☆ 4.6 Review

Current and Future Use of Long Axial Field-of-View Positron Emission Tomography/Computed Tomography Scanners in Clinical Oncology

CANCERS (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

First Total-Body Kinetic Modeling and Parametric Imaging of Dynamic 68Ga-FAPI-04 PET in Pancreatic and Gastric Cancer

Ruohua Chen et al.

Summary: The study aimed to explore the pharmacokinetics of 68Ga-FAPI-04 PET/CT in pancreatic cancer and gastric cancer, and compare the parametric imaging of dynamic total-body data with SUV imaging. The results showed that parametric imaging using the 2T4K model improved tumor conspicuity and image quality, which may be helpful for early diagnosis, better characterization of tumors, or evaluation of treatment response.

JOURNAL OF NUCLEAR MEDICINE (2023)

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Article Engineering, Biomedical

Deep learning-based attenuation map generation with simultaneously reconstructed PET activity and attenuation and low-dose application

Luyao Shi et al.

Summary: The objective of this study is to optimize the attenuation map generation framework for clinical full-dose F-18-FDG studies and investigate the effectiveness of the optimized network on predicting attenuation maps for synthetic low-dose oncological PET studies. The proposed deep learning framework was optimized through preprocessing steps and hyperparameter optimization, and evaluated on clinical full-dose and synthetic low-dose datasets. The results show promising performance of the proposed method.

PHYSICS IN MEDICINE AND BIOLOGY (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Accurate total-body Ki parametric imaging with shortened dynamic 18F-FDG PET scan durations via effective data processing

Zixiang Chen et al.

Summary: This study investigated the possibility and feasibility of shortening the total-body dynamic scan duration to 30 min post-injection (PI) with the help of a Patlak data processing algorithm. The results showed that acceptable K-i parametric images can be obtained with a scan duration of 30 min PI using Patlak data processing. The processed Patlak data resulted in better noise reduction and higher accuracy for tumor lesion K-i values.

MEDICAL PHYSICS (2023)

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Article Medicine, General & Internal

Long Axial Field-of-View PET for Ultra-Low-Dose Imaging of Non-Hodgkin Lymphoma during Pregnancy

Joyce van Sluis et al.

Summary: Generally, positron emission tomography imaging is not often performed in pregnant patients due to the risks of radiation exposure to the fetus. However, the use of long axial Field-of-View (LAFOV) PET systems can provide diagnostic quality images with a reduced level of injected F-18-FDG activity, allowing for safer imaging in pregnant patients. In this case, LAFOV PET imaging was successfully used for staging and therapy selection in a pregnant patient with follicular lymphoma, minimizing radiation exposure to the fetus.

DIAGNOSTICS (2023)

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Review Oncology

Malignancy in pregnancy: Multimodality imaging and treatment

Trinh Nguyen et al.

Summary: With the increasing average age of pregnancy and the use of prenatal fetal noninvasive screening techniques, more cases of cancer are being diagnosed in pregnant women. This poses complex challenges in terms of imaging, diagnosis, staging, and treatment, requiring specialized interdisciplinary management. This report discusses the use of multimodality imaging and safety considerations, reviews current guidelines for ionizing radiation imaging techniques, and presents diagnostic imaging guidelines for common and uncommon cancers in pregnancy.

CANCER (2023)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

[18F]mFBG long axial field of view PET-CT without general anaesthesia reveals concise extension of neuroblastoma in a 9-month-old boy

L. Borgwardt et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Validation of simplified uptake measures against dynamic Patlak Ki for quantification of lesional 89Zr-Immuno-PET antibody uptake

Jessica E. Wijngaarden et al.

Summary: This study assesses the validity of three commonly used quantification parameters (SUV, TPR, and TBR) in quantifying reversible Zr-89-Immuno-PET uptake. The results showed that SUV, TPR, and TBR are valid quantification parameters for constant mass doses. However, for variable mass doses, only TPR and TBR provide reliable quantification values, while SUV does not consider patient and mass dose-specific plasma clearance.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

One-stop [18F]FDG and [68Ga]Ga-DOTA-FAPI-04 total-body PET/CT examination with dual-low activity: a feasibility study

Guobing Liu et al.

Summary: This study aimed to investigate the feasibility of a one-stop FDG-FAPI dual-tracer imaging protocol in oncological imaging. The results showed that this protocol had higher sensitivity and specificity in detecting primary tumors and metastases compared to traditional FDG imaging.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

The potential of a medium-cost long axial FOV PET system for nuclear medicine departments

Stefaan Vandenberghe et al.

