Brain Plasticity Profiling as a Key Support to Therapeutic Decision-Making in Low-Grade Glioma Oncological Strategies

Article Oncology

Interactive Effects of Molecular, Therapeutic, and Patient Factors on Outcome of Diffuse Low-Grade Glioma

Shawn L. Hervey-Jumper et al.

Summary: In patients with diffuse low-grade glioma, the extent of surgical tumor resection has a controversial role in prognosis, but a randomized clinical trial is not feasible to determine different levels of resection.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article Neurosciences

Longitudinal DNA methylation analysis of adult-type IDH-mutant gliomas

Sandra Ferreyra Vega et al.

Summary: This study investigated the DNA methylation changes associated with tumor progression in primary and recurrent IDH-mutant gliomas. It was found that a subset of IDH-mutant astrocytomas exhibited a switch in methylation subtypes, with the primary tumors classified as low-grade astrocytomas progressing to high-grade astrocytomas in the recurrent tumors. The number of differentially methylated CpG sites increased over time, and astrocytomas accumulated more differentially methylated CpG sites than oligodendrogliomas during tumor progression.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2023)

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Article Oncology

Long-term wellbeing and neurocognitive functioning of diffuse low-grade glioma patients and their caregivers: A longitudinal study spanning two decades

Florien W. Boele et al.

Summary: HRQOL and NCF do not appear greatly impacted during long-term survivorship in LGG, but depressive symptoms and fatigue are persistent.

NEURO-ONCOLOGY (2023)

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Article Clinical Neurology

Intraoperative functional remapping unveils evolving patterns of cortical plasticity

Sam Ng et al.

Summary: The efficiency of brain reorganization after injury depends on the extent and severity of the lesion, as well as its temporal features. Diffuse low-grade gliomas (DLGG) induce compensatory changes in the brain's architecture, making them an ideal model to study neuroplasticity dynamics. By comparing cortical mappings obtained during two neurosurgeries in DLGG patients, researchers identified dynamic patterns of cortical rearrangements, particularly in regions such as the SMA, dlPFC, vPMC, and STG. These findings provide critical insight into the potential for ongoing cortical rearrangements in DLGG patients, with implications for re-operations.

BRAIN (2023)

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Article Oncology

Health-related quality of life and cognitive failures in patients with lower-grade gliomas treated with radiotherapy

Di Perri et al.

Summary: This study evaluated the health-related quality of life (HRQOL) and cognitive failures in low-grade glioma (LGG) patients who had been previously treated with radiotherapy (RT). The results showed that these patients had significant impairments in HRQOL and cognitive functioning after treatment. Further efforts are needed to improve the quality of life and cognitive outcomes of LGG patients.

CANCER RADIOTHERAPIE (2023)

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Article Clinical Neurology

Transcriptomic and connectomic correlates of differential spatial patterning among gliomas

Rafael Romero-Garcia et al.

Summary: This study investigates the spatial patterns of brain tumour occurrence and identifies the functional connectivity and transcriptomic correlates of vulnerability to low-grade glioma and glioblastoma multiforme. By combining open-access data from various sources and analyzing MRI and mRNA transcription data, the researchers reveal the associations between grade-related frequency, expression, and brain network features. These findings shed light on the mechanisms underlying brain tumour occurrence and provide insights into potential therapeutic targets.

BRAIN (2023)

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Article Multidisciplinary Sciences

Glioblastoma remodelling of human neural circuits decreases survival

Saritha Krishna et al.

Summary: This study reveals that gliomas can influence neural circuits and cognition through bidirectional interactions with neurons. Gliomas remodel functional neural circuitry and promote tumor progression while impairing cognition. The degree of functional connectivity between glioblastoma and the normal brain negatively affects patient survival and performance in language tasks.

NATURE (2023)

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Article Biochemistry & Molecular Biology

Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial

Ingo K. Mellinghoff et al.

Summary: In a pilot perioperative randomized clinical trial, the dual IDH1/IDH2 inhibitor vorasidenib was found to have better brain permeability and target engagement than ivosidenib in patients with IDH1-mutant glioma. Both agents showed significant reduction in tumor 2-HG concentrations, with vorasidenib demonstrating more consistent suppression. Exploratory analyses revealed additional positive effects of 2-HG reduction. Vorasidenib was selected for further testing in phase 3 trials. This study was funded by Agios Pharmaceuticals, Inc. and Servier Pharmaceuticals LLC.

