Osseous Metastases in Thyroid Cancer: Unveiling Risk Factors, Disease Outcomes, and Treatment Impact

Article Surgery

Incidence and Predictors of Synchronous Bone Metastasis in Newly Diagnosed Differentiated Thyroid Cancer: A Real-World Population-Based Study

Lin Qi et al.

Summary: This study identified predictors and prognostic factors of synchronous bone metastasis in patients with differentiated thyroid cancer (DTC). Patients with risk factors should receive more attention in clinical practice.

FRONTIERS IN SURGERY (2022)

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Article Oncology

Bone metastases in newly diagnosed patients with thyroid cancer: A large population-based cohort study

Ruiguo Zhang et al.

Summary: This study analyzed data from 2010 to 2015 and found that bone metastases have a significant impact on the incidence and prognosis of thyroid cancer, with ATC showing higher risk in developing BM and worse survival rates. Patients with additional sites of extraskeletal metastases have lower survival rates.

FRONTIERS IN ONCOLOGY (2022)

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Article Surgery

Mid and long-term overall survival after carcinologic resections of thyroid cancer bone metastases

Henri Fragnaud et al.

Summary: A multicentric study on thyroid cancer patients with bone metastases found that resection of single bone metastasis may lead to improved long term 10-year overall survival, suggesting potential benefits of this surgical strategy.

FRONTIERS IN SURGERY (2022)

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Review Endocrinology & Metabolism

Bone metastases from differentiated thyroid carcinoma: current knowledge and open issues

A. Nervo et al.

Summary: Bone metastases in differentiated thyroid cancer are often associated with low survival rates and high morbidity, requiring multimodal treatment approaches. Management is challenging and personalized care is essential for improving patient outcomes. Prospective studies focusing on this specific aspect of DTC are scarce, highlighting the need for further research in this area.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2021)

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Article Oncology

Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer

Wen-Cai Liu et al.

Summary: The study aimed to establish a machine learning prediction model for bone metastasis in newly diagnosed thyroid cancer patients. A total of 17,138 patients were included, with 166 (0.97%) developing bone metastases. The RF model had better predictive performance compared to other models, with an AUC of 0.917, accuracy of 0.904, recall rate of 0.833, and specificity of 0.905.

CANCER MEDICINE (2021)

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Article Oncology

Site-Specific Metastasis and Survival in Papillary Thyroid Cancer: The Importance of Brain and Multi-Organ Disease

Eman A. Toraih et al.

Summary: The study examined the impact of different distant metastasis sites on the survival of PTC patients and found that metastasis to specific organs can significantly affect prognosis. Patients with brain and liver metastases had lower 5-year survival rates compared to those with bone and liver metastases, with risk factors such as male gender, multiple organ involvement, and brain metastasis influencing overall survival. Clinicians should consider these factors when developing treatment strategies.

CANCERS (2021)

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Review Oncology