Summary: This article proposes medium-cost long axial FOV scanners as an alternative to total body positron emission tomography (TB-PET) systems, with the advantages of higher throughput, more cost-effective scanning, a larger group of indications, and novel research opportunities.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Combined [68 Ga]Ga-PSMA-11 and low-dose 2-[18F]FDG PET/CT using a long-axial field of view scanner for patients referred for [177Lu]-PSMA-radioligand therapy

Ian Alberts et al.

Summary: Adding a low-dose 2-[F-18]FDG PET/CT as part of a same-day imaging protocol is feasible and can help detect lesions with low PSMA expression and play a role in therapy assessment.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2023)

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Article Engineering, Biomedical

Evaluation of cost-effective system designs for long axial field-of-view PET scanners

Suleman Surti et al.

Summary: The development of total-body PET scanners with longer AFOV has increased the sensitivity for single organ imaging and enabled multi-organ dynamic imaging. However, the cost of these scanners has limited their widespread adoption in the clinic. This study evaluates alternative designs that provide the advantages of long AFOV PET while utilizing cost-effective detector hardware.

PHYSICS IN MEDICINE AND BIOLOGY (2023)

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Review Oncology

Long-axial field-of-view PET/CT: perspectives and review of a revolutionary development in nuclear medicine based on clinical experience in over 7000 patients

Ian Alberts et al.

Summary: Recently introduced long-axial field-of-view (LAFOV) PET/CT systems have greatly advanced nuclear medicine by providing higher sensitivity, reductions in applied activity, and the ability to image the entire body in a single field of view. This allows for capturing a wider dynamic range of a tracer and enables improved quantification and non-invasive analysis of human function and physiology. The article shares insights from clinical operation of the LAFOV system and discusses the current state-of-the-art in PET technology, as well as the barriers that need to be overcome for routine clinical use.

CANCER IMAGING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Role of breath-hold lung PET in stage IA pulmonary adenocarcinoma

Zhaoping Cheng et al.

Summary: This study aimed to evaluate the additional value of a 20-second breath-hold (BH) lung PET in patients with stage IA pulmonary adenocarcinoma. The results showed that BH lung PET images accurately identified all lung nodules and had significant differences in nodule SUVmax and TBR compared to whole-body PET. The differences in SUVmax and TBR were higher in nodules adjacent to pleura compared to those away from pleura, and the lesion detectability of BH lung PET was significantly higher than that of whole-body PET.

INSIGHTS INTO IMAGING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Long Versus Short Axial Field of View Immuno-PET/CT: Semiquantitative Evaluation for89Zr-Trastuzumab

Philipp Mohr et al.

JOURNAL OF NUCLEAR MEDICINE (2023)

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Article Engineering, Biomedical

Simultaneous quantitative imaging of two PET radiotracers via the detection of positron-electron annihilation and prompt gamma emissions

Edwin C. Pratt et al.

Summary: This article describes a new image reconstruction method for positron emission tomography (PET) that allows for the simultaneous imaging of two radiotracers, enabling the independent quantification of two molecular signals.

NATURE BIOMEDICAL ENGINEERING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

The diagnostic and prognostic role of combined [18F]FDG and [68Ga]-DOTA-peptides PET/CT in primary pulmonary carcinoids: a multicentric experience

Domenico Albano et al.

Summary: This study combined [Ga-68]-DOTA-peptides and [F-18]FDG-PET/CT findings to differentiate typical and atypical pulmonary carcinoids and investigate their prognostic role. The dual-tracer analysis effectively distinguished tumor types and had prognostic implications for patient outcomes.

EUROPEAN RADIOLOGY (2023)

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Article Oncology

Feasibility, Safety and Impact of (18F)-FDG PET/CT in patients with pregnancy-associated cancer: experience of the French CALG (Cancer Associe a La Grossesse) network

Marie Despierres et al.

Summary: This study evaluated the feasibility, safety, and impact of (18F)-FDG PET/CT performed during pregnancy in patients with pregnancy-associated cancers. The results showed that PET/CT had a major impact on cancer management during pregnancy and did not cause fetal side effects, indicating the feasibility of the exam during pregnancy with maternal benefits outweighing fetal risks.