NATURE MEDICINE (2023)

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Review Oncology

Cognitive outcomes after multimodal treatment in adult glioma patients: A meta-analysis

Laurien De Roeck et al.

Summary: In this meta-analysis, the researchers aimed to investigate the longer-term test-specific cognitive outcomes in adult glioma patients. The results showed that semantic fluency was the most sensitive test to detect cognitive decline over time. Glioma patients performed worse than controls on various cognitive tests, indicating significant cognitive impairment after treatment.

NEURO-ONCOLOGY (2023)

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Article Medicine, General & Internal

Vorasidenib in IDH1-or IDH2-Mutant Low-Grade Glioma

Ingo K. Mellinghoff et al.

Summary: In a phase 3 trial, vorasidenib showed significant improvement in progression-free survival and delay in the time to the next intervention for patients with grade 2 IDH-mutant glioma.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

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Article Clinical Neurology

Precuneal gliomas promote behaviorally relevant remodeling of the functional connectome

Sam Ng et al.

Summary: This study investigated functional connectivity changes induced by gliomas and found that patients who had connectivity changes related to preoperative state showed better maintenance of cognitive performance after surgery. These findings provide a new perspective on neural plasticity and cognitive compensation mechanisms in patients with gliomas.

JOURNAL OF NEUROSURGERY (2023)

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Article Oncology

Quality of life following awake surgery depends on ability of executive function, verbal fluency, and movement

Riho Nakajima et al.

Summary: In patients undergoing awake surgery, a subset of patients had low QOL due to poor RCS. Functional factors influencing QOL included executive function, verbal fluency, and movement.

JOURNAL OF NEURO-ONCOLOGY (2022)

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Article Oncology

Volumetric measurements are preferred in the evaluation of mutant IDH inhibition in non-enhancing diffuse gliomas: Evidence from a phase I trial of ivosidenib

Benjamin M. Ellingson et al.

Summary: In IDH-mutant low-grade gliomas, using 3D volumetric measurements is better for determining response assessment, as it provides more stable measures of tumor growth rates, highest inter-reader agreement, and lowest reader discordance rates.

NEURO-ONCOLOGY (2022)

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Article Oncology

Cognitive preservation following awake mapping-based neurosurgery for low-grade gliomas: A longitudinal, within-patient design study

Anne-Laure Lemaitre et al.

Summary: This study assessed the cognitive status of 157 DLGG patients before and after awake mapping-based surgery and found that 86% of patients showed no cognitive decline. This supports the use of awake surgery with cognitive mapping as a safe and effective approach in DLGG patients.

NEURO-ONCOLOGY (2022)

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Article Clinical Neurology

Recurrent Low-Grade Gliomas: Does Reoperation Affect Neurocognitive Functioning?

Sam Ng et al.

Summary: The study showed that reoperation with awake monitoring in RLGG patients can lead to early recovery of neurocognitive abilities, with most patients experiencing no permanent neurological deficits postoperatively. However, 6.5% of patients developed new cognitive deficits at 3 months postoperatively. Most patients achieved total/subtotal resections, indicating favorable outcomes for reoperation in RLGG patients.

NEUROSURGERY (2022)

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Article Oncology

The benefit of early surgery on overall survival in incidental low-grade glioma patients: A multicenter study

Tamara Ius et al.

Summary: Surgery for incidentally discovered diffuse low-grade gliomas can improve overall survival, with factors such as tumor volume and extent of resection playing significant roles.

NEURO-ONCOLOGY (2022)

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Article Clinical Neurology

Factors Associated With Long-term Survival in Women Who Get Pregnant After Surgery for WHO Grade II Glioma

Sam Ng et al.

Summary: Postpregnancy outcomes and predictive factors affecting overall survival in female patients who underwent GIIG surgery were investigated. Tumor residual volume and tumor speed growth were found to be strong predictive factors for postpregnancy long-term survival.

NEUROLOGY (2022)

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Article Clinical Neurology

Awake Mapping With Transopercular Approach in Right Insular-Centered Low-Grade Gliomas Improves Neurological Outcomes and Return to Work

Hugues Duffau

Summary: This study compared asleep surgery and awake surgery for right insula-centered low-grade glioma. Despite similar extent of resection, awake patients had better functional outcomes and a higher rate of return to work.

NEUROSURGERY (2022)

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Article Oncology

Constant Multi-Tasking With Time Constraint to Preserve Across-Network Dynamics Throughout Awake Surgery for Low-Grade Glioma: A Necessary Step to Enable Patients Resuming an Active Life

Hugues Duffau et al.

