期刊
CANCERS
卷 15, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/cancers15194783
关键词
etoposide; plerixafor; mobilization; multiple myeloma
类别
This study compared the mobilization effects and safety of single-dose etoposide plus G-CSF versus G-CSF alone with risk-adapted plerixafor in MM patients. The findings showed that the etoposide group had a higher count of CD34+ cells collected, but there was no significant difference in the optimal collection rate between the two groups. The etoposide group had higher rates of thrombocytopenia and nausea, but overall adverse events were low in both groups.
To explore the optimal mobilization for multiple myeloma (MM) patients, we conducted a prospective trial comparing single-dose etoposide (375 mg/m2 for one day) plus G-CSF versus G-CSF alone, followed by risk-adapted plerixafor. After randomization, 27 patients in the etoposide group and 29 patients in the G-CSF alone group received mobilizations. Six (22.2%) patients in the etoposide group and 15 (51.7%) patients in the G-CSF alone group received plerixafor based on a peripheral blood CD34+ cell count of < 15/mm(3) (p = 0.045). The median count of CD34+ cells collected was significantly higher in the etoposide group (9.5 x 106/kg vs. 7.9 x 106/kg; p = 0.018), but the optimal collection rate (CD34+ cells >= 6 x 106/kg) was not significantly different between the two groups (96.3% vs. 82.8%; p = 0.195). The rate of CD34+ cells collected of >= 8.0 x 106/kg was significantly higher in the etoposide group (77.8% vs. 44.8%; p = 0.025). Although the rates of grade II-IV thrombocytopenia (63.0% vs. 31.0%; p = 0.031) and grade I-IV nausea (14.8% vs. 0%; p = 0.048) were significantly higher in the etoposide group, the rates of adverse events were low in both groups, with no neutropenic fever or septic shock. Thus, both single-dose etoposide plus G-CSF and G-CSF alone with risk-adapted plerixafor were effective and safe, but the former may be the better option for patients who are expected to receive two or more transplantations.
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