ACTA ONCOLOGICA (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

First results on kinetic modelling and parametric imaging of dynamic 18F-FDG datasets from a long axial FOV PET scanner in oncological patients

Hasan Sari et al.

Summary: This study investigated the kinetics of F-18-fluorodeoxyglucose (F-18-FDG) in multiple organs using positron emission tomography (PET) and tested the feasibility of total-body parametric imaging. Parametric imaging showed improved tumor contrast compared to standard uptake value (SUV) images. The study demonstrated the potential of total-body kinetic modeling and parametric imaging in basic research and oncological studies.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Total-Body PET Multiparametric Imaging of Cancer Using a Voxelwise Strategy of Compartmental Modeling

Guobao Wang et al.

Summary: Quantitative dynamic PET with compartmental modeling allows for multiparametric imaging and more accurate quantification. This study evaluates the necessity of voxelwise compartmental modeling strategies for total-body multiparametric imaging and finds that time delay correction and model selection improve the imaging results.

JOURNAL OF NUCLEAR MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

A CT-less approach to quantitative PET imaging using the LSO intrinsic radiation for long-axial FOV PET scanners

Mohammadreza Teimoorisichani et al.

Summary: This study proposed a quantitative CT-less PET imaging technique utilizing the high sensitivity of long-axial FOV PET scanners. By utilizing the background radiation of lutetium-based scintillators, an improved attenuation map was created for PET image reconstruction, resulting in an average quantitative error between 6.5%-8.3%.

MEDICAL PHYSICS (2022)

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Article Clinical Neurology

The impact of probable rapid eye movement sleep behavior disorder on Parkinson's disease: A dual-tracer PET imaging study

Qian Xu et al.

Summary: This study aimed to compare differences between PD patients with and without probable RBD and the influence of timing of RBD onset. The results showed that PD patients with probable RBD have worse dopaminergic dysfunction and higher metabolic activity in specific brain regions. Furthermore, RBD preceding PD onset may indicate a steeper disease decline.

PARKINSONISM & RELATED DISORDERS (2022)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

First-time imaging of [89Zr]trastuzumab in breast cancer using a long axial field-of-view PET/CT scanner

Adrienne H. Brouwers et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Deep learning-based time-of-flight (ToF) image enhancement of non-ToF PET scans

Abolfazl Mehranian et al.

Summary: The study aimed to enhance PET images reconstructed without ToF using deep learning models trained for ToF image enhancement. DL-ToF medium strength showed the best performance in terms of diagnostic confidence.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Diagnostic performance of total-body 18F-FDG PET/CT with fast 2-min acquisition for liver tumours: comparison with conventional PET/CT

Yan Hu et al.

Summary: The diagnostic performance of total-body F-18-FDG PET/CT with 2-minute acquisition was comparable to that with 15-minute acquisition in liver cancer patients. Additionally, the diagnostic efficiency of total-body PET/CT imaging with fast 2-minute acquisition was similar to conventional PET/CT.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Ultrafast 30-s total-body PET/CT scan: a preliminary study

Yiqiu Zhang et al.

Summary: The aim of this study was to evaluate the diagnostic value of ultrafast 30-second total-body PET/CT scans and explore whether they meet the requirements of clinical diagnosis. The results showed that the 30-second total-body PET/CT scans could meet the clinical diagnostic requirements for malignant tumors, especially in patients intolerant to prolonged horizontal positioning.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Abbreviated scan protocols to capture 18F-FDG kinetics for long axial FOV PET scanners

Varsha Viswanath et al.

Summary: Kinetic parameters from dynamic F-18-fluorodeoxyglucose (FDG) imaging provide complementary insights for the study of diseases compared to static clinical imaging. Long axial field-of-view (LAFOV) PET scanners have advantages over standard axial field-of-view (SAFOV) scanners, including the ability to perform multi-organ dynamic imaging in a single bed position and the potential for abbreviated dynamic imaging protocols. This study demonstrates that dynamic imaging for 10-15 minutes immediately post-injection, followed by a 5-minute scan at 1-hour post-injection, can accurately and precisely quantify F-18-FDG on a long axial FOV scanner, potentially allowing for more widespread use of dynamic F-18-FDG imaging.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Whole-Body Parametric Imaging of 18F-FDG PET Using uEXPLORER with Reduced Scanning Time

Yaping Wu et al.

Summary: This study explores the possibility of acquiring K-i images with a much-reduced scanning time and proposes two new scanning protocols. The results suggest that it is feasible to obtain K-i images using a nonlinear estimation approach and a hybrid input function. The differences in K-i values among different protocols are minimal, and the protocol with dual injection shows the greatest promise in practicality.