Summary: Awake surgery for brain gliomas improves surgical resection and reduces postoperative complications. In addition to preventing hemiparesis and aphasia, awake surgery should also consider patients' cognitive and emotional functions. By implementing more tasks and exploring inter-network communication, higher-order functions can be monitored more accurately, and the surgical onco-functional balance can be tailored based on each patient's expectations, enabling them to resume an active life.

FRONTIERS IN ONCOLOGY (2022)

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Review Biology

Current Status of Neuromodulation-Induced Cortical Prehabilitation and Considerations for Treatment Pathways in Lower-Grade Glioma Surgery

Ryan P. Hamer et al.

Summary: The infiltrative nature of supratentorial lower grade glioma makes complete surgical resection challenging. A method called Neuromodulation-Induced Cortical Prehabilitation (NICP) aims to reduce the risk of neurological complications following surgery. This review discusses current approaches using repetitive transcranial magnetic stimulation (rTMS-NICP) and extraoperative direct cortical stimulation (eDCS-NICP) to induce cortical reorganization before surgery. Preliminary findings suggest that cortical prehabilitation relating to the perisylvian cortex may be effective, but there is a need for further investigation and clarification of optimal stimulation parameters.

LIFE-BASEL (2022)

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Article Oncology

Changes in clinical management of diffuse IDH-mutated lower-grade gliomas: patterns of care in a 15-year period

Caroline Svenjeby et al.

Summary: In a Scandinavian population-based setting, treatment patterns for IDH-mutated diffuse lower-grade gliomas have changed over the past 15 years, with an increase in complete resections and a shift towards providing chemotherapy and combined chemoradiotherapy. Postoperative neurological deficits were mostly minor and transient, and there were differences in oncological therapy between the investigated subgroups, including the choice of radiotherapy modality.

JOURNAL OF NEURO-ONCOLOGY (2022)

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Article Neurosciences

Effects of Hippocampal Sparing Radiotherapy on Brain Microstructure-A Diffusion Tensor Imaging Analysis

Johannes G. Dinkel et al.

Summary: Hippocampal-sparing radiotherapy is a promising approach for alleviating cognitive side effects after cranial radiotherapy. This study used Diffusion Tensor Imaging (DTI) to examine the effects of radiation on white matter and hippocampal microstructure, and found that hippocampal microstructure differed between patients undergoing hippocampal-sparing radiotherapy and conventional cranial radiotherapy.

BRAIN SCIENCES (2022)

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Article Clinical Neurology

Regional healthy brain activity, glioma occurrence and symptomatology

Tianne Numan et al.

Summary: Gliomas occur more frequently in brain regions with higher intrinsic brain activity, and intrinsic brain activity at individual tumor locations is related to tumor biology and patients' functional status.

BRAIN (2022)

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Article Behavioral Sciences

Language reorganization in patients with left- hemispheric gliomas is associated with increased cortical volume in language-related areas and in the default mode network

Luca Pasquini et al.

Summary: The relationship between functional and structural changes in patients with brain tumors remains unclear. This study found that in patients with left frontal-insular glioma, atypical language dominance was associated with increased cortical volume in the right hemisphere. Furthermore, greater cortical volume in default mode network nodes was observed in atypical language dominant patients regardless of tumor grade.

CORTEX (2022)

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Article Oncology

Tumor BOLD connectivity profile correlates with glioma patients' survival

Giulia Sprugnoli et al.

Summary: The study demonstrates synchronized neurovascular activity between gliomas and other brain regions, with strong connectivity correlating with individual survival, potentially serving as a diagnostic and prognostic biomarker.

NEURO-ONCOLOGY ADVANCES (2022)

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Article Oncology

Time- and dose-dependent volume decreases in subcortical grey matter structures of glioma patients after radio(chemo)therapy

F. Raschke et al.

Summary: This study measured the atrophy of subcortical structures including the hippocampus, amygdala, thalamus, putamen, pallidum, and caudate nucleus in glioma patients before and after radiotherapy using MRI. The results showed significant atrophy in the hippocampus, amygdala, thalamus, putamen, and pallidum after radiotherapy, with the hippocampus having the highest atrophy rate. The findings suggest that these structures should be further investigated in relation to neurocognitive decline after radiotherapy.

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY (2022)

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Review Clinical Neurology

The need to consider return to work as a main outcome in patients undergoing surgery for diffuse low-grade glioma: a systematic review

Juan Silvestre G. Pascual et al.

