platform for comprehensive analysis of (prote)omics data

Stefka Tyanova et al.

NATURE METHODS (2016)

Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

J. Larkin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Statistics & Probability

High-Dimensional Graphical Model Search with thegRapHDRPackage

Gabriel C. G. Abreu et al.

Journal of Statistical Software (2015)

Article Medicine, General & Internal

Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma

G. V. Long et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Biochemical Research Methods

Shotgun proteomics of archival triple-negative breast cancer samples

Angelo Gamez-Pozo et al.

PROTEOMICS CLINICAL APPLICATIONS (2013)

Article Biochemical Research Methods

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

Juergen Cox et al.

JOURNAL OF PROTEOME RESEARCH (2011)

Article Medicine, General & Internal

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Paul B. Chapman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Mathematical & Computational Biology

Ensembl BioMarts: a hub for data retrieval across taxonomic space

Rhoda J. Kinsella et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2011)

Article Medicine, General & Internal

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Biochemical Research Methods

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Da Wei Huang et al.

NATURE PROTOCOLS (2009)

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)