JOURNAL OF NUCLEAR MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Performance Characteristics of the Biograph Vision Quadra PET/CT System with a Long Axial Field of View Using the NEMA NU 2-2018 Standard

George A. Prenosil et al.

Summary: The performance of the Biograph Vision Quadra PET/CT system was evaluated in this study. The system showed improved sensitivity and count rates compared to the Biograph Vision 600 due to its larger field of view. The physical performance and image quality were assessed through various experiments and compared with existing PET scanners.

JOURNAL OF NUCLEAR MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Exploration of the total-body PET/CT reconstruction protocol with ultra-low 18F-FDG activity over a wide range of patient body mass indices

Xiuli Sui et al.

Summary: The study investigated the image quality and diagnostic performance of different reconstructions in patients with different body mass indices (BMIs). The results showed that increased BMI was associated with increased image noise, and there were differences in the effects of reconstruction algorithms on different BMI groups. Overall image quality and image noise scores decreased with increasing BMI, while lesion conspicuity scores did not show significant differences. The image quality score of the obese group was not qualified in one of the reconstruction methods. Different reconstruction methods had an impact on lesion size and quantitative indicators.

EJNMMI PHYSICS (2022)

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Review Oncology

Extending the clinical capabilities of short- and long-lived positron-emitting radionuclides through high sensitivity PET/CT

Joyce van Sluis et al.

Summary: This review discusses the benefits of using long axial field of view (LAFOV) PET in clinical applications. LAFOV PET systems have ultra-high sensitivity and offer various clinical applications, including dual tracer imaging and whole body dynamic PET imaging. It is expected that this generation of PET systems will significantly advance the field of nuclear medicine and molecular imaging.

CANCER IMAGING (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

High-quality PET image synthesis from ultra-low-dose PET/MRI using bi-task deep learning

Hanyu Sun et al.

Summary: This paper introduces a method for generating high-quality PET images from ultra-low-dose input. By combining PET and MRI modalities and utilizing a two-task-based end-to-end generative adversarial network (bi-c-GAN), this method improves image quality and reduces radiation exposure.

QUANTITATIVE IMAGING IN MEDICINE AND SURGERY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for 18F-FDG

Ivo Rausch et al.

Summary: This study aimed to assess the extent of useful aFOV of the Biograph Vision Quadra PET/CT system, with results showing stable image noise and contrast within the central 80 cm but increasing variability and noise beyond this range, particularly evident at short acquisition times.

EJNMMI PHYSICS (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Dual time point imaging in locally advanced head and neck cancer to assess residual nodal disease after chemoradiotherapy

Frederik Soffers et al.

Summary: Dual time point FDG-PET/CT imaging did not significantly improve the overall diagnostic accuracy of detecting residual disease after radiotherapy in head and neck cancer patients. However, it improved the specificity due to differences in tracer kinetics between malignant and benign lymph nodes.

EJNMMI RESEARCH (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Patlak plot based on the first 30 minutes post-injection dynamic 18F-florbetaben positron emission tomography scan separates amyloid-β positive from negative studies

Francisco PM Oliveira et al.

BRITISH JOURNAL OF RADIOLOGY (2022)

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Editorial Material Engineering, Biomedical

Long axial field-of-view PET/CT devices: are we ready for the technological revolution?

Luca Filippi et al.

EXPERT REVIEW OF MEDICAL DEVICES (2022)

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Article Medicine, General & Internal

Dual-tracer positron emission tomography/computed tomography as an imaging probe of de novo lipogenesis in preclinical models of hepatocellular carcinoma

Chin-Ho Tsao et al.

Summary: Proposed a imaging probe that can assess the lipogenic activity of hepatocellular carcinoma (HCC) and predict the response to lipogenesis-targeted therapy.

FRONTIERS IN MEDICINE (2022)

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Article Chemistry, Physical

The influence of iterative reconstruction level on image quality and radiation dose in CT pulmonary angiography examinations

H. H. Harun et al.

Summary: This study evaluated the effects of using iterative reconstruction algorithm and different tube potentials on Computed Tomography Pulmonary Angiography (CTPA) examination, and established the relationship between radiation exposure and image quality. The research found that as tube voltage and patient size increased, radiation dose also increased, but SNR, CNR, and FOM values remained comparable with different parameters.