Summary: Return to work (RTW) has been neglected in patients with low-grade glioma (LGG) who underwent resection. However, given the young age and longer life expectancy of these patients, postoperative RTW should be assessed more systematically. RTW could also be included as a critical endpoint for future studies on LGGs.

ACTA NEUROCHIRURGICA (2022)

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Article Clinical Neurology

Extending the multistage surgical strategy for recurrent initially low-grade gliomas: functional and oncological outcomes in 31 consecutive patients who underwent a third resection under awake mapping

Noor Hamdan et al.

Summary: This study demonstrates that in select patients with progressive DLGG, a third functional-based surgery can be achieved using awake mapping with low neurological risk and a high rate of total resection.

JOURNAL OF NEUROSURGERY (2022)

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Article Oncology

Association of supratotal resection with progression-free survival, malignant transformation, and overall survival in lower-grade gliomas

Marco Rossi et al.

Summary: The study found that supratotal resection is strongly associated with good oncological outcomes in molecularly defined lower-grade gliomas, regardless of molecular subtypes and grading.

NEURO-ONCOLOGY (2021)

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Article Clinical Neurology

Neuropsychological assessments before and after awake surgery for incidental low-grade gliomas

Sam Ng et al.

Summary: Early surgical treatment in presumed asymptomatic patients with ILGG was associated with stable or improved neuropsychological outcomes in 87.2% of patients at 3 months, with only mild cognitive decline observed in 6 patients.

JOURNAL OF NEUROSURGERY (2021)

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Article Oncology

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

Michael Weller et al.

Summary: The European Association of Neuro-Oncology (EANO) has released guidelines for the diagnosis, treatment, and follow-up of adult patients with diffuse gliomas, incorporating major changes in diagnostic algorithms based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System, as well as evidence from recent large clinical trials.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Functional alterations in cortical processing of speech in glioma-infiltrated cortex

Alexander A. Aabedi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Oncology

Longitudinal change in fine motor skills after brain radiotherapy and in vivo imaging biomarkers associated with decline

Mia Salans et al.

Summary: The study focuses on exploring the impact of brain radiotherapy on fine motor skills, indicating that higher treatment doses may result in microstructural damage in certain motor-associated brain regions, which can affect motor skill performance.

NEURO-ONCOLOGY (2021)

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Article Multidisciplinary Sciences

A vaccine targeting mutant IDH1 in newly diagnosed glioma

Michael Platten et al.

Summary: Mutated isocitrate dehydrogenase 1 (IDH1) defines a molecularly distinct subtype of diffuse glioma. The most common IDH1 mutation in gliomas affects codon 132 and encodes IDH1(R132H), which harbours a shared clonal neoepitope that is presented on major histocompatibility complex (MHC) class II. An IDH1(R132H)-specific peptide vaccine (IDH1-vac) induces specific therapeutic T helper cell responses that are effective against IDH1(R132H)+ tumours.

NATURE (2021)

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Article Oncology

Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas

Yao Yu et al.

Summary: The study found that hypermutation induced by temozolomide greatly increased the risk of high-grade disease recurrence in low-grade IDH-mutant glioma patients previously treated with TMZ, and was associated with shorter survival after transformation. Tumors with hypermutation were more likely to develop discontiguous foci of disease in the brain and spine.

NEURO-ONCOLOGY (2021)

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Article Clinical Neurology

A randomized clinical trial of plasticity-based cognitive training in mild traumatic brain injury

Henry W. Mahncke et al.

Summary: This study evaluated the efficacy of self-administered plasticity-based cognitive training for individuals with a history of mild traumatic brain injury and cognitive impairment. The treatment group showed significant improvement in cognitive function compared to the active control group, with equivalent results in depressive and cognitive symptoms between the two groups.

BRAIN (2021)

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Article Clinical Neurology

Navigated repetitive transcranial magnetic stimulation improves the outcome of postsurgical paresis in glioma patients-A randomized, double-blinded trial

Sebastian Ille et al.

Summary: This study investigated the effect of postoperative nrTMS therapy on the unaffected hemisphere in glioma patients with acute surgery-related paresis of the upper extremity. Results showed significant improvement in outcomes compared to sham stimulation, with a focus on the Fugl-Meyer Assessment scale and the National Institutes of Health Stroke Scale. The findings suggest that low-frequency nrTMS stimulation therapy is beneficial for these patients in achieving a clinically important difference in upper extremity function.

