☆ 4.6 Review

Modelling the Tumour Microenvironment, but What Exactly Do We Mean by Model?

CANCERS (2023)

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Summary: In this opinion, the significance of agent-based modeling in exploring cell-cell and cell-environment interactions related to cancer progression, therapeutic resistance, and metastasis is emphasized. These modeling approaches, which enable cell-scale resolution, complement experimental work and contribute to driving new experiments by generating predictions.

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Summary: Solid tumors consist of tumor cells associated with stromal and immune cells, secreted factors and extracellular matrix (ECM), which together constitute the tumor microenvironment. Cancer-associated fibroblasts (CAFs) secrete a variety of ECM components including collagen and modulate the architecture of the ECM, thereby influencing cancer cell migration. Investigating the characteristics and modifications of the collagen fiber network is crucial for understanding cell-ECM interactions.

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Summary: Organ-on-a-chip models, or organ chips, are tiny devices that accurately recreate the physiological and mechanical forces experienced by cells in the human body. These chips, lined with living human cells, can reproduce blood and airflow, and simulate breathing motions and muscle contractions. They offer a unique opportunity to build models of human organs and study cancer development and spread. They are simpler and cheaper than animal models, and could speed up drug discovery and testing in cancer research. The UK is actively researching organ chip technology for various cancer types.

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Weiren Luo

Summary: This review outlines the ecological nature of nasopharyngeal carcinoma (NPC) and its progression, proposing that NPC is an ecological disease rather than a genetic one. NPC is characterized as an invasive species with multidirectional ecological dispersal. The tumor-host interface is seen as an ecological transition zone, and tumor buddings are considered ecological islands. The importance of understanding cancer ecology and its potential applications in prevention and therapy are emphasized.

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A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma

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Investigation of cancer response to chemotherapy: a hybrid multi-scale mathematical and computational model of the tumor microenvironment

Mohammad R. Nikmaneshi et al.

Summary: Tumor microenvironment (TME) is a complex biological environment that plays a crucial role in tumor dynamics. In this study, a hybrid multi-scale mathematical model of TME was developed to simulate tumor progression and response to different chemotherapy approaches. The results showed that combination therapy of anti-angiogenic drug and anti-cancer drug improved treatment performance and reduced side effects. The model also suggested that lower dose chemotherapy over a long period could effectively treat cancer with fewer side effects.

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A theoretical analysis of the scale separation in a model to predict solid tumour growth

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Summary: This article discusses the factors affecting solid tumor growth and the importance of constructing personalized mathematical models. In order to address the wide range of scales in solid tumors, a multiscale model is proposed, which separates scales based on experimental and computational limitations.

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Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a murine model of perimenopausal depression

Guangda Yao et al.

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An in silico Model of T Cell Infiltration Dynamics Based on an Advanced in vitro System to Enhance Preclinical Decision Making in Cancer Immunotherapy

Thomas D. Lewin et al.

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Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model

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3D cell cultures, as a surrogate for animal models, enhance the diagnostic value of preclinical in vitro investigations by adding information on the tumour microenvironment: a comparative study of new dual-mode HDAC inhibitors

Sofia I. Baer et al.

Summary: Anchorage-independent 3D cultures of multicellular tumour spheroids (MCTS) and in vitro microtumours can provide valuable information on the effects of anticancer drug candidates. This study compared the effects of two new dual-mode anticancer agents with their monomodal congeners using MCTS and in vitro microtumours. The results showed significant reductions in size, induction of apoptosis, and elevated levels of reactive oxygen species in response to the new investigational compounds. The use of 3D cultures and bioreactors allows for earlier study of the communication between tumour cells and their microenvironment.

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Potential of Gold Nanoparticles in Current Radiotherapy Using a Co-Culture Model of Cancer Cells and Cancer Associated Fibroblasts

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CANCERS (2022)

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Riccardo Rizzo et al.

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Summary: Primary liver cancer, including hepatocellular carcinoma and cholangiocarcinoma, is a common and major cause of cancer-related mortality worldwide. Despite advancements in immunotherapies, survival rates for liver cancer remain poor, with limited responses to certain treatments.

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Three-dimensional models to study breast cancer (Review)

Maira Huerta-Reyes et al.

Summary: Breast cancer is the most common cancer in women globally, with research focused on in vitro and in vivo models. Three-dimensional in vitro models have been developed to better replicate interactions between tumor cells and the tumor environment observed in vivo. These models offer advantages in studying breast cancer physiology.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

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CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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E. Elizabeth Patton et al.

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CANCER CELL (2021)

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BIOMED RESEARCH INTERNATIONAL (2021)

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Organoid and Spheroid Tumor Models: Techniques and Applications

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GENOME MEDICINE (2021)

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EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment

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PROCESSES (2019)

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Review Immunology

Emerging Mechanisms of Insulin-Mediated Antiviral Immunity in Drosophila melanogaster

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FRONTIERS IN IMMUNOLOGY (2019)

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Nanoparticles' interactions with vasculature in diseases

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CHEMICAL SOCIETY REVIEWS (2019)

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Role of Microenvironment in Glioma Invasion: What We Learned from In Vitro Models

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Pathology

Using deep convolutional neural networks to identify and classify tumor-associated stroma in diagnostic breast biopsies

Babak Ehteshami Bejnordi et al.