RADIATION PHYSICS AND CHEMISTRY (2021)

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Article Health Care Sciences & Services

Low-count whole-body PET with deep learning in a multicenter and externally validated study

Akshay S. Chaudhari et al.

Summary: This study demonstrated that a deep-learning-based image-quality enhancement algorithm applied to fourfold reduced-count whole-body PET scans maintained diagnostic image quality and diagnostic confidence comparable to standard scans, independent of the underlying PET scanner used. The method generalized well to external validation set of clinical patients from multiple institutions and scanner types, suggesting its potential for dose or exam-duration reduction in PET imaging, increasing safety and lowering costs.

NPJ DIGITAL MEDICINE (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Performance Evaluation of the uEXPLORER Total-Body PET/CT Scanner Based on NEMA NU 2-2018 with Additional Tests to Characterize PET Scanners with a Long Axial Field of View

Benjamin A. Spencer et al.

Summary: This study presents a detailed physical characterization and performance evaluation of the world's first total-body PET scanner with a 194 cm AFOV. Results demonstrate high sensitivity, good spatial resolution, excellent image quality, and contrast recovery across the entire field of view, supporting the system's ultra-high performance in both phantom and human imaging.

JOURNAL OF NUCLEAR MEDICINE (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Total-Body Quantitative Parametric Imaging of Early Kinetics of 18F-FDG

Tao Feng et al.

Summary: This study successfully derived parametric images using data from total-body PET system, demonstrating the potential of estimating early dynamics after F-18-FDG injection. The estimated parameter k(1) could be used as a clinical indicator for identifying abnormalities.

JOURNAL OF NUCLEAR MEDICINE (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

Cumulative radiation doses from recurrent PET-CT examinations

Makoto Hosono et al.

Summary: PET-CT is essential for managing various diseases, but concerns exist about cumulative radiation doses in patients. Implementation of justification for examinations and dose reduction measures are key in coping with cumulative doses.

BRITISH JOURNAL OF RADIOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Deep learning-assisted ultra-fast/low-dose whole-body PET/CT imaging

Amirhossein Sanaat et al.

Summary: The study aimed to evaluate the performance of synthesizing regular full-dose PET images from fast/low-dose whole-body PET images using deep learning techniques. The results showed that the predicted full-dose images had almost similar performance in terms of lesion detectability, qualitative scores, and quantification bias and variance.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Ultra-low-activity total-body dynamic PET imaging allows equal performance to full-activity PET imaging for investigating kinetic metrics of 18F-FDG in healthy volunteers

Guobing Liu et al.

Summary: The study found that total-body dynamic PET imaging with a 10-fold reduction in injected activity can achieve relevant kinetic metrics of F-18-FDG and comparable image contrast with full-activity imaging, while significantly reducing radiation dose and data size.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Kinetic metrics of 18F-FDG in normal human organs identified by systematic dynamic total-body positron emission tomography

Guobing Liu et al.

Summary: The kinetic rates and MRFDG significantly differed among organs, with four groups of organs identified based on similar kinetic characteristics. The findings provide valuable reference for future dynamic PET imaging and research.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Validation of low-dose lung cancer PET-CT protocol and PET image improvement using machine learning

Ying-Hwey Nai et al.

Summary: The study aimed to conduct a lesion-detection task using a low-dose PET-CT protocol and investigate the feasibility of increasing clinical value of low-statistics scans through machine learning. Results showed that the LD PET-CT protocol had good performance in lesion detection, and machine learning methods could achieve substantial image quality improvement or additional dose reduction while preserving clinical values, although SUV quantification may be biased.

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS (2021)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Dynamic PET imaging with ultra-low-activity of 18F-FDG: unleashing the potential of total-body PET

Xiaoli Lan et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Use of population input functions for reduced scan duration whole-body Patlak 18F-FDG PET imaging

Joyce van Sluis et al.

Summary: The study evaluates the effects of using population-averaged IFs and rescaling them to image-derived values on the accuracy of the Patlak method for whole-body imaging. Simulations suggest that scaling an incorrect PIF to IF values obtained from 30 to 60 minutes pi can provide accurate Ki estimates, reducing biases in most cases. This indicates that dynamic Patlak imaging protocols may be performed for 30-60 minutes pi, making whole-body Patlak imaging clinically feasible.

EJNMMI PHYSICS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Artificial intelligence for reduced dose 18F-FDG PET examinations: a real-world deployment through a standardized framework and business case assessment

Katia Katsari et al.

