4.6 Article

Maintenance Treatment for Metastatic Pancreatic Cancer: Balancing Therapeutic Intensity with Tolerable Toxicity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Oncology

Overall Survival Results From the POLO Trial: A Phase III Study of Active Maintenance Olaparib Versus Placebo for Germline BRCA-Mutated Metastatic Pancreatic Cancer

Hedy L. Kindler et al.

Summary: The POLO study demonstrated that active olaparib maintenance therapy did not show a statistically significant overall survival benefit for patients with metastatic pancreatic adenocarcinoma, but did show significant benefits in other secondary endpoints.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Oncology

Niraparib plus nivolumab or niraparib plus ipilimumab in patients with platinum-sensitive advanced pancreatic cancer: a randomised, phase 1b/2 trial

Kim A. Reiss et al.

Summary: This study examined the safety and efficacy of maintenance therapy with PARP inhibition combined with immune checkpoint blockade in patients with advanced pancreatic cancer who responded well to platinum-based chemotherapy. The results demonstrated that the combination of niraparib plus ipilimumab was superior to niraparib plus nivolumab in terms of progression-free survival at 6 months.

LANCET ONCOLOGY (2022)

Article Oncology

Docetaxel maintenance therapy versus best supportive care after first-line chemotherapy with different dose docetaxel plus cisplatin for advanced non-small cell lung cancer (TFINE study, CTONG-0904): an open-label, randomized, phase III trial

Li Zhang et al.

Summary: The TFINE study confirmed the efficacy and safety of docetaxel continuation maintenance therapy in patients with advanced non-small cell lung cancer, with the dose of 60 mg/m(2) being potentially preferred by patients. Both docetaxel doses showed comparable toxicities.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Immunology

PARP Inhibitor Upregulates PD-L1 Expression and Provides a New Combination Therapy in Pancreatic Cancer

Yali Wang et al.

Summary: This study demonstrates that PARP inhibitors can increase PD-L1 expression in pancreatic cancer cells, and when used in combination with PD-L1 blockers, the therapeutic efficacy is significantly improved along with an increase in CD8(+) T cell density. Therefore, the combination therapy of PARP inhibitors with anti-PD-L1/PD-1 drugs may hold potential clinical significance for the treatment of pancreatic cancer.

FRONTIERS IN IMMUNOLOGY (2021)

Article Gastroenterology & Hepatology

Genomic Features and Classification of Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma

Talia Golan et al.

Summary: By analyzing whole genome sequencing data of PDAC patients, HRD-PDAC can be better identified, and patients without BRCA/PALB2 mutations may also benefit from DNA damage response agents.

GASTROENTEROLOGY (2021)

Article Oncology

Phase II Study of Maintenance Rucaparib in Patients With Platinum-Sensitive Advanced Pancreatic Cancer and a Pathogenic Germline or Somatic Variant in BRCA1, BRCA2, or PALB2

Kim A. Reiss et al.

Summary: This study assessed the role of the PARPi rucaparib as maintenance therapy in advanced pancreatic cancer patients with germline or somatic pathogenic variants in BRCA1, BRCA2, or PALB2, and found it to be a safe and effective treatment option, showing efficacy in a subset of patients.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Pharmacology & Pharmacy

Cost-Effectiveness Analysis of Olaparib Maintenance Treatment for Germline BRCA-Mutated Metastatic Pancreatic Cancer

Na Li et al.

Summary: The study found that olaparib was more cost-effective than placebo for maintenance therapy in metastatic pancreatic cancer in both China and the United States.

FRONTIERS IN PHARMACOLOGY (2021)

Article Medicine, General & Internal

Estimated Projection of US Cancer Incidence and Death to 2040

Lola Rahib et al.

Summary: This cross-sectional study projected cancer incidences and deaths in the United States up to 2040. The findings indicate significant changes in the most common cancers by 2040, with breast cancer projected to become the most common cancer and lung cancer remaining the leading cause of cancer-related death.

JAMA NETWORK OPEN (2021)

Review Oncology

Homologous Recombination Deficiency in Pancreatic Cancer: A Systematic Review and Prevalence Meta-Analysis

Raffaella Casolino et al.

Summary: The study analyzed the prevalence of HRD in PDAC patients, finding that surrogate markers of HRD identified more patients than gene-level approaches. There is a need to harmonize HRD definitions and validate the optimal biomarker for treatment selection. Universal HRD screening, including integrated somatic and germline analysis, should be offered to all PDAC patients.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Randomized Phase II Trial Evaluating Two Sequential Treatments in First Line of Metastatic Pancreatic Cancer: Results of the PANOPTIMOX-PRODIGE 35 Trial

Laetitia Dahan et al.

Summary: This study found that maintenance treatment with leucovorin plus fluorouracil is feasible and effective in patients with mPC controlled after 4 months of induction chemotherapy with FOLFIRINOX. However, there was a higher incidence of severe neurotoxicity in the maintenance therapy arm.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Clinical Effects of Stereotactic Body Radiation Therapy Targeting the Primary Tumor of Liver-Only Oligometastatic Pancreatic Cancer

Xiaoqin Ji et al.

Summary: The addition of SBRT to chemotherapy has shown to improve overall survival in liver-only oligometastatic pancreatic cancer patients, especially those with primary tumor located in the head of pancreas or good performance status. Moreover, SBRT is a safe and effective method for local progression control and local symptomatic relief in patients with metastatic pancreatic cancer.

FRONTIERS IN ONCOLOGY (2021)

Article Medicine, General & Internal

Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer

Talia Golan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

A. Gonzalez-Martin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer

I. Ray-Coquard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Oncology

Development of PARP and Immune-Checkpoint Inhibitor Combinations

Ross A. Stewart et al.

CANCER RESEARCH (2018)

Review Multidisciplinary Sciences

PARP inhibitors: Synthetic lethality in the clinic

Christopher J. Lord et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

Feasibility of alternating induction and maintenance chemotherapy in pancreatic cancer

Alexander Hann et al.

SCIENTIFIC REPORTS (2017)

Article Medicine, General & Internal

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

Daniel D. Von Hoff et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

Thierry Conroy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)