BRAIN STIMULATION (2021)

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Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Common genetic variation influencing human white matter microstructure

Bingxin Zhao et al.

Summary: The study identified common genetic variants influencing white matter microstructure and detected multiple associated loci, some of which were related to brain diseases. Additionally, genetic correlations were observed between white matter microstructure and a wide range of complex traits and diseases.

SCIENCE (2021)

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Article Oncology

Dynamic Interplay between Lower-Grade Glioma Instability and Brain Metaplasticity: Proposal of an Original Model to Guide the Therapeutic Strategy

Hugues Duffau

Summary: The behavior of lower-grade glioma (LGG) changes over time, spontaneously, and in reaction to treatments. This tumor may switch from a proliferative pattern to a more diffuse profile, and the brain adapts to the tumor and treatment, maintaining neural equilibrium.

CANCERS (2021)

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Article Oncology

Memory in low-grade glioma patients treated with radiotherapy or temozolomide: a correlative analysis of EORTC study 22033-26033

Martin Klein et al.

Summary: The study found no significant difference in memory functioning between high-risk low-grade glioma patients receiving radiotherapy and those receiving TMZ chemotherapy as primary treatment. Both treatment arms showed improvement in immediate recall and total number of words recalled in the first year, with delayed improvement in the radiotherapy group.

NEURO-ONCOLOGY (2021)

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Article Neuroimaging

Homotopic redistribution of functional connectivity in insula-centered diffuse low-grade glioma

Fabien Almairac et al.

Summary: In patients with glioma, infiltration of the insular cortex leads to significant increase in functional connectivity in the contralesional hemisphere, especially in cortical areas involved in visual and sensorimotor networks. This functional redistribution is not observed in control regions unaffected by the tumor.

NEUROIMAGE-CLINICAL (2021)

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Article Oncology

An epidemiology report for primary central nervous system tumors in adolescents and young adults: a nationwide population-based study in France, 2008-2013

Sam Ng et al.

NEURO-ONCOLOGY (2020)

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Article Neurosciences

Mapping critical cortical hubs and white matter pathways by direct electrical stimulation: an original functional atlas of the human brain

Silvio Sarubbo et al.

NEUROIMAGE (2020)

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Article Clinical Neurology

Postoperative follow-up for selected diffuse low-grade gliomas with WHO grade III/IV foci

Amelie Darlix et al.

NEUROLOGY (2020)

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Article Clinical Neurology

Return to Work Following Surgery for Incidental Diffuse Low-Grade Glioma: A Prospective Series With 74 Patients

Sam Ng et al.

NEUROSURGERY (2020)

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Review Physiology

REVISITING THE FUNCTIONAL ANATOMY OF THE HUMAN BRAIN: TOWARD A META-NETWORKING THEORY OF CEREBRAL FUNCTIONS

Guillaume Herbet et al.

PHYSIOLOGICAL REVIEWS (2020)

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Article Oncology

Cognitive Functions in Repeated Glioma Surgery

Gabriele Capo et al.

CANCERS (2020)

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Article Multidisciplinary Sciences

Mechanisms and therapeutic implications of hypermutation in gliomas

Mehdi Touat et al.

NATURE (2020)

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Article Cell Biology

Structural plasticity of the bilateral hippocampus in glioma patients

Taoyang Yuan et al.

AGING-US (2020)

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Review Oncology

Why brain radiation therapy should take account of the individual structural and functional connectivity: Toward an irradiation a la carte

Hugues Duffau

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

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Article Oncology

Impact of repeated operations for progressive low-grade gliomas

Ben Shofty et al.

EJSO (2020)

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Article Clinical Neurology

Return to work following diagnosis of low-grade glioma A nationwide matched cohort study

Isabelle Ryden et al.

NEUROLOGY (2020)

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Article Clinical Neurology

The economic impact of glioma survivorship The cost of care from a patient perspective

Sameah A. Haider et al.

NEUROLOGY (2020)

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Article Oncology

Adult Diffuse Low-Grade Gliomas: 35-Year Experience at the Nancy France Neurooncology Unit

Tiphaine Obara et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Clinical Neurology

Iterative Surgical Resections of Diffuse Glioma With Awake Mapping: How to Deal With Cortical Plasticity and Connectomal Constraints?

Thiebaud Picart et al.

NEUROSURGERY (2019)

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Article Clinical Neurology

Perioperative outcomes following reoperation for recurrent insular gliomas

Ramin A. Morshed et al.

