4.6 Article

Naringin-Dextrin Nanocomposite Abates Diethylnitrosamine/Acetylaminofluorene-Induced Lung Carcinogenesis by Modulating Oxidative Stress, Inflammation, Apoptosis, and Cell Proliferation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action

Hadeer M. Morsy et al.

Summary: This study aimed to evaluate the ameliorative effects of eugenol and propose its possible mechanisms of action in DENA/AAF-induced lung cancer in Wistar rats. The results demonstrated that eugenol treatment could alleviate lung histological lesions and exert its effects through effective antioxidant, anti-inflammatory, proapoptotic, and antiproliferative mechanisms.

APOPTOSIS (2023)

Article Environmental Sciences

Protective effects of Persea americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities

Osama M. Ahmed et al.

Summary: This study demonstrates that avocado extracts can attenuate hepatocarcinogenesis in rats administered DEN/2AAF through the activation of antioxidant, anti-inflammatory, and apoptotic properties.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

Review Plant Sciences

Quercetin- and rutin-based nano-formulations for cancer treatment: A systematic review of improved efficacy and molecular mechanisms

Maryam Ghanbari-Movahed et al.

Summary: This study comprehensively evaluates the anticancer ability of different nano-formulations of rutin and quercetin and reveals their molecular mechanisms through preclinical studies. The results indicate that nano-formulations have stronger anticancer activities and can improve cancer treatment efficacy.

PHYTOMEDICINE (2022)

Article Chemistry, Medicinal

Protective Effects of Naringin-Dextrin Nanoformula against Chemically Induced Hepatocellular Carcinoma in Wistar Rats: Roles of Oxidative Stress, Inflammation, Cell Apoptosis, and Proliferation

Eman E. Mohamed et al.

Summary: This study found that naringin-dextrin nanoparticles (NDNPs) have antioxidant and anti-inflammatory effects against hepatocellular carcinoma (HCC) and can inhibit tumor cell growth. Compared to pure naringin, NDNP showed better anti-tumor efficacy.

PHARMACEUTICALS (2022)

Review Biochemistry & Molecular Biology

Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities

Jolita Stabrauskiene et al.

Summary: Naringin and naringenin, the main bioactive polyphenols in citrus fruits, have antioxidant and anticancer properties. They can suppress cancer development, modulate cellular signaling pathways, and have the potential to improve the condition of cancer patients.

BIOMEDICINES (2022)

Article Pharmacology & Pharmacy

Anticancer activity of a novel naringin-dextrin nanoformula: Preparation, characterization, and in vitro induction of apoptosis in human hepatocellular carcinoma cells by inducing ROS generation, DNA fragmentation, and cell cycle arrest

Eman E. Mohamed et al.

Summary: This study developed a naringin-dextrin nanoformula that improved the therapeutic effects of naringin against liver cancer cells by inducing reactive oxygen species and anti-inflammatory responses, leading to apoptosis.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

Article Toxicology

The chemoprevention of spirulina platensis and garlic against diethylnitrosamine induced liver cancer in rats via amelioration of inflammatory cytokines expression and oxidative stress

Tarek Kamal Abouzed et al.

Summary: Spirulina and garlic have similar chemoprotective effects against hepatocellular carcinoma by reducing liver damage, inflammation, and oxidative stress, and regulating the expression of pro-inflammatory cytokines and tumor-associated proteins.

TOXICOLOGY RESEARCH (2022)

Article Oncology

Natural product-based nanoformulations for cancer therapy: Opportunities and challenges

Dharambir Kashyap et al.

Summary: The application of natural product-based nanoformulations in the treatment of various human diseases, such as cancer, is a growing field. Nanotechnology in cancer therapeutics has overcome the limitations of conventional drug delivery systems, with promising results in targeting tumor cells and reducing side effects. The integration of phytotherapy and nanotechnology in clinical settings may lead to better pharmacological responses and improved clinical outcomes for patients.

SEMINARS IN CANCER BIOLOGY (2021)

Article Genetics & Heredity

Effect of 2-acetylaminofluorene and its genotoxic metabolites on DNA adduct formation and DNA damage in 3D reconstructed human skin tissue models

Thomas R. Downs et al.