MODERN PATHOLOGY (2018)

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Role of Extracellular Matrix in Development and Cancer Progression

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail

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JOURNAL OF TRANSLATIONAL MEDICINE (2018)

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Review Oncology

A history of exploring cancer in context

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NATURE REVIEWS CANCER (2018)

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Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

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GUT (2017)

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Article Oncology

The prognostic benefit of tumour-infiltrating Natural Killer cells in endometrial cancer is dependent on concurrent overexpression of Human Leucocyte Antigen-E in the tumour microenvironment

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EUROPEAN JOURNAL OF CANCER (2017)

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Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

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JOURNAL OF CELL BIOLOGY (2017)

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Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

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Addressing current challenges in cancer immunotherapy with mathematical and computational modelling

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JOURNAL OF THE ROYAL SOCIETY INTERFACE (2017)

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MEDICAL PHYSICS (2017)

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The proportion of cancer-related entries in PubMed has increased considerably; is cancer truly The Emperor of All Maladies?

Constantino Carlos Reyes-Aldasoro

PLOS ONE (2017)

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In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles

Altug Ozcelikkale et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2017)

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BIOMED RESEARCH INTERNATIONAL (2017)

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Automated quantification of steatosis: agreement with stereological point counting

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DIAGNOSTIC PATHOLOGY (2017)

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BIO-PROTOCOL (2017)

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COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2017)

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COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2017)

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COMMUNICATIONS OF THE ACM (2017)

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BULLETIN OF MATHEMATICAL BIOLOGY (2017)

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BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2016)

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A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer

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Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment

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NATURE COMMUNICATIONS (2016)

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Spatial Heterogeneity in the Tumor Microenvironment

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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

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Evolutionary Ecology of Organs: A Missing Link in Cancer Development?

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TRENDS IN CANCER (2016)

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NATURE (2015)

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Bridging scales in cancer progression: Mapping genotype to phenotype using neural networks

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SEMINARS IN CANCER BIOLOGY (2015)

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Systems oncology: Towards patient-specific treatment regimes informed by multiscale mathematical modelling

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SEMINARS IN CANCER BIOLOGY (2015)

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Simulating cancer growth with multiscale agent-based modeling

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ELIFE (2015)

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The mathematics of cancer: integrating quantitative models

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ELIFE (2015)

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In vitro modeling of the prostate cancer microenvironment

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An Integrated Computational Model of the Bone Microenvironment in Bone-Metastatic Prostate Cancer

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CANCER RESEARCH (2014)

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Suitable drug combination with bortezomib for multiple myeloma under stroma-free conditions and in contact with fibronectin or bone marrow stromal cells

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INTERNATIONAL JOURNAL OF HEMATOLOGY (2014)

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Biomimetic Urothelial Tissue Models for the in Vitro Evaluation of Barrier Physiology and Bladder Drug Efficacy

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Tumour Cells Expressing Single VEGF Isoforms Display Distinct Growth, Survival and Migration Characteristics

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Genomic responses in mouse models poorly mimic human inflammatory diseases

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Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells

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Vascular effects dominate solid tumor response to treatment with combretastatin A-4-phosphate

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Exact solution of a two-type branching process: models of tumor progression

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Application of intravital microscopy in studies of tumor microcirculation

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Accumulation of driver and passenger mutations during tumor progression

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Can Animal Models of Disease Reliably Inform Human Studies?

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PLOS MEDICINE (2010)

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Dissecting cancer through mathematics: from the cell to the animal model

Helen M. Byrne

NATURE REVIEWS CANCER (2010)

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Article Biochemical Research Methods

The virtual cell-a candidate co-ordinator for 'middle-out' modelling of biological systems

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BRIEFINGS IN BIOINFORMATICS (2009)

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Modelling tissues in 3D: the next future of pharmaco-toxicology and food research?

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GENES AND NUTRITION (2009)

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Microvessel area using automated image analysis is reproducible and is associated with prognosis in breast cancer

C. A. W. Sullivan et al.

HUMAN PATHOLOGY (2009)

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Multi-scale modelling of cancer cell intravasation: the role of cadherins in metastasis

Ignacio Ramis-Conde et al.

PHYSICAL BIOLOGY (2009)

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Measuring the velocity of fluorescently labelled red blood cells with a keyhole tracking algorithm

C. C. Reyes-Aldasoro et al.

JOURNAL OF MICROSCOPY (2008)

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Estimation of apparent tumor vascular permeability from multiphoton fluorescence microscopic images of P22 rat sarcomas in vivo

Constantino Carlos Reyes-Aldasoro et al.

MICROCIRCULATION (2008)

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Alexander R. A. Anderson et al.

NATURE REVIEWS CANCER (2008)

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A mathematical model of breast cancer development, local treatment and recurrence

Heiko Enderling et al.

JOURNAL OF THEORETICAL BIOLOGY (2007)

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An integrated agent-mathematical model of the effect of intercellular signalling via the epidermal growth factor receptor on cell proliferation

Dawn Walker et al.

JOURNAL OF THEORETICAL BIOLOGY (2006)

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Review Oncology

Experimental models of human bladder carcinogenesis

RA Crallan et al.

CARCINOGENESIS (2006)

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Review Oncology

Mouse models of breast cancer metastasis

Anna Fantozzi et al.

BREAST CANCER RESEARCH (2006)

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A model for human ventricular tissue

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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)

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Mathematical modelling of the use of macrophages as vehicles for drug delivery to hypoxic tumour sites

MR Owen et al.

JOURNAL OF THEORETICAL BIOLOGY (2004)

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Review Immunology

Mathematical and computational models of immune-receptor signalling

B Goldstein et al.

NATURE REVIEWS IMMUNOLOGY (2004)

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A microscale model for prediction of breast cancer cell damage during cryosurgery

AL Zhang et al.

CRYOBIOLOGY (2003)

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Survival Analysis Part II: Multivariate data analysis - an introduction to concepts and methods

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Survival analysis part I: Basic concepts and first analyses

TG Clark et al.

BRITISH JOURNAL OF CANCER (2003)

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Review Multidisciplinary Sciences

Modeling the heart - from genes to cells to the whole organ

D Noble

SCIENCE (2002)

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