JOURNAL OF NEUROSURGERY (2019)

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Article Multidisciplinary Sciences

Electrical and synaptic integration of glioma into neural circuits

Humsa S. Venkatesh et al.

NATURE (2019)

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Article Multidisciplinary Sciences

Glutamatergic synaptic input to glioma cells drives brain tumour progression

Varun Venkataramani et al.

NATURE (2019)

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Article Oncology

Evaluation of the Hippocampal Normal Tissue Complication Model in a Prospective Cohort of Low Grade Glioma Patients-An Analysis Within the EORTC 22033 Clinical Trial

Jaap Jaspers et al.

FRONTIERS IN ONCOLOGY (2019)

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Editorial Material Oncology

On high-risk, low-grade glioma: What distinguishes high from low?

Marjolein Geurts et al.

CANCER (2019)

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Article Neurosciences

Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop

Jun Wang et al.

NATURE NEUROSCIENCE (2019)

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Article Clinical Neurology

Chemotherapy and diffuse low-grade gliomas: a survey within the European Low-Grade Glioma Network

Amelie Darlix et al.

NEURO-ONCOLOGY PRACTICE (2019)

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Article Neurosciences

Radiation-induced brain structural and functional abnormalities in presymptomatic phase and outcome prediction

Zhongxiang Ding et al.

HUMAN BRAIN MAPPING (2018)

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Article Oncology

The impact of surgery in molecularly defined low-grade glioma: an integrated clinical, radiological, and molecular analysis

Maarten M. J. Wijnenga et al.

NEURO-ONCOLOGY (2018)

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Article Clinical Neurology

The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033

Pierre Bady et al.

ACTA NEUROPATHOLOGICA (2018)

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Review Clinical Neurology

Analysis of Legal, Cultural, and Socioeconomic Parameters in Low-Grade Glioma Management: Variability Across Countries and Implications for Awake Surgery

Clarissa Vanacor et al.

WORLD NEUROSURGERY (2018)

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Article Clinical Neurology

Contralesional macrostructural plasticity of the insular cortex in patients with glioma A VBM study

Fabien Almairac et al.

NEUROLOGY (2018)

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Article Oncology

Epidemiology for primary brain tumors: a nationwide population-based study

Amelie Darlix et al.

JOURNAL OF NEURO-ONCOLOGY (2017)

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Article Multidisciplinary Sciences

Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1

Tali Mazor et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Oncology

Regional susceptibility to dose-dependent white matter damage after brain radiotherapy

Michael Connor et al.

RADIOTHERAPY AND ONCOLOGY (2017)

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Article Oncology

Surgical resection versus watchful waiting in low-grade gliomas

A. S. Jakola et al.

ANNALS OF ONCOLOGY (2017)

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Article Clinical Neurology

Patients with incidental WHO grade II glioma frequently suffer from neuropsychological disturbances

Jerome Cochereau et al.

ACTA NEUROCHIRURGICA (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of low-grade glioma structural changes after chemotherapy using DTI-based histogram analysis and functional diffusion maps

Antonella Castellano et al.

EUROPEAN RADIOLOGY (2016)

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Article Clinical Neurology

Mapping neuroplastic potential in brain-damaged patients

Guillaume Herbet et al.

BRAIN (2016)

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Article Biochemistry & Molecular Biology

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

Michele Ceccarelli et al.

CELL (2016)

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Article Oncology

Effect of the Maximum Dose on White Matter Fiber Bundles Using Longitudinal Diffusion Tensor Imaging

Tong Zhu et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2016)

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Article Clinical Neurology

Intraoperative mapping during repeat awake craniotomy reveals the functional plasticity of adult cortex

Derek G. Southwell et al.

JOURNAL OF NEUROSURGERY (2016)

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Article Oncology

Health-related quality of life in patients with high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

Jaap C. Reijneveld et al.

LANCET ONCOLOGY (2016)

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Article Oncology

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

Brigitta G. Baumert et al.

LANCET ONCOLOGY (2016)

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Article Medicine, General & Internal

Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma

Jan C. Buckner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Oncology

Dosimetric advantages of proton therapy over conventional radiotherapy with photons in young patients and adults with low-grade glioma

S. B. M. D. Harrabi et al.

STRAHLENTHERAPIE UND ONKOLOGIE (2016)

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Review Oncology

Treatment Strategies for Low-Grade Glioma in Adults

Nancy Ann Oberheim Bush et al.

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