Summary: The metabolites of 2-AAF are more efficiently detected in the skin comet assay than the RSMN assay, and after multiple exposures and enzyme induction, 2-AAF-induced DNA damage can be detected in the APC-modified comet assay.

MUTAGENESIS (2021)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Biochemistry & Molecular Biology

The use of nanotechnology to combat liver cancer: Progress and perspectives

Keenan J. Mintz et al.

Summary: Liver cancer, particularly hepatocellular carcinoma, poses a significant threat with high mortality rates worldwide. Nanotechnology plays a crucial role in treating liver cancer, with various types of nanoparticles being used to combat the disease. The multifunctional nature of nanoparticles allows for high anticancer activity both in vitro and in vivo, emphasizing the importance of combinatorial therapy for this challenging cancer.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

Review Biochemistry & Molecular Biology

The Role of the Inflammatory Response in Mediating Functional Recovery Following Composite Tissue Injuries

Naveena B. Janakiram et al.

Summary: Composite tissue injuries are common among US Military Service members during combat operations, leading to a high morbidity rate and complex complications due to dysregulated immune responses. Various factors, including ischemia, hypoxia, and low nutrient levels, contribute to impaired immune cell response and disrupted wound healing in CTI.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Environmental Sciences

Prophylactic effects of Cynara scolymus L. leaf and flower hydroethanolic extracts against diethylnitrosamine/acetylaminoflourene-induced lung cancer in Wistar rats

Adel Abdel-Moneim et al.

Summary: The study found that ALE and AFE have anti-cancer prophylactic effects against DEN/AAF-induced lung cancer in rats by suppressing oxidative stress and improving apoptotic signal induction.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

Review Pharmacology & Pharmacy

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

Maryam Ghanbari-Movahed et al.

Summary: Naringin, a natural flavonoid, has shown promising anti-tumor activity through modulation of various signaling pathways implicated in cancer initiation, promotion, and progression. Studies have demonstrated that treatment with naringin alone or in combination with other drugs can effectively suppress tumor growth, with naringin-metal complexes showing even greater anticancer effects. Further preclinical and clinical studies are warranted to explore the full potential of naringin as a candidate for cancer prevention and treatment.

FRONTIERS IN PHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

Recent Advances in Improved Anticancer Efficacies of Camptothecin Nano-Formulations: A Systematic Review

Maryam Ghanbari-Movahed et al.

Summary: Camptothecin (CPT), a natural plant alkaloid, demonstrates potent antitumor activities by targeting intracellular topoisomerase I but faces limitations due to lactone ring instability and water insolubility. Studies indicate that nanoparticle formulations of CPT exhibit higher antitumor activity than free CPT, suggesting a more efficient approach for cancer treatment. Overall, CPT nano-formulations show promise as a potent candidate for cancer therapy and support the future clinical application of natural antitumor agents.

BIOMEDICINES (2021)

Review Chemistry, Multidisciplinary

Cytokines: From Clinical Significance to Quantification

Chao Liu et al.

Summary: Cytokines play a critical role in regulating immune and inflammatory responses, serving as biomarkers for many diseases. Quantification of cytokines provides valuable insights into physiological and pathological processes for diagnosis and treatment in both clinical medicine and biology. Advances in in vitro and in vivo assays, biosensors, and quantification platforms aim to achieve real-time multiplex cytokine analysis for biomedical research and clinical practice.

ADVANCED SCIENCE (2021)

Article Oncology

Prognostic Value of Ki-67 Expression in Advanced Lung Squamous Cell Carcinoma Patients Treated with Chemotherapy

Diming Wang et al.

Summary: The study revealed a correlation between the Ki-67 expression level and tumor staging, chemotherapy response, and survival prognosis in patients with advanced lung squamous cell carcinoma. High Ki-67 expression was associated with shorter overall survival and progression-free survival, serving as an independent prognostic biomarker.

CANCER MANAGEMENT AND RESEARCH (2021)

Review Cell Biology

Role of NRF2 in Lung Cancer

Miriam Sanchez-Ortega et al.

Summary: The NRF2 transcription factor is crucial in cell defense responses against oxidative stress, but recent studies suggest that it may also promote tumor growth and metastasis in cancer, leading to a controversial discussion in the scientific community.
Review Nanoscience & Nanotechnology

Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment

Sylwia Milewska et al.