Summary: This study demonstrated the non-inferiority of AI processed low-dose PET/CT images compared to standard dose native scans in terms of image quality and lesion detectability, with potential business benefits in cost savings.

EJNMMI PHYSICS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Image quality and lesion detectability in low-dose pediatric 18F-FDG scans using total-body PET/CT

Yu-Mo Zhao et al.

Summary: The study found that in pediatric patients, sufficient subjective image quality and lesion conspicuity could be maintained with a reduction in F-18-FDG administered dose to 1/30. Image noise increased significantly in 1/30 to 1/10 dose groups, while SUVmax and SD in the liver gradually increased.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Total-body 18F-FDG PET/CT scan in oncology patients: how fast could it be?

Pengcheng Hu et al.

Summary: The study demonstrates that a fast PET protocol with a 30-45-s acquisition time in the total-body uEXPLORER PET/CT can achieve equivalent image quality as the conventional digital uMI 780 PET/CT with longer clinical acquisition settings.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Clinical performance of long axial field of view PET/CT: a head-to-head intra-individual comparison of the Biograph Vision Quadra with the Biograph Vision PET/CT

Ian Alberts et al.

Summary: The study compared the performance of new LAFOV and standard SAFOV PET/CT systems using an intra-patient comparison. Results showed that the LAFOV system could achieve equivalent image quality and lesion quantification in a very short time, providing new possibilities for clinical applications.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Ultra-low dose whole-body CT for attenuation correction in a dual tracer PET/CT protocol for multiple myeloma

Elena Prieto et al.

Summary: The study found that using an ultra-low dose CT in PET/CT scans can accurately perform attenuation correction and significantly reduce the radiation dose received by patients. In most cases, the variation of PET contrast recovery coefficients is within +/-1.2%, and despite the poorer image quality of the ultra-low dose CT, it can still accurately identify bone lesions at a high rate.

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

Long axial field of view PET scanners: a road map to implementation and new possibilities

Riemer H. J. A. Slart et al.

Summary: This contribution discusses the opportunities and challenges of long axial field of view (LAFOV) PET, highlighting key issues and providing a comprehensive overview of camera system implementation, business and financial plan, opportunities, and challenges. The new PET/CT scanners are expected to provide more comprehensive information to clinicians in the nuclear medicine and molecular imaging community, advancing diagnosis, therapy evaluation, and clinical research.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Feasibility of late acquisition [68Ga]Ga-PSMA-11 PET/CT using a long axial field-of-view PET/CT scanner for the diagnosis of recurrent prostate cancer-first clinical experiences

Ian Alberts et al.

Summary: Late imaging with a LAFOV PET/CT system can improve tumor-to-background ratio and signal-to-noise ratio of Gallium-68 PSMA-11 images, with only modest impairment in subjective visual imaging quality.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Review Engineering, Biomedical

Motion estimation and correction in SPECT, PET and CT

Andre Z. Kyme et al.

Summary: Patient motion affects SPECT, PET, and CT imaging by causing projection data inconsistencies, leading to reconstruction artifacts and compromised image quality. Methods to estimate and correct for motion in these modalities have been developed over decades, with ongoing efforts to improve clinical feasibility and utility. Further developments in data-driven methods, including the use of deep learning, hold promise for enhancing clinical utility in motion estimation and correction.

PHYSICS IN MEDICINE AND BIOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Optimisation of CT protocols in PET-CT across different scanner models using different automatic exposure control methods and iterative reconstruction algorithms

Sarah-May Gould et al.

Summary: This study discusses the translation of low-dose CT protocols between different scanner models, with a focus on optimisation for obese patients. Comparisons of dose and image quality between Siemens and GE scanners revealed the need for careful consideration in protocol standardisation due to differences in acquisition parameters and reconstruction algorithms.

EJNMMI PHYSICS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

PennPET Explorer: Design and Preliminary Performance of a Whole-Body Imager

Joel S. Karp et al.

JOURNAL OF NUCLEAR MEDICINE (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

PennPET Explorer: Human Imaging on a Whole-Body Imager

Austin R. Pantel et al.

JOURNAL OF NUCLEAR MEDICINE (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Total-Body PET and Highly Stable Chelators Together Enable Meaningful 89Zr-Antibody PET Studies up to 30 Days After Injection

Eric Berg et al.