Summary: Nanotherapy, utilizing nanoparticles as carriers to deliver drugs, offers a targeted approach to resolving various problems, particularly in cancer treatment. The carrier's crucial role in handling challenges, such as protecting drugs and overcoming resistance mechanisms within cells, has contributed to the success of nanotherapy.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Review Biotechnology & Applied Microbiology

Advances in phytochemical delivery systems for improved anticancer activity

Ricardo Lagoa et al.

BIOTECHNOLOGY ADVANCES (2020)

Article Nanoscience & Nanotechnology

Core/Shell PEGS/HA Hybrid Nanoparticle Via Micelle-Coordinated Mineralization for Tumor-Specific Therapy

Zihan Wu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Engineering, Biomedical

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Zhaogang Yang et al.

NATURE BIOMEDICAL ENGINEERING (2020)

Review Oncology

Roles of IFN-γ in tumor progression and regression: a review

Dragica Jorgovanovic et al.

BIOMARKER RESEARCH (2020)

Article Biochemistry & Molecular Biology

Animal models for hepatocellular carcinoma

Hui Emma Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Review Biochemistry & Molecular Biology

Podoplanin in Inflammation and Cancer

Miguel Quintanilla et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

The emerging roles of inflammasome-dependent cytokines in cancer development

Hanne Van Gorp et al.

EMBO REPORTS (2019)

Article Food Science & Technology

Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats

Kalaiselvi Sivalingam et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Review Oncology

Flavonoids in Cancer and Apoptosis

Mariam Abotaleb et al.

CANCERS (2019)

Review Pharmacology & Pharmacy

Naringin: Biosynthesis and Pharmaceutical Applications

Priya Sharma et al.

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Article Oncology

Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse

Zsolt Mervai et al.

BMC CANCER (2018)

Review Oncology

NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega et al.

CANCER CELL (2018)

Article Biochemistry & Molecular Biology

Naringin protects acrolein-induced pulmonary injuries through modulating apoptotic signaling and inflammation signaling pathways in mice

Jae Kyeom Kim et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Targeting BCL-2 regulated apoptosis in cancer

Kirsteen J. Campbell et al.

OPEN BIOLOGY (2018)

Article Biotechnology & Applied Microbiology

Desflurane Attenuates Ventilator-Induced Lung Injury in Rats with Acute Respiratory Distress Syndrome

Xue Lin et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Review Cell Biology

The Dual Role of Inducible Nitric Oxide Synthase in Myocardial Ischemia/Reperfusion Injury: Friend or Foe?

Xin Yu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

Article Biochemistry & Molecular Biology

Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins

Shuli Man et al.

MOLECULAR CARCINOGENESIS (2017)

Review Chemistry, Medicinal

Direct Activation of Bax Protein for Cancer Therapy

Zhiqing Liu et al.

MEDICINAL RESEARCH REVIEWS (2016)

Review Oncology

Targeting Inflammation in Cancer Prevention and Therapy

Jelena Todoric et al.

CANCER PREVENTION RESEARCH (2016)

Article Plant Sciences

Therapeutic potential of naringin: an overview

Rui Chen et al.

PHARMACEUTICAL BIOLOGY (2016)

Article Oncology

Tissue Expression, Serum and Salivary Levels of IL-10 in Patients with Head and Neck Squamous Cell Carcinoma

Marzieh Hamzavi et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2013)

Article Multidisciplinary Sciences

p53 Dynamics Control Cell Fate

Jeremy E. Purvis et al.

SCIENCE (2012)

Article Immunology

Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway

Ying Liu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2011)

Article Critical Care Medicine

Interleukin-6 in Surgery, Trauma, and Critical Care Part II: Clinical Implications

Randeep S. Jawa et al.

JOURNAL OF INTENSIVE CARE MEDICINE (2010)

Article Oncology

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

Min H. Kang et al.

CLINICAL CANCER RESEARCH (2009)

Review Physiology

Nitric oxide and peroxynitrite in health and disease

Pal Pacher et al.

PHYSIOLOGICAL REVIEWS (2007)

Review Pharmacology & Pharmacy

Inflammation and cancer: How hot is the link?

Bharat B. Aggarwal et al.

BIOCHEMICAL PHARMACOLOGY (2006)