JOURNAL OF NUCLEAR MEDICINE (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Newly Developed Methods for Reducing Motion Artifacts in Pediatric Abdominal MRI: Tips and Pearls

Suraj D. Serai et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

The image quality, lesion detectability, and acquisition time of 18F-FDG total-body PET/CT in oncological patients

Yi-Qiu Zhang et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

State of the art in total body PET

Stefaan Vandenberghe et al.

EJNMMI PHYSICS (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

CD38-targeted Immuno-PET of Multiple Myeloma: From Xenograft Models to First-in-Human Imaging

Gary A. Ulaner et al.

RADIOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET

Mika Naganawa et al.

EJNMMI PHYSICS (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators

Pawel Moskal et al.

PET CLINICS (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Immuno-PET Imaging to Assess Target Engagement: Experience from 89Zr-Anti-HER3 mAb (GSK2849330) in Patients with Solid Tumors

C. Willemien Menke-van der Houven van Oordt et al.

JOURNAL OF NUCLEAR MEDICINE (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

First Human Imaging Studies with the EXPLORER Total-Body PET Scanner

Ramsey D. Badawi et al.

JOURNAL OF NUCLEAR MEDICINE (2019)

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Article Medicine, Research & Experimental

Comparative biodistribution analysis across four different 89Zr-monoclonal antibody tracers-The first step towards an imaging warehouse

Frederike Bensch et al.

THERANOSTICS (2018)

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Article Biochemistry & Molecular Biology

Zr-89-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer

Frederike Bensch et al.

NATURE MEDICINE (2018)

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Article Oncology

ImmunoPET with Anti-Mesothelin Antibody in Patients with Pancreatic and Ovarian Cancer before Anti-Mesothelin Antibody-Drug Conjugate Treatment

Laetitia E. Lamberts et al.

CLINICAL CANCER RESEARCH (2016)

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Article Medicine, General & Internal

Radiation Dose from Whole-Body F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: Nationwide Survey in Korea

Hyun Woo Kwon et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2016)

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Review Radiology, Nuclear Medicine & Medical Imaging

Physics of pure and non-pure positron emitters for PET: a review and a discussion

Maurizio Conti et al.

EJNMMI PHYSICS (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

Dual-time-point Imaging and Delayed-time-point Fluorodeoxyglucose-PET/Computed Tomography Imaging in Various Clinical Settings

Sina Houshmand et al.

PET CLINICS (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

Dynamic Changes of FDG Uptake and Clearance in Normal Tissues

Gang Cheng et al.

MOLECULAR IMAGING AND BIOLOGY (2013)

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Article Anesthesiology

Feasibility and Pilot Study of the Pediatric Anesthesia NeuroDevelopment Assessment (PANDA) Project

Lena S. Sun et al.

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY (2012)

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Article Pharmacology & Pharmacy

Biodistribution of 89Zr-trastuzumab and PET Imaging of HER2-Positive Lesions in Patients With Metastatic Breast Cancer

E. C. Dijkers et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2010)

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Article Radiology, Nuclear Medicine & Medical Imaging

F-18-FDG PET/CT-related metabolic parameters and their value in early prediction of chemotherapy response in a VX2 tumor model

Shao-li Song et al.

NUCLEAR MEDICINE AND BIOLOGY (2010)

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Article Gastroenterology & Hepatology

Quantification of liver perfusion with [O-15]H2O-PET and its relationship with glucose metabolism and substrate levels

Lotfi Slimani et al.

JOURNAL OF HEPATOLOGY (2008)

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Article Radiology, Nuclear Medicine & Medical Imaging

Tumor blood flow measured by PET dynamic imaging of first-pass 18F-FDG uptake:: A comparison with 15O-Labeled water-measured blood flow

Nizar A. Mullani et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

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Article Radiology, Nuclear Medicine & Medical Imaging

Deep-inspiration breath-hold PET/CT:: Clinical findings with a new technique for detection and characterization of thoracic lesions

Gustavo S. P. Meirelles et al.

JOURNAL OF NUCLEAR MEDICINE (2007)

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Article Radiology, Nuclear Medicine & Medical Imaging

How should we analyse FDG PET studies for monitoring tumour response?

Adriaan A. Lammertsma et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2006)

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Article Radiology, Nuclear Medicine & Medical Imaging

[11C]flumazenil metabolite measurement in plasma is not necessary for accurate brain benzodiazepine receptor quantification

SM Sanabria-Bohórquez et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE (2000)

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